Manuela Neumann

Manuela Neumann

UNVERIFIED PROFILE

Are you Manuela Neumann?   Register this Author

Register author
Manuela Neumann

Manuela Neumann

Publications by authors named "Manuela Neumann"

Are you Manuela Neumann?   Register this Author

100Publications

2833Reads

21Profile Views

Subcortical TDP-43 pathology patterns validate cortical FTLD-TDP subtypes and demonstrate unique aspects of C9orf72 mutation cases.

Acta Neuropathol 2019 Sep 9. Epub 2019 Sep 9.

Department of Neuropathology, German Center for Neurodegenerative Diseases, University of Tübingen, Tübingen, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00401-019-02070-4DOI Listing
September 2019

CRISPR-based tools for targeted transcriptional and epigenetic regulation in plants.

PLoS One 2019 26;14(9):e0222778. Epub 2019 Sep 26.

Umeå Plant Science Centre, Department of Plant Physiology, Umeå University, Umeå, Sweden.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0222778PLOS
September 2019

Genome-wide analyses as part of the international FTLD-TDP whole-genome sequencing consortium reveals novel disease risk factors and increases support for immune dysfunction in FTLD.

Authors:
Cyril Pottier Yingxue Ren Ralph B Perkerson Matt Baker Gregory D Jenkins Marka van Blitterswijk Mariely DeJesus-Hernandez Jeroen G J van Rooij Melissa E Murray Elizabeth Christopher Shannon K McDonnell Zachary Fogarty Anthony Batzler Shulan Tian Cristina T Vicente Billie Matchett Anna M Karydas Ging-Yuek Robin Hsiung Harro Seelaar Merel O Mol Elizabeth C Finger Caroline Graff Linn Öijerstedt Manuela Neumann Peter Heutink Matthis Synofzik Carlo Wilke Johannes Prudlo Patrizia Rizzu Javier Simon-Sanchez Dieter Edbauer Sigrun Roeber Janine Diehl-Schmid Bret M Evers Andrew King M Marsel Mesulam Sandra Weintraub Changiz Geula Kevin F Bieniek Leonard Petrucelli Geoffrey L Ahern Eric M Reiman Bryan K Woodruff Richard J Caselli Edward D Huey Martin R Farlow Jordan Grafman Simon Mead Lea T Grinberg Salvatore Spina Murray Grossman David J Irwin Edward B Lee EunRan Suh Julie Snowden David Mann Nilufer Ertekin-Taner Ryan J Uitti Zbigniew K Wszolek Keith A Josephs Joseph E Parisi David S Knopman Ronald C Petersen John R Hodges Olivier Piguet Ethan G Geier Jennifer S Yokoyama Robert A Rissman Ekaterina Rogaeva Julia Keith Lorne Zinman Maria Carmela Tartaglia Nigel J Cairns Carlos Cruchaga Bernardino Ghetti Julia Kofler Oscar L Lopez Thomas G Beach Thomas Arzberger Jochen Herms Lawrence S Honig Jean Paul Vonsattel Glenda M Halliday John B Kwok Charles L White Marla Gearing Jonathan Glass Sara Rollinson Stuart Pickering-Brown Jonathan D Rohrer John Q Trojanowski Vivianna Van Deerlin Eileen H Bigio Claire Troakes Safa Al-Sarraj Yan Asmann Bruce L Miller Neill R Graff-Radford Bradley F Boeve William W Seeley Ian R A Mackenzie John C van Swieten Dennis W Dickson Joanna M Biernacka Rosa Rademakers

Acta Neuropathol 2019 Jun 9;137(6):879-899. Epub 2019 Feb 9.

Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL, 32224, USA.

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s00401-019-01962-9
Publisher Site
http://dx.doi.org/10.1007/s00401-019-01962-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6533145PMC
June 2019

FT Modulates Genome-Wide DNA-Binding of the bZIP Transcription Factor FD.

Plant Physiol 2019 05 15;180(1):367-380. Epub 2019 Feb 15.

Umeå Plant Science Centre, Department of Plant Physiology, Umeå University, SE-901 87 Umeå, Sweden

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1104/pp.18.01505DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6501114PMC
May 2019

High frequency of H3 K27M mutations in adult midline gliomas.

J Cancer Res Clin Oncol 2019 Apr 4;145(4):839-850. Epub 2019 Jan 4.

Department of Neuropathology, Institute of Pathology and Neuropathology, University Hospital of Tuebingen, Eberhard Karls University of Tuebingen, 72076, Tuebingen, Germany.

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s00432-018-02836-5
Publisher Site
http://dx.doi.org/10.1007/s00432-018-02836-5DOI Listing
April 2019

Fine-Grained Analysis of Spontaneous Mutation Spectrum and Frequency in .

Genetics 2019 02 4;211(2):703-714. Epub 2018 Dec 4.

Department of Biology and Microbiology, South Dakota State University, Brookings, South Dakota 57007.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1534/genetics.118.301721DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366913PMC
February 2019

Phloem Companion Cell-Specific Transcriptomic and Epigenomic Analyses Identify MRF1, a Regulator of Flowering.

Plant Cell 2019 Feb 22;31(2):325-345. Epub 2019 Jan 22.

Max Planck Institute for Developmental Biology, Department of Molecular Biology, 72076 Tübingen, Germany

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1105/tpc.17.00714DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447005PMC
February 2019

EIF2AK3 variants in Dutch patients with Alzheimer's disease.

Neurobiol Aging 2019 01 24;73:229.e11-229.e18. Epub 2018 Aug 24.

Alzheimer Center and Department of Neurology, Erasmus Medical Center, Rotterdam, The Netherlands; Alzheimer Center, Department of Neurology, VU University Medical Center, Amsterdam, The Netherlands. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neurobiolaging.2018.08.016DOI Listing
January 2019

Potential genetic modifiers of disease risk and age at onset in patients with frontotemporal lobar degeneration and GRN mutations: a genome-wide association study.

Authors:
Cyril Pottier Xiaolai Zhou Ralph B Perkerson Matt Baker Gregory D Jenkins Daniel J Serie Roberta Ghidoni Luisa Benussi Giuliano Binetti Adolfo López de Munain Miren Zulaica Fermin Moreno Isabelle Le Ber Florence Pasquier Didier Hannequin Raquel Sánchez-Valle Anna Antonell Albert Lladó Tammee M Parsons NiCole A Finch Elizabeth C Finger Carol F Lippa Edward D Huey Manuela Neumann Peter Heutink Matthis Synofzik Carlo Wilke Robert A Rissman Jaroslaw Slawek Emilia Sitek Peter Johannsen Jørgen E Nielsen Yingxue Ren Marka van Blitterswijk Mariely DeJesus-Hernandez Elizabeth Christopher Melissa E Murray Kevin F Bieniek Bret M Evers Camilla Ferrari Sara Rollinson Anna Richardson Elio Scarpini Giorgio G Fumagalli Alessandro Padovani John Hardy Parastoo Momeni Raffaele Ferrari Francesca Frangipane Raffaele Maletta Maria Anfossi Maura Gallo Leonard Petrucelli EunRan Suh Oscar L Lopez Tsz H Wong Jeroen G J van Rooij Harro Seelaar Simon Mead Richard J Caselli Eric M Reiman Marwan Noel Sabbagh Mads Kjolby Anders Nykjaer Anna M Karydas Adam L Boxer Lea T Grinberg Jordan Grafman Salvatore Spina Adrian Oblak M-Marsel Mesulam Sandra Weintraub Changiz Geula John R Hodges Olivier Piguet William S Brooks David J Irwin John Q Trojanowski Edward B Lee Keith A Josephs Joseph E Parisi Nilüfer Ertekin-Taner David S Knopman Benedetta Nacmias Irene Piaceri Silvia Bagnoli Sandro Sorbi Marla Gearing Jonathan Glass Thomas G Beach Sandra E Black Mario Masellis Ekaterina Rogaeva Jean-Paul Vonsattel Lawrence S Honig Julia Kofler Amalia C Bruni Julie Snowden David Mann Stuart Pickering-Brown Janine Diehl-Schmid Juliane Winkelmann Daniela Galimberti Caroline Graff Linn Öijerstedt Claire Troakes Safa Al-Sarraj Carlos Cruchaga Nigel J Cairns Jonathan D Rohrer Glenda M Halliday John B Kwok John C van Swieten Charles L White Bernardino Ghetti Jill R Murell Ian R A Mackenzie Ging-Yuek R Hsiung Barbara Borroni Giacomina Rossi Fabrizio Tagliavini Zbigniew K Wszolek Ronald C Petersen Eileen H Bigio Murray Grossman Vivianna M Van Deerlin William W Seeley Bruce L Miller Neill R Graff-Radford Bradley F Boeve Dennis W Dickson Joanna M Biernacka Rosa Rademakers

Lancet Neurol 2018 06 30;17(6):548-558. Epub 2018 Apr 30.

Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S1474-4422(18)30126-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6237181PMC
June 2018

Fused in Sarcoma Neuropathology in Neurodegenerative Disease.

Cold Spring Harb Perspect Med 2017 Dec 1;7(12). Epub 2017 Dec 1.

Department of Neuropathology, University of Tübingen and German Center for Neurodegenerative Diseases (DZNE), Tübingen 72076, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1101/cshperspect.a024299DOI Listing
December 2017

Novel cases of amyotrophic lateral sclerosis after treatment of cerebral arteriovenous malformationss.

Swiss Med Wkly 2016 12;146:w14361. Epub 2016 Nov 12.

Department of Neurology, University of Rostock and German Centre for Neurodegenerative Diseases/ DZNE, Rostock, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4414/smw.2016.14361DOI Listing
September 2017

Reappraisal of TDP-43 pathology in FTLD-U subtypes.

Acta Neuropathol 2017 07 2;134(1):79-96. Epub 2017 May 2.

Department of Neuropathology, DZNE, German Center for Neurodegenerative Diseases, University of Tübingen, Tübingen, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00401-017-1716-8DOI Listing
July 2017

Temporal dynamics of gene expression and histone marks at the Arabidopsis shoot meristem during flowering.

Nat Commun 2017 05 17;8:15120. Epub 2017 May 17.

Department of Molecular Biology, Max Planck Institute for Developmental Biology, Spemannstrasse 35, 72076 Tübingen, Germany.

View Article

Download full-text PDF

Source
http://www.nature.com/doifinder/10.1038/ncomms15120
Publisher Site
http://dx.doi.org/10.1038/ncomms15120DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5442315PMC
May 2017

Pathological TDP-43 changes in Betz cells differ from those in bulbar and spinal α-motoneurons in sporadic amyotrophic lateral sclerosis.

Acta Neuropathol 2017 01 18;133(1):79-90. Epub 2016 Oct 18.

Clinical Neuroanatomy Section, Department of Neurology, Center for Biomedical Research, University of Ulm, Helmholtzstrasse 8/1, 89081, Ulm, Germany.

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s00401-016-1633-2
Publisher Site
http://dx.doi.org/10.1007/s00401-016-1633-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5209403PMC
January 2017

TDP-43 pathology and cognition in ALS: A prospective clinicopathologic correlation study.

Neurology 2016 Sep 3;87(10):1019-23. Epub 2016 Aug 3.

From the Departments of Neurology (J.P.) and Psychosomatic Medicine (E.K., S.T.) and Institute of Forensic Medicine (A.B.), Rostock University Medical Center; German Center for Neurodegenerative Diseases (DZNE) (J.P., S.T.), Rostock; Institute of Medical Biostatistics, Epidemiology and Informatics (J.K.), University Medical Center, Johannes Gutenberg University Mainz, Germany; Quantitative Neuroimaging Group (C.S.), Academic Unit of Neurology, Biomedical Sciences Institute, Trinity College Dublin, Ireland; Department of Neuropathology (M.N.), University Hospital of Tübingen; and German Center for Neurodegenerative Diseases (DZNE) (M.N.), Tübingen, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1212/WNL.0000000000003062DOI Listing
September 2016

Molecular neuropathology of frontotemporal dementia: insights into disease mechanisms from postmortem studies.

J Neurochem 2016 08 15;138 Suppl 1:54-70. Epub 2016 Jun 15.

Department of Neuropathology, University of Tübingen and German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jnc.13588DOI Listing
August 2016

Frontotemporal dementia: from molecular mechanisms to therapy.

J Neurochem 2016 08;138 Suppl 1:3-5

Department for Neuropathology, University Hospital of Tübingen, Tübingen, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jnc.13619DOI Listing
August 2016

Neurofilament Light Chain in Blood and CSF as Marker of Disease Progression in Mouse Models and in Neurodegenerative Diseases.

Neuron 2016 07 9;91(1):56-66. Epub 2016 Jun 9.

German Center for Neurodegenerative Diseases (DZNE), Tuebingen, D-72076 Tuebingen, Germany; Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tuebingen, D-72076 Tuebingen, Germany. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuron.2016.05.018DOI Listing
July 2016

Novel COL4A3 gene mutations in a consanguineous family with autosomal recessive Alport syndrome.

Nephrology (Carlton) 2015 Aug;20(8):580

Human Genetics Unit, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/nep.12430DOI Listing
August 2015

Malignant optic glioma - the spectrum of disease in a case series.

Graefes Arch Clin Exp Ophthalmol 2015 Jul 26;253(7):1187-94. Epub 2015 May 26.

Department of Ophthalmology, University Hospital Zurich, Frauenklinikstrasse 24, CH-8091, Zurich, Switzerland,

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00417-015-3045-8DOI Listing
July 2015

Reply: PRKAR1B mutations are a rare cause of FUS negative neuronal intermediate filament inclusion disease.

Brain 2015 Jun 19;138(Pt 6):e358. Epub 2014 Nov 19.

1 Department of Neurology, Erasmus Medical Centre, 3015 CE Rotterdam, The Netherlands 7 Alzheimer Centre, Neuroscience Campus Amsterdam, 1007 MB Amsterdam, The Netherlands 8 Department of Neurology, Neuroscience Campus Amsterdam, 1007 MB Amsterdam, The Netherlands

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/brain/awu333DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4614125PMC
June 2015

PART is part of Alzheimer disease.

Acta Neuropathol 2015 May 28;129(5):749-56. Epub 2015 Jan 28.

Laboratoire de Neuropathologie Escourolle, AP-HP, Hôpital de la Salpêtrière, 47 Bd de l'Hôpital, 75651, Paris Cedex 13, France,

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00401-015-1390-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4405349PMC
May 2015

Aβ seeds resist inactivation by formaldehyde.

Acta Neuropathol 2014 Oct 6;128(4):477-84. Epub 2014 Sep 6.

German Center for Neurodegenerative Diseases (DZNE), 72076, Tübingen, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00401-014-1339-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4169116PMC
October 2014

The neuropathology associated with repeat expansions in the C9ORF72 gene.

Acta Neuropathol 2014 Mar 20;127(3):347-57. Epub 2013 Dec 20.

Department of Pathology, University of British Columbia and Vancouver General Hospital, Vancouver, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00401-013-1232-4DOI Listing
March 2014

TMEM106B is a genetic modifier of frontotemporal lobar degeneration with C9orf72 hexanucleotide repeat expansions.

Acta Neuropathol 2014 Mar 19;127(3):407-18. Epub 2014 Jan 19.

Cell and Molecular Biology Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00401-013-1239-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4003885PMC
March 2014

Dipeptide repeat protein pathology in C9ORF72 mutation cases: clinico-pathological correlations.

Acta Neuropathol 2013 Dec 6;126(6):859-79. Epub 2013 Oct 6.

Department of Pathology, Vancouver General Hospital, University of British Columbia, Vancouver, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00401-013-1181-yDOI Listing
December 2013

Mechanisms of disease in frontotemporal lobar degeneration: gain of function versus loss of function effects.

Acta Neuropathol 2012 Sep 10;124(3):373-82. Epub 2012 Aug 10.

Neuroscience Research Australia, University of New South Wales, Sydney, Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00401-012-1030-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3445027PMC
September 2012

Advances in understanding the molecular basis of frontotemporal dementia.

Nat Rev Neurol 2012 Aug 26;8(8):423-34. Epub 2012 Jun 26.

Department of Neuroscience, Mayo Clinic Florida, Jacksonville, FL 32224, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nrneurol.2012.117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3629543PMC
August 2012

FET proteins in frontotemporal dementia and amyotrophic lateral sclerosis.

Brain Res 2012 Jun 13;1462:40-3. Epub 2011 Dec 13.

Department of Pathology, Vancouver General Hospital, 855 West 12th Avenue, Vancouver, BC, Canada V5Z 1M9.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.brainres.2011.12.010DOI Listing
June 2012

Requirements for stress granule recruitment of fused in sarcoma (FUS) and TAR DNA-binding protein of 43 kDa (TDP-43).

J Biol Chem 2012 Jun 4;287(27):23079-94. Epub 2012 May 4.

Adolf-Butenandt-Institute, Biochemistry, Ludwig-Maximilians-University, München, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M111.328757DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3391091PMC
June 2012

Novel types of frontotemporal lobar degeneration: beyond tau and TDP-43.

J Mol Neurosci 2011 Nov 21;45(3):402-8. Epub 2011 May 21.

Department of Pathology and Laboratory Medicine, University of British Columbia and Vancouver General Hospital, 855 West 12th Avenue, Vancouver, BC, V5Z 1M9, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12031-011-9551-1DOI Listing
November 2011

Neuropathological background of phenotypical variability in frontotemporal dementia.

Acta Neuropathol 2011 Aug 26;122(2):137-53. Epub 2011 May 26.

Behavioral Neurology and Movement Disorders, Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA.

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s00401-011-0839-6
Publisher Site
http://dx.doi.org/10.1007/s00401-011-0839-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3232515PMC
August 2011

Distinct pathological subtypes of FTLD-FUS.

Acta Neuropathol 2011 Feb 30;121(2):207-18. Epub 2010 Oct 30.

Department of Pathology, Vancouver General Hospital, University of British Columbia, BC, Canada.

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s00401-010-0764-0
Publisher Site
http://dx.doi.org/10.1007/s00401-010-0764-0DOI Listing
February 2011

TDP-43 and FUS in amyotrophic lateral sclerosis and frontotemporal dementia.

Lancet Neurol 2010 Oct;9(10):995-1007

Department of Pathology and Laboratory Medicine, Vancouver General Hospital, Vancouver, BC, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S1474-4422(10)70195-2DOI Listing
October 2010

Transgenic mice expressing mutant forms VCP/p97 recapitulate the full spectrum of IBMPFD including degeneration in muscle, brain and bone.

Hum Mol Genet 2010 May 10;19(9):1741-55. Epub 2010 Feb 10.

Department of Developmental Neurobiology, St. Jude Children's Research, Hospital, Memphis, TN 38105, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/hmg/ddq050DOI Listing
May 2010

Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions.

Authors:
Vivianna M Van Deerlin Patrick M A Sleiman Maria Martinez-Lage Alice Chen-Plotkin Li-San Wang Neill R Graff-Radford Dennis W Dickson Rosa Rademakers Bradley F Boeve Murray Grossman Steven E Arnold David M A Mann Stuart M Pickering-Brown Harro Seelaar Peter Heutink John C van Swieten Jill R Murrell Bernardino Ghetti Salvatore Spina Jordan Grafman John Hodges Maria Grazia Spillantini Sid Gilman Andrew P Lieberman Jeffrey A Kaye Randall L Woltjer Eileen H Bigio Marsel Mesulam Safa Al-Sarraj Claire Troakes Roger N Rosenberg Charles L White Isidro Ferrer Albert Lladó Manuela Neumann Hans A Kretzschmar Christine Marie Hulette Kathleen A Welsh-Bohmer Bruce L Miller Ainhoa Alzualde Adolfo Lopez de Munain Ann C McKee Marla Gearing Allan I Levey James J Lah John Hardy Jonathan D Rohrer Tammaryn Lashley Ian R A Mackenzie Howard H Feldman Ronald L Hamilton Steven T Dekosky Julie van der Zee Samir Kumar-Singh Christine Van Broeckhoven Richard Mayeux Jean Paul G Vonsattel Juan C Troncoso Jillian J Kril John B J Kwok Glenda M Halliday Thomas D Bird Paul G Ince Pamela J Shaw Nigel J Cairns John C Morris Catriona Ann McLean Charles DeCarli William G Ellis Stefanie H Freeman Matthew P Frosch John H Growdon Daniel P Perl Mary Sano David A Bennett Julie A Schneider Thomas G Beach Eric M Reiman Bryan K Woodruff Jeffrey Cummings Harry V Vinters Carol A Miller Helena C Chui Irina Alafuzoff Päivi Hartikainen Danielle Seilhean Douglas Galasko Eliezer Masliah Carl W Cotman M Teresa Tuñón M Cristina Caballero Martínez David G Munoz Steven L Carroll Daniel Marson Peter F Riederer Nenad Bogdanovic Gerard D Schellenberg Hakon Hakonarson John Q Trojanowski Virginia M-Y Lee

Nat Genet 2010 Mar 14;42(3):234-9. Epub 2010 Feb 14.

[1] Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA. [2] These authors contributed equally to this work.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ng.536DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2828525PMC
March 2010

Transactive response DNA-binding protein 43 burden in familial Alzheimer disease and Down syndrome.

Arch Neurol 2009 Dec;66(12):1483-8

Drexel University College of Medicine Philadelphia, Philadelphia, Pennsylvania 19102, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1001/archneurol.2009.277DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2864642PMC
December 2009

Abundant FUS-immunoreactive pathology in neuronal intermediate filament inclusion disease.

Acta Neuropathol 2009 Nov 9;118(5):605-16. Epub 2009 Aug 9.

Institute of Neuropathology, University Hospital of Zürich, Zurich, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00401-009-0581-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2864784PMC
November 2009

A new subtype of frontotemporal lobar degeneration with FUS pathology.

Brain 2009 Nov 11;132(Pt 11):2922-31. Epub 2009 Aug 11.

Institute of Neuropathology, University Hospital of Zürich, Zürich, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/brain/awp214DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2768659PMC
November 2009

FUS pathology in basophilic inclusion body disease.

Acta Neuropathol 2009 Nov 15;118(5):617-27. Epub 2009 Oct 15.

Division of Pathology, Department of Laboratory Medicine and Pathobiology, Room # 2-097 Cardinal Carter, St. Michael's Hospital, University of Toronto, 30 Bond Street, Toronto, ON M5B 1W8, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00401-009-0598-9DOI Listing
November 2009

Proteolytic processing of TAR DNA binding protein-43 by caspases produces C-terminal fragments with disease defining properties independent of progranulin.

J Neurochem 2009 Aug 9;110(3):1082-94. Epub 2009 Jun 9.

Deutsches Zentrum für Neurodegenerative Erkrankungen and Adolf-Butenandt-Institute, Department of Biochemistry, Ludwig-Maximilians-University, Munich, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1471-4159.2009.06211.xDOI Listing
August 2009

The molecular basis of frontotemporal dementia.

Expert Rev Mol Med 2009 Jul 29;11:e23. Epub 2009 Jul 29.

Institute of Neuropathology, University Hospital of Zürich, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1017/S1462399409001136DOI Listing
July 2009

Expression of TDP-43 C-terminal Fragments in Vitro Recapitulates Pathological Features of TDP-43 Proteinopathies.

J Biol Chem 2009 Mar 21;284(13):8516-24. Epub 2009 Jan 21.

Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M809462200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2659210PMC
March 2009

Phenotypic heterogeneity and genetic modifiers in prion disease caused by a Pro102Leu mutation in the PRNP gene.

Authors:
Manuela Neumann

Nat Clin Pract Neurol 2009 Feb 17;5(2):68-9. Epub 2008 Dec 17.

Institute of Neuropathology, University Hospital of Zürich, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ncpneuro0998DOI Listing
February 2009

Molecular neuropathology of TDP-43 proteinopathies.

Authors:
Manuela Neumann

Int J Mol Sci 2009 Jan 9;10(1):232-46. Epub 2009 Jan 9.

Institute of Neuropathology, University Hospital of Zurich, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/ijms10010232DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2662455PMC
January 2009

Two German kindreds with familial amyotrophic lateral sclerosis due to TARDBP mutations.

Arch Neurol 2008 Sep;65(9):1185-9

Center for Neuropathology and Prion Research, Ludwig-Maximilians University, Munich, Feodor-Lynen-Strasse 23, 81377 Munich, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1001/archneur.65.9.1185DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2742976PMC
September 2008

TDP-43-negative FTLD-U is a significant new clinico-pathological subtype of FTLD.

Acta Neuropathol 2008 Aug 7;116(2):147-57. Epub 2008 Jun 7.

Center for Neuropathology and Prion Research, Ludwig-Maximilians University Munich, Feodor-Lynen-Str. 23, 81377, Munich, Germany.

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s00401-008-0395-x
Publisher Site
http://dx.doi.org/10.1007/s00401-008-0395-xDOI Listing
August 2008

Dopaminergic midbrain neurons are the prime target for mitochondrial DNA deletions.

J Neurol 2008 Aug 11;255(8):1231-5. Epub 2008 Jul 11.

Dept. of Neurology, Mitochondrial Neurogenetics, University of Munich, Marchioninistr. 15, 81377, Munich, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00415-008-0892-9DOI Listing
August 2008

Enrichment of C-terminal fragments in TAR DNA-binding protein-43 cytoplasmic inclusions in brain but not in spinal cord of frontotemporal lobar degeneration and amyotrophic lateral sclerosis.

Am J Pathol 2008 Jul 5;173(1):182-94. Epub 2008 Jun 5.

Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, 3600 Spruce St., 3rd floor, Maloney Bldg., Philadelphia, PA 19104, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2353/ajpath.2008.080003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2438296PMC
July 2008

TDP-43 immunoreactivity in anoxic, ischemic and neoplastic lesions of the central nervous system.

Acta Neuropathol 2008 Mar 18;115(3):305-11. Epub 2007 Dec 18.

Department of Pathology and Laboratory Medicine, Center for Neurodegenerative Disease Research, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

View Article

Download full-text PDF

Source
http://link.springer.com/content/pdf/10.1007/s00401-007-0331
Web Search
http://link.springer.com/10.1007/s00401-007-0331-5
Publisher Site
http://dx.doi.org/10.1007/s00401-007-0331-5DOI Listing
March 2008

Missense mutations in the progranulin gene linked to frontotemporal lobar degeneration with ubiquitin-immunoreactive inclusions reduce progranulin production and secretion.

J Biol Chem 2008 Jan 5;283(3):1744-53. Epub 2007 Nov 5.

Munich Center for Integrated Protein Science and Adolf-Butenandt-Institute, Department of Biochemistry, Laboratory for Neurodegenerative Disease Research, Schillerstrasse 44, 80336 Munich, Germany.

View Article

Download full-text PDF

Source
http://www.jbc.org/lookup/doi/10.1074/jbc.M705115200
Publisher Site
http://dx.doi.org/10.1074/jbc.M705115200DOI Listing
January 2008

Microglial activation mediates neurodegeneration related to oligodendroglial alpha-synucleinopathy: implications for multiple system atrophy.

Mov Disord 2007 Nov;22(15):2196-203

Clinical Neurobiology Unit, Neurodegeneration Research Laboratory, Department of Neurology, Innsbruck Medical University, Innsbruck, Austria.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/mds.21671DOI Listing
November 2007

TDP-43 proteinopathy in frontotemporal lobar degeneration and amyotrophic lateral sclerosis: protein misfolding diseases without amyloidosis.

Arch Neurol 2007 Oct;64(10):1388-94

Center for Neuropathology and Prion Research, Ludwig Maximilians University of Munich, Feodor Lynen Strasse 23, 81377 Muenchen, Germany.

View Article

Download full-text PDF

Source
http://archneur.jamanetwork.com/article.aspx?doi=10.1001/arc
Publisher Site
http://dx.doi.org/10.1001/archneur.64.10.1388DOI Listing
October 2007

TDP-43 proteinopathy: the neuropathology underlying major forms of sporadic and familial frontotemporal lobar degeneration and motor neuron disease.

Acta Neuropathol 2007 Jul 10;114(1):63-70. Epub 2007 May 10.

Department of Pathology and Laboratory Medicine, Center for Neurodegenerative Disease Research, University of Pennsylvania School of Medicine, HUP, Philadelphia, PA, 19104-4283, USA.

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s00401-007-0226-5
Publisher Site
http://dx.doi.org/10.1007/s00401-007-0226-5DOI Listing
July 2007

Absence of heterogeneous nuclear ribonucleoproteins and survival motor neuron protein in TDP-43 positive inclusions in frontotemporal lobar degeneration.

Acta Neuropathol 2007 May 6;113(5):543-8. Epub 2007 Apr 6.

Center for Neuropathology and Prion Research, Ludwig-Maximilians University, Feodor-Lynen-Str. 23, 81377 Munich, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00401-007-0221-xDOI Listing
May 2007