Manja Meggendorfer

Manja Meggendorfer

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Manja Meggendorfer

Manja Meggendorfer

Publications by authors named "Manja Meggendorfer"

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Myeloid malignancies with isolated 7q deletion can be further characterized by their accompanying molecular mutations.

Authors:
Luise Hartmann Claudia Haferlach Manja Meggendorfer Wolfgang Kern Torsten Haferlach Anna Stengel

Genes Chromosomes Cancer 2019 10 1;58(10):698-704. Epub 2019 May 1.

MLL Munich Leukemia Laboratory, Max-Lebsche-Platz 31, Munich, 81377, Germany.

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http://dx.doi.org/10.1002/gcc.22761DOI Listing
October 2019

MARS: Mutation-Adjusted Risk Score for Advanced Systemic Mastocytosis.

Authors:
Mohamad Jawhar Juliana Schwaab Iván Álvarez-Twose Khalid Shoumariyeh Nicole Naumann Johannes Lübke Cecelia Perkins Javier I Muñoz-González Manja Meggendorfer Vanessa Kennedy Georgia Metzgeroth Alice Fabarius Dietmar Pfeifer Karl Sotlar Hans-Peter Horny Nikolas von Bubnoff Torsten Haferlach Nicholas C P Cross Wolf-Karsten Hofmann Wolfgang R Sperr Andrés C García-Montero Peter Valent Jason Gotlib Alberto Orfao Andreas Reiter

J Clin Oncol 2019 Sep 11:JCO1900640. Epub 2019 Sep 11.

University Hospital Mannheim, Heidelberg University, Mannheim, Germany.

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http://dx.doi.org/10.1200/JCO.19.00640DOI Listing
September 2019

Evidence of clonality in cases of hypereosinophilia of undetermined significance.

Authors:
Christian Pohlkamp Calogero Vetro Frank Dicker Manja Meggendorfer Wolfgang Kern Claudia Haferlach Torsten Haferlach

Leuk Lymphoma 2019 Aug 18;60(8):2071-2074. Epub 2019 Jan 18.

a MLL Munich Leukemia Laboratory , Munich , Germany.

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http://dx.doi.org/10.1080/10428194.2018.1564825DOI Listing
August 2019

"Somatic" and "pathogenic" - is the classification strategy applicable in times of large-scale sequencing?

Authors:
Constance Baer Wencke Walter Stephan Hutter Sven Twardziok Manja Meggendorfer Wolfgang Kern Torsten Haferlach Claudia Haferlach

Haematologica 2019 Aug 4;104(8):1515-1520. Epub 2019 Jul 4.

MLL Munich Leukemia Laboratory, Munich, Germany.

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http://dx.doi.org/10.3324/haematol.2019.218917DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6669162PMC
August 2019

Molecular characterization of acute myeloid leukemia patients who relapse more than 3 years after diagnosis: an exome sequencing study of 31 patients.

Authors:
Luise Hartmann Claudia Haferlach Manja Meggendorfer Niroshan Nadarajah Wolfgang Kern Torsten Haferlach Anna Stengel

Haematologica 2019 Aug 1. Epub 2019 Aug 1.

MLL Munich Leukemia Laboratory, Munich, Germany

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http://dx.doi.org/10.3324/haematol.2019.227702DOI Listing
August 2019

Dark-matter matters: Discriminating subtle blood cancers using the darkest DNA.

Authors:
Laxmi Parida Claudia Haferlach Kahn Rhrissorrakrai Filippo Utro Chaya Levovitz Wolfgang Kern Niroshan Nadarajah Sven Twardziok Stephan Hutter Manja Meggendorfer Wencke Walter Constance Baer Torsten Haferlach

PLoS Comput Biol 2019 Aug 30;15(8):e1007332. Epub 2019 Aug 30.

MLL Munich Leukemia Laboratory, Munich, Germany.

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http://dx.doi.org/10.1371/journal.pcbi.1007332DOI Listing
August 2019

Mutational landscape of the transcriptome offers putative targets for immunotherapy of myeloproliferative neoplasms.

Authors:
Fiorella Schischlik Roland Jäger Felix Rosebrock Eva Hug Michael Schuster Raimund Holly Elisabeth Fuchs Jelena D Milosevic Feenstra Edith Bogner Bettina Gisslinger Martin Schalling Elisa Rumi Daniela Pietra Gottfried Fischer Ingrid Faé Loan Vulliard Jörg Menche Torsten Haferlach Manja Meggendorfer Anna Stengel Christoph Bock Mario Cazzola Heinz Gisslinger Robert Kralovics

Blood 2019 Jul 7;134(2):199-210. Epub 2019 May 7.

CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.

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http://dx.doi.org/10.1182/blood.2019000519DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6624966PMC
July 2019

Detailed molecular analysis and evaluation of prognosis in cases with high grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements.

Authors:
Anna Stengel Wolfgang Kern Manja Meggendorfer Torsten Haferlach Claudia Haferlach

Br J Haematol 2019 Jun 20;185(5):951-954. Epub 2018 Nov 20.

MLL Munich Leukaemia Laboratory, Munich, Germany.

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http://dx.doi.org/10.1111/bjh.15653DOI Listing
June 2019

DNMT3A mutations are over-represented in young adults with NPM1 mutated AML and prompt a distinct co-mutational pattern.

Authors:
Luca Vincenzo Cappelli Manja Meggendorfer Frank Dicker Sabine Jeromin Stephan Hutter Wolfgang Kern Torsten Haferlach Claudia Haferlach Alexander Höllein

Leukemia 2019 Jun 17. Epub 2019 Jun 17.

MLL Munich Leukemia Laboratory, Munich, Germany.

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http://dx.doi.org/10.1038/s41375-019-0502-0DOI Listing
June 2019

Detection and characterization of homozygosity of mutated by copy neutral loss of heterozygosity in myeloproliferative neoplasms among cases with high mutation loads or with progressive disease.

Authors:
Anna Stengel Sabine Jeromin Torsten Haferlach Manja Meggendorfer Wolfgang Kern Claudia Haferlach

Haematologica 2019 May 8;104(5):e187-e190. Epub 2018 Nov 8.

MLL Munich Leukemia Laboratory, Germany.

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http://dx.doi.org/10.3324/haematol.2018.202952DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6518876PMC
May 2019

KIT D816 mutated/CBF-negative acute myeloid leukemia: a poor-risk subtype associated with systemic mastocytosis.

Authors:
Mohamad Jawhar Konstanze Döhner Sebastian Kreil Juliana Schwaab Khalid Shoumariyeh Manja Meggendorfer Lambert L F Span Stephan Fuhrmann Nicole Naumann Hans-Peter Horny Karl Sotlar Boris Kubuschok Nikolas von Bubnoff Karsten Spiekermann Michael Heuser Georgia Metzgeroth Alice Fabarius Stefan Klein Wolf-Karsten Hofmann Hanneke C Kluin-Nelemans Torsten Haferlach Hartmut Döhner Nicholas C P Cross Wolfgang R Sperr Peter Valent Andreas Reiter

Leukemia 2019 05 11;33(5):1124-1134. Epub 2019 Jan 11.

Department of Hematology and Oncology, University Hospital Mannheim, Heidelberg University, Mannheim, Germany.

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http://www.nature.com/articles/s41375-018-0346-z
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http://dx.doi.org/10.1038/s41375-018-0346-zDOI Listing
May 2019

RUNX1 mutations in MDS, s-AML, and de novo AML: differences in accompanying genetic alterations and outcome.

Authors:
Anna Stengel Wolfgang Kern Manja Meggendorfer Torsten Haferlach Claudia Haferlach

Leuk Lymphoma 2019 May;60(5):1334-1336

a MLL Munich Leukemia Laboratory , Munich , Germany.

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http://dx.doi.org/10.1080/10428194.2018.1522439DOI Listing
May 2019

IDH1-R132 changes vary according to NPM1 and other mutations status in AML.

Authors:
Brunangelo Falini Orietta Spinelli Manja Meggendorfer Maria Paola Martelli Barbara Bigerna Stefano Ascani Harald Stein Alessandro Rambaldi Torsten Haferlach

Leukemia 2019 04 8;33(4):1043-1047. Epub 2019 Jan 8.

The Munich Leukemia Laboratory, Munich, Germany.

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http://www.nature.com/articles/s41375-018-0299-2
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http://dx.doi.org/10.1038/s41375-018-0299-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6484707PMC
April 2019

Genomic subtyping and therapeutic targeting of acute erythroleukemia.

Authors:
Ilaria Iacobucci Ji Wen Manja Meggendorfer John K Choi Lei Shi Stanley B Pounds Catherine L Carmichael Katherine E Masih Sarah M Morris R Coleman Lindsley Laura J Janke Thomas B Alexander Guangchun Song Chunxu Qu Yongjin Li Debbie Payne-Turner Daisuke Tomizawa Nobutaka Kiyokawa Marcus Valentine Virginia Valentine Giuseppe Basso Franco Locatelli Eric J Enemark Shirley K Y Kham Allen E J Yeoh Xiaotu Ma Xin Zhou Edgar Sioson Michael Rusch Rhonda E Ries Elliot Stieglitz Stephen P Hunger Andrew H Wei L Bik To Ian D Lewis Richard J D'Andrea Benjamin T Kile Anna L Brown Hamish S Scott Christopher N Hahn Paula Marlton Deqing Pei Cheng Cheng Mignon L Loh Benjamin L Ebert Soheil Meshinchi Torsten Haferlach Charles G Mullighan

Nat Genet 2019 04 29;51(4):694-704. Epub 2019 Mar 29.

Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA.

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http://dx.doi.org/10.1038/s41588-019-0375-1DOI Listing
April 2019

Comprehensive molecular characterization of myeloid malignancies with 9q deletion.

Authors:
Luise Hartmann Torsten Haferlach Manja Meggendorfer Wolfgang Kern Claudia Haferlach Anna Stengel

Leuk Lymphoma 2019 Mar 7:1-3. Epub 2019 Mar 7.

a MLL Munich Leukemia Laboratory , Munich , Germany.

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https://www.tandfonline.com/doi/full/10.1080/10428194.2019.1
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http://dx.doi.org/10.1080/10428194.2019.1585840DOI Listing
March 2019

More than a fusion gene: the - AML.

Authors:
Torsten Haferlach Manja Meggendorfer

Blood 2019 Mar;133(10):1006-1007

MLL Munich Leukemia Laboratory.

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http://dx.doi.org/10.1182/blood-2019-01-896076DOI Listing
March 2019

Impact of 9q deletions on the classification of patients with acute myeloid leukemia.

Authors:
Bettina Balk Torsten Haferlach Manja Meggendorfer Wolfgang Kern Claudia Haferlach Anna Stengel

J Cancer Res Clin Oncol 2019 Mar 29. Epub 2019 Mar 29.

MLL Munich Leukemia Laboratory, Max-Lebsche-Platz 31, 81377, Munich, Germany.

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http://dx.doi.org/10.1007/s00432-019-02908-0DOI Listing
March 2019

ASXL2 regulates hematopoiesis in mice and its deficiency promotes myeloid expansion.

Authors:
Vikas Madan Lin Han Norimichi Hattori Weoi Woon Teoh Anand Mayakonda Qiao-Yang Sun Ling-Wen Ding Hazimah Binte Mohd Nordin Su Lin Lim Pavithra Shyamsunder Pushkar Dakle Janani Sundaresan Ngan B Doan Masashi Sanada Aiko Sato-Otsubo Manja Meggendorfer Henry Yang Jonathan W Said Seishi Ogawa Torsten Haferlach Der-Cherng Liang Lee-Yung Shih Tsuyoshi Nakamaki Q Tian Wang H Phillip Koeffler

Haematologica 2018 Dec 9;103(12):1980-1990. Epub 2018 Aug 9.

Cancer Science Institute of Singapore, National University of Singapore.

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http://dx.doi.org/10.3324/haematol.2018.189928DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269306PMC
December 2018

mutated AML can relapse with wild-type : persistent clonal hematopoiesis can drive relapse.

Authors:
Alexander Höllein Manja Meggendorfer Frank Dicker Sabine Jeromin Niroshan Nadarajah Wolfgang Kern Claudia Haferlach Torsten Haferlach

Blood Adv 2018 11;2(22):3118-3125

MLL Munich Leukemia Laboratory, Munich, Germany.

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http://dx.doi.org/10.1182/bloodadvances.2018023432DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6258925PMC
November 2018

Minimal residual disease (MRD) monitoring and mutational landscape in AML with RUNX1-RUNX1T1: a study on 134 patients.

Authors:
Alexander Höllein Sabine Jeromin Manja Meggendorfer Annette Fasan Niroshan Nadarajah Wolfgang Kern Claudia Haferlach Torsten Haferlach

Leukemia 2018 10 6;32(10):2270-2274. Epub 2018 Mar 6.

MLL Munich Leukemia Laboratory, Munich, Germany.

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http://dx.doi.org/10.1038/s41375-018-0086-0DOI Listing
October 2018

Identification of prognostic parameters in CLL with no abnormalities detected by chromosome banding and FISH analyses.

Authors:
Calogero Vetro Torsten Haferlach Sabine Jeromin Anna Stengel Melanie Zenger Niroshan Nadarajah Constance Baer Sandra Weissmann Wolfgang Kern Manja Meggendorfer Claudia Haferlach

Br J Haematol 2018 10 18;183(1):47-59. Epub 2018 Jul 18.

MLL Munich Leukaemia Laboratory, Munich, Germany.

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http://dx.doi.org/10.1111/bjh.15498DOI Listing
October 2018

Consequences of mutant TET2 on clonality and subclonal hierarchy.

Authors:
Cassandra M Hirsch Aziz Nazha Kassy Kneen Mohamed E Abazeed Manja Meggendorfer Bartlomiej P Przychodzen Niroshan Nadarajah Vera Adema Yasunobu Nagata Abhinav Goyal Hassan Awada Mohammad Fahad Asad Valeria Visconte Yihong Guan Mikkael A Sekeres Ryszard Olinski Babal Kant Jha Thomas LaFramboise Tomas Radivoyevitch Torsten Haferlach Jaroslaw P Maciejewski

Leukemia 2018 08 24;32(8):1751-1761. Epub 2018 May 24.

Department of Translational Hematology and Oncology Research, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.

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http://dx.doi.org/10.1038/s41375-018-0150-9DOI Listing
August 2018

Clonal interference of signaling mutations worsens prognosis in core-binding factor acute myeloid leukemia.

Authors:
Raphael Itzykson Nicolas Duployez Annette Fasan Gauthier Decool Alice Marceau-Renaut Manja Meggendorfer Eric Jourdan Arnaud Petit Hélène Lapillonne Jean-Baptiste Micol Pascale Cornillet-Lefebvre Norbert Ifrah Guy Leverger Hervé Dombret Nicolas Boissel Torsten Haferlach Claude Preudhomme

Blood 2018 07 24;132(2):187-196. Epub 2018 Apr 24.

INSERM Lille, University of Lille, Lille, France.

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http://dx.doi.org/10.1182/blood-2018-03-837781DOI Listing
July 2018

Efficacy of azacitidine is independent of molecular and clinical characteristics - an analysis of 128 patients with myelodysplastic syndromes or acute myeloid leukemia and a review of the literature.

Authors:
Andrea Kuendgen Catharina Müller-Thomas Michael Lauseker Torsten Haferlach Petra Urbaniak Thomas Schroeder Carolin Brings Michael Wulfert Manja Meggendorfer Barbara Hildebrandt Beate Betz Brigitte Royer-Pokora Norbert Gattermann Rainer Haas Ulrich Germing Katharina S Götze

Oncotarget 2018 Jun 12;9(45):27882-27894. Epub 2018 Jun 12.

Department of Medicine III, Hematology and Oncology, Technische Universität München, Munich, Germany.

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http://dx.doi.org/10.18632/oncotarget.25328DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6021252PMC
June 2018

Incidence and prognostic impact of cytogenetic aberrations in patients with systemic mastocytosis.

Authors:
Nicole Naumann Mohamad Jawhar Juliana Schwaab Sebastian Kluger Johannes Lübke Georgia Metzgeroth Henning D Popp Nada Khaled Hans-Peter Horny Karl Sotlar Peter Valent Claudia Haferlach Gudrun Göhring Brigitte Schlegelberger Manja Meggendorfer Wolf-Karsten Hofmann Nicholas C P Cross Andreas Reiter Alice Fabarius

Genes Chromosomes Cancer 2018 05 19;57(5):252-259. Epub 2018 Feb 19.

Department of Hematology and Oncology, University Hospital Mannheim, Heidelberg University, Heidelberg, Germany.

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http://dx.doi.org/10.1002/gcc.22526DOI Listing
May 2018

Detection of recurrent and of novel fusion transcripts in myeloid malignancies by targeted RNA sequencing.

Authors:
Anna Stengel Niroshan Nadarajah Torsten Haferlach Frank Dicker Wolfgang Kern Manja Meggendorfer Claudia Haferlach

Leukemia 2018 05 26;32(5):1229-1238. Epub 2018 Feb 26.

MLL Munich Leukemia Laboratory, Max-Lebsche-Platz 31, 81377, Munich, Germany.

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http://dx.doi.org/10.1038/s41375-017-0002-zDOI Listing
May 2018

IDH1R132, IDH2R140 and IDH2R172 in AML: different genetic landscapes correlate with outcome and may influence targeted treatment strategies.

Authors:
Manja Meggendorfer Luca Vincenzo Cappelli Wencke Walter Claudia Haferlach Wolfgang Kern Brunangelo Falini Torsten Haferlach

Leukemia 2018 05 30;32(5):1249-1253. Epub 2018 Jan 30.

MLL Munich Leukemia Laboratory, Munich, Germany.

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http://dx.doi.org/10.1038/s41375-018-0026-zDOI Listing
May 2018

The mutational landscape of 18 investigated genes clearly separates four subtypes of myelodysplastic/myeloproliferative neoplasms.

Authors:
Manja Meggendorfer Sabine Jeromin Claudia Haferlach Wolfgang Kern Torsten Haferlach

Haematologica 2018 05;103(5):e192-e195

MLL Munich Leukemia Laboratory, Germany.

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http://dx.doi.org/10.3324/haematol.2017.183160DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5927999PMC
May 2018

Molecular analysis of myelodysplastic syndrome with isolated deletion of the long arm of chromosome 5 reveals a specific spectrum of molecular mutations with prognostic impact: a study on 123 patients and 27 genes.

Authors:
Manja Meggendorfer Claudia Haferlach Wolfgang Kern Torsten Haferlach

Haematologica 2017 09 22;102(9):1502-1510. Epub 2017 Jun 22.

MLL Munich Leukemia Laboratory, Germany.

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http://dx.doi.org/10.3324/haematol.2017.166173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5685225PMC
September 2017

Response and progression on midostaurin in advanced systemic mastocytosis: D816V and other molecular markers.

Authors:
Mohamad Jawhar Juliana Schwaab Nicole Naumann Hans-Peter Horny Karl Sotlar Torsten Haferlach Georgia Metzgeroth Alice Fabarius Peter Valent Wolf-Karsten Hofmann Nicholas C P Cross Manja Meggendorfer Andreas Reiter

Blood 2017 07 19;130(2):137-145. Epub 2017 Apr 19.

Department of Hematology and Oncology, Mannheim University Medical Center, Mannheim, Germany.

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http://www.bloodjournal.org/lookup/doi/10.1182/blood-2017-01
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http://dx.doi.org/10.1182/blood-2017-01-764423DOI Listing
July 2017

The clinical and molecular diversity of mast cell leukemia with or without associated hematologic neoplasm.

Authors:
Mohamad Jawhar Juliana Schwaab Manja Meggendorfer Nicole Naumann Hans-Peter Horny Karl Sotlar Torsten Haferlach Karla Schmitt Alice Fabarius Peter Valent Wolf-Karsten Hofmann Nicholas C P Cross Georgia Metzgeroth Andreas Reiter

Haematologica 2017 06 2;102(6):1035-1043. Epub 2017 Mar 2.

Department of Hematology and Oncology, University Medical Centre Mannheim, Germany

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http://dx.doi.org/10.3324/haematol.2017.163964DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5451335PMC
June 2017

Disease-modifying activity of ruxolitinib in a patient with JAK2-negative CMML-2.

Authors:
Silvan Francke Anna Mies Manja Meggendorfer Uta Oelschlaegel Ekaterina Balaian Silke Gloaguen Torsten Haferlach Gerhard Ehninger Martin Bornhäuser Uwe Platzbecker

Leuk Lymphoma 2017 05 23;58(5):1271-1272. Epub 2016 Sep 23.

a Medizinische Klinik und Poliklinik I, Universitätsklinikum Carl-Gustav-Carus, Technische Universität , Dresden , Germany.

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http://dx.doi.org/10.1080/10428194.2016.1225209DOI Listing
May 2017

Dynamics of clonal evolution in myelodysplastic syndromes.

Authors:
Hideki Makishima Tetsuichi Yoshizato Kenichi Yoshida Mikkael A Sekeres Tomas Radivoyevitch Hiromichi Suzuki Bartlomiej Przychodzen Yasunobu Nagata Manja Meggendorfer Masashi Sanada Yusuke Okuno Cassandra Hirsch Teodora Kuzmanovic Yusuke Sato Aiko Sato-Otsubo Thomas LaFramboise Naoko Hosono Yuichi Shiraishi Kenichi Chiba Claudia Haferlach Wolfgang Kern Hiroko Tanaka Yusuke Shiozawa Inés Gómez-Seguí Holleh D Husseinzadeh Swapna Thota Kathryn M Guinta Brittney Dienes Tsuyoshi Nakamaki Shuichi Miyawaki Yogen Saunthararajah Shigeru Chiba Satoru Miyano Lee-Yung Shih Torsten Haferlach Seishi Ogawa Jaroslaw P Maciejewski

Nat Genet 2017 Feb 19;49(2):204-212. Epub 2016 Dec 19.

Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, USA.

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http://dx.doi.org/10.1038/ng.3742DOI Listing
February 2017

Application of an NGS-based 28-gene panel in myeloproliferative neoplasms reveals distinct mutation patterns in essential thrombocythaemia, primary myelofibrosis and polycythaemia vera.

Authors:
Sabit Delic Dominic Rose Wolfgang Kern Niroshan Nadarajah Claudia Haferlach Torsten Haferlach Manja Meggendorfer

Br J Haematol 2016 Nov 22;175(3):419-426. Epub 2016 Jul 22.

MLL Munich Leukemia Laboratory, Munich, Germany.

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http://dx.doi.org/10.1111/bjh.14269DOI Listing
November 2016

The 5q deletion size in myeloid malignancies is correlated to additional chromosomal aberrations and to TP53 mutations.

Authors:
Anna Stengel Wolfgang Kern Torsten Haferlach Manja Meggendorfer Claudia Haferlach

Genes Chromosomes Cancer 2016 10 4;55(10):777-85. Epub 2016 Jul 4.

MLL Munich Leukemia Laboratory, Max-Lebsche-Platz 31, Munich, 81377, Germany.

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http://dx.doi.org/10.1002/gcc.22377DOI Listing
October 2016

Mutational hierarchies in myelodysplastic syndromes dynamically adapt and evolve upon therapy response and failure.

Authors:
Maximilian Mossner Johann-Christoph Jann Janina Wittig Florian Nolte Stephanie Fey Verena Nowak Julia Obländer Jovita Pressler Iris Palme Christina Xanthopoulos Tobias Boch Georgia Metzgeroth Henning Röhl Stephanie H Witt Helene Dukal Corinna Klein Steffen Schmitt Patrick Gelß Uwe Platzbecker Ekaterina Balaian Alice Fabarius Helmut Blum Torsten J Schulze Manja Meggendorfer Claudia Haferlach Andreas Trumpp Wolf-Karsten Hofmann Hind Medyouf Daniel Nowak

Blood 2016 09 6;128(9):1246-59. Epub 2016 Jun 6.

Department of Hematology and Oncology.

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http://dx.doi.org/10.1182/blood-2015-11-679167DOI Listing
September 2016

Integrating clinical features and genetic lesions in the risk assessment of patients with chronic myelomonocytic leukemia.

Authors:
Chiara Elena Anna Gallì Esperanza Such Manja Meggendorfer Ulrich Germing Ettore Rizzo Jose Cervera Elisabetta Molteni Annette Fasan Esther Schuler Ilaria Ambaglio Maria Lopez-Pavia Silvia Zibellini Andrea Kuendgen Erica Travaglino Reyes Sancho-Tello Silvia Catricalà Ana I Vicente Torsten Haferlach Claudia Haferlach Guillermo F Sanz Luca Malcovati Mario Cazzola

Blood 2016 09 6;128(10):1408-17. Epub 2016 Jul 6.

Department of Molecular Medicine, University of Pavia, Pavia, Italy; Department of Hematology Oncology, Istituto di Ricovero e Cura a Carattere Scientifico Fondazione Policlinico San Matteo, Pavia, Italy;

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http://dx.doi.org/10.1182/blood-2016-05-714030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5036538PMC
September 2016

Ultra-deep sequencing leads to earlier and more sensitive detection of the tyrosine kinase inhibitor resistance mutation T315I in chronic myeloid leukemia.

Authors:
Constance Baer Wolfgang Kern Sarah Koch Niroshan Nadarajah Sonja Schindela Manja Meggendorfer Claudia Haferlach Torsten Haferlach

Haematologica 2016 07 21;101(7):830-8. Epub 2016 Apr 21.

MLL Munich Leukemia Laboratory, Germany

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http://dx.doi.org/10.3324/haematol.2016.145888DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5004462PMC
July 2016

Molecular subtypes of NPM1 mutations have different clinical profiles, specific patterns of accompanying molecular mutations and varying outcomes in intermediate risk acute myeloid leukemia.

Authors:
Tamara Alpermann Susanne Schnittger Christiane Eder Frank Dicker Manja Meggendorfer Wolfgang Kern Christoph Schmid Carlo Aul Peter Staib Clemens-Martin Wendtner Norbert Schmitz Claudia Haferlach Torsten Haferlach

Haematologica 2016 Feb 15;101(2):e55-8. Epub 2015 Oct 15.

MLL Munich Leukemia Laboratory, Klinikum Augsburg, University of Munich, Augsburg, Germany

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http://dx.doi.org/10.3324/haematol.2015.133819DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4938334PMC
February 2016

Karyotype evolution and acquisition of FLT3 or RAS pathway alterations drive progression of myelodysplastic syndrome to acute myeloid leukemia.

Authors:
Manja Meggendorfer Andreia de Albuquerque Niroshan Nadarajah Tamara Alpermann Wolfgang Kern Kimberly Steuer Karolína Perglerová Claudia Haferlach Susanne Schnittger Torsten Haferlach

Haematologica 2015 Dec 20;100(12):e487-90. Epub 2015 Aug 20.

MLL Munich Leukemia Laboratory, Munich, Germany

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http://dx.doi.org/10.3324/haematol.2015.127985DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4666337PMC
December 2015

Recurrent CDKN1B (p27) mutations in hairy cell leukemia.

Authors:
Sascha Dietrich Jennifer Hüllein Stanley Chun-Wei Lee Barbara Hutter David Gonzalez Sandrine Jayne Martin J S Dyer Małgorzata Oleś Monica Else Xiyang Liu Mikołaj Słabicki Bian Wu Xavier Troussard Jan Dürig Mindaugas Andrulis Claire Dearden Christof von Kalle Martin Granzow Anna Jauch Stefan Fröhling Wolfgang Huber Manja Meggendorfer Torsten Haferlach Anthony D Ho Daniela Richter Benedikt Brors Hanno Glimm Estella Matutes Omar Abdel Wahab Thorsten Zenz

Blood 2015 Aug 11;126(8):1005-8. Epub 2015 Jun 11.

Department of Medicine V, University Hospital Heidelberg, Department of Translational Oncology, National Center for Tumor Diseases and German Cancer Research Center (DKFZ), Heidelberg, Germany;

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http://dx.doi.org/10.1182/blood-2015-04-643361DOI Listing
August 2015

A new model for post-integration latency in macroglial cells to study HIV-1 reservoirs of the brain.

Authors:
Martha Schneider Bianca Tigges Manja Meggendorfer Markus Helfer Christoph Ziegenhain Ruth Brack-Werner

AIDS 2015 Jun;29(10):1147-59

Institute of Virology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.

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http://dx.doi.org/10.1097/QAD.0000000000000691DOI Listing
June 2015

Refractory anemia with ring sideroblasts and marked thrombocytosis cases harbor mutations in SF3B1 or other spliceosome genes accompanied by JAK2V617F and ASXL1 mutations.

Authors:
Sabine Jeromin Torsten Haferlach Sandra Weissmann Manja Meggendorfer Christiane Eder Niroshan Nadarajah Tamara Alpermann Alexander Kohlmann Wolfgang Kern Claudia Haferlach Susanne Schnittger

Haematologica 2015 Apr 19;100(4):e125-7. Epub 2014 Dec 19.

MLL Munich Leukemia Laboratory, Munich, Germany

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http://dx.doi.org/10.3324/haematol.2014.119032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4380732PMC
April 2015

AML with gain of chromosome 8 as the sole chromosomal abnormality (+8sole) is associated with a specific molecular mutation pattern including ASXL1 mutations in 46.8% of the patients.

Authors:
Tamara Alpermann Claudia Haferlach Christiane Eder Niroshan Nadarajah Manja Meggendorfer Wolfgang Kern Torsten Haferlach Susanne Schnittger

Leuk Res 2015 Mar 16;39(3):265-72. Epub 2014 Dec 16.

MLL Munich Leukemia Laboratory, Munich, Germany(1). Electronic address:

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http://dx.doi.org/10.1016/j.leukres.2014.11.026DOI Listing
March 2015

Specific molecular mutation patterns delineate chronic neutrophilic leukemia, atypical chronic myeloid leukemia, and chronic myelomonocytic leukemia.

Authors:
Manja Meggendorfer Torsten Haferlach Tamara Alpermann Sabine Jeromin Claudia Haferlach Wolfgang Kern Susanne Schnittger

Haematologica 2014 Dec 19;99(12):e244-6. Epub 2014 Sep 19.

MLL Munich Leukemia Laboratory, Germany.

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http://dx.doi.org/10.3324/haematol.2014.113159DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4258749PMC
December 2014

RAS signaling promotes resistance to JAK inhibitors by suppressing BAD-mediated apoptosis.

Authors:
Peter S Winter Kristopher A Sarosiek Kevin H Lin Manja Meggendorfer Susanne Schnittger Anthony Letai Kris C Wood

Sci Signal 2014 Dec 23;7(357):ra122. Epub 2014 Dec 23.

Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC 27710, USA.

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http://dx.doi.org/10.1126/scisignal.2005301DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4353591PMC
December 2014

Investigation of 305 patients with myelodysplastic syndromes and 20q deletion for associated cytogenetic and molecular genetic lesions and their prognostic impact.

Authors:
Ulrike Bacher Torsten Haferlach Susanne Schnittger Melanie Zenger Manja Meggendorfer Sabine Jeromin Andreas Roller Vera Grossmann Maria-Theresa Krauth Tamara Alpermann Wolfgang Kern Claudia Haferlach

Br J Haematol 2014 Mar 26;164(6):822-33. Epub 2013 Dec 26.

MLL Munich Leukemia Laboratory, Munich, Germany.

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http://dx.doi.org/10.1111/bjh.12710DOI Listing
March 2014

Comprehensive mutational profiling in advanced systemic mastocytosis.

Authors:
Juliana Schwaab Susanne Schnittger Karl Sotlar Christoph Walz Alice Fabarius Markus Pfirrmann Alexander Kohlmann Vera Grossmann Manja Meggendorfer Hans-Peter Horny Peter Valent Mohamad Jawhar Martina Teichmann Georgia Metzgeroth Philipp Erben Thomas Ernst Andreas Hochhaus Torsten Haferlach Wolf-Karsten Hofmann Nicholas C P Cross Andreas Reiter

Blood 2013 Oct 19;122(14):2460-6. Epub 2013 Aug 19.

III. Medizinische Klinik, Hämatologie und Onkologie, Universitätsmedizin Mannheim, Mannheim, Germany;

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http://dx.doi.org/10.1182/blood-2013-04-496448DOI Listing
October 2013

Prognostic score including gene mutations in chronic myelomonocytic leukemia.

Authors:
Raphaël Itzykson Olivier Kosmider Aline Renneville Véronique Gelsi-Boyer Manja Meggendorfer Margot Morabito Céline Berthon Lionel Adès Pierre Fenaux Odile Beyne-Rauzy Norbert Vey Thorsten Braun Torsten Haferlach François Dreyfus Nicholas C P Cross Claude Preudhomme Olivier A Bernard Michaela Fontenay William Vainchenker Susanne Schnittger Daniel Birnbaum Nathalie Droin Eric Solary

J Clin Oncol 2013 Jul 20;31(19):2428-36. Epub 2013 May 20.

Institut Gustave Roussy, Villejuif, France.

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http://dx.doi.org/10.1200/JCO.2012.47.3314DOI Listing
July 2013

SRSF2 mutations in 275 cases with chronic myelomonocytic leukemia (CMML).

Authors:
Manja Meggendorfer Andreas Roller Torsten Haferlach Christiane Eder Frank Dicker Vera Grossmann Alexander Kohlmann Tamara Alpermann Kenichi Yoshida Seishi Ogawa H Phillip Koeffler Wolfgang Kern Claudia Haferlach Susanne Schnittger

Blood 2012 Oct 23;120(15):3080-8. Epub 2012 Aug 23.

MLL Munich Leukemia Laboratory, Munich, Germany.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2012-01-40
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http://dx.doi.org/10.1182/blood-2012-01-404863DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3580040PMC
October 2012

Stably integrated and expressed retroviral sequences can influence nuclear location and chromatin condensation of the integration locus.

Authors:
Jens Nagel Birgit Gross Manja Meggendorfer Carolin Preiss Manuel Grez Ruth Brack-Werner Steffen Dietzel

Chromosoma 2012 Aug 14;121(4):353-67. Epub 2012 Mar 14.

Department Biologie II, Ludwig-Maximilians-Universität München, Grosshaderner Str. 2, 82152 Planegg-Martinsried, Germany.

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http://link.springer.com/10.1007/s00412-012-0366-9
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http://dx.doi.org/10.1007/s00412-012-0366-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3401306PMC
August 2012

Functional nuclear topography of transcriptionally inducible extra-chromosomal transgene clusters.

Authors:
Manja Meggendorfer Claudia Weierich Horst Wolff Ruth Brack-Werner Thomas Cremer

Chromosome Res 2010 Jun 8;18(4):401-17. Epub 2010 Jun 8.

Institute of Virology, Helmholtz Zentrum München-German Research Center for Environmental Health, Ingolstaedter Landstr. 1, 85764, Neuherberg, Germany.

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http://dx.doi.org/10.1007/s10577-010-9133-zDOI Listing
June 2010