Manling Zhang

Manling Zhang

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Publications by authors named "Manling Zhang"

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Loss of GCN5L1 in cardiac cells disrupts glucose metabolism and promotes cell death via reduced Akt/mTORC2 signaling.

Biochem J 2019 Jun 19;476(12):1713-1724. Epub 2019 Jun 19.

Division of Cardiology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, U.S.A.

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http://dx.doi.org/10.1042/BCJ20190302DOI Listing
June 2019

BOLA (BolA Family Member 3) Deficiency Controls Endothelial Metabolism and Glycine Homeostasis in Pulmonary Hypertension.

Circulation 2019 May;139(19):2238-2255

Center for Pulmonary Vascular Biology and Medicine, Center for Metabolism and Mitochondrial Medicine, Pittsburgh Heart, Lung, Blood, and Vascular Medicine Institute, Division of Cardiology and Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, PA (Q.Y., Y.-Y.T., Y.T., J.Z., V.N., M.K.C., J.P., W.S., J.S., M.R., M.S., N.K., T.S., M.Z., N.F., S.S., S.Y.C.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.035889DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6519484PMC
May 2019

Derivation of novel naive-like porcine embryonic stem cells by a reprogramming factor-assisted strategy.

FASEB J 2019 May 24:fj201802809R. Epub 2019 May 24.

Jiangsu Key Laboratory of Xenotransplantation, Nanjing Medical University, Nanjing, China.

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http://dx.doi.org/10.1096/fj.201802809RDOI Listing
May 2019

Cardiac-specific deletion of GCN5L1 restricts recovery from ischemia-reperfusion injury.

J Mol Cell Cardiol 2019 Apr 15;129:69-78. Epub 2019 Feb 15.

Division of Cardiology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, United States; Vascular Medicine Institute, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, United States; Center for Metabolism and Mitochondrial Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, United States. Electronic address:

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http://dx.doi.org/10.1016/j.yjmcc.2019.02.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6486843PMC
April 2019

Adropin treatment restores cardiac glucose oxidation in pre-diabetic obese mice.

J Mol Cell Cardiol 2019 Apr 26;129:174-178. Epub 2019 Feb 26.

Division of Cardiology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA; Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA, USA; Center for Metabolism and Mitochondrial Medicine, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.yjmcc.2019.02.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6486841PMC
April 2019

LncRNA ZBTB40-IT1 modulated by osteoporosis GWAS risk SNPs suppresses osteogenesis.

Hum Genet 2019 Feb 19;138(2):151-166. Epub 2019 Jan 19.

Hubei Key Laboratory of Genetic Regulation and Integrative Biology, School of Life Sciences, Central China Normal University, Wuhan, 430079, China.

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http://dx.doi.org/10.1007/s00439-019-01969-yDOI Listing
February 2019

Involvement of glucose-regulated protein 78 and spliced X-box binding protein 1 in the protective effect of gliclazide in diabetic nephropathy.

Diabetes Res Clin Pract 2018 Dec 4;146:41-47. Epub 2017 May 4.

Department of Chinese with Western Medicine, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan 430071, China.

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http://dx.doi.org/10.1016/j.diabres.2017.04.019DOI Listing
December 2018

Adropin regulates pyruvate dehydrogenase in cardiac cells via a novel GPCR-MAPK-PDK4 signaling pathway.

Redox Biol 2018 09 9;18:25-32. Epub 2018 Jun 9.

Division of Cardiology, Department of Medicine, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, PA 15261, United States; Vascular Medicine Institute, University of Pittsburgh, United States; Center for Metabolism and Mitochondrial Medicine, University of Pittsburgh, United States. Electronic address:

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http://dx.doi.org/10.1016/j.redox.2018.06.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6008287PMC
September 2018

Validation of goose liver fat measurement by QCT and CSE-MRI with biochemical extraction and pathology as reference.

Eur Radiol 2018 May 13;28(5):2003-2012. Epub 2017 Dec 13.

Department of Radiology, Beijing Jishuitan Hospital, 31 Xinjiekou East Street, Beijing, 100035, China.

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http://dx.doi.org/10.1007/s00330-017-5189-xDOI Listing
May 2018

Reducing immunoreactivity of porcine bioprosthetic heart valves by genetically-deleting three major glycan antigens, GGTA1/β4GalNT2/CMAH.

Acta Biomater 2018 05 7;72:196-205. Epub 2018 Apr 7.

Jiangsu Key Laboratory of Xenotransplantation, Nanjing Medical University, Nanjing 211166, China; Key Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, Nanjing 211166, China; State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing 211166, China; Shenzhen Xenotransplantation Medical Engineering Research and Development Center, Institute of Translational Medicine, Shenzhen Second People's Hospital, First Affiliated Hospital of Shenzhen University, Shenzhen 518035, China. Electronic address:

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http://dx.doi.org/10.1016/j.actbio.2018.03.055DOI Listing
May 2018

Prevention of PKG-1α Oxidation Suppresses Antihypertrophic/Antifibrotic Effects From PDE5 Inhibition but not sGC Stimulation.

Circ Heart Fail 2018 03;11(3):e004740

From the Division of Cardiology, Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, MD (T.N., G.Z., M.J.R., K.K.-S., M.Z., G.E.K., D.A.K.); and Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Japan (T.N., K.T.).

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http://dx.doi.org/10.1161/CIRCHEARTFAILURE.117.004740DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5858464PMC
March 2018

Overexpressing dominant-negative FGFR2-IIIb impedes lung branching morphogenesis in pigs.

J Genet Genomics 2018 03 14;45(3):147-154. Epub 2018 Feb 14.

Jiangsu Key Laboratory of Xenotransplantation, Nanjing Medical University, Nanjing 211166, China; Key Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, Nanjing 211166, China; State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing 211166, China; Shenzhen Xenotransplantation Medical Engineering Research and Development Center, Institute of Translational Medicine, Shenzhen Second People's Hospital, First Affiliated Hospital of Shenzhen University, Shenzhen 518035, China. Electronic address:

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http://dx.doi.org/10.1016/j.jgg.2018.02.002DOI Listing
March 2018

DNA demethylation pattern of in-vitro fertilized and cloned porcine pronuclear stage embryos.

Clin Chim Acta 2017 Oct 27;473:45-50. Epub 2017 Jul 27.

State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing 210029, the People's Republic of China; Jiangsu Key Laboratory of Xenotransplantation, Nanjing Medical University, Nanjing 210029, the People's Republic of China. Electronic address:

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http://dx.doi.org/10.1016/j.cca.2017.07.025DOI Listing
October 2017

Acetylation of mitochondrial proteins by GCN5L1 promotes enhanced fatty acid oxidation in the heart.

Am J Physiol Heart Circ Physiol 2017 Aug 19;313(2):H265-H274. Epub 2017 May 19.

Division of Cardiology, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania;

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http://dx.doi.org/10.1152/ajpheart.00752.2016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5582919PMC
August 2017

Effect of Water-Cooled Nd:YAG Laser on Dentinal Tubule Occlusion In Vitro.

Photomed Laser Surg 2017 Feb 3;35(2):98-104. Epub 2016 Nov 3.

1 State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University , Chengdu, China .

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http://dx.doi.org/10.1089/pho.2016.4169DOI Listing
February 2017

The Efficient Derivation of Trophoblast Cells from Porcine In Vitro Fertilized and Parthenogenetic Blastocysts and Culture with ROCK Inhibitor Y-27632.

PLoS One 2015 10;10(11):e0142442. Epub 2015 Nov 10.

The Key Laboratory of National Education Ministry for Mammalian Reproductive Biology and Biotechnology, Inner Mongolia University, Hohhot, Inner Mongolia, P. R. China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0142442PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4640852PMC
June 2016

α-Lipoic acid promotes α-tubulin hyperacetylation and blocks the turnover of mitochondria through mitophagy.

Biochem J 2016 06 20;473(12):1821-30. Epub 2016 Apr 20.

Division of Cardiology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, U.S.A.

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http://dx.doi.org/10.1042/BCJ20160281DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6040678PMC
June 2016

Generation of B cell-deficient pigs by highly efficient CRISPR/Cas9-mediated gene targeting.

J Genet Genomics 2015 Aug 27;42(8):437-44. Epub 2015 May 27.

State Key Laboratory of Reproductive Medicine and Jiangsu Key Laboratory of Xenotransplantation, Nanjing Medical University, Nanjing 210029, China. Electronic address:

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http://dx.doi.org/10.1016/j.jgg.2015.05.002DOI Listing
August 2015

Karyotype characterization of in vivo- and in vitro-derived porcine parthenogenetic cell lines.

PLoS One 2014 20;9(5):e97974. Epub 2014 May 20.

State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, Jiangsu, China; Jiangsu Key Laboratory of Xenotransplantation, Nanjing Medical University, Nanjing, Jiangsu, China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0097974PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4028241PMC
January 2015

Establishment of bovine trophoblast stem-like cells from in vitro-produced blastocyst-stage embryos using two inhibitors.

Stem Cells Dev 2014 Jul 10;23(13):1501-14. Epub 2014 Apr 10.

1 The Key Laboratory of National Education Ministry for Mammalian Reproductive Biology and Biotechnology, Inner Mongolia University , Hohhot, China .

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http://dx.doi.org/10.1089/scd.2013.0329DOI Listing
July 2014

Serine protease inhibitor 6 is required to protect dendritic cells from the kiss of death.

J Immunol 2012 Feb 6;188(3):1057-63. Epub 2012 Jan 6.

Section of Immunobiology, Division of Immunology and Inflammation, Department of Medicine, Faculty of Medicine, Imperial College London, London W12 0NN, United Kingdom.

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http://www.jimmunol.org/cgi/doi/10.4049/jimmunol.1102667
Publisher Site
http://dx.doi.org/10.4049/jimmunol.1102667DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3270301PMC
February 2012

Phosphodiesterases and cardiac cGMP: evolving roles and controversies.

Trends Pharmacol Sci 2011 Jun 7;32(6):360-5. Epub 2011 Apr 7.

Division of Cardiology, Department of Medicine, Johns Hopkins University Medical Institutions, Baltimore, MD, USA.

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http://dx.doi.org/10.1016/j.tips.2011.02.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3106121PMC
June 2011

Myocardial remodeling is controlled by myocyte-targeted gene regulation of phosphodiesterase type 5.

J Am Coll Cardiol 2010 Dec 21;56(24):2021-30. Epub 2010 Oct 21.

Department of Medicine, Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1016/j.jacc.2010.08.612DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3036840PMC
December 2010

CD95 is cytoprotective for intestinal epithelial cells in colitis.

Inflamm Bowel Dis 2010 Jun;16(6):1063-70

Ben May Department for Cancer Research, Johns Hopkins Medical Institute, Baltimore, Maryland, USA.

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https://academic.oup.com/ibdjournal/article/16/6/1063-1070/4
Publisher Site
http://dx.doi.org/10.1002/ibd.21195DOI Listing
June 2010

Pressure-overload magnitude-dependence of the anti-hypertrophic efficacy of PDE5A inhibition.

J Mol Cell Cardiol 2009 Apr 29;46(4):560-7. Epub 2008 Dec 29.

Division of Cardiology, Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, Maryland, MD 21287, USA.

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http://dx.doi.org/10.1016/j.yjmcc.2008.12.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2703675PMC
April 2009

Phosphodiesterase 5 inhibition blocks pressure overload-induced cardiac hypertrophy independent of the calcineurin pathway.

Cardiovasc Res 2009 Feb 24;81(2):301-9. Epub 2008 Nov 24.

Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Ross-Building, Room 850, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1093/cvr/cvn324DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2721646PMC
February 2009

Expression, activity, and pro-hypertrophic effects of PDE5A in cardiac myocytes.

Cell Signal 2008 Dec 26;20(12):2231-6. Epub 2008 Aug 26.

Division of Cardiology, Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1016/j.cellsig.2008.08.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2601628PMC
December 2008

Sustained soluble guanylate cyclase stimulation offsets nitric-oxide synthase inhibition to restore acute cardiac modulation by sildenafil.

J Pharmacol Exp Ther 2008 Aug 2;326(2):380-7. Epub 2008 May 2.

Division of Cardiology, Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1124/jpet.108.137422DOI Listing
August 2008

CD95 signaling deficient mice with a wild-type hematopoietic system are prone to hepatic neoplasia.

Apoptosis 2008 Jan;13(1):41-51

Ben May Department for Cancer Research, The University of Chicago, Chicago, IL 60637, USA.

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http://dx.doi.org/10.1007/s10495-007-0149-6DOI Listing
January 2008

Differential survival of cytotoxic T cells and memory cell precursors.

J Immunol 2007 Mar;178(6):3483-91

Department of Pathology, Ben May Institute for Cancer Research and Committee on Immunology, University of Chicago, Chicago, IL 60637, USA.

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http://dx.doi.org/10.4049/jimmunol.178.6.3483DOI Listing
March 2007

[Mechanism of watershed soil erosion control by vegetation].

Ying Yong Sheng Tai Xue Bao 2005 Sep;16(9):1618-22

Key Laboratory of Soil and Water Conservation and Desertification Combating of Education Ministry, College of Soil and Water Conservation, Beijing Forestry University, Beijing, China.

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September 2005

Serine protease inhibitor 2A is a protective factor for memory T cell development.

Nat Immunol 2004 Sep 15;5(9):919-26. Epub 2004 Aug 15.

Committees on Immunology and Developmental Biology, Department of Pathology, Ben May Institute for Cancer Research and Gwen Knapp Center for Lupus and Immunology Research, The University of Chicago, 924 East 57th Street, Chicago, Illinois 60637, USA.

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http://dx.doi.org/10.1038/ni1107DOI Listing
September 2004