Publications by authors named "Marc Bigaud"

22Publications

Discovery of Potent, Highly Selective, and Efficacious, Allosteric MALT1 Inhibitors by Iterative Scaffold Morphing.

J Med Chem 2020 12 30;63(23):14576-14593. Epub 2020 Nov 30.

Novartis Institutes for BioMedical Research, Novartis Campus, CH-4002 Basel, Switzerland.

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December 2020

Optimization of the Potency of Pyrazolopyrimidine MALT1 Protease Inhibitors by Reducing Metabolism and Increasing Potency in Whole Blood.

J Med Chem 2020 12 20;63(23):14594-14608. Epub 2020 Nov 20.

Novartis Pharma AG, Novartis Institutes for BioMedical Research, Novartis Campus, CH-4056 Basel, Switzerland.

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December 2020

Pharmacological Inhibition of MALT1 Protease Leads to a Progressive IPEX-Like Pathology.

Front Immunol 2020 30;11:745. Epub 2020 Apr 30.

Autoimmunity, Transplantation and Inflammation, Novartis Institutes for Biomedical Research, Basel, Switzerland.

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April 2020

Requirement of Mucosa-Associated Lymphoid Tissue Lymphoma Translocation Protein 1 Protease Activity for Fcγ Receptor-Induced Arthritis, but Not Fcγ Receptor-Mediated Platelet Elimination, in Mice.

Arthritis Rheumatol 2020 06 26;72(6):919-930. Epub 2020 Apr 26.

Novartis Institutes for BioMedical Research, Basel, Switzerland.

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June 2020

Malt1 Protease Deficiency in Mice Disrupts Immune Homeostasis at Environmental Barriers and Drives Systemic T Cell-Mediated Autoimmunity.

Authors:

Kea Martin Ratiba Touil Yeter Kolb Grozdan Cvijetic Kiichi Murakami Laura Israel Fernanda Duraes David Buffet Anton Glück Satoru Niwa Marc Bigaud Tobias Junt Natasa Zamurovic Philip Smith Kathy D McCoy Pamela S Ohashi Frédéric Bornancin Thomas Calzascia

J Immunol 2019 12 28;203(11):2791-2806. Epub 2019 Oct 28.

Novartis Institutes for BioMedical Research, Novartis Pharma AG, 4002 Basel, Switzerland;

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December 2019

Blockade of CD40-CD154 pathway interactions suppresses ectopic lymphoid structures and inhibits pathology in the NOD/ShiLtJ mouse model of Sjögren's syndrome.

Authors:

Grazyna Wieczorek Marc Bigaud Sabina Pfister Melanie Ceci Katriona McMichael Catherine Afatsawo Meike Hamburger Celine Texier Maurane Henry Celine Cojean Marinette Erard Nadja Mamber James S Rush

Ann Rheum Dis 2019 07 22;78(7):974-978. Epub 2019 Mar 22.

Department of Autoimmunity, Transplantation and Inflammation, Novartis Institutes for BioMedical Research Basel, Basel, Switzerland

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July 2019

Utility of food pellets containing 1-aminobenzotriazole for longer term in vivo inhibition of cytochrome P450 in mice.

Authors:

Rowan Stringer Valerie Cordier Catherine Afatsawo Philip Arabin Sandrine Desrayaud Laurent Hoffmann Daniel Lehmann Philip John Lowe Francis Risser Julia Thiel Toni Widmer Peter Wipfli Marc Bigaud

Xenobiotica 2019 Jan 29;49(1):13-21. Epub 2018 Jan 29.

a Novartis Institutes for BioMedical Research , Basel , Switzerland.

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January 2019

Pathophysiological Consequences of a Break in S1P1-Dependent Homeostasis of Vascular Permeability Revealed by S1P1 Competitive Antagonism.

Authors:

Marc Bigaud Zuhal Dincer Birgit Bollbuck Janet Dawson Nicolau Beckmann Christian Beerli Gina Fishli-Cavelti Michaela Nahler Daniela Angst Philipp Janser Heike Otto Elisabeth Rosner Rene Hersperger Christian Bruns Jean Quancard

PLoS One 2016 22;11(12):e0168252. Epub 2016 Dec 22.

Novartis Institutes for Biomedical Research, Autoimmunity, Transplantation and Inflammation, Basel, Switzerland.

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July 2017

Deficiency of MALT1 paracaspase activity results in unbalanced regulatory and effector T and B cell responses leading to multiorgan inflammation.

J Immunol 2015 Apr 11;194(8):3723-34. Epub 2015 Mar 11.

Novartis Institutes for BioMedical Research, Novartis Pharma AG, 4056 Basel, Switzerland;

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April 2015

Gene expression profiling of immunomagnetically separated cells directly from stabilized whole blood for multicenter clinical trials.

Authors:

Martin Letzkus Evert Luesink Sandrine Starck-Schwertz Marc Bigaud Fareed Mirza Nicole Hartmann Bernhard Gerstmayer Uwe Janssen Andreas Scherer Martin M Schumacher Aurelie Verles Alessandra Vitaliti Nanguneri Nirmala Keith J Johnson Frank Staedtler

Clin Transl Med 2014 13;3:36. Epub 2014 Nov 13.

Biomarker Development, Novartis Institutes for BioMedical Research (NIBR), Basel, Switzerland.

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May 2015

Second generation S1P pathway modulators: research strategies and clinical developments.

Authors:

Marc Bigaud Danilo Guerini Andreas Billich Frederic Bassilana Volker Brinkmann

Biochim Biophys Acta 2014 May 12;1841(5):745-58. Epub 2013 Nov 12.

Novartis Institutes for Biomedical Research, CH-4056 Basel, Switzerland. Electronic address:

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May 2014

Partial deficiency of sphingosine-1-phosphate lyase confers protection in experimental autoimmune encephalomyelitis.

Authors:

Andreas Billich Thomas Baumruker Christian Beerli Marc Bigaud Christian Bruns Thomas Calzascia Andrea Isken Bernd Kinzel Erika Loetscher Barbara Metzler Matthias Mueller Barbara Nuesslein-Hildesheim Bernadette Kleylein-Sohn

PLoS One 2013 27;8(3):e59630. Epub 2013 Mar 27.

Novartis Institutes for BioMedical Research, Basel, Switzerland.

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September 2013

A potent and selective S1P(1) antagonist with efficacy in experimental autoimmune encephalomyelitis.

Authors:

Jean Quancard Birgit Bollbuck Philipp Janser Daniela Angst Frédéric Berst Peter Buehlmayer Markus Streiff Christian Beerli Volker Brinkmann Danilo Guerini Paul A Smith Timothy J Seabrook Martin Traebert Klaus Seuwen René Hersperger Christian Bruns Frédéric Bassilana Marc Bigaud

Chem Biol 2012 Sep;19(9):1142-51

Novartis Institutes for Biomedical Research, CH-4056 Basel, Switzerland.

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September 2012

Sotrastaurin (AEB071) alone and in combination with cyclosporine A prolongs survival times of non-human primate recipients of life-supporting kidney allografts.

Authors:

Marc Bigaud Grazyna Wieczorek Christian Beerli Maxime Audet Antoine Blancher Christoph Heusser Randall E Morris Jürgen Wagner

Transplantation 2012 Jan;93(2):156-64

Novartis Institutes for Biomedical Research, Novartis Pharma AG, Basel, Switzerland.

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January 2012

BZM055, an iodinated radiotracer candidate for PET and SPECT imaging of myelin and FTY720 brain distribution.

Authors:

Emmanuelle Briard David Orain Christian Beerli Andreas Billich Markus Streiff Marc Bigaud Yves P Auberson

ChemMedChem 2011 Apr 30;6(4):667-77. Epub 2011 Jan 30.

Novartis Institutes for BioMedical Research, Basel, Global Discovery Chemistry, Neurosciences and Molecular Imaging, Postfach, 4002 Basel, Switzerland.

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April 2011

Analysis of independent microarray datasets of renal biopsies identifies a robust transcript signature of acute allograft rejection.

Authors:

Pierre Saint-Mezard Céline C Berthier Hai Zhang Alexandre Hertig Sergio Kaiser Martin Schumacher Grazyna Wieczorek Marc Bigaud Jeanne Kehren Eric Rondeau Friedrich Raulf Hans-Peter Marti

Transpl Int 2009 Mar 6;22(3):293-302. Epub 2008 Nov 6.

Novartis Institutes for BioMedical Research, Basel, Switzerland.

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March 2009

Reduced cardiac side-effect potential by introduction of polar groups: discovery of NIBR-1282, an orally bioavailable CCR5 antagonist which is active in vivo.

Authors:

Gebhard Thoma Christian Beerli Marc Bigaud Christian Bruns Nigel G Cooke Markus B Streiff Hans-Guenter Zerwes

Bioorg Med Chem Lett 2008 Mar 2;18(6):2000-5. Epub 2008 Feb 2.

Novartis Institutes for BioMedical Research, Forum 1, Novartis Campus, CH-4002 Basel, Switzerland.

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March 2008

Study of Cynomolgus monkey (Macaca fascicularis) MhcDRB (Mafa-DRB) polymorphism in two populations.

Authors:

Antoine Blancher Pierre Tisseyre Marianne Dutaur Pol-André Apoil Claudine Maurer Valérie Quesniaux Friedrich Raulf Marc Bigaud Michel Abbal

Immunogenetics 2006 May 30;58(4):269-82. Epub 2006 Mar 30.

Laboratoire d'Immunogenetique moleculaire, Universite Paul Sabatier, Faculte de Medecine de Rangueil, Batiment A2, 133, Route de Narbonne, 31062, Toulouse cedex 4, France.

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May 2006

Combinations of anti-LFA-1, everolimus, anti-CD40 ligand, and allogeneic bone marrow induce central transplantation tolerance through hemopoietic chimerism, including protection from chronic heart allograft rejection.

Authors:

Barbara Metzler Patrick Gfeller Marc Bigaud Jianping Li Grazyna Wieczorek Christoph Heusser Philip Lake Andreas Katopodis

J Immunol 2004 Dec;173(11):7025-36

Autoimmunity and Transplantation, Novartis Institutes for Biomedical Research, Basel, Switzerland.

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December 2004

A simple method to optimize peripheral blood mononuclear cell preparation from cynomolgus monkeys and improve mixed lymphocyte reactions.

Authors:

Marc Bigaud Claudine Maurer Corrine Vedrine Bénédicte Puissant Antoine Blancher

J Pharmacol Toxicol Methods 2004 Sep-Oct;50(2):153-9

Novartis Pharma AG, Transplantation Research, WSJ-386 1.55A, CH-4002 Basel, Switzerland.

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March 2005

Efficacy and safety of ABI793, a novel human anti-human CD154 monoclonal antibody, in cynomolgus monkey renal allotransplantation.

Authors:

Walter Schuler Marc Bigaud Volker Brinkmann Franco Di Padova Sabine Geisse Hermann Gram Valerie Hungerford Beate Kleuser Colette Kristofic Klaus Menninger Reet Tees Grazyna Wieczorek Corinne Wilt Catherine Wioland Mauro Zurini

Transplantation 2004 Mar;77(5):717-26

Novartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland.

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March 2004

Transplantation-induced functional/morphological changes in rat aorta allografts differ from those in arteries of rat kidney allografts.

Authors:

Emile Andriambeloson Catherine Cannet Charles Pally Bernd Klanke Christian Bruns Hans-Günter Zerwes Marc Bigaud

Am J Transplant 2004 Feb;4(2):188-95

Novartis Pharma AG, Transplantation Research Global Business Unit, Basel, Switzerland.

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February 2004