Manuela Porru

Manuela Porru

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Manuela Porru

Manuela Porru

Publications by authors named "Manuela Porru"

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36Publications

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BRCA2 abrogation triggers innate immune responses potentiated by treatment with PARP inhibitors.

Nat Commun 2019 07 17;10(1):3143. Epub 2019 Jul 17.

Genome Stability and Tumourigenesis Group, The CR-UK/MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Old Road Campus Research Building, Oxford, OX3 7DQ, UK.

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http://dx.doi.org/10.1038/s41467-019-11048-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6637138PMC
July 2019

Xenograft as In Vivo Experimental Model.

Methods Mol Biol 2018 ;1692:97-105

Experimental Chemotherapy Laboratory, UOSD SAFU, Regina Elena National Cancer Institute, Via Elio Chianesi 53, 00144, Rome, Italy.

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http://dx.doi.org/10.1007/978-1-4939-7401-6_9DOI Listing
June 2018

EMICORON: A multi-targeting G4 ligand with a promising preclinical profile.

Biochim Biophys Acta Gen Subj 2017 May 9;1861(5 Pt B):1362-1370. Epub 2016 Nov 9.

Oncogenomic and Epigenetic Unit, Regina Elena National Cancer Institute, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bbagen.2016.11.010DOI Listing
May 2017

Patient-derived xenografts: a relevant preclinical model for drug development.

J Exp Clin Cancer Res 2016 12 5;35(1):189. Epub 2016 Dec 5.

UOSD SAFU, Department of Research, Diagnosis and Innovative Technologies, Traslational Research Area, Regina Elena National Cancer Institute, Via Elio Chianesi 53, Rome, 00144, Italy.

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http://dx.doi.org/10.1186/s13046-016-0462-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5139018PMC
December 2016

Targeting BRCA1 and BRCA2 Deficiencies with G-Quadruplex-Interacting Compounds.

Mol Cell 2016 Feb 31;61(3):449-460. Epub 2015 Dec 31.

Genome Stability and Tumourigenesis Group, CRUK/MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Old Road Campus Research Building, Oxford OX3 7DQ, UK. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2015.12.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4747901PMC
February 2016

Identification of novel RHPS4-derivative ligands with improved toxicological profiles and telomere-targeting activities.

J Exp Clin Cancer Res 2014 Oct 6;33:81. Epub 2014 Oct 6.

Experimental Chemotherapy Laboratory, Regina Elena National Cancer Institute, via delle Messi d'Oro 156, 00158, Rome, Italy.

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http://dx.doi.org/10.1186/s13046-014-0081-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4193996PMC
October 2014

A new avenue toward androgen receptor pan-antagonists: C2 sterically hindered substitution of hydroxy-propanamides.

J Med Chem 2014 Sep 28;57(17):7263-79. Epub 2014 Aug 28.

Institute for the Organic Synthesis and Photoreactivity, Italian National Research Council , Via Gobetti 101, 40129 Bologna, Italy.

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http://dx.doi.org/10.1021/jm5005122DOI Listing
September 2014

Evidence for G-quadruplex in the promoter of vegfr-2 and its targeting to inhibit tumor angiogenesis.

Nucleic Acids Res 2014 Mar 11;42(5):2945-57. Epub 2013 Dec 11.

Experimental Chemotherapy Laboratory, Regina Elena National Cancer Institute, Rome, Italy, Laboratory of Molecular Pathology, Department of Pharmacy, University of Naples "Federico II", Naples, Italy, Department of Clinical and Molecular Medicine, University of Rome "La Sapienza", Rome, Italy, Laboratory of Molecular Pathology, Regina Elena National Cancer Institute, Rome, Italy, Institute for Research on Cancer and Aging, Nice (IRCAN), Nice University, CNRS UMR7284/INSERM U1081, Faculty of Medicine, Nice, France and Department of Medical Genetics, Archet 2 Hospital, CHU of Nice, France.

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http://dx.doi.org/10.1093/nar/gkt1289DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3950687PMC
March 2014