Publications by authors named "Manu Rangachari"

22Publications

Protein translocation and retro-translocation across the endoplasmic reticulum are crucial to inflammatory effector CD4 T cell function.

Cytokine 2020 May 5;129:154944. Epub 2020 Mar 5.

axe Neurosciences, Centre de recherche du CHU de Québec - Université Laval, Quebec City, QC, Canada; Department of Molecular Medicine, Faculty of Medicine, Laval University, Quebec City, QC, Canada. Electronic address:

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May 2020

Tim-3: A co-receptor with diverse roles in T cell exhaustion and tolerance.

Semin Immunol 2019 04;42:101302

Evergrande Center for Immunologic Diseases and Ann Romney Center for Neurologic Diseases, Harvard Medical School and Brigham & Women's Hospital, 60 Fenwood Rd., Boston, MA, 02115, USA; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA. Electronic address:

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April 2019

Peripheral adaptive immunity of the triple transgenic mouse model of Alzheimer's disease.

J Neuroinflammation 2019 Jan 5;16(1). Epub 2019 Jan 5.

Axe Neurosciences, Centre de recherche du CHU de Québec-Université Laval, QC, Québec, Canada.

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January 2019

Editorial: Lymphocytes in MS and EAE: More Than Just a CD4 World.

Front Immunol 2017 13;8:133. Epub 2017 Feb 13.

Department of Pathobiology, University of Pennsylvania , Philadelphia, PA , USA.

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February 2017

Cholesterol and markers of cholesterol turnover in multiple sclerosis: relationship with disease outcomes.

Mult Scler Relat Disord 2016 Jan 19;5:53-65. Epub 2015 Oct 19.

Department of Neuroscience, Centre de recherche du CHU de Québec - Université Laval, Québec, Canada; Department of Molecular Medicine, Faculty of Medicine, Université Laval, Québec, Canada. Electronic address:

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January 2016

The Non-Obese Diabetic Mouse Strain as a Model to Study CD8(+) T Cell Function in Relapsing and Progressive Multiple Sclerosis.

Front Immunol 2015 22;6:541. Epub 2015 Oct 22.

Department of Neurosciences, Centre de recherche du CHU de Québec - Université Laval (Pavillon CHUL) , Québec, QC , Canada ; Department of Molecular Medicine, Faculty of Medicine, Université Laval , Québec, QC , Canada.

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November 2015

Interferon-β suppresses murine Th1 cell function in the absence of antigen-presenting cells.

PLoS One 2015 17;10(4):e0124802. Epub 2015 Apr 17.

Department of Neuroscience, Centre de recherche du CHU de Québec-Université Laval, Québec QC, Canada G1V 4G2; Department of Molecular Medicine, Faculty of Medicine, Université Laval, Québec QC, Canada G1V 0A6.

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April 2016

An IL-27/NFIL3 signalling axis drives Tim-3 and IL-10 expression and T-cell dysfunction.

Nat Commun 2015 Jan 23;6:6072. Epub 2015 Jan 23.

Evergrande Center for Immunologic Diseases, Ann Romney Center for Neurologic Diseases, Harvard Medical School and Brigham and Women's Hospital, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA.

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January 2015

Using EAE to better understand principles of immune function and autoimmune pathology.

J Autoimmun 2013 Sep 9;45:31-9. Epub 2013 Jul 9.

Department of Neuroscience, Centre de recherche du CHU de Québec, Pavillon CHUL, 2705 Boul Laurier, QC G1V 4G2, Canada; Department of Molecular Medicine, Faculty of Medicine, Pavillon Ferdinand-Vandry, Université Laval, QC G1V 406, Canada. Electronic address:

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September 2013

Metallothioneins negatively regulate IL-27-induced type 1 regulatory T-cell differentiation.

Proc Natl Acad Sci U S A 2013 May 29;110(19):7802-7. Epub 2013 Apr 29.

Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

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May 2013

Aiolos promotes TH17 differentiation by directly silencing Il2 expression.

Nat Immunol 2012 Jul 1;13(8):770-7. Epub 2012 Jul 1.

Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

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July 2012

Spontaneous tumor rejection by cbl-b-deficient CD8+ T cells.

J Exp Med 2007 Apr 2;204(4):879-91. Epub 2007 Apr 2.

Institute of Molecular Biotechnology, Austrian Academy of Science, 1030 Vienna, Austria.

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April 2007

T-bet negatively regulates autoimmune myocarditis by suppressing local production of interleukin 17.

J Exp Med 2006 Aug 31;203(8):2009-19. Epub 2006 Jul 31.

Institute for Molecular Biotechnology of the Austrian Academy of Sciences, A-1030 Vienna, Austria.

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August 2006

Negative regulation of T cell receptor signals.

Curr Opin Pharmacol 2004 Aug;4(4):415-22

University of Toronto, Ontario, Canada.

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August 2004