Marc A Giulianotti

Marc A Giulianotti

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Marc A Giulianotti

Marc A Giulianotti

Publications by authors named "Marc A Giulianotti"

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Pharmaceutical Research Enabled Through Microgravity: Perspectives on the Use of the International Space Station U.S. National Laboratory.

Pharm Res 2019 12 10;37(1). Epub 2019 Dec 10.

National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1007/s11095-019-2719-zDOI Listing
December 2019

Tissue Chips in Space: Modeling Human Diseases in Microgravity.

Pharm Res 2019 Dec 17;37(1). Epub 2019 Dec 17.

ISS National Laboratory, 6905 N. Wickham Road, Suite 500, Melbourne, Florida, 32940, USA.

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http://dx.doi.org/10.1007/s11095-019-2742-0DOI Listing
December 2019

Differential regulation of alcohol taking and seeking by antagonism at α4β2 and α3β4 nAChRs.

Psychopharmacology (Berl) 2018 06 23;235(6):1745-1757. Epub 2018 Mar 23.

Torrey Pines Institute for Molecular Studies, 11350 SW Village Parkway, Port St. Lucie, FL, 34987, USA.

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http://link.springer.com/10.1007/s00213-018-4883-y
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http://dx.doi.org/10.1007/s00213-018-4883-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5949259PMC
June 2018

A one-pot multicomponent approach to a new series of morphine derivatives and their biological evaluation.

Org Biomol Chem 2017 Sep;15(37):7796-7801

Department of Chemistry, Zhejiang Sci-Tech University, Hangzhou, Zhejiang 310018, P. R. China.

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http://dx.doi.org/10.1039/c7ob01924fDOI Listing
September 2017

Identification of a Hit Series of Antileishmanial Compounds through the Use of Mixture-Based Libraries.

ACS Med Chem Lett 2017 Aug 10;8(8):802-807. Epub 2017 Jul 10.

Department of Chemistry, University of South Florida, CHE 205, 4202 East Fowler Avenue, Tampa, Florida 33620, United States.

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http://dx.doi.org/10.1021/acsmedchemlett.7b00045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5554901PMC
August 2017

Identification of Protein Palmitoylation Inhibitors from a Scaffold Ranking Library.

Comb Chem High Throughput Screen 2016 ;19(4):262-74

Department of Molecular Medicine, University of South Florida, 12901 Bruce B. Downs Blvd., MDC07, Tampa, FL 33612, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5068503PMC
http://dx.doi.org/10.2174/1386207319666160324123844DOI Listing
July 2017

Small-Molecule Inhibitors Targeting Topoisomerase I as Novel Antituberculosis Agents.

Antimicrob Agents Chemother 2016 07 20;60(7):4028-36. Epub 2016 Jun 20.

Department of Chemistry and Biochemistry, Florida International University, Miami, Florida, USA Biomolecular Sciences Institute, Florida International University, Miami, Florida, USA

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http://dx.doi.org/10.1128/AAC.00288-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4914652PMC
July 2016

Identification of Small Molecule Inhibitors of Human As(III) S-Adenosylmethionine Methyltransferase (AS3MT).

Chem Res Toxicol 2015 Dec 6;28(12):2419-25. Epub 2015 Dec 6.

Department of Cellular Biology and Pharmacology, Herbert Wertheim College of Medicine, Florida International University , Miami, Florida 33199, United States.

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http://dx.doi.org/10.1021/acs.chemrestox.5b00432DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4688878PMC
December 2015

Combinatorial Libraries As a Tool for the Discovery of Novel, Broad-Spectrum Antibacterial Agents Targeting the ESKAPE Pathogens.

J Med Chem 2015 Apr 1;58(8):3340-55. Epub 2015 Apr 1.

∥Torrey Pines Institute for Molecular Studies, Port St. Lucie, Florida 34987, United States.

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http://dx.doi.org/10.1021/jm501628sDOI Listing
April 2015

Synthesis and biological evaluations of novel endomorphin analogues containing α-hydroxy-β-phenylalanine (AHPBA) displaying mixed μ/δ opioid receptor agonist and δ opioid receptor antagonist activities.

Eur J Med Chem 2015 Mar 29;92:270-81. Epub 2014 Dec 29.

Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, PR China; Torrey Pines Institute for Molecular Studies, 11350 SW Village Parkway, Port St. Lucie, FL 34987, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2014.12.049DOI Listing
March 2015

Scaffold ranking and positional scanning utilized in the discovery of nAChR-selective compounds suitable for optimization studies.

J Med Chem 2013 Dec 12;56(24):10103-17. Epub 2013 Dec 12.

Torrey Pines Institute for Molecular Studies , 11350 SW Village Parkway, Port St. Lucie, Florida 34987, United States.

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http://dx.doi.org/10.1021/jm401543hDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4106133PMC
December 2013

Conditional probabilistic analysis for prediction of the activity landscape and relative compound activities.

J Chem Inf Model 2013 Oct 17;53(10):2613-25. Epub 2013 Sep 17.

Torrey Pines Institute for Molecular Studies , 11350 SW Village Parkway, Port St. Lucie, Florida 34987, United States.

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http://dx.doi.org/10.1021/ci400243eDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3850180PMC
October 2013

Ligand/kappa-opioid receptor interactions: insights from the X-ray crystal structure.

Eur J Med Chem 2013 Aug 30;66:114-21. Epub 2013 May 30.

Instituto de Química, UNAM, Av. Universidad 3000, México DF, Mexico.

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http://dx.doi.org/10.1016/j.ejmech.2013.05.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3775475PMC
August 2013

Libraries from Libraries: A Series of Sulfonamide Linked Heterocycles Derived from the Same Scaffold.

Tetrahedron Lett 2013 Aug;54(32)

Torrey Pines Institute for Molecular Studies, 11350 SW Village Parkway, Port St. Lucie FL 34987.

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http://dx.doi.org/10.1016/j.tetlet.2013.06.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3867824PMC
August 2013

Parallel synthesis of 1,6-disubstituted-1,2,4-triazin-3-ones on solid-phase.

ACS Comb Sci 2013 Jul 13;15(7):335-9. Epub 2013 Jun 13.

Institute of Materia Medica, College of Pharmaceutical Sciences, Zhejiang University , Hangzhou 310058, P.R. China.

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http://dx.doi.org/10.1021/co400064dDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3875618PMC
July 2013

Shifting from the single to the multitarget paradigm in drug discovery.

Drug Discov Today 2013 May 20;18(9-10):495-501. Epub 2013 Jan 20.

Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, México, D.F. 04510, Mexico.

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http://dx.doi.org/10.1016/j.drudis.2013.01.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3642214PMC
May 2013

Fluorescent mu selective opioid ligands from a mixture based cyclic peptide library.

ACS Comb Sci 2012 Dec 8;14(12):673-9. Epub 2012 Nov 8.

Torrey Pines Institute for Molecular Studies, Port Saint Lucie, Florida 34987, United States.

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http://pubs.acs.org/doi/10.1021/co300110t
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http://dx.doi.org/10.1021/co300110tDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3607207PMC
December 2012

Palladium-catalyzed C-H functionalization using guanidine as a directing group: ortho arylation and olefination of arylguanidines.

Org Lett 2012 Nov 24;14(21):5452-5. Epub 2012 Oct 24.

Institute of Materia Medica, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, P. R. China.

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http://dx.doi.org/10.1021/ol302533wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3786205PMC
November 2012

A novel method for the determination of isokinetic ratios and its application in the synthesis of two new positional scanning libraries.

ACS Comb Sci 2012 Sep 28;14(9):503-12. Epub 2012 Aug 28.

Torrey Pines Institute for Molecular Studies , 11350 SW Village Parkway, Port St. Lucie, Florida 34987, United States.

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http://dx.doi.org/10.1021/co300060sDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3825827PMC
September 2012

Expanding the medicinally relevant chemical space with compound libraries.

Drug Discov Today 2012 Jul 10;17(13-14):718-26. Epub 2012 Apr 10.

Torrey Pines Institute for Molecular Studies, 11350 SW Village Parkway, Port St. Lucie, FL 34987, USA.

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http://dx.doi.org/10.1016/j.drudis.2012.04.001DOI Listing
July 2012

Synthesis and biological evaluation of 2-indolinone derivatives as potential antitumor agents.

Eur J Med Chem 2011 Dec 13;46(12):5970-7. Epub 2011 Oct 13.

College of Pharmaceutical Sciences, Zhejiang University, 388 Yuhangtang Road, Hangzhou 310058, PR China.

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http://dx.doi.org/10.1016/j.ejmech.2011.10.009DOI Listing
December 2011

Parallel synthesis of novel antitumor agents: 1,2,3-triazoles bearing biologically active sulfonamide moiety and their 3D-QSAR.

Mol Divers 2011 Nov 10;15(4):927-46. Epub 2011 Jul 10.

College of Pharmaceutical Science, Zijin Campus, Zhejiang University, Hangzhou 310058, People's Republic of China.

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http://dx.doi.org/10.1007/s11030-011-9324-3DOI Listing
November 2011

Integrating virtual screening and combinatorial chemistry for accelerated drug discovery.

Comb Chem High Throughput Screen 2011 Jul;14(6):475-87

Torrey Pines Institute for Molecular Studies, 11350 SW Village Parkway, Port St. Lucie, FL 34987, USA.

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http://dx.doi.org/10.2174/138620711795767866DOI Listing
July 2011

Integrating computational and mixture-based screening of combinatorial libraries.

J Mol Model 2011 Jun 21;17(6):1473-82. Epub 2010 Sep 21.

Torrey Pines Institute for Molecular Studies, Port St Lucie, FL 34987, USA.

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http://dx.doi.org/10.1007/s00894-010-0850-1DOI Listing
June 2011

Use and implications of the harmonic mean model on mixtures for basic research and drug discovery.

ACS Comb Sci 2011 May 11;13(3):337-44. Epub 2011 Mar 11.

Torrey Pines Institute for Molecular Studies , Port St. Lucie, Florida 34987, United States.

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http://dx.doi.org/10.1021/co100065aDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3096014PMC
May 2011

Towards a systematic characterization of the antiprotozoal activity landscape of benzimidazole derivatives.

Bioorg Med Chem 2010 Nov 15;18(21):7380-91. Epub 2010 Sep 15.

Facultad de Química, Departamento de Farmacia, Universidad Nacional Autónoma de México, México DF 04510, Mexico.

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http://dx.doi.org/10.1016/j.bmc.2010.09.019DOI Listing
November 2010

Conformational landscape of platinum(II)-tetraamine complexes: DFT and NBO studies.

J Comput Aided Mol Des 2010 Mar 24;24(3):225-35. Epub 2010 Mar 24.

Torrey Pines Institute for Molecular Studies, 11350 SW Village Parkway, Port St. Lucie, FL 34987, USA.

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http://dx.doi.org/10.1007/s10822-010-9328-6DOI Listing
March 2010

Modeling of peptides containing D-amino acids: implications on cyclization.

J Comput Aided Mol Des 2009 Sep 11;23(9):677-89. Epub 2009 Jul 11.

Torrey Pines Institute for Molecular Studies, Port Saint Lucie, FL 34987, USA.

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http://dx.doi.org/10.1007/s10822-009-9295-yDOI Listing
September 2009

Identification, structure-activity relationships and molecular modeling of potent triamine and piperazine opioid ligands.

Bioorg Med Chem 2009 Aug 21;17(15):5583-97. Epub 2009 Jun 21.

Torrey Pines Institute for Molecular Studies, 11350 SW Village Parkway, Room 132, Port St. Lucie, FL 34987, USA.

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http://dx.doi.org/10.1016/j.bmc.2009.06.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2746904PMC
August 2009

Discovery of a novel protein kinase B inhibitor by structure-based virtual screening.

Bioorg Med Chem Lett 2009 Aug 25;19(16):4634-8. Epub 2009 Jun 25.

Torrey Pines Institute for Molecular Studies, Port St Lucie, FL 34987, USA.

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http://dx.doi.org/10.1016/j.bmcl.2009.06.078DOI Listing
August 2009

Chemoinformatic analysis of combinatorial libraries, drugs, natural products, and molecular libraries small molecule repository.

J Chem Inf Model 2009 Apr;49(4):1010-24

Torrey Pines Institute for Molecular Studies, 11350 SW Village Parkway, Port St. Lucie, Florida 34987, USA.

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http://dx.doi.org/10.1021/ci800426uDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2686115PMC
April 2009

Characterization of activity landscapes using 2D and 3D similarity methods: consensus activity cliffs.

J Chem Inf Model 2009 Feb;49(2):477-91

Torrey Pines Institute for Molecular Studies, 11350 SW Village Parkway, Port St. Lucie, Florida 34987, USA.

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http://pubs.acs.org/doi/abs/10.1021/ci800379q
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http://dx.doi.org/10.1021/ci800379qDOI Listing
February 2009

Conformation-opioid activity relationships of bicyclic guanidines from 3D similarity analysis.

Bioorg Med Chem 2008 Jun 27;16(11):5932-8. Epub 2008 Apr 27.

Torrey Pines Institute for Molecular Studies, 5775 Old Dixie Highway, Fort Pierce, FL 34946, USA.

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http://dx.doi.org/10.1016/j.bmc.2008.04.061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2533277PMC
June 2008

A similarity-based data-fusion approach to the visual characterization and comparison of compound databases.

Chem Biol Drug Des 2007 Nov 10;70(5):393-412. Epub 2007 Oct 10.

College of Pharmacy & BIO5 Institute, University of Arizona, Tucson, AZ 85721, USA.

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http://dx.doi.org/10.1111/j.1747-0285.2007.00579.xDOI Listing
November 2007