Manuel Comabella

Manuel Comabella

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Manuel Comabella

Manuel Comabella

Publications by authors named "Manuel Comabella"

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Cerebrospinal fluid mitochondrial DNA levels in patients with multiple sclerosis.

Mult Scler 2019 Oct 9;25(11):1535-1538. Epub 2018 Jul 9.

Servei de Neurologia-Neuroimmunologia, Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Institut de Recerca Vall d'Hebron (VHIR), Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain.

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http://dx.doi.org/10.1177/1352458518786055DOI Listing
October 2019

The long-term outcomes of CIS patients in the Barcelona inception cohort: Looking back to recognize aggressive MS.

Mult Scler 2019 Oct 15:1352458519877810. Epub 2019 Oct 15.

Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Servei de Neurologia/Neuroimmunologia, Vall d'Hebron Institut de Recerca (VHIR), Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain/Division of Neurology, University of Toronto, St Michael's Hospital, Toronto, ON, Canada.

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http://dx.doi.org/10.1177/1352458519877810DOI Listing
October 2019

A pharmacogenetic study implicates in the response to Interferon-β in multiple sclerosis.

Mult Scler 2019 Jun 21:1352458519851428. Epub 2019 Jun 21.

Laboratory of Human Genetics of Neurological Disorders, Institute of Experimental Neurology (INSPE), IRCCS San Raffaele Scientific Institute, Milan, Italy/Department of Biomedical Sciences for Health, University of Milan, Milan, Italy/Department of Neurology, IRCCS Policlinico San Donato, San Donato Milanese, Italy.

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http://dx.doi.org/10.1177/1352458519851428DOI Listing
June 2019

Biomarkers in Multiple Sclerosis.

Cold Spring Harb Perspect Med 2019 Mar 1;9(3). Epub 2019 Mar 1.

Department of Neurology, Ann Romney Center for Neurological Diseases, Brigham and Women's Hospital, Boston, Massachusetts 02115.

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http://dx.doi.org/10.1101/cshperspect.a029058DOI Listing
March 2019

Menarche, pregnancies, and breastfeeding do not modify long-term prognosis in multiple sclerosis.

Neurology 2019 03 1;92(13):e1507-e1516. Epub 2019 Mar 1.

From the Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Department of Neurology/Neuroimmunology (M.I.Z., S.O.-R., G.A., L.N., I.G., J.R., M.C., C.N., M.J.A., A.V.-J., J.C., B.R., L.M., P.M., J.S.-G., X.M., M.T.), and Unitat de RM, Servei de Radiologia (M.I.Z., A.R., L.N., R.M., C.A., X.M.), Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona; Unitat d'Estadística i Bioinformàtica (UEB) (M.I.Z., S.P.-H., L.N., X.M.), Vall d'Hebron Institut de Recerca (VHIR), Barcelona, Spain; Servicio de Neurología (M.I.Z., L.N., X.M.), Instituto Neurológico de Colombia, Medellín, Colombia; Raul Carrea Institute for Neurological Research (L.N., X.M.), FLENI, Buenos Aires, Argentina; and Division of Neurology (X.M.), St. Michael's Hospital, University of Toronto, Canada.

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http://dx.doi.org/10.1212/WNL.0000000000007178DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453769PMC
March 2019

Simultaneous CMV and infection following alemtuzumab treatment for multiple sclerosis.

Neurology 2019 02 26;92(6):296-298. Epub 2018 Dec 26.

From the Department of Neurology-Neuroimmunology, Multiple Sclerosis Centre of Catalonia (Cemcat) (A.P., L.M., J.C., P.M., A.V.-J., G.A., B.R.-A., J.S.-G., J.R., M.C., I.G., M.T., X.M.), Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Spain; Department of Internal Medicine (C.P.B.R.) and Center of Biomedical Research in Network on Neurodegenerative Diseases (CIBERNED) (C.P.B.R.), Sant Joan d'Alacant University Hospital, Alicante, Spain; Department of Neurology (A.P.), Hospital Italiano, Buenos Aires, Argentina; Department of Infectious Diseases (C.P.B.R., A.A.P., I.R.C.) and Microbiology Department (M.L.), Vall d'Hebron University Hospital, Barcelona, Spain; and Division of Neurology (X.M.), University of Toronto, St Michael's Hospital, Toronto, Canada.

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http://dx.doi.org/10.1212/WNL.0000000000006801DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382059PMC
February 2019

NLRP3 polymorphisms and response to interferon-beta in multiple sclerosis patients.

Mult Scler 2018 10 9;24(11):1507-1510. Epub 2017 Nov 9.

Servei de Neurologia-Neuroimmunologia, Centre d'Esclerosi Múltiple de Catalunya (Cemcat) and Institut de Recerca Vall d'Hebron (VHIR), Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain.

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http://dx.doi.org/10.1177/1352458517739137DOI Listing
October 2018

Neurofilaments as biomarkers in neurological disorders.

Nat Rev Neurol 2018 10;14(10):577-589

Neurologic Clinic and Policlinic, Departments of Medicine, Clinical Research, and Biomedicine, University Hospital Basel, University of Basel, Basel, Switzerland.

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http://www.nature.com/articles/s41582-018-0058-z
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http://dx.doi.org/10.1038/s41582-018-0058-zDOI Listing
October 2018

Circulating EZH2-positive T cells are decreased in multiple sclerosis patients.

J Neuroinflammation 2018 Oct 26;15(1):296. Epub 2018 Oct 26.

Servei de Neurologia-Neuroimmunologia, Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Institut de Recerca Vall d'Hebron (VHIR), Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain.

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http://dx.doi.org/10.1186/s12974-018-1336-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6202809PMC
October 2018

Multiple sclerosis, and other demyelinating and autoimmune inflammatory diseases of the central nervous system.

Handb Clin Neurol 2017 ;146:67-84

Neurology and Neuroimmunology Service, Multiple Sclerosis Center of Catalunya and Institut de Recerca Vall d'Hebron, Hospital Universitari Vall d'Hebron, Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1016/B978-0-12-804279-3.00005-8DOI Listing
June 2018

The value of oligoclonal bands in the multiple sclerosis diagnostic criteria.

Brain 2018 04;141(4):1075-1084

Servei de Neurologia-Neuroimmunologia, Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Vall d'Hebron Institut de Recerca, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain.

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http://dx.doi.org/10.1093/brain/awy006DOI Listing
April 2018

Disability progression markers over 6-12 years in interferon-β-treated multiple sclerosis patients.

Mult Scler 2018 03 13;24(3):322-330. Epub 2017 Mar 13.

Servicio de Neurologia-Neuroimmunolgia, Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Hospital Universitari Vall d'Hebron, Barcelona, Spain.

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http://journals.sagepub.com/doi/10.1177/1352458517698052
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http://dx.doi.org/10.1177/1352458517698052DOI Listing
March 2018

Spinal cord lesions: A modest contributor to diagnosis in clinically isolated syndromes but a relevant prognostic factor.

Mult Scler 2018 03 16;24(3):301-312. Epub 2017 Mar 16.

Servei de Neurologia-Neuroimmunologia, Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Vall d'Hebron Institut de Recerca, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain.

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http://journals.sagepub.com/doi/10.1177/1352458517697830
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http://dx.doi.org/10.1177/1352458517697830DOI Listing
March 2018

Lesion topographies in multiple sclerosis diagnosis: A reappraisal.

Neurology 2017 Dec 3;89(23):2351-2356. Epub 2017 Nov 3.

From Servei de Neurologia-Neuroimmunologia, Centre d'Esclerosi Múltiple de Catalunya (CEMCAT) (G.A., M.T., J.R., J.C., A.V.-J., I.G., C.N., M.C., P.M., B.R.-A., L.M., J.S.-G., X.M.), and Magnetic Resonance Unit, Department of Radiology (IDI) (C.A., R.M., A.d.B., A.R.), Vall d'Hebron Institut de Recerca, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Spain; and Division of Neurology (X.M.), St. Michael's Hospital, University of Toronto, Canada.

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http://dx.doi.org/10.1212/WNL.0000000000004715DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5719929PMC
December 2017

Reply.

Ann Neurol 2017 10 4;82(4):647-648. Epub 2017 Oct 4.

Servei de Neurologia-Neuroimmunologia, Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Institut de Recerca Vall d'Hebron (VHIR), Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain.

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http://doi.wiley.com/10.1002/ana.25039
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http://dx.doi.org/10.1002/ana.25039DOI Listing
October 2017

Neuroimmunology: B cells and variant BAFF in autoimmune disease.

Authors:
Manuel Comabella

Nat Rev Neurol 2017 Aug 16;13(8):453-454. Epub 2017 Jun 16.

Centre d'Esclerosi Múltiple de Catalunya, Department of Neurology/Neuroimmunology, Hospital Universitari Vall d'Hebron, Passeig Vall d'Hebron 119-129, Universitat Autònoma de Barcelona, Barcelona 08035, Spain.

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http://dx.doi.org/10.1038/nrneurol.2017.87DOI Listing
August 2017

Decreased soluble IFN-β receptor (sIFNAR2) in multiple sclerosis patients: A potential serum diagnostic biomarker.

Mult Scler 2017 Jun 9;23(7):937-945. Epub 2016 Sep 9.

Unidad de Gestión Clínica de Neurociencias, Instituto de Biomedicina de Málaga (IBIMA), Hospital Regional Universitario de Málaga, Universidad de Málaga, Málaga, Spain/Red Española de Esclerosis Múltiple (REEM).

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http://dx.doi.org/10.1177/1352458516667564DOI Listing
June 2017

Metabolomic signatures associated with disease severity in multiple sclerosis.

Neurol Neuroimmunol Neuroinflamm 2017 Mar 27;4(2):e321. Epub 2017 Jan 27.

Center of Neuroimmunology (P.V., I.A., E.K., I.Z., I.P.-V., A.S.), Institute d'Investigaciones Biomediques August Pi Sunyer (IDIBAPS)-Hospital Clinic, Barcelona, Spain; University of California (P.V.), San Francisco; OWL (C.A., A.C.), Parque Tecnológico de Bizkaia, Derio; Cemcat (M.C., X.M.), Hospital Vall d'Hebron, Barcelona; Hospital Ramon y Cajal (L.V., J.C.A.-C.), Madrid; Hospital Universitario Regional (O.F.), Instituto de Investigación Biomédica (IBIMA), Malaga; and Hospital Clinico San Carlos (R.A.-L., R.A.), Madrid, Spain.

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http://dx.doi.org/10.1212/NXI.0000000000000321DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5278923PMC
March 2017

Chitinase 3-like 1 is associated with the response to interferon-beta treatment in multiple sclerosis.

J Neuroimmunol 2017 02 18;303:62-65. Epub 2016 Dec 18.

Servei de Neurologia-Neuroimmunologia, Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Institut de Recerca Vall d'Hebron (VHIR), Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01655728163031
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http://dx.doi.org/10.1016/j.jneuroim.2016.12.006DOI Listing
February 2017

CD62L test at 2 years of natalizumab predicts progressive multifocal leukoencephalopathy.

Neurology 2016 12 4;87(23):2491-2494. Epub 2016 Nov 4.

From the CHU Toulouse Purpan (B.P., F.B., D.B., D.A.-P., D.B.), Pôle Neurosciences; INSERM U1043-CNRS UMR 5282 (B.P., F.B., D.B.), Université Toulouse III, Centre de Physiopathologie Toulouse Purpan, France; University of Münster (N.S., T.S.-H., H.W.), Germany; University of Lille (O.O., H.Z., P.V.); Hôpital Civil (J.-C. Ongagna, J.d.S.), Strasbourg; CHU Pellegrin (B.B., J.-C. Ouallet), Bordeaux; CHU Nancy (M.D., S.P.); CHU Caen (G.D., N.D.); CH St Vincent (P.H.), GHICL, Lille; CHU Reims (A.T.); CHU Montpellier (P.L.); CHU Nîmes (G.C., W.C., O.C.); CHRU Clermont Ferrand (P.C.); CHU Besançon (E.B.); Aix Marseille University (J.P., A.R.), APHM, CHU Timone, Marseille; CHU Nantes (D.L., S.W.); CHU Grenoble (E.T.); CHU Dijon (T.M., A.F.); CHU Lyon (S.V.), Bron; Hôpital de la Salpêtrière (C.P.), Paris, France; Centre d'Esclerosi Múltiple de Catalunya (CEMCAT) (M.C.), Institut de Recerca Vall d'Hebron (VHIR), Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Spain; and CHU Nice (C.L.-F.), France.

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http://dx.doi.org/10.1212/WNL.0000000000003401DOI Listing
December 2016

Neurofilament light chain level is a weak risk factor for the development of MS.

Neurology 2016 Sep 12;87(11):1076-84. Epub 2016 Aug 12.

From Servei de Neurologia-Neuroimmunologia (G.A., C.E., H.E., J.S.-G., E.S., M.C., J.R., C.N., C.T., J.C., A.V.-J., I.G., M.J.A., X.M., M.T.), Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Vall d'Hebron Institut de Recerca, Hospital Universitari Vall d'Hebron, Barcelona; Universitat Autònoma de Barcelona (G.A., C.E., H.E., J.S.-G., E.S., M.C., J.R., C.N., C.T., J.C., A.V.-J., I.G., X.M., M.T.), Bellaterra; Departments of Neurology and Immunology (L.M.V., J.C.A.-C., C.P.), Multiple Sclerosis Unit, Hospital Ramón y Cajal, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Madrid, Spain; Department of Neurology (J.K., L.K.), University Hospital Basel; Neurocentre of Southern Switzerland (G.D.), Ospedale Civico, Lugano, Switzerland; and Magnetic Resonance Unit (IDI) (D.P., C.A., A.R.), Hospital Universitari Vall d'Hebron, Barcelona, Spain.

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http://dx.doi.org/10.1212/WNL.0000000000003085DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5027802PMC
September 2016

Contribution of the symptomatic lesion in establishing MS diagnosis and prognosis.

Neurology 2016 Sep 26;87(13):1368-74. Epub 2016 Aug 26.

From Centre d'Esclerosi Múltiple de Catalunya (CEMCAT), Department of Neurology/Neuroimmunology (M.T., S.O.-R., J.R., G.A., B.P., C.T., I.G., M.C., C.N., M.J.A., A.V.-J., J.C., B.R.-A., L.M., J.S.-G., X.M.), and Magnetic Resonance Unit, Department of Radiology (R.M., C.A., À.R.), Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Spain.

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http://dx.doi.org/10.1212/WNL.0000000000003144DOI Listing
September 2016

The clinical perspective: How to personalise treatment in MS and how may biomarkers including imaging contribute to this?

Mult Scler 2016 08;22(2 Suppl):18-33

Department of Basic Medical Sciences, Neuroscience and Sense Organs, University of Bari Aldo Moro, Bari, Italy.

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http://dx.doi.org/10.1177/1352458516650739DOI Listing
August 2016

Precision medicine in multiple sclerosis: biomarkers for diagnosis, prognosis, and treatment response.

Curr Opin Neurol 2016 06;29(3):254-62

Servei de Neurologia-Neuroimmunologia, Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Institut de Recerca Vall d'Hebron (VHIR), Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain.

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http://dx.doi.org/10.1097/WCO.0000000000000336DOI Listing
June 2016

Novel Insights into the Multiple Sclerosis Risk Gene ANKRD55.

J Immunol 2016 06 4;196(11):4553-65. Epub 2016 May 4.

Neurogenomiks Laboratory, University of the Basque Country (University of Pais Vasco/Euskal Herriko University), 48170 Zamudio, Spain; Achucarro Basque Center for Neuroscience, 48170 Zamudio, Spain; IKERBASQUE, Basque Foundation for Science, 48013 Bilbao, Spain

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http://dx.doi.org/10.4049/jimmunol.1501205DOI Listing
June 2016

DNA Vaccination Techniques.

Methods Mol Biol 2016 ;1304:39-50

Department of Neurology-Neuroimmunology, Centre d'Esclerosi Múltiple de Catalunya, Cemcat, Institut de Recerca Vall d'Hebron, Hospital Universitari Vall d´Hebron (HUVH), Barcelona, Spain,

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http://dx.doi.org/10.1007/7651_2014_87DOI Listing
May 2016

Cytokine profiles show heterogeneity of interferon-β response in multiple sclerosis patients.

Neurol Neuroimmunol Neuroinflamm 2016 Apr 27;3(2):e202. Epub 2016 Jan 27.

Department of Neurology (H.H., A.M., M.H., D.R., F.D.), Medical University of Innsbruck, Austria; Department of Arthritis and Clinical Immunology (I.A., C.J.L., R.C.A.), Oklahoma Medical Research Foundation, Oklahoma City; Centro di Riferimento Regionale Sclerosi Multipla (A.B., S.N.), Neurologia 2, Azienda Ospedaliero Universitaria San Luigi Gonzaga, Orbassano, Turin, Italy; Centre d'Esclerosi Múltiple de Catalunya (Cemcat) (M.C., X.M.), Unitat de Neuroimmunologia Clínica, Hospital Universitari Vall d'Hebron, Barcelona, Spain; Queen Mary University London (G.G.), Blizard Institute, Barts and The London School of Medicine and Dentistry, London, UK; Clinical Department of Neurology (M.G.), Allgemeines Krankenhaus Linz, Austria; Department of Neurology (M.K., F.F.), Medical University of Graz, Austria; Department of Neurology (J.K.), Vrije Universiteit Medical Center, Amsterdam, the Netherlands; Department of Biomedicines and Neurology (R.L.P.L., M.M.), Clinical Neuroimmunology, University of Basel, University Hospital Basel, Switzerland; Clinical Department of Neurology (F. Schautzer), Landeskrankenhaus Villach, Austria; Danish Multiple Sclerosis Center (F. Sellebjerg, P.S.S.), Department of Neurology, Rigshospitalet, University of Copenhagen, Denmark; and Department of Neurology and Neurological Sciences (L.S.), Stanford University School of Medicine, CA.

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http://dx.doi.org/10.1212/NXI.0000000000000202DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4747480PMC
April 2016

Tocilizumab and multiple sclerosis: a causal relationship? Clinical Commentary on the case report entitled--MS arising during Tocilizumab therapy for rheumatoid arthritis.

Authors:
Manuel Comabella

Mult Scler 2016 Feb 7;22(2):257-8. Epub 2016 Jan 7.

Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Unitat de Neuroimmunologia Clínica, Hospital Universitari Vall d'Hebron (HUVH), Universitat Autònoma de Barcelona, Barcelona, Spain

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http://dx.doi.org/10.1177/1352458515623863DOI Listing
February 2016

Protein-Based Classifier to Predict Conversion from Clinically Isolated Syndrome to Multiple Sclerosis.

Mol Cell Proteomics 2016 Jan 9;15(1):318-28. Epub 2015 Nov 9.

From the ‡Proteomics Unit, Centre de Regulació Genòmica (CRG), Dr. Aiguader 88, 08003 Barcelona, Spain; §Universitat Pompeu Fabra (UPF), Dr. Aiguader 88, 08003 Barcelona, Spain;

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http://dx.doi.org/10.1074/mcp.M115.053256DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4762525PMC
January 2016

MRI phenotypes with high neurodegeneration are associated with peripheral blood B-cell changes.

Hum Mol Genet 2016 Jan 24;25(2):308-16. Epub 2015 Nov 24.

Servei de Neurologia-Neuroimmunologia, Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Institut de Recerca Vall d'Hebron (VHIR).

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http://dx.doi.org/10.1093/hmg/ddv473DOI Listing
January 2016

Teriflunomide in Patients with Relapsing-Remitting Forms of Multiple Sclerosis.

CNS Drugs 2016 Jan;30(1):41-51

Servei de Neurologia-Neuroimmunologia, Centre d'Esclerosi Múltiple de Catalunya, Cemcat, Hospital Universitari Vall d'Hebron, Barcelona, Spain.

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http://dx.doi.org/10.1007/s40263-015-0299-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4733135PMC
January 2016

Genome-wide significant association with seven novel multiple sclerosis risk loci.

J Med Genet 2015 Dec 16;52(12):848-55. Epub 2015 Oct 16.

Platform for Genome Analytics, Institutes of Neurogenetics & Integrative and Experimental Genomics, University of Lübeck, Lübeck, Germany Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin, Germany Department of Medicine, School of Public Health, Imperial College London, London, UK.

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http://dx.doi.org/10.1136/jmedgenet-2015-103442DOI Listing
December 2015

Molecular dynamics and intracellular signaling of the TNF-R1 with the R92Q mutation.

J Neuroimmunol 2015 Dec 22;289:12-20. Epub 2015 Oct 22.

Servei de Neurologia-Neuroimmunologia, Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Institut de Recerca Vall d'Hebron (VHIR), Hospital Universitari Vall d'Hebron, 08035 Barcelona, Spain.

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http://dx.doi.org/10.1016/j.jneuroim.2015.10.003DOI Listing
December 2015

Peripheral blood non-MAIT CD8+CD161hi cells are decreased in relapsing-remitting multiple sclerosis patients treated with interferon beta.

J Neuroimmunol 2015 Nov 25;288:98-101. Epub 2015 Sep 25.

Department of Neurology-Neuroimmunology, Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Institut de Recerca Vall d'Hebron (VHIR), Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain.

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http://dx.doi.org/10.1016/j.jneuroim.2015.09.007DOI Listing
November 2015

Cell-specific effects in different immune subsets associated with SOCS1 genotypes in multiple sclerosis.

Mult Scler 2015 Oct 26;21(12):1498-512. Epub 2015 Jan 26.

Neurogenomiks Group, Universidad del País Vasco (UPV/EHU), Spain/ Achucarro Basque Center for Neuroscience, Spain/ IKERBASQUE, Basque Foundation for Science, Spain

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http://dx.doi.org/10.1177/1352458514566418DOI Listing
October 2015

Breast regression protein-39 is not required for experimental autoimmune encephalomyelitis induction.

Clin Immunol 2015 Oct 12;160(2):133-41. Epub 2015 Jun 12.

Servei de Neurologia-Neuroimmunologia, Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Institut de Recerca Vall d'Hebron (VHIR), Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain; Universitat Autònoma de Barcelona, 08193 Bellaterra, Cerdanyola del Vallès, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.clim.2015.06.004DOI Listing
October 2015

Pharmacogenomic study in patients with multiple sclerosis: Responders and nonresponders to IFN-β.

Neurol Neuroimmunol Neuroinflamm 2015 Oct 24;2(5):e154. Epub 2015 Sep 24.

Servei de Neurologia-Neuroimmunologia (M.F.B., S.M., J.R., X.M., M.C.), Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Institut de Recerca Vall d'Hebron (VHIR), Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain; Institute of Evolutionary Biology (UPF-CSIC) (C.M.-S., X.F., A.N.), PRBB, Barcelona, Spain; National Institute for Bioinformatics (C.M.-S., X.F., A.N.), Universitat Pompeu Fabra, Barcelona, Spain; Servicio de Neurología (L.L., O.F.), Instituto de Neurociencias Clínicas, Hospital Regional Universitario de Málaga, IBIMA, Málaga, Spain; Department of Neurology (U.K.Z.), University of Rostock, Rostock, Germany; Department of Neurology (J.K.), Multiple Sclerosis Centre Amsterdam, Vrije University Medical Centre, Amsterdam, the Netherlands; Pole des neurosciences et INSERM U1043 (D.B.), Université de Toulouse III, Hopital Purpan, Toulouse, France; Neuroinmunología (J.A.G.-M., A.J.S.), Hospital Universitario Puerta de Hierro, Madrid, Spain; Servicio de Neurología (E.U., R.A.-L.), Hospital Clínico San Carlos, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, Spain; Department of Neurology and Immunology (L.M.V., J.C.A.-C.), Hospital Ramón y Cajal, IRYCIS, Madrid, Spain; Department of Neurology (J.L.-S.), John Hunter Hospital, Newcastle, Australia; Hunter Medical Research Institute (J.L.-S.), University Newcastle, Australia; University Newcastle (J.L.-S.), Callaghan Campus, Australia; Neurogenomiks Group (K.V.), Universidad del País Vasco (UPV/EHU), Leioa, Spain; IKERBASQUE (K.V.), Basque Foundation for Science, Bilbao, Spain; Achucarro Basque Center for Neuroscience (K.V.), Zamudio, Spain; Servicio de Neurología (A.R.-A.), Hospital de Basurto, Bilbao, Spain; Clinic of Neurology (J.S.D.), Clinical Centre of Serbia (CCS), Faculty of Medicine, University of Belgrade, Serbia; Laboratory of Genetics of Neurological Complex Disorders and Department of Neuro-rehabilitation (F.M.B

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http://dx.doi.org/10.1212/NXI.0000000000000154DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4582905PMC
October 2015

Defining high, medium and low impact prognostic factors for developing multiple sclerosis.

Brain 2015 Jul 21;138(Pt 7):1863-74. Epub 2015 Apr 21.

1 Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Department of Neurology/Neuroimmunology, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain.

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http://dx.doi.org/10.1093/brain/awv105DOI Listing
July 2015

Concise review: modeling multiple sclerosis with stem cell biological platforms: toward functional validation of cellular and molecular phenotypes in inflammation-induced neurodegeneration.

Stem Cells Transl Med 2015 Mar 15;4(3):252-60. Epub 2015 Jan 15.

Multiple Sclerosis Center and Laboratory for Neural Stem Cells, Departments of Neurology and Neuroscience, The Ohio State University College of Medicine Wexner Medical Center, Columbus, Ohio, USA; Department of Neurodegenerative Diseases and German Center for Neurodegenerative Diseases, Hertie-Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany; Department of Neurology and Immunobiology, Yale School of Medicine, New Haven, Connecticut, USA; Department of Neurology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA; Servei de Neurologia-Neuroimmunologia, Centre d'Esclerosi Múltiple de Catalunya, Institut de Recerca Vall d'Hebron, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain

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http://dx.doi.org/10.5966/sctm.2014-0133DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4339849PMC
March 2015

Role of high mobility group box protein 1 (HMGB1) in peripheral blood from patients with multiple sclerosis.

J Neuroinflammation 2015 Mar 11;12:48. Epub 2015 Mar 11.

Servei de Neurologia-Neuroimmunologia, Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Institut de Receca Vall d'Hebron (VHIR), Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain.

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http://dx.doi.org/10.1186/s12974-015-0269-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4359557PMC
March 2015

Natalizumab-related anaphylactoid reactions in MS patients are associated with HLA class II alleles.

Neurol Neuroimmunol Neuroinflamm 2014 Dec 11;1(4):e47. Epub 2014 Dec 11.

Department of Immunology (B.d.l.H., E.U., A.G.V.) and Department of Neurology, Multiple Sclerosis Unit (R.A.), Hospital Clínico San Carlos (IdISSC), Madrid, Spain; Pole des neurosciences et INSERM U1043 (D.B.), Université de Toulouse III, Hopital Purpan, Toulouse, France; Department of Neurology (A.C., A. Salmen), St. Josef-Hospital, Ruhr University, Bochum, Germany; Servei de Neurologia-Neuroimmunologia (A.V.-J., S.M., N.F., A.H., X.M., M.C.), Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Institut de Recerca Vall d'Hebron (VHIR), Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Spain; Departments of Neurology and Immunology (L.M.V., J.C.A.-C.), Hospital Universitario Ramón y Cajal, Instituto Ramón y Cajal de Investigacion Sanitaria, Madrid, Spain; Hospital Universitario Virgen Macarena (G.I.), Seville, Spain; Unidad de Gestión Clínica de Neurociencias (O.F., B.O.), Instituto de Biomedicina de Málaga (IBIMA), Hospital Universitario Regional de Málaga, Universidad de Málaga, Spain; Service of Neurology (A. Saiz), Hospital Clínic, Universitat de Barcelona and Institut d´Investigació Biomèdica August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Department of Biochemistry, Molecular and Cellular Biology (J.R.A.), Science Faculty, University of Zaragoza, Spain; and Fundación de Investigación Biomédica (V.M.), Hospital Universitario de la Princesa, Madrid, Spain.

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http://dx.doi.org/10.1212/NXI.0000000000000047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4268037PMC
December 2014

Validation of semaphorin 7A and ala-β-his-dipeptidase as biomarkers associated with the conversion from clinically isolated syndrome to multiple sclerosis.

J Neuroinflammation 2014 Nov 13;11:181. Epub 2014 Nov 13.

Servei de Neurologia-Neuroimmunologia, Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Institut de Recerca Vall d'Hebron (VHIR), Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Ps, Vall d'Hebron 119-129, Barcelona, 08035, Spain.

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http://dx.doi.org/10.1186/s12974-014-0181-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4236472PMC
November 2014

Evaluating the response to glatiramer acetate in relapsing-remitting multiple sclerosis (RRMS) patients.

Mult Scler 2014 Oct 12;20(12):1602-8. Epub 2014 Mar 12.

Centre d'esclerosi múltiple de Catalunya (CEM-Cat), Servei de Neurologia-Neuroimmunologia, Hospital Universitario Vall d'Hebron, Barcelona, Spain.

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http://dx.doi.org/10.1177/1352458514527863DOI Listing
October 2014

Activation-induced cell death in T lymphocytes from multiple sclerosis patients.

J Neuroimmunol 2014 Jul 16;272(1-2):51-5. Epub 2014 Apr 16.

Department of Neurology-Neuroimmunology, Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Institut de Recerca Vall d'Hebron (VHIR), Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.jneuroim.2014.04.007DOI Listing
July 2014

HLA alleles as biomarkers of high-titre neutralising antibodies to interferon-β therapy in multiple sclerosis.

J Med Genet 2014 Jun 19;51(6):395-400. Epub 2014 Apr 19.

Immunology Department, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, Spain.

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http://dx.doi.org/10.1136/jmedgenet-2014-102348DOI Listing
June 2014

Levels of soluble TNF-RII are increased in serum of patients with primary progressive multiple sclerosis.

J Neuroimmunol 2014 Jun 16;271(1-2):56-9. Epub 2014 Apr 16.

Department of Neurology-Neuroimmunology, Centre d'Esclerosi Múltiple de Catalunya, Cemcat, Institut de Recerca Vall d'Hebron, Hospital Universitari Vall d'Hebron (HUVH), Barcelona, Spain.

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http://dx.doi.org/10.1016/j.jneuroim.2014.04.001DOI Listing
June 2014

Up-regulation of inducible heat shock protein-70 expression in multiple sclerosis patients.

Autoimmunity 2014 Mar 12;47(2):127-33. Epub 2013 Dec 12.

Servei de Neurologia-Neuroimmunologia, Centre d'Esclerosi Múltiple de Catalunya (CEM-Cat), Vall d'Hebron Institut de Recerca (VHIR), Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona , Barcelona , Spain and.

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http://dx.doi.org/10.3109/08916934.2013.866104DOI Listing
March 2014

A case of neuromyelitis optica harboring both anti-aquaporin-4 antibodies and a pathogenic mitochondrial DNA mutation for Leber's hereditary optic neuropathy: clinical commentary.

Authors:
Manuel Comabella

Mult Scler 2014 Feb 9;20(2):261. Epub 2013 Dec 9.

Unitat de Neuroimmunologia Clínica, Centre d'Esclerosi Multiple de Catalunya, Barcelona, Spain.

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http://dx.doi.org/10.1177/1352458513512711DOI Listing
February 2014

Body fluid biomarkers in multiple sclerosis.

Lancet Neurol 2014 Jan;13(1):113-26

Department of Neurology and Neuroimmunology, Centre d'Esclerosi Múltiple de Catalunya, Cemcat, Hospital Universitari Vall d'Hebron, Barcelona, Spain.

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http://dx.doi.org/10.1016/S1474-4422(13)70233-3DOI Listing
January 2014

Baseline gene expression signatures in monocytes from multiple sclerosis patients treated with interferon-beta.

PLoS One 2013 18;8(4):e60994. Epub 2013 Apr 18.

Servei de Neurología/Neuroimmunología. Centre d'Esclerosi Múltiple de Catalunya, Cemcat. Hospital Universitari Vall dHebron (HUVH), Barcelona, Spain.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0060994PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3630153PMC
December 2013

Circulating levels of soluble apoptosis-related molecules in patients with multiple sclerosis.

J Neuroimmunol 2013 Oct 26;263(1-2):152-4. Epub 2013 Jul 26.

Department of Neurology-Neuroimmunology, Centre d'Esclerosi Múltiple de Catalunya, Cemcat, Institut de Recerca Vall d'Hebron, Hospital Universitari Vall d´Hebron (HUVH), Barcelona, Spain.

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http://dx.doi.org/10.1016/j.jneuroim.2013.07.013DOI Listing
October 2013

[Reply].

Med Clin (Barc) 2013 Jun 4;140(12):571. Epub 2013 Apr 4.

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http://dx.doi.org/10.1016/j.medcli.2013.02.007DOI Listing
June 2013

TNFRSF1A polymorphisms rs1800693 and rs4149584 in patients with multiple sclerosis.

Neurology 2013 May 26;80(22):2010-6. Epub 2013 Apr 26.

Department of Neurology-Neuroimmunology, Centre d'Esclerosi Múltiple de Catalunya, Cemcat, Hospital Universitari Vall d´Hebron, Barcelona, Spain.

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http://dx.doi.org/10.1212/WNL.0b013e318294b2d6DOI Listing
May 2013

Natalizumab discontinuation after PML risk stratification: outcome from a shared and informed decision.

Mult Scler 2012 Aug 1;18(8):1193-6. Epub 2012 Mar 1.

Clinical Neuroimmunology Unit, Multiple Sclerosis Centre of Catalonia (Centre d'Esclerosi Múltiple de Catalunya, CEM-Cat), Vall d'Hebron University Hospital, Barcelona, Spain.

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http://dx.doi.org/10.1177/1352458512439238DOI Listing
August 2012

[Stem cell-based treatment of neurologic diseases].

Med Clin (Barc) 2012 Jul 22;139(5):208-14. Epub 2012 Feb 22.

Unitat de Neuroimmunologia Clinica, Centre d'Esclerosi Múltiple de Catalunya (CEM-Cat), Vall d'Hebron Institut de Recerca, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain.

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https://linkinghub.elsevier.com/retrieve/pii/S00257753120004
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http://dx.doi.org/10.1016/j.medcli.2011.12.009DOI Listing
July 2012

Transcriptomics: mRNA and alternative splicing.

J Neuroimmunol 2012 Jul 22;248(1-2):23-31. Epub 2012 May 22.

Departament d'Estadística, Universitat de Barcelona, Spain.

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http://dx.doi.org/10.1016/j.jneuroim.2012.04.008DOI Listing
July 2012

New technologies for biomarker discovery in multiple sclerosis.

J Neuroimmunol 2012 Jul;248(1-2)

Centre d'Esclerosi Múltiple de Catalunya, CEM-Cat, Unitat de Neuroimmunologia Clínica, Hospital Universitari Vall d´Hebron (HUVH), Barcelona, Spain.

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http://dx.doi.org/10.1016/j.jneuroim.2012.05.018DOI Listing
July 2012

Treatment with MOG-DNA vaccines induces CD4+CD25+FoxP3+ regulatory T cells and up-regulates genes with neuroprotective functions in experimental autoimmune encephalomyelitis.

J Neuroinflammation 2012 Jun 22;9:139. Epub 2012 Jun 22.

Centre d'Esclerosi Múltiple de Catalunya, CEM-Cat, Unitat de Neuroimmunologia Clínica, Hospital Universitari Vall d´Hebron (HUVH), Barcelona, Spain.

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http://dx.doi.org/10.1186/1742-2094-9-139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3464883PMC
June 2012