Marc A Seelen

Marc A Seelen

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Marc A Seelen

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Complement Activation in Inflammatory Skin Diseases.

Front Immunol 2018 16;9:639. Epub 2018 Apr 16.

Department of Pathology, Erasmus Medical Center Rotterdam, Rotterdam, Netherlands.

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http://dx.doi.org/10.3389/fimmu.2018.00639DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5911619PMC
June 2019

Complement Activation in Autoimmune Bullous Dermatoses: A Comprehensive Review.

Front Immunol 2019 26;10:1477. Epub 2019 Jun 26.

Department of Pathology, Erasmus Medical Center Rotterdam, Rotterdam, Netherlands.

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http://dx.doi.org/10.3389/fimmu.2019.01477DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6606728PMC
June 2019

The Complement System in Dialysis: A Forgotten Story?

Front Immunol 2018 25;9:71. Epub 2018 Jan 25.

Department of Internal Medicine, Division of Nephrology, University Medical Center Groningen, Groningen, Netherlands.

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http://dx.doi.org/10.3389/fimmu.2018.00071DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5788899PMC
February 2019

Complement Therapeutics in the Multi-Organ Donor: Do or Don't?

Front Immunol 2019 27;10:329. Epub 2019 Feb 27.

Division of Nephrology, Department of Internal Medicine, University Medical Center Groningen, Groningen, Netherlands.

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http://dx.doi.org/10.3389/fimmu.2019.00329DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6400964PMC
February 2019

Taming hemodialysis-induced inflammation: Are complement C3 inhibitors a viable option?

Clin Immunol 2019 Jan 22;198:102-105. Epub 2018 Nov 22.

Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, USA. Electronic address:

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http://dx.doi.org/10.1016/j.clim.2018.11.010DOI Listing
January 2019

The lectin pathway in renal disease: old concept and new insights.

Nephrol Dial Transplant 2018 12;33(12):2073-2079

Department of Internal Medicine, Division of Nephrology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

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http://dx.doi.org/10.1093/ndt/gfy073DOI Listing
December 2018

Age and Sex-Associated Changes of Complement Activity and Complement Levels in a Healthy Caucasian Population.

Front Immunol 2018 20;9:2664. Epub 2018 Nov 20.

Division of Nephrology, Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.

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http://dx.doi.org/10.3389/fimmu.2018.02664DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6255829PMC
November 2018

Intradialytic Complement Activation Precedes the Development of Cardiovascular Events in Hemodialysis Patients.

Front Immunol 2018 13;9:2070. Epub 2018 Sep 13.

Division of Nephrology, Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.

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http://dx.doi.org/10.3389/fimmu.2018.02070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6146103PMC
September 2018

Distinct in vitro Complement Activation by Various Intravenous Iron Preparations.

Am J Nephrol 2017 26;45(1):49-59. Epub 2016 Nov 26.

Department of Internal Medicine, Division of Nephrology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

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http://dx.doi.org/10.1159/000451060DOI Listing
January 2018

C1-Inhibitor Treatment Decreases Renal Injury in an Established Brain-Dead Rat Model.

Transplantation 2018 01;102(1):79-87

Department of Pathology, Academic Medical Centre Amsterdam, University of Amsterdam, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1097/TP.0000000000001895DOI Listing
January 2018

Murine Precision-Cut Kidney Slices as an Model to Evaluate the Role of Transforming Growth Factor-β1 Signaling in the Onset of Renal Fibrosis.

Front Physiol 2017 12;8:1026. Epub 2017 Dec 12.

Department of Pharmaceutical Technology and Biopharmacy, Groningen Research Institute of Pharmacy, University of Groningen, Groningen, Netherlands.

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http://dx.doi.org/10.3389/fphys.2017.01026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5732966PMC
December 2017

Complement in renal transplantation: The road to translation.

Mol Immunol 2017 09 27;89:22-35. Epub 2017 May 27.

Department of Internal Medicine, Division of Nephrology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

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http://dx.doi.org/10.1016/j.molimm.2017.05.014DOI Listing
September 2017

Critical role for complement receptor C5aR2 in the pathogenesis of renal ischemia-reperfusion injury.

FASEB J 2017 07 10;31(7):3193-3204. Epub 2017 Apr 10.

Division of Nephrology, Department of Internal Medicine, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands;

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http://dx.doi.org/10.1096/fj.201601218RDOI Listing
July 2017

Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney.

Authors:
Louise V Wain Ahmad Vaez Rick Jansen Roby Joehanes Peter J van der Most A Mesut Erzurumluoglu Paul F O'Reilly Claudia P Cabrera Helen R Warren Lynda M Rose Germaine C Verwoert Jouke-Jan Hottenga Rona J Strawbridge Tonu Esko Dan E Arking Shih-Jen Hwang Xiuqing Guo Zoltan Kutalik Stella Trompet Nick Shrine Alexander Teumer Janina S Ried Joshua C Bis Albert V Smith Najaf Amin Ilja M Nolte Leo-Pekka Lyytikäinen Anubha Mahajan Nicholas J Wareham Edith Hofer Peter K Joshi Kati Kristiansson Michela Traglia Aki S Havulinna Anuj Goel Mike A Nalls Siim Sõber Dragana Vuckovic Jian'an Luan Fabiola Del Greco M Kristin L Ayers Jaume Marrugat Daniela Ruggiero Lorna M Lopez Teemu Niiranen Stefan Enroth Anne U Jackson Christopher P Nelson Jennifer E Huffman Weihua Zhang Jonathan Marten Ilaria Gandin Sarah E Harris Tatijana Zemunik Yingchang Lu Evangelos Evangelou Nabi Shah Martin H de Borst Massimo Mangino Bram P Prins Archie Campbell Ruifang Li-Gao Ganesh Chauhan Christopher Oldmeadow Gonçalo Abecasis Maryam Abedi Caterina M Barbieri Michael R Barnes Chiara Batini John Beilby Tineka Blake Michael Boehnke Erwin P Bottinger Peter S Braund Morris Brown Marco Brumat Harry Campbell John C Chambers Massimiliano Cocca Francis Collins John Connell Heather J Cordell Jeffrey J Damman Gail Davies Eco J de Geus Renée de Mutsert Joris Deelen Yusuf Demirkale Alex S F Doney Marcus Dörr Martin Farrall Teresa Ferreira Mattias Frånberg He Gao Vilmantas Giedraitis Christian Gieger Franco Giulianini Alan J Gow Anders Hamsten Tamara B Harris Albert Hofman Elizabeth G Holliday Jennie Hui Marjo-Riitta Jarvelin Åsa Johansson Andrew D Johnson Pekka Jousilahti Antti Jula Mika Kähönen Sekar Kathiresan Kay-Tee Khaw Ivana Kolcic Seppo Koskinen Claudia Langenberg Marty Larson Lenore J Launer Benjamin Lehne David C M Liewald Li Lin Lars Lind François Mach Chrysovalanto Mamasoula Cristina Menni Borbala Mifsud Yuri Milaneschi Anna Morgan Andrew D Morris Alanna C Morrison Peter J Munson Priyanka Nandakumar Quang Tri Nguyen Teresa Nutile Albertine J Oldehinkel Ben A Oostra Elin Org Sandosh Padmanabhan Aarno Palotie Guillaume Paré Alison Pattie Brenda W J H Penninx Neil Poulter Peter P Pramstaller Olli T Raitakari Meixia Ren Kenneth Rice Paul M Ridker Harriëtte Riese Samuli Ripatti Antonietta Robino Jerome I Rotter Igor Rudan Yasaman Saba Aude Saint Pierre Cinzia F Sala Antti-Pekka Sarin Reinhold Schmidt Rodney Scott Marc A Seelen Denis C Shields David Siscovick Rossella Sorice Alice Stanton David J Stott Johan Sundström Morris Swertz Kent D Taylor Simon Thom Ioanna Tzoulaki Christophe Tzourio André G Uitterlinden Uwe Völker Peter Vollenweider Sarah Wild Gonneke Willemsen Alan F Wright Jie Yao Sébastien Thériault David Conen John Attia Peter Sever Stéphanie Debette Dennis O Mook-Kanamori Eleftheria Zeggini Tim D Spector Pim van der Harst Colin N A Palmer Anne-Claire Vergnaud Ruth J F Loos Ozren Polasek John M Starr Giorgia Girotto Caroline Hayward Jaspal S Kooner Cecila M Lindgren Veronique Vitart Nilesh J Samani Jaakko Tuomilehto Ulf Gyllensten Paul Knekt Ian J Deary Marina Ciullo Roberto Elosua Bernard D Keavney Andrew A Hicks Robert A Scott Paolo Gasparini Maris Laan YongMei Liu Hugh Watkins Catharina A Hartman Veikko Salomaa Daniela Toniolo Markus Perola James F Wilson Helena Schmidt Jing Hua Zhao Terho Lehtimäki Cornelia M van Duijn Vilmundur Gudnason Bruce M Psaty Annette Peters Rainer Rettig Alan James J Wouter Jukema David P Strachan Walter Palmas Andres Metspalu Erik Ingelsson Dorret I Boomsma Oscar H Franco Murielle Bochud Christopher Newton-Cheh Patricia B Munroe Paul Elliott Daniel I Chasman Aravinda Chakravarti Joanne Knight Andrew P Morris Daniel Levy Martin D Tobin Harold Snieder Mark J Caulfield Georg B Ehret

Hypertension 2017 Jul 24. Epub 2017 Jul 24.

From the Department of Health Sciences (L.V.W., A.M.E., N. Shrine, C.B., T.B., M.D.T.), and Department of Cardiovascular Sciences and NIHR Leicester Biomedical Research Centre (C.P.N., P.S.B., N.J.S.), University of Leicester, United Kingdom; Department of Epidemiology (A.V., P.J.v.d.M., I.M.N., H. Snieder), Division of Nephrology, Department of Internal Medicine (M.H.d.B., M.A.S.), Interdisciplinary Center Psychopathology and Emotion Regulation (IPCE) (A.J.O., H.R., C.A.H.), Department of Genetics, (M.S.), and Department of Cardiology (P.v.d.H.), University of Groningen, University Medical Center Groningen, The Netherlands; Research Institute for Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences, Iran (A.V.); Department of Psychiatry, VU University Medical Center, Neuroscience Campus Amsterdam, The Netherlands (R. Jansen); Hebrew SeniorLife, Harvard Medical School, Boston, MA (R. Joehanes); National Heart, Lung and Blood Institute's Framingham Heart Study, MA (R. Joehanes, A.D.J., M. Larson); Institute of Psychiatry, Psychology and Neuroscience (P.F.O.), and Department of Twin Research and Genetic Epidemiology (M.M., C. Menni, T.D.S.), King's College London, United Kingdom; Clinical Pharmacology, William Harvey Research Institute (C.P.C., H.R.W., M.R.B., M. Brown, B.M., M.R., P.B.M., M.J.C.) and NIHR Barts Cardiovascular Biomedical Research Unit (C.P.C., H.R.W., M.R.B., M. Brown, P.B.M., M.J.C.), Barts and The London School of Medicine and Dentistry, Queen Mary University of London, United Kingdom; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA (L.M.R., F.G., P.M.R., D.I.C.); Department of Epidemiology (G.C.V., A. Hofman, A.G.U., O.H.F.), Genetic Epidemiology Unit, Department of Epidemiology (N.A., B.A.O., C.M.v.D.), and Department of Internal Medicine (A.G.U.), Erasmus MC, Rotterdam, The Netherlands; Department of Biological Psychology, Vrije Universiteit, Amsterdam, EMGO+ Institute, VU University Medical Center, The Netherlands (J.-J.H., E.J.d.G., G.W., D.I.B.); Cardiovascular Medicine Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden (R.J.S., M. Frånberg, A. Hamsten); Centre for Molecular Medicine, Karolinska Universitetsjukhuset, Solna, Sweden (R.J.S., M. Frånberg, A. Hamsten); Estonian Genome Center (T.E., E.O., A. Metspalu), Institute of Biomedicine and Translational Medicine (S.S., M. Laan), and Estonian Genome Center (M.P.), University of Tartu, Estonia; Divisions of Endocrinology/Children's Hospital, Boston, MA (T.E.); Broad Institute of Harvard and MIT, Cambridge, MA (T.E., C.M.L., C.N.-C.); Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD (D.E.A., P.N., A. Chakravarti, G.B.E.); The Population Science Branch, Division of Intramural Research, National Heart Lung and Blood Institute (S.-J.H., D.L.), Laboratory of Neurogenetics, National Institute on Aging (M.A.N.), Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute (F.C.), and Center for Information Technology (Y.D., P.J.M., Q.T.N.), National Institutes of Health, Bethesda, MD; The Framingham Heart Study, Framingham, MA (S.-J.H., D.L.); The Institute for Translational Genomics and Population Sciences, Department of Pediatrics (X.G., J.Y.), and The Institute for Translational Genomics and Population Sciences, Departments of Pediatrics and Medicine (J.I.R.), LABioMed at Harbor-UCLA Medical Center, Torrance, CA; Institute of Social and Preventive Medicine, Lausanne University Hospital, Lausanne, Switzerland (Z.K., M. Bochud); Swiss Institute of Bioinformatics, Lausanne, Switzerland (Z.K.); Department of Cardiology (S. Trompet, J.W.J.) Department of Gerontology and Geriatrics (S. Trompet), Department of Clinical Epidemiology (R.L.-G., R.d.M., D.O.M.-K.), Department of Molecular Epidemiology (J.D.), and Department of Public Health and Primary Care (D.O.M.-K.), Leiden University Medical Center, The Netherlands; Institute for Community Medicine (A.T.), Department of Internal Medicine B (M.D.), and Interfaculty Institute for Genetics and Functional Genomics (U.V.), University Medicine Greifswald, Germany; DZHK (German Centre for Cardiovascular Research), partner site Greifswald, Germany (A.T., M.D., U.V.); Institute of Epidemiology II, Helmholtz Zentrum München, Neuherberg, Germany (J.S.R., A. Peters); Cardiovascular Health Research Unit, Department of Medicine (J.C.B., B.M.P.) and Departments of Biostatistics (K.R.), Epidemiology (B.M.P.), and Health Services (B.M.P.), University of Washington, Seattle; Icelandic Heart Association, Kopavogur, Iceland (A.V.S., V. Gudnason); Faculty of Medicine, University of Iceland, Reykjavik, Iceland (A.V.S., V. Gudnason); Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland (L.-P.L., T.L.); Department of Clinical Chemistry, Faculty of Medicine and Life Sciences, University of Tampere, Finland (L.-P.L., T.L.); Wellcome Trust Centre for Human Genetics (A. Mahajan, A.G., M. Farrall, T.F., C.M.L., H.W., A.P.M.), and Division of Cardiovascular Medicine, Radcliffe Department of Medicine (A.G., M. Farrall, H.W.), University of Oxford, United Kingdom; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, United Kingdom (N.J.W., J.L., C.L., R.J.F.L., R.A.S., J.H.Z.); Clinical Division of Neurogeriatrics, Department of Neurology (E.H., R. Schmidt), Institute of Medical Informatics, Statistics and Documentation (E.H.), and Department of Neurology (H. Schmidt), Medical University Graz, Austria; Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics (P.K.J., H.C., I.R., S.W., J.F.W.), Centre for Cognitive Ageing and Cognitive Epidemiology (L.M.L., S.E.H., G.D., A.J.G., D.C.M.L., J.M.S., I.J.D.), Medical Genetics Section, Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine (A. Campbell), Generation Scotland, Centre for Genomic and Experimental Medicine (A. Campbell, S.P., C.H.), Department of Psychology (G.D., D.C.M.L., A. Pattie, I.J.D.), Alzheimer Scotland Dementia Research Centre (J.M.S.), and Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine (C.H.), University of Edinburgh, Scotland, United Kingdom; Department of Health (K.K., A.S.H., T. Niiranen, P.J., A.J., S. Koskinen, P.K., V.S., M.P.), and Chronic Disease Prevention Unit (J.T.), National Institute for Health and Welfare (THL), Helsinki, Finland; Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milano, Italy (M.T., C.M.B., C.F.S., D.T.); Data Tecnica International, Glen Echo, MD (M.A.N.); Medical Genetics, IRCCS-Burlo Garofolo Children Hospital, Trieste, Italy (D.V., G.G., P.G.); Department of Medical, Surgical and Health Sciences, University of Trieste, Italy (D.V., I.G., M. Brumat, M. Cocca, A. Morgan, G.G., P.G.); Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck, Bolzano, Italy (F.D.G.M., P.P.P., A.S.P., A.A.H.); Department of Genetics and Genomic Sciences (K.L.A.), The Charles Bronfman Institute for Personalized Medicine (Y.L., E.P.B., R.J.F.L.), and Mindich Child health Development Institute (R.J.F.L.), Icahn School of Medicine at Mount Sinai, New York; Cardiovascular Epidemiology and Genetics, IMIM, and CIBERCV, Barcelona, Spain (J. Marrugat, R.E.); Institute of Genetics and Biophysics A. Buzzati-Traverso, CNR, Napoli, Italy (D.R., T. Nutile, R. Sorice, M. Ciullo); Department of Psychiatry, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin (L.M.L.); UCD Conway Institute, Centre for Proteome Research (L.M.L.), and School of Medicine, Conway Institute (D.C.S.), University College Dublin, Belfield, Ireland; Department of Immunology, Genetics and Pathology, Uppsala Universitet, Science for Life Laboratory, Sweden (S.E., Å. Johansson, U.G.); Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor (A.U.J., M. Boehnke); NIHR Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester United Kingdom (C.P.N., P.S.B., N.J.S.); MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine (J.E.H., V.V., J. Marten, A.F.W., J.F.W.), and Medical Genetics Section, Centre for Genomic and Experimental Medicine and MRC Institute of Genetics and Molecular Medicine (S.E.H.), University of Edinburgh, Western General Hospital, Scotland, United Kingdom; Department of Epidemiology and Biostatistics, School of Public Health (W.Z., E.E., J.C.C., H.G., B.L., I.T., A.-C.V.), MRC-PHE Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health (M.-R.J., P.E.), School of Public Health (N.P.), International Centre for Circulatory Health (S. Thom), and National Heart and Lung Institute (P.S.), Imperial College London, United Kingdom; Department of Cardiology, Ealing Hospital, London North West Healthcare NHS Trust, Southall, United Kingdom (W.Z., J.C.C., J.S.K.); Department of Medical Biology, Faculty of Medicine, University of Split, Croatia (T.Z.); Department of Hygiene and Epidemiology, University of Ioannina Medical School, Greece (E.E.); Medical Research Institute, University of Dundee, Ninewells Hospital and Medical School, Scotland, United Kingdom (N. Shah, A.S.F.D., C.N.A.P.); Department of Pharmacy, COMSATS Institute of Information Technology, Abbottabad, Pakistan (N. Shah); National Institute for Health Research Biomedical Research Centre, London, United Kingdom (M.M.); Department of Human Genetics, Wellcome Trust Sanger Institute, United Kingdom (B.P.P., E.Z.); INSERM U 1219, Bordeaux Population Health Center, France (G.C., C.T., S.D.); Bordeaux University, France (G.C., C.T., S.D.); Hunter Medical Research Institute, New Lambton, NSW, Australia (C.O., E.G.H., R. Scott, J.A.); Center for Statistical Genetics, Department of Biostatistics, Ann Arbor, MI (G.A.); Department of Genetics and Molecular Biology, Isfahan University of Medical Sciences, Iran (M.A.); Busselton Population Medical Research Institute, Western Australia (J.B., J.H.); PathWest Laboratory Medicine of Western Australia, Nedlands (J.B., J.H.); School of Pathology and Laboratory Medicine (J.B., J.H.), School of Population and Global Health (J.H.), and School of Medicine and Pharmacology (A. James), The University of Western Australia, Nedlands; Imperial College Healthcare NHS Trust, London, United Kingdom (J.C.C., J.S.K.); University of Dundee, Ninewells Hospital & Medical School, United Kingdom (J.C.); Institute of Genetic Medicine (H.J.C.), and Institute of Health and Society (C. Mamasoula), Newcastle University, Newcastle upon Tyne, United Kingdom; Department of Pathology, Amsterdam Medical Center, The Netherlands (J.J.D.); Department of Numerical Analysis and Computer Science, Stockholm University, Sweden (M. Frånberg); Department of Public Health and Caring Sciences, Geriatrics, Uppsala, Sweden (V. Giedraitis); Helmholtz Zentrum Muenchen, Deutsches Forschungszentrum fuer Gesundheit und Umwelt (GmbH), Neuherberg, Germany (C.G.); Department of Psychology, School of Social Sciences, Heriot-Watt University, Edinburgh, United Kingdom (A.J.G.); Intramural Research Program, Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging (T.B.H., L.J.L.); Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA (A. Hofman); Center For Life-Course Health Research (M.-R.J.), and Biocenter Oulu (M.-R.J.), University of Oulu, Finland; Unit of Primary Care, Oulu University Hospital, Finland (M.-R.J.); National Heart, Lung and Blood Institute, Cardiovascular Epidemiology and Human Genomics Branch, Bethesda, MD (A.D.J.); Department of Clinical Physiology, Tampere University Hospital, Finland (M.K.); Department of Clinical Physiology, Faculty of Medicine and Life Sciences, University of Tampere, Finland (M.K.); Cardiovascular Research Center (S. Kathiresan, C.N.-C.); Center for Human Genetics (S. Kathiresan), and Center for Human Genetic Research (C.N.-C.), Massachusetts General Hospital, Boston; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA (S. Kathiresan, C.N.-C.); Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, United Kingdom (K.-T.K.); Department of Public Health, Faculty of Medicine, University of Split, Croatia (I.K., O.P.); Cardiology, Department of Specialties of Medicine, Geneva University Hospital, Switzerland (L. Lin, F.M., G.B.E.); Department of Medical Sciences, Cardiovascular Epidemiology (L. Lind, J.S.), and Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory (E.I.), Uppsala University, Sweden; Department of Psychiatry, EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands (Y.M., B.W.J.H.P.); School of Molecular, Genetic and Population Health Sciences, University of Edinburgh, Medical School, Teviot Place, Scotland, United Kingdom (A.D.M.); Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston (A.C.M.); British Heart Foundation Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences (S.P.), and Institute of Cardiovascular and Medical Sciences, Faculty of Medicine (D.J.S.), University of Glasgow, United Kingdom; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Finland (A. Palotie, S.R., A.-P.S., M.P.); Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Canada (G.P., S. Thériault); Department of Neurology, General Central Hospital, Bolzano, Italy (P.P.P.); Department of Neurology, University of Lübeck, Germany (P.P.P.); Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Finland (O.T.R.); Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Finland (O.T.R.); Department of Cardiology, Fujian Provincial Hospital, Fujian Medical University, Fuzhou, China (M.R.); Harvard Medical School, Boston, MA (P.M.R., D.I.C.); Institute for Maternal and Child Health IRCCS Burlo Garofolo, Trieste, Italy (A.R.); Institute of Molecular Biology and Biochemistry, Centre for Molecular Medicine, Medical University of Graz, Austria (Y.S., H. Schmidt); INSERM U1078, Etablissement Français du Sang, Brest Cedex, France (A.S.P.); Faculty of Health, University of Newcastle, Callaghan, NSW, Australia (R. Scott, J.A.); John Hunter Hospital, New Lambton, NSW, Australia (R. Scott, J.A.); The New York Academy of Medicine, New York (D.S.); IRCCS Neuromed, Pozzilli, Isernia, Italy (R. Sorice, M. Ciullo); Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin 2, Ireland (A.S.); Institute for Translational Genomics and Population Sciences, Los Angeles BioMedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA (K.D.T.); Division of Genetic Outcomes, Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA (K.D.T.); Department of Public Health (C.T.), and Department of Neurology (S.D.), Bordeaux University Hospital, France; Department of Internal Medicine, Lausanne University Hospital, CHUV, Switzerland (P.V.); Population Health Research Institute, McMaster University, Hamilton Ontario, Canada (D.C.); National Heart and Lung Institute, Imperial College London, Hammersmith Hospital Campus, United Kingdom (J.S.K.); Dasman Diabetes Institute, Kuwait (J.T.); Diabetes Research Group, King Abdulaziz University, Jeddah, Saudi Arabia (J.T.); Department of Neurosciences and Preventive Medicine, Danube-University Krems, Austria (J.T.); Division of Cardiovascular Sciences, The University of Manchester and Central Manchester University Hospitals NHS Foundation Trust, United Kingdom (B.D.K.); Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem (Y.M.L.); Kaiser Permanent Washington Health Research Institute, Seattle, WA (B.M.P.); Institute of Physiology, University Medicine Greifswald, Karlsburg, Germany (R.R); Department of Pulmonary Physiology and Sleep, Sir Charles Gairdner Hospital, Nedlands, Western Australia (A. James); Population Health Research Institute, St George's, University of London, United Kingdom (D.P.S.); Department of Medicine, Columbia University Medical Center, New York (W.P.); Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, CA (E.I.); Data Science Institute and Lancaster Medical School, Lancaster University, United Kingdom (J.K.); and Department of Biostatistics, University of Liverpool, United Kingdom (A.P.M.).

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.117.09438DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5783787PMC
July 2017

Complement-mediated inflammation and injury in brain dead organ donors.

Mol Immunol 2017 04 15;84:77-83. Epub 2016 Dec 15.

Department of Internal Medicine, Division of Nephrology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01615890163023
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http://dx.doi.org/10.1016/j.molimm.2016.11.004DOI Listing
April 2017

Strong predictive value of mannose-binding lectin levels for cardiovascular risk of hemodialysis patients.

J Transl Med 2016 08 5;14(1):236. Epub 2016 Aug 5.

Department of Internal Medicine, Division of Nephrology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

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http://dx.doi.org/10.1186/s12967-016-0995-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4974702PMC
August 2016

Erratum to: Strong predictive value of mannose-binding lectin levels for cardiovascular risk of hemodialysis patients.

J Transl Med 2016 08 24;14(1):245. Epub 2016 Aug 24.

Division of Nephrology, Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

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http://translational-medicine.biomedcentral.com/articles/10.
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http://dx.doi.org/10.1186/s12967-016-1004-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4997692PMC
August 2016

Functional Studies on Primary Tubular Epithelial Cells Indicate a Tumor Suppressor Role of SETD2 in Clear Cell Renal Cell Carcinoma.

Neoplasia 2016 06 26;18(6):339-46. Epub 2016 May 26.

Department of Genetics, University of Groningen, University Medical Center Groningen, PO Box 30.001, 9700 RB Groningen, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.neo.2016.04.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4916950PMC
June 2016

Precision-cut human kidney slices as a model to elucidate the process of renal fibrosis.

Transl Res 2016 Apr 25;170:8-16.e1. Epub 2015 Nov 25.

Department of Pharmaceutical Technology and Biopharmacy, Groningen Research Institute of Pharmacy, University of Groningen, Groningen, The Netherlands.

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http://dx.doi.org/10.1016/j.trsl.2015.11.007DOI Listing
April 2016

Assessment of Cotinine Reveals a Dose-Dependent Effect of Smoking Exposure on Long-term Outcomes After Renal Transplantation.

Transplantation 2015 Sep;99(9):1926-32

1 Department of Internal Medicine, University Medical Center Groningen and University of Groningen, Groningen, the Netherlands. 2 Department of Laboratory Medicine, University Medical Center Groningen and University of Groningen, Groningen, the Netherlands. 3 Department of Epidemiology, University Medical Center Groningen and University of Groningen, Groningen, the Netherlands.

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http://dx.doi.org/10.1097/TP.0000000000000636DOI Listing
September 2015

Early Posttransplant Tryptophan Metabolism Predicts Long-term Outcome of Human Kidney Transplantation.

Transplantation 2015 Aug;99(8):e97-104

1 Department of Clinical Pharmacy and Pharmacology, University of Groningen, University Medical Center Groningen, the Netherlands. 2 Graduate School for Drug Exploration (GUIDE), University of Groningen, University Medical Center Groningen, the Netherlands. 3 Department of Pharmacology and Toxicology, Faculty of Pharmacy, Comenius University in Bratislava, Bratislava, Slovakia. 4 Department of Internal Medicine, University of Groningen, University Medical Center Groningen, the Netherlands. 5 Department of Laboratory Medicine, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands. 6 Department of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, the Netherlands. 7 Ludwig Institute for Cancer Research, Brussels, Belgium. 8 de Duve Institute, Université Catholique de Louvain, Brussels, Belgium. 9 Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.

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http://pdfs.journals.lww.com/transplantjournal/2015/08000/Ea
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http://dx.doi.org/10.1097/TP.0000000000000603DOI Listing
August 2015

Hypoxia and Complement-and-Coagulation Pathways in the Deceased Organ Donor as the Major Target for Intervention to Improve Renal Allograft Outcome.

Transplantation 2015 Jun;99(6):1293-300

1 Department of Pathology, Academic Medical Center Amsterdam, the Netherlands. 2 Department of Pediatrics, University Medical Center Groningen, University of Groningen, the Netherlands. 3 Department of Nephrology, Leiden University Medical Center, Leiden, the Netherlands. 4 Department of Nephrology, University Medical Center Groningen, Groningen, the Netherlands. 5 Department of Epidemiology, Unit of Genetic Epidemiology and Bioinformatics, University Medical Center Groningen, University of Groningen, the Netherlands. 6 Department of Genetics, University Medical Center Groningen, University of Groningen, the Netherlands. 7 Department of Surgery, University of Oxford, Oxford, United Kingdom. 8 Department of Surgery, University Medical Center Groningen, Groningen, the Netherlands.

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http://dx.doi.org/10.1097/TP.0000000000000500DOI Listing
June 2015

Urinary Urea Excretion and Long-term Outcome After Renal Transplantation.

Transplantation 2015 May;99(5):1009-15

1 Department of Medicine, University of Groningen, University Medical Center Groningen, the Netherlands. 2 Division of Human Nutrition, Wageningen University, the Netherlands. 3 Department of Laboratory Medicine, University Medical Center Groningen, the Netherlands. 4 Top Institute Food & Nutrition, Wageningen, the Netherlands.

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http://dx.doi.org/10.1097/TP.0000000000000464DOI Listing
May 2015

Renal expression of Toll-like receptor 2 and 4: dynamics in human allograft injury and comparison to rodents.

Mol Immunol 2015 Mar 29;64(1):82-9. Epub 2014 Nov 29.

Department of Internal Medicine, Division of Nephrology, University of Groningen, University Medical Center Groningen, The Netherlands.

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http://dx.doi.org/10.1016/j.molimm.2014.11.003DOI Listing
March 2015

Uncovering of body mass index as a risk factor for poor long-term outcome after renal transplantation.

Transplantation 2015 Jan;99(1):e5-6

1 Division of Nephrology, Department of Medicine, University Medical Center Groningen and University of Groningen, the Netherlands. 2 Top Institute Food and Nutrition, Wageningen, the Netherlands.

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http://dx.doi.org/10.1097/TP.0000000000000484DOI Listing
January 2015

Heparin/heparan sulphate interactions with complement--a possible target for reduction of renal function loss?

Nephrol Dial Transplant 2014 Mar 22;29(3):515-22. Epub 2013 Jul 22.

Department of Internal Medicine, Division of Nephrology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.

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March 2014

Novel insights in localization and expression levels of C5aR and C5L2 under native and post-transplant conditions in the kidney.

Mol Immunol 2013 Mar 6;53(3):237-45. Epub 2012 Sep 6.

Department of Internal Medicine, Division of Nephrology, University of Groningen, University Medical Center Groningen, Postbus 30001, 9700 RB Groningen, The Netherlands.

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http://dx.doi.org/10.1016/j.molimm.2012.08.013DOI Listing
March 2013

Mannan binding lectin: a two-faced regulator of renal allograft injury?

Kidney Int 2013 Feb;83(2):191-3

Department of Pathology, University Medical Center Groningen, Groningen, The Netherlands.

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http://dx.doi.org/10.1038/ki.2012.397DOI Listing
February 2013

Factor h and properdin recognize different epitopes on renal tubular epithelial heparan sulfate.

J Biol Chem 2012 Sep 19;287(37):31471-81. Epub 2012 Jul 19.

Department of Nephrology, University Medical Center, 9713 GZ Groningen, The Netherlands.

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http://dx.doi.org/10.1074/jbc.M112.380386DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3438980PMC
September 2012

ADAM17 up-regulation in renal transplant dysfunction and non-transplant-related renal fibrosis.

Nephrol Dial Transplant 2012 May 19;27(5):2114-22. Epub 2011 Oct 19.

Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

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http://dx.doi.org/10.1093/ndt/gfr583DOI Listing
May 2012

Local renal complement C3 induction by donor brain death is associated with reduced renal allograft function after transplantation.

Nephrol Dial Transplant 2011 Jul 2;26(7):2345-54. Epub 2010 Dec 2.

Department of Surgery, University Medical Center Groningen, Groningen, The Netherlands.

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http://dx.doi.org/10.1093/ndt/gfq717DOI Listing
July 2011

Targeting complement activation in brain-dead donors improves renal function after transplantation.

Transpl Immunol 2011 May 1;24(4):233-7. Epub 2011 Apr 1.

Department of Surgery, University Medical Center Groningen, Groningen, The Netherlands.

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http://dx.doi.org/10.1016/j.trim.2011.03.001DOI Listing
May 2011

Crosstalk between complement and Toll-like receptor activation in relation to donor brain death and renal ischemia-reperfusion injury.

Am J Transplant 2011 Apr;11(4):660-9

Surgery Nephrology, University Medical Center Groningen, Groningen, The Netherlands Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1111/j.1600-6143.2011.03475.xDOI Listing
April 2011

Heparin binding epidermal growth factor in renal ischaemia/reperfusion injury.

J Pathol 2010 Jun;221(2):183-92

Department of Pathology and Medical Biology, University Medical Center Groningen and University of Groningen, Groningen, The Netherlands.

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http://dx.doi.org/10.1002/path.2698DOI Listing
June 2010

Genetic loci influencing kidney function and chronic kidney disease.

Authors:
John C Chambers Weihua Zhang Graham M Lord Pim van der Harst Debbie A Lawlor Joban S Sehmi Daniel P Gale Mark N Wass Kourosh R Ahmadi Stephan J L Bakker Jacqui Beckmann Henk J G Bilo Murielle Bochud Morris J Brown Mark J Caulfield John M C Connell H Terence Cook Ioana Cotlarciuc George Davey Smith Ranil de Silva Guohong Deng Olivier Devuyst Lambert D Dikkeschei Nada Dimkovic Mark Dockrell Anna Dominiczak Shah Ebrahim Thomas Eggermann Martin Farrall Luigi Ferrucci Jurgen Floege Nita G Forouhi Ron T Gansevoort Xijin Han Bo Hedblad Jaap J Homan van der Heide Bouke G Hepkema Maria Hernandez-Fuentes Elina Hypponen Toby Johnson Paul E de Jong Nanne Kleefstra Vasiliki Lagou Marta Lapsley Yun Li Ruth J F Loos Jian'an Luan Karin Luttropp Céline Maréchal Olle Melander Patricia B Munroe Louise Nordfors Afshin Parsa Leena Peltonen Brenda W Penninx Esperanza Perucha Anneli Pouta Inga Prokopenko Paul J Roderick Aimo Ruokonen Nilesh J Samani Serena Sanna Martin Schalling David Schlessinger Georg Schlieper Marc A J Seelen Alan R Shuldiner Marketa Sjögren Johannes H Smit Harold Snieder Nicole Soranzo Timothy D Spector Peter Stenvinkel Michael J E Sternberg Ramasamyiyer Swaminathan Toshiko Tanaka Lielith J Ubink-Veltmaat Manuela Uda Peter Vollenweider Chris Wallace Dawn Waterworth Klaus Zerres Gerard Waeber Nicholas J Wareham Patrick H Maxwell Mark I McCarthy Marjo-Riitta Jarvelin Vincent Mooser Goncalo R Abecasis Liz Lightstone James Scott Gerjan Navis Paul Elliott Jaspal S Kooner

Nat Genet 2010 May 11;42(5):373-5. Epub 2010 Apr 11.

Department of Epidemiology and Biostatistics, School of Public Health, Imperial College of London, London, UK.

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http://dx.doi.org/10.1038/ng.566DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3748585PMC
May 2010

Gastrointestinal symptoms in kidney transplant recipients: what about silent sufferers?

Prog Transplant 2010 Mar;20(1):75-80

University Medical Centre Groningen, The Netherlands.

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March 2010

Plasma procalcitonin is an independent predictor of graft failure late after renal transplantation.

Transplantation 2009 Jul;88(2):279-87

Department of Internal Medicine, Renal Transplant Program, University Medical Center Groningen and University of Groningen, 9700 RB Groningen, The Netherlands.

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http://dx.doi.org/10.1097/TP.0b013e3181ac9ea0DOI Listing
July 2009

The additional detrimental effects of cold preservation on transplantation-associated injury in kidneys from living and brain-dead donor rats.

Transplantation 2009 Jan;87(1):52-8

Department of Medicine V (Nephrology/Endocrinology/Rheumatology), University Medical Center Mannheim, University of Heidelberg, Mannheim, Germany.

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http://dx.doi.org/10.1097/TP.0b013e318191b2caDOI Listing
January 2009

Donor dopamine treatment in brain dead rats is associated with an improvement in renal function early after transplantation and a reduction in renal inflammation.

Transpl Int 2008 Nov 6;21(11):1072-80. Epub 2008 Aug 6.

Department of Medicine V, Nephrology/Endocrinology/Rheumatology, University Medical Center Mannheim, University of Heidelberg, Mannheim, Germany.

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http://dx.doi.org/10.1111/j.1432-2277.2008.00725.xDOI Listing
November 2008

Complement and renal transplantation: from donor to recipient.

Transplantation 2008 Apr;85(7):923-7

Department of Surgery, University Medical Center Groningen, Groningen, The Netherlands.

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http://dx.doi.org/10.1097/TP.0b013e3181683cf5DOI Listing
April 2008

Role of complement in innate and autoimmunity.

J Nephrol 2005 Nov-Dec;18(6):642-53

Department of Nephrology, Leiden University Medical Center, Leiden - The Netherlands.

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January 2006

Activation of the lectin pathway in murine lupus nephritis.

Mol Immunol 2005 Apr;42(6):731-40

Department of Nephrology, C3, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands.

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http://dx.doi.org/10.1016/j.molimm.2004.09.024DOI Listing
April 2005

Maturation of dendritic cells abrogates C1q production in vivo and in vitro.

Blood 2004 May 15;103(10):3813-20. Epub 2004 Jan 15.

Department of Nephrology, Leiden University Medical Center, Leiden, the Netherlands.

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http://dx.doi.org/10.1182/blood-2003-09-3046DOI Listing
May 2004

Diagnostic and prognostic significance of anti-C1q antibodies in systemic lupus erythematosus.

Curr Opin Nephrol Hypertens 2003 Nov;12(6):619-24

Department of Nephrology, Leiden University Medical Center, The Netherlands.

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http://dx.doi.org/10.1097/01.mnh.0000098768.18213.70DOI Listing
November 2003