Manuela Porru

Manuela Porru

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Manuela Porru

Manuela Porru

Publications by authors named "Manuela Porru"

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Chlorambucil targets BRCA1/2-deficient tumours and counteracts PARP inhibitor resistance.

Authors:
Eliana Mc Tacconi Sophie Badie Giuliana De Gregoriis Timo Reisländer Xianning Lai Manuela Porru Cecilia Folio John Moore Arnaud Kopp Júlia Baguña Torres Deborah Sneddon Marcus Green Simon Dedic Jonathan W Lee Ankita Sati Batra Oscar M Rueda Alejandra Bruna Carlo Leonetti Carlos Caldas Bart Cornelissen Laurent Brino Anderson Ryan Annamaria Biroccio Madalena Tarsounas

EMBO Mol Med 2019 07 24;11(7):e9982. Epub 2019 May 24.

Genome Stability and Tumorigenesis Group, Department of Oncology, The CR-UK/MRC Oxford Institute for Radiation Oncology, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.15252/emmm.201809982DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6609913PMC
July 2019

BRCA2 abrogation triggers innate immune responses potentiated by treatment with PARP inhibitors.

Authors:
Timo Reisländer Emilia Puig Lombardi Florian J Groelly Ana Miar Manuela Porru Serena Di Vito Benjamin Wright Helen Lockstone Annamaria Biroccio Adrian Harris Arturo Londoño-Vallejo Madalena Tarsounas

Nat Commun 2019 07 17;10(1):3143. Epub 2019 Jul 17.

Genome Stability and Tumourigenesis Group, The CR-UK/MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Old Road Campus Research Building, Oxford, OX3 7DQ, UK.

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http://dx.doi.org/10.1038/s41467-019-11048-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6637138PMC
July 2019

TRF2 positively regulates SULF2 expression increasing VEGF-A release and activity in tumor microenvironment.

Authors:
Pasquale Zizza Roberto Dinami Manuela Porru Chiara Cingolani Erica Salvati Angela Rizzo Carmen D'Angelo Eleonora Petti Carla Azzurra Amoreo Marcella Mottolese Isabella Sperduti Angela Chambery Rosita Russo Paola Ostano Giovanna Chiorino Giovanni Blandino Andrea Sacconi Julien Cherfils-Vicini Carlo Leonetti Eric Gilson Annamaria Biroccio

Nucleic Acids Res 2019 04;47(7):3365-3382

Oncogenomic and Epigenetic Unit, IRCCS - Regina Elena National Cancer Institute, Via Elio Chianesi 53, Rome 00144, Italy.

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http://dx.doi.org/10.1093/nar/gkz041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468246PMC
April 2019

Adipose-derived stem cell-mediated paclitaxel delivery inhibits breast cancer growth.

Authors:
Maria Giovanna Scioli Simona Artuso Carmen D'Angelo Manuela Porru Federico D'Amico Alessandra Bielli Pietro Gentile Valerio Cervelli Carlo Leonetti Augusto Orlandi

PLoS One 2018 7;13(9):e0203426. Epub 2018 Sep 7.

Anatomic Pathology, Department of Biomedicine and Prevention, Tor Vergata University, Rome, Italy.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0203426PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6128546PMC
February 2019

HSP90 Inhibition Drives Degradation of FGFR2 Fusion Proteins: Implications for Treatment of Cholangiocarcinoma.

Authors:
Dante Lamberti Giulia Cristinziano Manuela Porru Carlo Leonetti Jan B Egan Chang-Xin Shi Simonetta Buglioni Carla A Amoreo Loriana Castellani Mitesh J Borad Stefano Alemà Sergio Anastasi Oreste Segatto

Hepatology 2019 Jan 14;69(1):131-142. Epub 2018 Dec 14.

Unit of Oncogenomics and Epigenetics, IRCCS Regina Elena National Cancer Institute, Rome, Italy.

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http://dx.doi.org/10.1002/hep.30127DOI Listing
January 2019

Chitosan-Based Polyelectrolyte Complexes for Doxorubicin and Zoledronic Acid Combined Therapy to Overcome Multidrug Resistance.

Authors:
Simona Giarra Silvia Zappavigna Virginia Campani Marianna Abate Alessia Maria Cossu Carlo Leonetti Manuela Porru Laura Mayol Michele Caraglia Giuseppe De Rosa

Pharmaceutics 2018 Oct 9;10(4). Epub 2018 Oct 9.

Department of Pharmacy, University of Naples Federico II, D. Montesano 49, 80131 Naples, Italy.

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http://www.mdpi.com/1999-4923/10/4/180
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http://dx.doi.org/10.3390/pharmaceutics10040180DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321278PMC
October 2018

Xenograft as In Vivo Experimental Model.

Authors:
Manuela Porru Luca Pompili Carla Caruso Carlo Leonetti

Methods Mol Biol 2018 ;1692:97-105

Experimental Chemotherapy Laboratory, UOSD SAFU, Regina Elena National Cancer Institute, Via Elio Chianesi 53, 00144, Rome, Italy.

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http://dx.doi.org/10.1007/978-1-4939-7401-6_9DOI Listing
June 2018

Targeting KRAS in metastatic colorectal cancer: current strategies and emerging opportunities.

Authors:
Manuela Porru Luca Pompili Carla Caruso Annamaria Biroccio Carlo Leonetti

J Exp Clin Cancer Res 2018 Mar 13;37(1):57. Epub 2018 Mar 13.

UOSD SAFU, Regina Elena National Cancer Institute, Rome, Italy.

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https://jeccr.biomedcentral.com/articles/10.1186/s13046-018-
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http://dx.doi.org/10.1186/s13046-018-0719-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5850913PMC
March 2018

BRCA1 and BRCA2 tumor suppressors protect against endogenous acetaldehyde toxicity.

Authors:
Eliana Mc Tacconi Xianning Lai Cecilia Folio Manuela Porru Gijs Zonderland Sophie Badie Johanna Michl Irene Sechi Mélanie Rogier Verónica Matía García Ankita Sati Batra Oscar M Rueda Peter Bouwman Jos Jonkers Anderson Ryan Bernardo Reina-San-Martin Joannie Hui Nelson Tang Alejandra Bruna Annamaria Biroccio Madalena Tarsounas

EMBO Mol Med 2017 10;9(10):1398-1414

Department of Oncology, Genome Stability and Tumorigenesis Group, The CR-UK/MRC Oxford Institute for Radiation Oncology, University of Oxford, Oxford, UK

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http://embomolmed.embopress.org/lookup/doi/10.15252/emmm.201
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http://dx.doi.org/10.15252/emmm.201607446DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5623864PMC
October 2017

EMICORON: A multi-targeting G4 ligand with a promising preclinical profile.

Authors:
Manuela Porru Pasquale Zizza Marco Franceschin Carlo Leonetti Annamaria Biroccio

Biochim Biophys Acta Gen Subj 2017 May 9;1861(5 Pt B):1362-1370. Epub 2016 Nov 9.

Oncogenomic and Epigenetic Unit, Regina Elena National Cancer Institute, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bbagen.2016.11.010DOI Listing
May 2017

Focal adhesion kinase depletion reduces human hepatocellular carcinoma growth by repressing enhancer of zeste homolog 2.

Authors:
Daniela Gnani Ilaria Romito Simona Artuso Marco Chierici Cristiano De Stefanis Nadia Panera Annalisa Crudele Sara Ceccarelli Elena Carcarino Valentina D'Oria Manuela Porru Ezio Giorda Karin Ferrari Luca Miele Erica Villa Clara Balsano Diego Pasini Cesare Furlanello Franco Locatelli Valerio Nobili Rossella Rota Carlo Leonetti Anna Alisi

Cell Death Differ 2017 05 24;24(5):889-902. Epub 2017 Mar 24.

Liver Research Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.

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http://dx.doi.org/10.1038/cdd.2017.34DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5423113PMC
May 2017

Patient-derived xenografts: a relevant preclinical model for drug development.

Authors:
Luca Pompili Manuela Porru Carla Caruso Annamaria Biroccio Carlo Leonetti

J Exp Clin Cancer Res 2016 12 5;35(1):189. Epub 2016 Dec 5.

UOSD SAFU, Department of Research, Diagnosis and Innovative Technologies, Traslational Research Area, Regina Elena National Cancer Institute, Via Elio Chianesi 53, Rome, 00144, Italy.

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http://dx.doi.org/10.1186/s13046-016-0462-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5139018PMC
December 2016

Intragenic G-quadruplex structure formed in the human CD133 and its biological and translational relevance.

Authors:
Pasquale Zizza Chiara Cingolani Simona Artuso Erica Salvati Angela Rizzo Carmen D'Angelo Manuela Porru Bruno Pagano Jussara Amato Antonio Randazzo Ettore Novellino Antonella Stoppacciaro Eric Gilson Giorgio Stassi Carlo Leonetti Annamaria Biroccio

Nucleic Acids Res 2016 Feb 27;44(4):1579-90. Epub 2015 Oct 27.

Area of Translational Research, Regina Elena National Cancer Institute, via E. Chianesi 53, 00144 Rome, Italy

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http://nar.oxfordjournals.org/content/early/2015/10/27/nar.g
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http://nar.oxfordjournals.org/lookup/doi/10.1093/nar/gkv1122
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http://dx.doi.org/10.1093/nar/gkv1122DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4770210PMC
February 2016

Targeting BRCA1 and BRCA2 Deficiencies with G-Quadruplex-Interacting Compounds.

Authors:
Jutta Zimmer Eliana M C Tacconi Cecilia Folio Sophie Badie Manuela Porru Kerstin Klare Manuela Tumiati Enni Markkanen Swagata Halder Anderson Ryan Stephen P Jackson Kristijan Ramadan Sergey G Kuznetsov Annamaria Biroccio Julian E Sale Madalena Tarsounas

Mol Cell 2016 Feb 31;61(3):449-460. Epub 2015 Dec 31.

Genome Stability and Tumourigenesis Group, CRUK/MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Old Road Campus Research Building, Oxford OX3 7DQ, UK. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2015.12.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4747901PMC
February 2016

Targeting G-Quadruplex DNA Structures by EMICORON Has a Strong Antitumor Efficacy against Advanced Models of Human Colon Cancer.

Authors:
Manuela Porru Simona Artuso Erica Salvati Armandodoriano Bianco Marco Franceschin Maria Grazia Diodoro Daniela Passeri Augusto Orlandi Francesco Savorani Maurizio D'Incalci Annamaria Biroccio Carlo Leonetti

Mol Cancer Ther 2015 Nov 24;14(11):2541-51. Epub 2015 Aug 24.

Experimental Chemotherapy Laboratory, Regina Elena National Cancer Institute, Rome, Italy.

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http://dx.doi.org/10.1158/1535-7163.MCT-15-0253DOI Listing
November 2015

Down-regulation of the Lamin A/C in neuroblastoma triggers the expansion of tumor initiating cells.

Authors:
Marta Nardella Loredana Guglielmi Carla Musa Ilaria Iannetti Giovanna Maresca Donatella Amendola Manuela Porru Elisabetta Carico Giuseppe Sessa Rosalba Camerlingo Carlo Dominici Francesca Megiorni Marika Milan Claudia Bearzi Roberto Rizzi Giuseppe Pirozzi Carlo Leonetti Barbara Bucci Delio Mercanti Armando Felsani Igea D'Agnano

Oncotarget 2015 Oct;6(32):32821-40

Institute of Cell Biology and Neurobiology-CNR, Monterotondo, Rome, Italy.

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http://dx.doi.org/10.18632/oncotarget.5104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741732PMC
October 2015

Sema6A and Mical1 control cell growth and survival of BRAFV600E human melanoma cells.

Authors:
Rossella Loria Giulia Bon Valentina Perotti Enzo Gallo Ilaria Bersani Paola Baldassari Manuela Porru Carlo Leonetti Selene Di Carlo Paolo Visca Maria Felice Brizzi Andrea Anichini Roberta Mortarini Rita Falcioni

Oncotarget 2015 Feb;6(5):2779-93

Department of Experimental Oncology, Regina Elena National Cancer Institute, Rome, Italy.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4413617PMC
http://dx.doi.org/10.18632/oncotarget.2995DOI Listing
February 2015

A basal level of DNA damage and telomere deprotection increases the sensitivity of cancer cells to G-quadruplex interactive compounds.

Authors:
Erica Salvati Angela Rizzo Sara Iachettini Pasquale Zizza Chiara Cingolani Carmen D'Angelo Manuela Porru Chiara Mondello Aurora Aiello Antonella Farsetti Eric Gilson Carlo Leonetti Annamaria Biroccio

Nucleic Acids Res 2015 Feb 23;43(3):1759-69. Epub 2015 Jan 23.

Experimental Chemotherapy Laboratory, Regina Elena National Cancer Institute, Rome, Italy

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http://dx.doi.org/10.1093/nar/gkv006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4330372PMC
February 2015

Erratum: identification of novel RHPS4-derivative ligands with improved toxicological profiles and telomere-targeting activities.

Authors:
Angela Rizzo Sara Iachettini Pasquale Zizza Chiara Cingolani Manuela Porru Simona Artuso Malcolm Stevens Marc Hummersone Annamaria Biroccio Erica Salvati Carlo Leonetti

J Exp Clin Cancer Res 2015 Feb 5;34. Epub 2015 Feb 5.

Experimental Chemotherapy Laboratory, Regina Elena National Cancer Institute, Nottingham, NG7 2RD, UK.

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http://dx.doi.org/10.1186/s13046-014-0101-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4326507PMC
February 2015

Medical treatment of orthotopic glioblastoma with transferrin-conjugated nanoparticles encapsulating zoledronic acid.

Authors:
Manuela Porru Silvia Zappavigna Giuseppina Salzano Amalia Luce Antonella Stoppacciaro Maria Luisa Balestrieri Simona Artuso Sara Lusa Giuseppe De Rosa Carlo Leonetti Michele Caraglia

Oncotarget 2014 Nov;5(21):10446-59

Department of Biochemistry, Biophysics and General Pathology, Second University of Naples, Via Costantinopoli, Naples, Italy.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4279385PMC
http://dx.doi.org/10.18632/oncotarget.2182DOI Listing
November 2014

Identification of novel RHPS4-derivative ligands with improved toxicological profiles and telomere-targeting activities.

Authors:
Angela Rizzo Sara Iachettini Pasquale Zizza Chiara Cingolani Manuela Porru Simona Artuso Malcolm Stevens Marc Hummersone Annamaria Biroccio Erica Salvati Carlo Leonetti

J Exp Clin Cancer Res 2014 Oct 6;33:81. Epub 2014 Oct 6.

Experimental Chemotherapy Laboratory, Regina Elena National Cancer Institute, via delle Messi d'Oro 156, 00158, Rome, Italy.

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http://dx.doi.org/10.1186/s13046-014-0081-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4193996PMC
October 2014

A new avenue toward androgen receptor pan-antagonists: C2 sterically hindered substitution of hydroxy-propanamides.

Authors:
Andrea Guerrini Anna Tesei Claudia Ferroni Giulia Paganelli Alice Zamagni Silvia Carloni Marzia Di Donato Gabriella Castoria Carlo Leonetti Manuela Porru Michelandrea De Cesare Nadia Zaffaroni Giovanni Luca Beretta Alberto Del Rio Greta Varchi

J Med Chem 2014 Sep 28;57(17):7263-79. Epub 2014 Aug 28.

Institute for the Organic Synthesis and Photoreactivity, Italian National Research Council , Via Gobetti 101, 40129 Bologna, Italy.

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http://dx.doi.org/10.1021/jm5005122DOI Listing
September 2014

Human placenta-derived neurospheres are susceptible to transformation after extensive in vitro expansion.

Authors:
Donatella Amendola Marta Nardella Loredana Guglielmi Lidia Cerquetti Elisabetta Carico Viola Alesi Manuela Porru Carlo Leonetti Claudia Bearzi Roberto Rizzi Igea D'Agnano Antonio Stigliano Giuseppe Novelli Barbara Bucci

Stem Cell Res Ther 2014 Apr 22;5(2):55. Epub 2014 Apr 22.

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http://dx.doi.org/10.1186/scrt444DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055136PMC
April 2014

Evidence for G-quadruplex in the promoter of vegfr-2 and its targeting to inhibit tumor angiogenesis.

Authors:
Erica Salvati Pasquale Zizza Angela Rizzo Sara Iachettini Chiara Cingolani Carmen D'Angelo Manuela Porru Antonio Randazzo Bruno Pagano Ettore Novellino Maria Elena Pisanu Antonella Stoppacciaro Francesca Spinella Anna Bagnato Eric Gilson Carlo Leonetti Annamaria Biroccio

Nucleic Acids Res 2014 Mar 11;42(5):2945-57. Epub 2013 Dec 11.

Experimental Chemotherapy Laboratory, Regina Elena National Cancer Institute, Rome, Italy, Laboratory of Molecular Pathology, Department of Pharmacy, University of Naples "Federico II", Naples, Italy, Department of Clinical and Molecular Medicine, University of Rome "La Sapienza", Rome, Italy, Laboratory of Molecular Pathology, Regina Elena National Cancer Institute, Rome, Italy, Institute for Research on Cancer and Aging, Nice (IRCAN), Nice University, CNRS UMR7284/INSERM U1081, Faculty of Medicine, Nice, France and Department of Medical Genetics, Archet 2 Hospital, CHU of Nice, France.

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http://dx.doi.org/10.1093/nar/gkt1289DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3950687PMC
March 2014

Effect of small molecules modulating androgen receptor (SARMs) in human prostate cancer models.

Authors:
Anna Tesei Carlo Leonetti Marzia Di Donato Elisa Gabucci Manuela Porru Greta Varchi Andrea Guerrini Dino Amadori Chiara Arienti Sara Pignatta Giulia Paganelli Michele Caraglia Gabriella Castoria Wainer Zoli

PLoS One 2013 8;8(5):e62657. Epub 2013 May 8.

Biosciences Laboratory, IRCCS Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori-IRST, Meldola, Italy.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0062657PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3648536PMC
December 2013

A fluorescent curcumin-based Zn(II)-complex reactivates mutant (R175H and R273H) p53 in cancer cells.

Authors:
Alessia Garufi Daniela Trisciuoglio Manuela Porru Carlo Leonetti Antonella Stoppacciaro Valerio D'Orazi Maria Avantaggiati Alessandra Crispini Daniela Pucci Gabriella D'Orazi

J Exp Clin Cancer Res 2013 Oct 7;32:72. Epub 2013 Oct 7.

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http://jeccr.biomedcentral.com/articles/10.1186/1756-9966-32
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http://dx.doi.org/10.1186/1756-9966-32-72DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3851540PMC
October 2013

On and off-target effects of telomere uncapping G-quadruplex selective ligands based on pentacyclic acridinium salts.

Authors:
Sara Iachettini Malcolm Fg Stevens Mark Frigerio Marc G Hummersone Ian Hutchinson Thomas P Garner Mark S Searle David W Wilson Manoj Munde Rupesh Nanjunda Carmen D'Angelo Pasquale Zizza Angela Rizzo Chiara Cingolani Federica De Cicco Manuela Porru Maurizio D'Incalci Carlo Leonetti Annamaria Biroccio Erica Salvati

J Exp Clin Cancer Res 2013 Sep 19;32:68. Epub 2013 Sep 19.

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http://dx.doi.org/10.1186/1756-9966-32-68DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3849007PMC
September 2013

Influence of MLH1 on colon cancer sensitivity to poly(ADP-ribose) polymerase inhibitor combined with irinotecan.

Authors:
Lucio Tentori Carlo Leonetti Alessia Muzi Annalisa Susanna Dorio Manuela Porru Susanna Dolci Federica Campolo Patrizia Vernole Pedro Miguel Lacal Françoise Praz Grazia Graziani

Int J Oncol 2013 Jul 8;43(1):210-8. Epub 2013 May 8.

Department of System Medicine, University of Rome 'Tor Vergata', I-00133 Rome, Italy.

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http://dx.doi.org/10.3892/ijo.2013.1932DOI Listing
July 2013

Evaluation of the in vitro and in vivo antiangiogenic effects of denosumab and zoledronic acid.

Authors:
Gabriella Misso Manuela Porru Antonella Stoppacciaro Maria Castellano Federica De Cicco Carlo Leonetti Daniele Santini Michele Caraglia

Cancer Biol Ther 2012 Dec 18;13(14):1491-500. Epub 2012 Sep 18.

Department of Biochemistry and Biophysics, Second University of Naples, Naples, Italy.

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http://www.tandfonline.com/doi/abs/10.4161/cbt.22274
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http://dx.doi.org/10.4161/cbt.22274DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3542241PMC
December 2012

Aromatic core extension in the series of N-cyclic bay-substituted perylene G-quadruplex ligands: increased telomere damage, antitumor activity, and strong selectivity for neoplastic over healthy cells.

Authors:
Marco Franceschin Angela Rizzo Valentina Casagrande Erica Salvati Antonello Alvino Alessandro Altieri Alina Ciammaichella Sara Iachettini Carlo Leonetti Giancarlo Ortaggi Manuela Porru Armandodoriano Bianco Annamaria Biroccio

ChemMedChem 2012 Dec 24;7(12):2144-54. Epub 2012 Oct 24.

Dipartimento di Chimica, Sapienza Università di Roma, P.le.A. Moro 5, 00185 Roma, Italy.

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http://dx.doi.org/10.1002/cmdc.201200348DOI Listing
December 2012

New self-assembly nanoparticles and stealth liposomes for the delivery of zoledronic acid: a comparative study.

Authors:
Monica Marra Giuseppina Salzano Carlo Leonetti Manuela Porru Renato Franco Silvia Zappavigna Giuseppina Liguori Gerardo Botti Paolo Chieffi Monica Lamberti Giovanni Vitale Alberto Abbruzzese Maria Immacolata La Rotonda Giuseppe De Rosa Michele Caraglia

Biotechnol Adv 2012 Jan-Feb;30(1):302-9. Epub 2011 Jun 30.

Department of Biochemistry and Biophysics, Second University of Naples, Via Costantinopoli, Naples, Italy.

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http://dx.doi.org/10.1016/j.biotechadv.2011.06.018DOI Listing
July 2012

Restoring p53 active conformation by zinc increases the response of mutant p53 tumor cells to anticancer drugs.

Authors:
Rosa Puca Lavinia Nardinocchi Manuela Porru Amos J Simon Gideon Rechavi Carlo Leonetti David Givol Gabriella D'Orazi

Cell Cycle 2011 May 15;10(10):1679-89. Epub 2011 May 15.

National Cancer Institute Regina Elena, Rome, Italy.

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http://dx.doi.org/10.4161/cc.10.10.15642DOI Listing
May 2011

DNA damage persistence as determinant of tumor sensitivity to the combination of Topo I inhibitors and telomere-targeting agents.

Authors:
Annamaria Biroccio Manuela Porru Angela Rizzo Erica Salvati Carmen D'Angelo Augusto Orlandi Daniela Passeri Marco Franceschin Malcolm F G Stevens Eric Gilson Giovanni Beretta Gabriella Zupi Claudio Pisano Franco Zunino Carlo Leonetti

Clin Cancer Res 2011 Apr 25;17(8):2227-36. Epub 2011 Feb 25.

Experimental Chemotherapy Laboratory, Regina Elena Cancer Institute, Tor Vergata University, Rome, Italy.

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http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
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http://dx.doi.org/10.1158/1078-0432.CCR-10-3033DOI Listing
April 2011

N-cyclic bay-substituted perylene G-quadruplex ligands have selective antiproliferative effects on cancer cells and induce telomere damage.

Authors:
Valentina Casagrande Erica Salvati Antonello Alvino Armandodoriano Bianco Alina Ciammaichella Carmen D'Angelo Luca Ginnari-Satriani Anna Maria Serrilli Sara Iachettini Carlo Leonetti Stephen Neidle Giancarlo Ortaggi Manuela Porru Angela Rizzo Marco Franceschin Annamaria Biroccio

J Med Chem 2011 Mar 31;54(5):1140-56. Epub 2011 Jan 31.

Dipartimento di Chimica, Università degli Studi La Sapienza, Ple A Moro 5, 00185 Roma, Italy.

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http://dx.doi.org/10.1021/jm1013665DOI Listing
March 2011

Zinc downregulates HIF-1α and inhibits its activity in tumor cells in vitro and in vivo.

Authors:
Lavinia Nardinocchi Valentina Pantisano Rosa Puca Manuela Porru Aurora Aiello Annalisa Grasselli Carlo Leonetti Michal Safran Gideon Rechavi David Givol Antonella Farsetti Gabriella D'Orazi

PLoS One 2010 Dec 13;5(12):e15048. Epub 2010 Dec 13.

Molecular Oncogenesis Laboratory, Department of Experimental Oncology, National Cancer Institute Regina Elena, Rome, Italy.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0015048PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3001454PMC
December 2010

Stabilization of quadruplex DNA perturbs telomere replication leading to the activation of an ATR-dependent ATM signaling pathway.

Authors:
Angela Rizzo Erica Salvati Manuela Porru Carmen D'Angelo Malcolm F Stevens Maurizio D'Incalci Carlo Leonetti Eric Gilson Gabriella Zupi Annamaria Biroccio

Nucleic Acids Res 2009 Sep 13;37(16):5353-64. Epub 2009 Jul 13.

Department of Experimental Chemotherapy, Regina Elena Cancer Institute, 00158 Rome, Italy.

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http://dx.doi.org/10.1093/nar/gkp582DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2760797PMC
September 2009