Manolis Pasparakis

Manolis Pasparakis

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RIPK1 mediates TNF-induced intestinal crypt apoptosis during chronic NF-κB activation.

Cell Mol Gastroenterol Hepatol 2019 Oct 10. Epub 2019 Oct 10.

Rheumatology; Department of Medicine, Autonomous University of Barcelona, Plaça Cívica, 08193 Bellaterra, Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.jcmgh.2019.10.002DOI Listing
October 2019

Temporally Distinct Functions of the Cytokines IL-12 and IL-23 Drive Chronic Colon Inflammation in Response to Intestinal Barrier Impairment.

Immunity 2019 Aug 23;51(2):367-380.e4. Epub 2019 Jul 23.

Institute for Genetics, University of Cologne, 50674 Cologne, Germany; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, 50931 Cologne, Germany; Center for Molecular Medicine Cologne (CMMC), University of Cologne, 50931 Cologne, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2019.06.008DOI Listing
August 2019

A20 prevents inflammasome-dependent arthritis by inhibiting macrophage necroptosis through its ZnF7 ubiquitin-binding domain.

Nat Cell Biol 2019 06 13;21(6):731-742. Epub 2019 May 13.

Institute for Genetics, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) and Center for Molecular Medicine, University of Cologne, Cologne, Germany.

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http://dx.doi.org/10.1038/s41556-019-0324-3DOI Listing
June 2019

RIP Kinases in Liver Cell Death, Inflammation and Cancer.

Trends Mol Med 2019 01 16;25(1):47-63. Epub 2018 Nov 16.

Institute for Genetics, University of Cologne, D-50674 Cologne, Germany; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, D-50931 Cologne, Germany; Center for Molecular Medicine (CMMC), University of Cologne, D-50931, Cologne, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S14714914183020
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http://dx.doi.org/10.1016/j.molmed.2018.10.007DOI Listing
January 2019

Innate Sensing through Mesenchymal TLR4/MyD88 Signals Promotes Spontaneous Intestinal Tumorigenesis.

Cell Rep 2019 01;26(3):536-545.e4

Biomedical Sciences Research Centre (BSRC) "Alexander Fleming," Vari 16672, Greece; Department of Physiology, Medical School, National and Kapodistrian University of Athens, Athens 11527, Greece. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22111247183201
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http://dx.doi.org/10.1016/j.celrep.2018.12.072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334226PMC
January 2019

The Cdkn1a Mouse as a Tool to Study p53-Mediated Tumor Suppression.

Cell Rep 2018 10;25(4):1027-1039.e6

Department I of Internal Medicine, University Hospital Cologne, Weyertal 115b, 50931 Cologne, Germany; Cologne Excellence Cluster on Cellular Stress Response in Aging-Associated Diseases (CECAD), University of Cologne, Joseph Stelzmann Straße 26, 50931 Cologne, Germany; Center for Molecular Medicine, University Hospital Cologne, Robert Koch Straße 21, 50931 Cologne. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22111247183153
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http://dx.doi.org/10.1016/j.celrep.2018.09.079DOI Listing
October 2018

Connecting immune deficiency and inflammation.

Science 2018 08;361(6404):756-757

Department of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA.

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http://www.sciencemag.org/lookup/doi/10.1126/science.aau6962
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http://dx.doi.org/10.1126/science.aau6962DOI Listing
August 2018

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

Authors:
Lorenzo Galluzzi Ilio Vitale Stuart A Aaronson John M Abrams Dieter Adam Patrizia Agostinis Emad S Alnemri Lucia Altucci Ivano Amelio David W Andrews Margherita Annicchiarico-Petruzzelli Alexey V Antonov Eli Arama Eric H Baehrecke Nickolai A Barlev Nicolas G Bazan Francesca Bernassola Mathieu J M Bertrand Katiuscia Bianchi Mikhail V Blagosklonny Klas Blomgren Christoph Borner Patricia Boya Catherine Brenner Michelangelo Campanella Eleonora Candi Didac Carmona-Gutierrez Francesco Cecconi Francis K-M Chan Navdeep S Chandel Emily H Cheng Jerry E Chipuk John A Cidlowski Aaron Ciechanover Gerald M Cohen Marcus Conrad Juan R Cubillos-Ruiz Peter E Czabotar Vincenzo D'Angiolella Ted M Dawson Valina L Dawson Vincenzo De Laurenzi Ruggero De Maria Klaus-Michael Debatin Ralph J DeBerardinis Mohanish Deshmukh Nicola Di Daniele Francesco Di Virgilio Vishva M Dixit Scott J Dixon Colin S Duckett Brian D Dynlacht Wafik S El-Deiry John W Elrod Gian Maria Fimia Simone Fulda Ana J García-Sáez Abhishek D Garg Carmen Garrido Evripidis Gavathiotis Pierre Golstein Eyal Gottlieb Douglas R Green Lloyd A Greene Hinrich Gronemeyer Atan Gross Gyorgy Hajnoczky J Marie Hardwick Isaac S Harris Michael O Hengartner Claudio Hetz Hidenori Ichijo Marja Jäättelä Bertrand Joseph Philipp J Jost Philippe P Juin William J Kaiser Michael Karin Thomas Kaufmann Oliver Kepp Adi Kimchi Richard N Kitsis Daniel J Klionsky Richard A Knight Sharad Kumar Sam W Lee John J Lemasters Beth Levine Andreas Linkermann Stuart A Lipton Richard A Lockshin Carlos López-Otín Scott W Lowe Tom Luedde Enrico Lugli Marion MacFarlane Frank Madeo Michal Malewicz Walter Malorni Gwenola Manic Jean-Christophe Marine Seamus J Martin Jean-Claude Martinou Jan Paul Medema Patrick Mehlen Pascal Meier Sonia Melino Edward A Miao Jeffery D Molkentin Ute M Moll Cristina Muñoz-Pinedo Shigekazu Nagata Gabriel Nuñez Andrew Oberst Moshe Oren Michael Overholtzer Michele Pagano Theocharis Panaretakis Manolis Pasparakis Josef M Penninger David M Pereira Shazib Pervaiz Marcus E Peter Mauro Piacentini Paolo Pinton Jochen H M Prehn Hamsa Puthalakath Gabriel A Rabinovich Markus Rehm Rosario Rizzuto Cecilia M P Rodrigues David C Rubinsztein Thomas Rudel Kevin M Ryan Emre Sayan Luca Scorrano Feng Shao Yufang Shi John Silke Hans-Uwe Simon Antonella Sistigu Brent R Stockwell Andreas Strasser Gyorgy Szabadkai Stephen W G Tait Daolin Tang Nektarios Tavernarakis Andrew Thorburn Yoshihide Tsujimoto Boris Turk Tom Vanden Berghe Peter Vandenabeele Matthew G Vander Heiden Andreas Villunger Herbert W Virgin Karen H Vousden Domagoj Vucic Erwin F Wagner Henning Walczak David Wallach Ying Wang James A Wells Will Wood Junying Yuan Zahra Zakeri Boris Zhivotovsky Laurence Zitvogel Gerry Melino Guido Kroemer

Cell Death Differ 2018 03 23;25(3):486-541. Epub 2018 Jan 23.

Paris Descartes/Paris V University, Paris, France.

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http://dx.doi.org/10.1038/s41418-017-0012-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5864239PMC
March 2018

CCR2 monocytic myeloid-derived suppressor cells (M-MDSCs) inhibit collagen degradation and promote lung fibrosis by producing transforming growth factor-β1.

J Pathol 2017 11 21;243(3):320-330. Epub 2017 Sep 21.

Louvain Centre for Toxicology and Applied Pharmacology (LTAP), Institut de Recherche Experimentale et Clinique (IREC), Université catholique de Louvain, Brussels, Belgium.

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http://dx.doi.org/10.1002/path.4956DOI Listing
November 2017

Epithelial Cell Death and Inflammation in Skin.

Curr Top Microbiol Immunol 2017;403:77-93

Institute for Genetics, University of Cologne, 50674, Cologne, Germany.

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http://dx.doi.org/10.1007/82_2015_466DOI Listing
July 2017

MK2 Phosphorylates RIPK1 to Prevent TNF-Induced Cell Death.

Mol Cell 2017 Jun 11;66(5):698-710.e5. Epub 2017 May 11.

Breast Cancer Now Toby Robins Research Centre, Institute of Cancer Research, Mary-Jean Mitchell Green Building, Chester Beatty Laboratories, Fulham Road, London SW3 6JB, UK. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2017.05.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5459754PMC
June 2017

The interplay of IKK, NF-κB and RIPK1 signaling in the regulation of cell death, tissue homeostasis and inflammation.

Immunol Rev 2017 05;277(1):113-127

Institute for Genetics, University of Cologne, Cologne, Germany.

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http://dx.doi.org/10.1111/imr.12550DOI Listing
May 2017

RIPK1 counteracts ZBP1-mediated necroptosis to inhibit inflammation.

Nature 2016 12 7;540(7631):124-128. Epub 2016 Nov 7.

Institute for Genetics, Centre for Molecular Medicine (CMMC), and Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, 50931 Cologne, Germany.

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http://dx.doi.org/10.1038/nature20558DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5755685PMC
December 2016

Opposing role of tumor necrosis factor receptor 1 signaling in T cell-mediated hepatitis and bacterial infection in mice.

Hepatology 2016 08 18;64(2):508-21. Epub 2016 Apr 18.

I. Department of Internal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

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http://dx.doi.org/10.1002/hep.28551DOI Listing
August 2016

RIPK1 mediates axonal degeneration by promoting inflammation and necroptosis in ALS.

Science 2016 Aug;353(6299):603-8

Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA. Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 26 QiuYue Road, PuDong District, Shanghai, 201210, China.

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http://www.sciencemag.org/lookup/doi/10.1126/science.aaf6803
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http://dx.doi.org/10.1126/science.aaf6803DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5444917PMC
August 2016

The tumour suppressor CYLD regulates the p53 DNA damage response.

Nat Commun 2016 08 26;7:12508. Epub 2016 Aug 26.

Institute for Genetics, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) and Centre for Molecular Medicine (CMMC), University of Cologne, Joseph-Stelzmann-Straβe 26, Cologne 50931, Germany.

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http://dx.doi.org/10.1038/ncomms12508DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007442PMC
August 2016

TLR-independent anti-inflammatory function of intestinal epithelial TRAF6 signalling prevents DSS-induced colitis in mice.

Gut 2016 06 11;65(6):935-43. Epub 2015 Mar 11.

Institute for Genetics, University of Cologne, Cologne, Germany Centre for Molecular Medicine (CMMC), University of Cologne, Cologne, Germany Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany Department of Medical Protein Research, VIB, Ghent, Belgium Department of Biochemistry, Ghent University, Ghent, Belgium.

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http://dx.doi.org/10.1136/gutjnl-2014-308323DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4893119PMC
June 2016

B-cell-specific conditional expression of Myd88p.L252P leads to the development of diffuse large B-cell lymphoma in mice.

Blood 2016 06 5;127(22):2732-41. Epub 2016 Apr 5.

Department I of Internal Medicine, University Hospital of Cologne, Cologne, Germany; Cologne Excellence Cluster on Cellular Stress Response in Aging-Associated Diseases, University of Cologne, Cologne, Germany; Center of Integrated Oncology, University Hospital of Cologne, Cologne, Germany; and Center of Molecular Medicine, University of Cologne, Cologne, Germany.

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http://dx.doi.org/10.1182/blood-2015-11-684183DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4891954PMC
June 2016

A brain microvasculature endothelial cell-specific viral vector with the potential to treat neurovascular and neurological diseases.

EMBO Mol Med 2016 06 1;8(6):609-25. Epub 2016 Jun 1.

Hubertus Wald Cancer Center, Department of Oncology and Hematology University Medical Center Hamburg-Eppendorf, Hamburg, Germany Department of Hematology and Oncology, Augsburg Medical Center, Augsburg, Germany

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http://dx.doi.org/10.15252/emmm.201506078DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4888852PMC
June 2016

NF-κB Essential Modulator (NEMO) Is Critical for Thyroid Function.

J Biol Chem 2016 Mar 19;291(11):5765-73. Epub 2016 Jan 19.

the Dipartimento di Scienze e Tecnologie, Università del Sannio, Via Port'Arsa 11, 82100 Benevento, Italy, the Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università di Napoli, 80131 Napoli, Italy.

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http://dx.doi.org/10.1074/jbc.M115.711697DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4786713PMC
March 2016

Transplantation from a symptomatic carrier sister restores host defenses but does not prevent colitis in NEMO deficiency.

Clin Immunol 2016 Mar 23;164:52-6. Epub 2016 Jan 23.

Center of Chronic Immunodeficiency, University Medical Center Freiburg, Germany; Center for Pediatrics and Adolescent Medicine, University Medical Center Freiburg, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15216616163001
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http://dx.doi.org/10.1016/j.clim.2016.01.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6101191PMC
March 2016

NEMO Prevents RIP Kinase 1-Mediated Epithelial Cell Death and Chronic Intestinal Inflammation by NF-κB-Dependent and -Independent Functions.

Immunity 2016 Mar;44(3):553-567

Institute for Genetics, University of Cologne, 50674 Cologne, Germany; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, 50931 Cologne, Germany; Center for Molecular Medicine (CMMC), University of Cologne, 50931 Cologne, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2016.02.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4803910PMC
March 2016

NF-κB/RelA and Nrf2 cooperate to maintain hepatocyte integrity and to prevent development of hepatocellular adenoma.

J Hepatol 2016 Jan 5;64(1):94-102. Epub 2015 Sep 5.

Department of Biology, Institute of Molecular Health Sciences, Swiss Federal Institute of Technology (ETH) Zurich, 8093 Zurich, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2015.08.033DOI Listing
January 2016

IKKβ in intestinal mesenchymal cells promotes initiation of colitis-associated cancer.

J Exp Med 2015 Dec 30;212(13):2235-51. Epub 2015 Nov 30.

Biomedical Sciences Research Center "Alexander Fleming", 16672 Vari, Greece Department of Physiology, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece

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http://dx.doi.org/10.1084/jem.20150542DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4683996PMC
December 2015

NEMO Prevents Steatohepatitis and Hepatocellular Carcinoma by Inhibiting RIPK1 Kinase Activity-Mediated Hepatocyte Apoptosis.

Cancer Cell 2015 11;28(5):582-598

Institute for Genetics, University of Cologne, 50674 Cologne, Germany; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, 50931 Cologne, Germany; Center for Molecular Medicine (CMMC), University of Cologne, 50931, Cologne, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2015.10.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4644221PMC
November 2015

Brain endothelial TAK1 and NEMO safeguard the neurovascular unit.

J Exp Med 2015 Sep 7;212(10):1529-49. Epub 2015 Sep 7.

Institute of Experimental and Clinical Pharmacology and Toxicology and Department of Radiation Oncology, University of Lübeck, 23562 Lübeck, Germany German Research Centre for Cardiovascular Research (DZHK), Partner Site Hamburg/Lübeck/Kiel, 23562 Lübeck, Germany

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http://dx.doi.org/10.1084/jem.20150165DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4577837PMC
September 2015

Epithelial IKKα licenses ILC3s to defend the intestinal barrier.

J Exp Med 2015 Sep;212(10):1483

Institute for Genetics and CECAD Research Center, University of Cologne

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http://dx.doi.org/10.1084/jem.21210insight2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4577834PMC
September 2015

Hematopoietic stem cell quiescence and function are controlled by the CYLD-TRAF2-p38MAPK pathway.

J Exp Med 2015 Apr 30;212(4):525-38. Epub 2015 Mar 30.

Division of Stem Cells and Cancer, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH), 69120 Heidelberg, Germany The German Cancer Consortium (DKTK), 69120 Heidelberg, Germany

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http://dx.doi.org/10.1084/jem.20141438DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4387289PMC
April 2015

Necroptosis and its role in inflammation.

Nature 2015 Jan;517(7534):311-20

1] VIB Inflammation Research Center, Ghent University, UGhent-VIB Research Building FSVM, 9052 Ghent, Belgium [2] Department of Biomedical Molecular Biology, Ghent University, 9000 Ghent, Belgium. [3] Methusalem program, Ghent University, Technologiepark 927, B-9052 Ghent, Belgium.

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http://www.nature.com/articles/nature14191
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http://dx.doi.org/10.1038/nature14191DOI Listing
January 2015

Postsurgical adjuvant tumor therapy by combining anti-angiopoietin-2 and metronomic chemotherapy limits metastatic growth.

Cancer Cell 2014 Dec;26(6):880-895

Division of Vascular Oncology and Metastasis, German Cancer Research Center Heidelberg (DKFZ-ZMBH Alliance), 69121 Heidelberg, Germany; Department of Vascular Biology and Tumor Angiogenesis (CBTM), Medical Faculty Mannheim, Heidelberg University, 68167 Mannheim, Germany; German Cancer Consortium, 69120 Heidelberg, Germany. Electronic address:

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http://www.cell.com/cancer-cell/pdf/S1535-6108(14)00456-5.pd
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http://linkinghub.elsevier.com/retrieve/pii/S153561081400456
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http://dx.doi.org/10.1016/j.ccell.2014.11.005DOI Listing
December 2014

IKK2 inhibition attenuates laser-induced choroidal neovascularization.

PLoS One 2014 28;9(1):e87530. Epub 2014 Jan 28.

Departments of Ophthalmology and Visual Sciences, University of Louisville School of Medicine, Louisville, Kentucky, United States of America ; James Graham Brown Cancer Center, University of Louisville School of Medicine, Louisville, Kentucky, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0087530PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3905033PMC
November 2014

Hematopoietic RIPK1 deficiency results in bone marrow failure caused by apoptosis and RIPK3-mediated necroptosis.

Proc Natl Acad Sci U S A 2014 Oct 22;111(40):14436-41. Epub 2014 Sep 22.

Department of Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605;

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http://dx.doi.org/10.1073/pnas.1409389111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4209989PMC
October 2014

Akt-dependent activation of mTORC1 complex involves phosphorylation of mTOR (mammalian target of rapamycin) by IκB kinase α (IKKα).

J Biol Chem 2014 Sep 2;289(36):25227-40. Epub 2014 Jul 2.

From the Lineberger Comprehensive Cancer Center University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599,

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http://dx.doi.org/10.1074/jbc.M114.554881DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4155685PMC
September 2014

RIPK1 maintains epithelial homeostasis by inhibiting apoptosis and necroptosis.

Nature 2014 Sep 17;513(7516):90-4. Epub 2014 Aug 17.

1] Institute for Genetics, Centre for Molecular Medicine (CMMC), and Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, 50931 Cologne, Germany [2].

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http://dx.doi.org/10.1038/nature13608DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4206266PMC
September 2014

IRF5:RelA interaction targets inflammatory genes in macrophages.

Cell Rep 2014 Sep 21;8(5):1308-17. Epub 2014 Aug 21.

Kennedy Institute of Rheumatology, University of Oxford, Roosevelt Drive, Oxford OX37FY, UK. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2014.07.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4471814PMC
September 2014

Germinal center B cell maintenance and differentiation are controlled by distinct NF-κB transcription factor subunits.

J Exp Med 2014 Sep 1;211(10):2103-18. Epub 2014 Sep 1.

Herbert Irving Comprehensive Cancer Center, Department of Pathology and Cell Biology, and Department of Microbiology and Immunology, Columbia University, New York, NY 10032 Herbert Irving Comprehensive Cancer Center, Department of Pathology and Cell Biology, and Department of Microbiology and Immunology, Columbia University, New York, NY 10032 Herbert Irving Comprehensive Cancer Center, Department of Pathology and Cell Biology, and Department of Microbiology and Immunology, Columbia University, New York, NY 10032

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http://dx.doi.org/10.1084/jem.20132613DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4172226PMC
September 2014

The deubiquitinating enzyme CYLD controls apical docking of basal bodies in ciliated epithelial cells.

Nat Commun 2014 Aug 19;5:4585. Epub 2014 Aug 19.

1] Institut Curie/INSERM U759, Campus Universitaire, Bat 112, 91405 Orsay Cedex, France [2] CNRS, Centre de Génétique Moléculaire, UPR3404, Avenue de la Terrasse, F-91198 Gif-sur-Yvette, France.

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http://www.nature.com/articles/ncomms5585
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http://dx.doi.org/10.1038/ncomms5585DOI Listing
August 2014

Epidermal p65/NF-κB signalling is essential for skin carcinogenesis.

EMBO Mol Med 2014 Jul;6(7):970-83

Institute for Genetics, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Centre for Molecular Medicine (CMMC), University of Cologne, Cologne, Germany

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http://dx.doi.org/10.15252/emmm.201303541DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4119358PMC
July 2014

Mechanisms regulating skin immunity and inflammation.

Nat Rev Immunol 2014 May 11;14(5):289-301. Epub 2014 Apr 11.

St John's Institute of Dermatology and Guy's and St Thomas' Hospital National Institute for Health Research Biomedical Research Centre, King's College London, SE1 9RT London, UK.

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http://dx.doi.org/10.1038/nri3646DOI Listing
May 2014

Selective ablation of lung epithelial IKK2 impairs pulmonary Th17 responses and delays the clearance of Pneumocystis.

J Immunol 2013 Nov 27;191(9):4720-30. Epub 2013 Sep 27.

Department of Microbiology and Immunology, School of Medicine and Dentistry, University of Rochester, Rochester, NY 14642;

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http://www.jimmunol.org/cgi/doi/10.4049/jimmunol.1301679
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http://dx.doi.org/10.4049/jimmunol.1301679DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3811920PMC
November 2013

Tumor necrosis factor receptor signaling in keratinocytes triggers interleukin-24-dependent psoriasis-like skin inflammation in mice.

Immunity 2013 Nov 7;39(5):899-911. Epub 2013 Nov 7.

Department of Dermatology, University of Cologne, Kerpener Strasse 62, 50931 Cologne, Germany; Institute for Genetics, Center for Molecular Medicine (CMMC), and Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Zülpicher Str. 47a, 50674 Cologne, Germany.

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http://linkinghub.elsevier.com/retrieve/pii/S107476131300468
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http://dx.doi.org/10.1016/j.immuni.2013.10.009DOI Listing
November 2013

K63 polyubiquitination and activation of mTOR by the p62-TRAF6 complex in nutrient-activated cells.

Mol Cell 2013 Aug 1;51(3):283-96. Epub 2013 Aug 1.

Sanford-Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1016/j.molcel.2013.06.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3971544PMC
August 2013

A20 (Tnfaip3) deficiency in myeloid cells protects against influenza A virus infection.

PLoS Pathog 2012 1;8(3):e1002570. Epub 2012 Mar 1.

Unit of Molecular Signal Transduction in Inflammation, Department for Molecular Biomedical Research, VIB, Ghent, Belgium [corrected].

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http://dx.doi.org/10.1371/journal.ppat.1002570DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3291650PMC
July 2012

A way to DAI.

Cell Host Microbe 2012 Mar;11(3):223-5

Institute for Genetics, University of Cologne, Cologne, Germany.

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http://linkinghub.elsevier.com/retrieve/pii/S193131281200063
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http://dx.doi.org/10.1016/j.chom.2012.02.003DOI Listing
March 2012

Role of NF-κB in epithelial biology.

Immunol Rev 2012 Mar;246(1):346-58

Institute for Genetics, University of Cologne, Cologne, Germany.

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http://dx.doi.org/10.1111/j.1600-065X.2012.01109.xDOI Listing
March 2012

Hepatocyte IKK2 protects Mdr2-/- mice from chronic liver failure.

PLoS One 2011 14;6(10):e25942. Epub 2011 Oct 14.

Institute for Genetics, Centre for Molecular Medicine (CMMC), Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0025942PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3195080PMC
February 2012

Endothelial and macrophage-specific deficiency of P38α MAPK does not affect the pathogenesis of atherosclerosis in ApoE-/- mice.

PLoS One 2011 9;6(6):e21055. Epub 2011 Jun 9.

Centre for Molecular Medicine, Institute for Genetics, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases, University of Cologne, Cologne, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0021055PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3111465PMC
October 2011

The adaptor protein FADD protects epidermal keratinocytes from necroptosis in vivo and prevents skin inflammation.

Immunity 2011 Oct 13;35(4):572-82. Epub 2011 Oct 13.

Institute for Genetics, Center for Molecular Medicine, and Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases, University of Cologne, Zülpicher Str. 47a, 50674 Cologne, Germany.

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http://dx.doi.org/10.1016/j.immuni.2011.08.014DOI Listing
October 2011

A20 (TNFAIP3) deficiency in myeloid cells triggers erosive polyarthritis resembling rheumatoid arthritis.

Nat Genet 2011 Aug 14;43(9):908-12. Epub 2011 Aug 14.

Department for Molecular Biomedical Research, Unit of Molecular Signal Transduction in Inflammation, Vlaams Instituut voor Biotechnologie, Ghent, Belgium.

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http://dx.doi.org/10.1038/ng.874DOI Listing
August 2011

Constitutive IKK2 activation in intestinal epithelial cells induces intestinal tumors in mice.

J Clin Invest 2011 Jul 23;121(7):2781-93. Epub 2011 Jun 23.

Institute for Genetics, Center for Molecular Medicine, and Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases, University of Cologne, Cologne, Germany.

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http://dx.doi.org/10.1172/JCI45349DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3223831PMC
July 2011

FADD prevents RIP3-mediated epithelial cell necrosis and chronic intestinal inflammation.

Nature 2011 Jul 31;477(7364):330-4. Epub 2011 Jul 31.

Institute for Genetics, Centre for Molecular Medicine, University of Cologne, Zülpicher Str. 47a, 50674 Cologne, Germany.

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http://dx.doi.org/10.1038/nature10273DOI Listing
July 2011

NF-κB in the regulation of epithelial homeostasis and inflammation.

Cell Res 2011 Jan 14;21(1):146-58. Epub 2010 Dec 14.

Institute for Genetics, Centre for Molecular Medicine, and Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases, University of Cologne, Zülpicher Strasse 47a, 50674 Cologne, Germany.

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http://www.nature.com/articles/cr2010175
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http://dx.doi.org/10.1038/cr.2010.175DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3193399PMC
January 2011

Oligodendrocyte-specific FADD deletion protects mice from autoimmune-mediated demyelination.

J Immunol 2010 Dec 10;185(12):7646-53. Epub 2010 Nov 10.

Unit of Molecular Signal Transduction in Inflammation, Department for Molecular Biomedical Research, Flanders Institute for Biotechnology (VIB), Ghent, Belgium.

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http://dx.doi.org/10.4049/jimmunol.1000930DOI Listing
December 2010

Role of TNF in pathologies induced by nuclear factor kappaB deficiency.

Curr Dir Autoimmun 2010 18;11:80-93. Epub 2010 Feb 18.

Centre for Molecular Medicine and Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases, Institute of Genetics, University of Cologne, Zülpicher Strasse 47, Cologne, Germany.

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http://dx.doi.org/10.1159/000289198DOI Listing
May 2010

Regulation of tissue homeostasis by NF-kappaB signalling: implications for inflammatory diseases.

Nat Rev Immunol 2009 Nov;9(11):778-88

Institute of Genetics, Centre for Molecular Medicine (CMMC), and Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Zülpicher Strasse 47, 50674 Cologne, Germany.

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http://dx.doi.org/10.1038/nri2655DOI Listing
November 2009

Sustained oscillations of NF-kappaB produce distinct genome scanning and gene expression profiles.

PLoS One 2009 Sep 29;4(9):e7163. Epub 2009 Sep 29.

Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0007163PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2747007PMC
September 2009

GFP-p65 knock-in mice as a tool to study NF-kappaB dynamics in vivo.

Genesis 2009 May;47(5):323-9

Institute for Genetics, Centre for Molecular Medicine, and Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases, University of Cologne, Germany.

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http://dx.doi.org/10.1002/dvg.20468DOI Listing
May 2009

Endothelial cell-specific NF-kappaB inhibition protects mice from atherosclerosis.

Cell Metab 2008 Nov;8(5):372-83

Institute of Genetics, Centre for Molecular Medicine (CMMC), Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Zülpicher Str. 47, 50674 Cologne, Germany.

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http://dx.doi.org/10.1016/j.cmet.2008.08.016DOI Listing
November 2008