Manti Guha

Manti Guha

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Manti Guha

Manti Guha

Publications by authors named "Manti Guha"

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Cytochrome c oxidase dysfunction enhances phagocytic function and osteoclast formation in macrophages.

FASEB J 2019 Aug 7;33(8):9167-9181. Epub 2019 May 7.

Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1096/fj.201900010RRDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6662975PMC
August 2019

Mitochondrial genome and functional defects in osteosarcoma are associated with their aggressive phenotype.

PLoS One 2018 21;13(12):e0209489. Epub 2018 Dec 21.

Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0209489PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303035PMC
June 2019

Mitochondrial dysfunction and mitochondrial dynamics-The cancer connection.

Biochim Biophys Acta Bioenerg 2017 Aug 16;1858(8):602-614. Epub 2017 Jan 16.

The Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, 3800 Spruce Street, #189E, Philadelphia, PA 19104, United States. Electronic address:

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http://dx.doi.org/10.1016/j.bbabio.2017.01.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5487289PMC
August 2017

Mitochondrial LON protease-dependent degradation of cytochrome c oxidase subunits under hypoxia and myocardial ischemia.

Biochim Biophys Acta Bioenerg 2017 Jul 23;1858(7):519-528. Epub 2017 Apr 23.

Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, 3800 Spruce Street, Philadelphia, PA 19104-6009, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbabio.2017.04.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5507603PMC
July 2017

ALDH2 modulates autophagy flux to regulate acetaldehyde-mediated toxicity thresholds.

Am J Cancer Res 2016 15;6(4):781-96. Epub 2016 Mar 15.

Gastroenterology Division, Department of Medicine, University of Pennsylvania Perelman School of MedicinePhiladelphia, PA, USA; University of Pennsylvania Abramson Cancer CenterPhiladelphia, PA, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4859883PMC
May 2016

Mitochondrial respiratory defects promote the Warburg effect and cancer progression.

Mol Cell Oncol 2016 Mar 10;3(2):e1085120. Epub 2015 Dec 10.

Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania , Philadelphia, PA, USA.

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http://dx.doi.org/10.1080/23723556.2015.1085120DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905388PMC
March 2016

Enhanced osteoclastogenesis by mitochondrial retrograde signaling through transcriptional activation of the cathepsin K gene.

Ann N Y Acad Sci 2016 Jan 18;1364:52-61. Epub 2015 Mar 18.

Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1111/nyas.12709DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4575226PMC
January 2016

Defects in cytochrome c oxidase expression induce a metabolic shift to glycolysis and carcinogenesis.

Genom Data 2015 Dec 14;6:99-107. Epub 2015 Aug 14.

The Department of Biomedical Sciences, School of Veterinary Medicines, University of Pennsylvania, PA, United States.

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http://dx.doi.org/10.1016/j.gdata.2015.07.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4664720PMC
December 2015

DNA-damage-induced type I interferon promotes senescence and inhibits stem cell function.

Cell Rep 2015 May 23;11(5):785-797. Epub 2015 Apr 23.

Department of Animal Biology, School of Veterinary Medicine, Abramson Family Cancer Research Institute, Basser Research Center for BRCA, Perelman School of Medicine, University of Pennsylvania, 380 S. University Ave, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1016/j.celrep.2015.03.069DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4426031PMC
May 2015

Mitochondrial retrograde signaling at the crossroads of tumor bioenergetics, genetics and epigenetics.

Mitochondrion 2013 Nov 1;13(6):577-91. Epub 2013 Sep 1.

Department of Animal Biology and the Mari Lowe Center for Comparative Oncology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, United States. Electronic address:

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http://dx.doi.org/10.1016/j.mito.2013.08.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3832239PMC
November 2013

Silencing of IkBβ mRNA causes disruption of mitochondrial retrograde signaling and suppression of tumor growth in vivo.

Carcinogenesis 2012 Sep 27;33(9):1762-8. Epub 2012 May 27.

Department of Animal Biology and Marie Lowe Center for Comparative Oncology, University of Pennsylvania, Philadelphia, PA 19104,USA.

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http://dx.doi.org/10.1093/carcin/bgs190DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3514893PMC
September 2012

Role of calcineurin, hnRNPA2 and Akt in mitochondrial respiratory stress-mediated transcription activation of nuclear gene targets.

Biochim Biophys Acta 2010 Jun-Jul;1797(6-7):1055-65. Epub 2010 Feb 11.

Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1016/j.bbabio.2010.02.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2891149PMC
January 2011

Activation of Akt is essential for the propagation of mitochondrial respiratory stress signaling and activation of the transcriptional coactivator heterogeneous ribonucleoprotein A2.

Mol Biol Cell 2010 Oct 18;21(20):3578-89. Epub 2010 Aug 18.

Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1091/mbc.E10-03-0192DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2954122PMC
October 2010

Heterogeneous nuclear ribonucleoprotein A2 is a common transcriptional coactivator in the nuclear transcription response to mitochondrial respiratory stress.

Mol Biol Cell 2009 Sep 29;20(18):4107-19. Epub 2009 Jul 29.

Department of Animal Biology and Marie Lowe Center for Comparative Oncology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1091/mbc.e09-04-0296DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2743628PMC
September 2009

A distinctive physiological role for IkappaBbeta in the propagation of mitochondrial respiratory stress signaling.

J Biol Chem 2008 May 13;283(18):12586-94. Epub 2008 Feb 13.

Department of Animal Biology and Mari Lowe Center for Comparative Oncology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1074/jbc.M710481200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2335355PMC
May 2008

Activation of a novel calcineurin-mediated insulin-like growth factor-1 receptor pathway, altered metabolism, and tumor cell invasion in cells subjected to mitochondrial respiratory stress.

J Biol Chem 2007 May 13;282(19):14536-46. Epub 2007 Mar 13.

Department of Animal Biology and the Mari Lowe Center for Comparative Oncology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1074/jbc.M611693200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3800738PMC
May 2007

Mitochondria-to-nucleus stress signaling in mammalian cells: nature of nuclear gene targets, transcription regulation, and induced resistance to apoptosis.

Gene 2005 Jul;354:132-9

Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1016/j.gene.2005.03.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3800739PMC
July 2005

Impairment of stimulation by estrogen of insulin-activated nitric oxide synthase in human breast cancer.

Int J Cancer 2002 Jul;100(3):261-5

Sinha Institute of Medical Science and Technology, Tamluk, India.

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http://dx.doi.org/10.1002/ijc.10482DOI Listing
July 2002