Manu De Rycker

Manu De Rycker

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Manu De Rycker

Manu De Rycker

Publications by authors named "Manu De Rycker"

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31Publications

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The Q Site of Cytochrome is a Promiscuous Drug Target in and .

ACS Infect Dis 2020 Mar 30;6(3):515-528. Epub 2020 Jan 30.

Division of Biological Chemistry and Drug Discovery, Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, United Kingdom.

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http://dx.doi.org/10.1021/acsinfecdis.9b00426DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7076694PMC
March 2020

Identification of inhibitors of an unconventional Trypanosoma brucei kinetochore kinase.

PLoS One 2019 31;14(5):e0217828. Epub 2019 May 31.

Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0217828PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6544269PMC
January 2020

Phosphomannomutase and Guanosine Diphosphate-Mannose Pyrophosphorylase Ligandability Assessment.

Antimicrob Agents Chemother 2019 10 23;63(10). Epub 2019 Sep 23.

Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee, United Kingdom

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http://dx.doi.org/10.1128/AAC.01082-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6761512PMC
October 2019

Identification of Novel Trypanosoma cruzi Proteasome Inhibitors Using a Luminescence-Based High-Throughput Screening Assay.

Antimicrob Agents Chemother 2019 09 23;63(9). Epub 2019 Aug 23.

Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee, United Kingdom

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http://dx.doi.org/10.1128/AAC.00309-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6709497PMC
September 2019

Author Correction: Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need.

Nat Rev Microbiol 2018 Nov;16(11):714

Wellcome Centre for Anti-Infectives Research, University of Dundee, Dundee, DD1 5EH, UK.

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http://dx.doi.org/10.1038/s41579-018-0085-1DOI Listing
November 2018

2,4-Diamino-6-methylpyrimidines for the potential treatment of Chagas' disease.

Bioorg Med Chem Lett 2018 10 3;28(18):3025-3030. Epub 2018 Aug 3.

Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2018.08.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6970618PMC
October 2018

Development of Trypanosoma cruzi in vitro assays to identify compounds suitable for progression in Chagas' disease drug discovery.

PLoS Negl Trop Dis 2018 07 12;12(7):e0006612. Epub 2018 Jul 12.

Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee, United Kingdom.

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http://dx.doi.org/10.1371/journal.pntd.0006612DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6057682PMC
July 2018

Challenges and recent progress in drug discovery for tropical diseases.

Nature 2018 07 25;559(7715):498-506. Epub 2018 Jul 25.

Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee, UK.

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http://dx.doi.org/10.1038/s41586-018-0327-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6129172PMC
July 2018

Chemical Validation of Methionyl-tRNA Synthetase as a Druggable Target in Leishmania donovani.

ACS Infect Dis 2017 10 2;3(10):718-727. Epub 2017 Oct 2.

Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee , Dow Street, Dundee DD1 5EH, United Kingdom.

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http://dx.doi.org/10.1021/acsinfecdis.7b00047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5663395PMC
October 2017

Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need.

Nat Rev Microbiol 2017 Feb 27;15(4):217-231. Epub 2017 Feb 27.

Wellcome Centre for Anti-Infectives Research, University of Dundee, Dundee DD1 5EH, UK.

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http://dx.doi.org/10.1038/nrmicro.2016.193DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5582623PMC
February 2017

Identification of Trypanocidal Activity for Known Clinical Compounds Using a New Trypanosoma cruzi Hit-Discovery Screening Cascade.

PLoS Negl Trop Dis 2016 Apr 15;10(4):e0004584. Epub 2016 Apr 15.

Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, University of Dundee, Dundee, United Kingdom.

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https://dx.plos.org/10.1371/journal.pntd.0004584
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http://dx.doi.org/10.1371/journal.pntd.0004584DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4833300PMC
April 2016

Discovery of Indoline-2-carboxamide Derivatives as a New Class of Brain-Penetrant Inhibitors of Trypanosoma brucei.

J Med Chem 2015 Oct 29;58(19):7695-706. Epub 2015 Sep 29.

Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee , Sir James Black Centre, Dundee, DD1 5EH, U.K.

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http://dx.doi.org/10.1021/acs.jmedchem.5b00596DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4601051PMC
October 2015

The R enantiomer of the antitubercular drug PA-824 as a potential oral treatment for visceral Leishmaniasis.

Antimicrob Agents Chemother 2013 Oct 15;57(10):4699-706. Epub 2013 Jul 15.

Division of Biological Chemistry and Drug Discovery, Wellcome Trust Biocentre, College of Life Sciences, University of Dundee, Dundee, Scotland, United Kingdom.

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http://dx.doi.org/10.1128/AAC.00722-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3811480PMC
October 2013

Comparison of a high-throughput high-content intracellular Leishmania donovani assay with an axenic amastigote assay.

Antimicrob Agents Chemother 2013 Jul 9;57(7):2913-22. Epub 2013 Apr 9.

Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, University of Dundee, Dundee, United Kingdom.

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http://dx.doi.org/10.1128/AAC.02398-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3697379PMC
July 2013

ERK2 but not ERK1 mediates HGF-induced motility in non-small cell lung carcinoma cell lines.

J Cell Sci 2013 Jun 2;126(Pt 11):2381-91. Epub 2013 Apr 2.

London Research Institute, 44 Lincoln's Inn Fields, London WC2A 3LY, UK.

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http://jcs.biologists.org/cgi/doi/10.1242/jcs.115832
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http://dx.doi.org/10.1242/jcs.115832DOI Listing
June 2013

A static-cidal assay for Trypanosoma brucei to aid hit prioritisation for progression into drug discovery programmes.

PLoS Negl Trop Dis 2012 29;6(11):e1932. Epub 2012 Nov 29.

Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, University of Dundee, Dundee, United Kingdom.

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http://dx.doi.org/10.1371/journal.pntd.0001932DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3510075PMC
April 2013

A high-content, cell-based screen identifies micropolyin, a new inhibitor of microtubule dynamics.

Chem Biol Drug Des 2009 Jun;73(6):599-610

Protein Phosphorylation Laboratory, London Research Institute, Cancer Research UK, London, UK.

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http://dx.doi.org/10.1111/j.1747-0285.2009.00817.xDOI Listing
June 2009

Tankyrase polymerization is controlled by its sterile alpha motif and poly(ADP-ribose) polymerase domains.

Mol Cell Biol 2004 Nov;24(22):9802-12

Department of Molecular Genetics, Biochemistry & Microbiology, College of Medicine, University of Cincinnati, ML0524, 231 Albert Sabin Way, Cincinnati, OH 45267, USA.

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http://dx.doi.org/10.1128/MCB.24.22.9802-9812.2004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC525485PMC
November 2004

Vertebrate tankyrase domain structure and sterile alpha motif (SAM)-mediated multimerization.

Biochem J 2003 May;372(Pt 1):87-96

Deparment of Molecular Genetics, Biochemistry and Microbiology, College of Medicine, University of Cincinnati, ML0524, 231 Albert Sabin Way, Cincinnati, OH 45267, U.S.A.

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http://biochemj.org/lookup/doi/10.1042/bj20021450
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http://dx.doi.org/10.1042/BJ20021450DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1223374PMC
May 2003