Manish Gala

Manish Gala

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Manish Gala

Manish Gala

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Novel Common Genetic Susceptibility Loci for Colorectal Cancer.

Authors:
Stephanie L Schmit Christopher K Edlund Fredrick R Schumacher Jian Gong Tabitha A Harrison Jeroen R Huyghe Chenxu Qu Marilena Melas David J Van Den Berg Hansong Wang Stephanie Tring Sarah J Plummer Demetrius Albanes M Henar Alonso Christopher I Amos Kristen Anton Aaron K Aragaki Volker Arndt Elizabeth L Barry Sonja I Berndt Stéphane Bezieau Stephanie Bien Amanda Bloomer Juergen Boehm Marie-Christine Boutron-Ruault Hermann Brenner Stefanie Brezina Daniel D Buchanan Katja Butterbach Bette J Caan Peter T Campbell Christopher S Carlson Jose E Castelao Andrew T Chan Jenny Chang-Claude Stephen J Chanock Iona Cheng Ya-Wen Cheng Lee Soo Chin James M Church Timothy Church Gerhard A Coetzee Michelle Cotterchio Marcia Cruz Correa Keith R Curtis David Duggan Douglas F Easton Dallas English Edith J M Feskens Rocky Fischer Liesel M FitzGerald Barbara K Fortini Lars G Fritsche Charles S Fuchs Manuela Gago-Dominguez Manish Gala Steven J Gallinger W James Gauderman Graham G Giles Edward L Giovannucci Stephanie M Gogarten Clicerio Gonzalez-Villalpando Elena M Gonzalez-Villalpando William M Grady Joel K Greenson Andrea Gsur Marc Gunter Christopher A Haiman Jochen Hampe Sophia Harlid John F Harju Richard B Hayes Philipp Hofer Michael Hoffmeister John L Hopper Shu-Chen Huang Jose Maria Huerta Thomas J Hudson David J Hunter Gregory E Idos Motoki Iwasaki Rebecca D Jackson Eric J Jacobs Sun Ha Jee Mark A Jenkins Wei-Hua Jia Shuo Jiao Amit D Joshi Laurence N Kolonel Suminori Kono Charles Kooperberg Vittorio Krogh Tilman Kuehn Sébastien Küry Andrea LaCroix Cecelia A Laurie Flavio Lejbkowicz Mathieu Lemire Heinz-Josef Lenz David Levine Christopher I Li Li Li Wolfgang Lieb Yi Lin Noralane M Lindor Yun-Ru Liu Fotios Loupakis Yingchang Lu Frank Luh Jing Ma Christoph Mancao Frank J Manion Sanford D Markowitz Vicente Martin Koichi Matsuda Keitaro Matsuo Kevin J McDonnell Caroline E McNeil Roger Milne Antonio J Molina Bhramar Mukherjee Neil Murphy Polly A Newcomb Kenneth Offit Hanane Omichessan Domenico Palli Jesus P Paredes Cotoré Julyann Pérez-Mayoral Paul D Pharoah John D Potter Conghui Qu Leon Raskin Gad Rennert Hedy S Rennert Bridget M Riggs Clemens Schafmayer Robert E Schoen Thomas A Sellers Daniela Seminara Gianluca Severi Wei Shi David Shibata Xiao-Ou Shu Erin M Siegel Martha L Slattery Melissa Southey Zsofia K Stadler Mariana C Stern Sebastian Stintzing Darin Taverna Stephen N Thibodeau Duncan C Thomas Antonia Trichopoulou Shoichiro Tsugane Cornelia M Ulrich Franzel J B van Duijnhoven Bethany van Guelpan Joseph Vijai Jarmo Virtamo Stephanie J Weinstein Emily White Aung Ko Win Alicja Wolk Michael Woods Anna H Wu Kana Wu Yong-Bing Xiang Yun Yen Brent W Zanke Yi-Xin Zeng Ben Zhang Niha Zubair Sun-Seog Kweon Jane C Figueiredo Wei Zheng Loic Le Marchand Annika Lindblom Victor Moreno Ulrike Peters Graham Casey Li Hsu David V Conti Stephen B Gruber

J Natl Cancer Inst 2019 Feb;111(2):146-157

Department of Preventive Medicine, USC Norris Comprehensive Cancer Center.

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http://dx.doi.org/10.1093/jnci/djy099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6555904PMC
February 2019

Discovery of common and rare genetic risk variants for colorectal cancer.

Authors:
Jeroen R Huyghe Stephanie A Bien Tabitha A Harrison Hyun Min Kang Sai Chen Stephanie L Schmit David V Conti Conghui Qu Jihyoun Jeon Christopher K Edlund Peyton Greenside Michael Wainberg Fredrick R Schumacher Joshua D Smith David M Levine Sarah C Nelson Nasa A Sinnott-Armstrong Demetrius Albanes M Henar Alonso Kristin Anderson Coral Arnau-Collell Volker Arndt Christina Bamia Barbara L Banbury John A Baron Sonja I Berndt Stéphane Bézieau D Timothy Bishop Juergen Boehm Heiner Boeing Hermann Brenner Stefanie Brezina Stephan Buch Daniel D Buchanan Andrea Burnett-Hartman Katja Butterbach Bette J Caan Peter T Campbell Christopher S Carlson Sergi Castellví-Bel Andrew T Chan Jenny Chang-Claude Stephen J Chanock Maria-Dolores Chirlaque Sang Hee Cho Charles M Connolly Amanda J Cross Katarina Cuk Keith R Curtis Albert de la Chapelle Kimberly F Doheny David Duggan Douglas F Easton Sjoerd G Elias Faye Elliott Dallas R English Edith J M Feskens Jane C Figueiredo Rocky Fischer Liesel M FitzGerald David Forman Manish Gala Steven Gallinger W James Gauderman Graham G Giles Elizabeth Gillanders Jian Gong Phyllis J Goodman William M Grady John S Grove Andrea Gsur Marc J Gunter Robert W Haile Jochen Hampe Heather Hampel Sophia Harlid Richard B Hayes Philipp Hofer Michael Hoffmeister John L Hopper Wan-Ling Hsu Wen-Yi Huang Thomas J Hudson David J Hunter Gemma Ibañez-Sanz Gregory E Idos Roxann Ingersoll Rebecca D Jackson Eric J Jacobs Mark A Jenkins Amit D Joshi Corinne E Joshu Temitope O Keku Timothy J Key Hyeong Rok Kim Emiko Kobayashi Laurence N Kolonel Charles Kooperberg Tilman Kühn Sébastien Küry Sun-Seog Kweon Susanna C Larsson Cecelia A Laurie Loic Le Marchand Suzanne M Leal Soo Chin Lee Flavio Lejbkowicz Mathieu Lemire Christopher I Li Li Li Wolfgang Lieb Yi Lin Annika Lindblom Noralane M Lindor Hua Ling Tin L Louie Satu Männistö Sanford D Markowitz Vicente Martín Giovanna Masala Caroline E McNeil Marilena Melas Roger L Milne Lorena Moreno Neil Murphy Robin Myte Alessio Naccarati Polly A Newcomb Kenneth Offit Shuji Ogino N Charlotte Onland-Moret Barbara Pardini Patrick S Parfrey Rachel Pearlman Vittorio Perduca Paul D P Pharoah Mila Pinchev Elizabeth A Platz Ross L Prentice Elizabeth Pugh Leon Raskin Gad Rennert Hedy S Rennert Elio Riboli Miguel Rodríguez-Barranco Jane Romm Lori C Sakoda Clemens Schafmayer Robert E Schoen Daniela Seminara Mitul Shah Tameka Shelford Min-Ho Shin Katerina Shulman Sabina Sieri Martha L Slattery Melissa C Southey Zsofia K Stadler Christa Stegmaier Yu-Ru Su Catherine M Tangen Stephen N Thibodeau Duncan C Thomas Sushma S Thomas Amanda E Toland Antonia Trichopoulou Cornelia M Ulrich David J Van Den Berg Franzel J B van Duijnhoven Bethany Van Guelpen Henk van Kranen Joseph Vijai Kala Visvanathan Pavel Vodicka Ludmila Vodickova Veronika Vymetalkova Korbinian Weigl Stephanie J Weinstein Emily White Aung Ko Win C Roland Wolf Alicja Wolk Michael O Woods Anna H Wu Syed H Zaidi Brent W Zanke Qing Zhang Wei Zheng Peter C Scacheri John D Potter Michael C Bassik Anshul Kundaje Graham Casey Victor Moreno Goncalo R Abecasis Deborah A Nickerson Stephen B Gruber Li Hsu Ulrike Peters

Nat Genet 2019 01 3;51(1):76-87. Epub 2018 Dec 3.

Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

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http://www.nature.com/articles/s41588-018-0286-6
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http://dx.doi.org/10.1038/s41588-018-0286-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358437PMC
January 2019

Loss of Response to Anti-Tumor Necrosis Factor Alpha Therapy in Crohn's Disease Is Not Associated with Emergence of Novel Inflammatory Pathways.

Dig Dis Sci 2018 03 25;63(3):738-745. Epub 2018 Jan 25.

Gastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, Blake 4, 55 Fruit Street, Boston, MA, 02114, USA.

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http://dx.doi.org/10.1007/s10620-018-4932-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152907PMC
March 2018

Bariatric Surgery Prior to Index Screening Colonoscopy Is Associated With a Decreased Rate of Colorectal Adenomas in Obese Individuals.

Clin Transl Gastroenterol 2017 Feb 9;8(2):e73. Epub 2017 Feb 9.

Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/ctg.2017.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5387748PMC
February 2017

Telomere structure and maintenance gene variants and risk of five cancer types.

Int J Cancer 2016 Dec 8;139(12):2655-2670. Epub 2016 Sep 8.

Department of Epidemiology, Geisel School of Medicine at Dartmouth, Lebanon, NH.

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http://dx.doi.org/10.1002/ijc.30288DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5198774PMC
December 2016

Corrigendum: genome-wide association study of colorectal cancer identifies six new susceptibility loci.

Authors:
Fredrick R Schumacher Stephanie L Schmit Shuo Jiao Christopher K Edlund Hansong Wang Ben Zhang Li Hsu Shu-Chen Huang Christopher P Fischer John F Harju Gregory E Idos Flavio Lejbkowicz Frank J Manion Kevin McDonnell Caroline E McNeil Marilena Melas Hedy S Rennert Wei Shi Duncan C Thomas David J Van Den Berg Carolyn M Hutter Aaron K Aragaki Katja Butterbach Bette J Caan Christopher S Carlson Stephen J Chanock Keith R Curtis Charles S Fuchs Manish Gala Edward L Giovannucci Stephanie M Gogarten Richard B Hayes Brian Henderson David J Hunter Rebecca D Jackson Laurence N Kolonel Charles Kooperberg Sébastien Küry Andrea LaCroix Cathy C Laurie Cecelia A Laurie Mathieu Lemire David Levine Jing Ma Karen W Makar Conghui Qu Darin Taverna Cornelia M Ulrich Kana Wu Suminori Kono Dee W West Sonja I Berndt Stephane Bezieau Hermann Brenner Peter T Campbell Andrew T Chan Jenny Chang-Claude Gerhard A Coetzee David V Conti David Duggan Jane C Figueiredo Barbara K Fortini Steven J Gallinger W James Gauderman Graham Giles Roger Green Robert Haile Tabitha A Harrison Michael Hoffmeister John L Hopper Thomas J Hudson Eric Jacobs Motoki Iwasaki Sun Ha Jee Mark Jenkins Wei-Hua Jia Amit Joshi Li Li Noralene M Lindor Keitaro Matsuo Victor Moreno Bhramar Mukherjee Polly A Newcomb John D Potter Leon Raskin Gad Rennert Stephanie Rosse Gianluca Severi Robert E Schoen Daniela Seminara Xiao-Ou Shu Martha L Slattery Shoichiro Tsugane Emily White Yong-Bing Xiang Brent W Zanke Wei Zheng Loic Le Marchand Graham Casey Stephen B Gruber Ulrike Peters

Nat Commun 2015 Oct 26;6:8739. Epub 2015 Oct 26.

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http://dx.doi.org/10.1038/ncomms9739DOI Listing
October 2015

Identification of a common variant with potential pleiotropic effect on risk of inflammatory bowel disease and colorectal cancer.

Carcinogenesis 2015 Sep 12;36(9):999-1007. Epub 2015 Jun 12.

Gastrointestinal Unit, Massachusetts General Hospital, Boston, MA, USA, Department of Epidemiology, Indiana University School of Public Health, Indianapolis, IN, USA,

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http://carcin.oxfordjournals.org/content/early/2015/07/07/ca
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http://www.carcin.oxfordjournals.org/lookup/doi/10.1093/carc
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http://dx.doi.org/10.1093/carcin/bgv086DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4573660PMC
September 2015

TFF2-CXCR4 Axis Is Associated with BRAF V600E Colon Cancer.

Cancer Prev Res (Phila) 2015 Jul 21;8(7):614-9. Epub 2015 Apr 21.

Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts. Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts. Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1158/1940-6207.CAPR-14-0444DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4490961PMC
July 2015

Genome-wide association study of colorectal cancer identifies six new susceptibility loci.

Authors:
Fredrick R Schumacher Stephanie L Schmit Shuo Jiao Christopher K Edlund Hansong Wang Ben Zhang Li Hsu Shu-Chen Huang Christopher P Fischer John F Harju Gregory E Idos Flavio Lejbkowicz Frank J Manion Kevin McDonnell Caroline E McNeil Marilena Melas Hedy S Rennert Wei Shi Duncan C Thomas David J Van Den Berg Carolyn M Hutter Aaron K Aragaki Katja Butterbach Bette J Caan Christopher S Carlson Stephen J Chanock Keith R Curtis Charles S Fuchs Manish Gala Edward L Giovannucci Stephanie M Gogarten Richard B Hayes Brian Henderson David J Hunter Rebecca D Jackson Laurence N Kolonel Charles Kooperberg Sébastien Küry Andrea LaCroix Cathy C Laurie Cecelia A Laurie Mathieu Lemire David Levine Jing Ma Karen W Makar Conghui Qu Darin Taverna Cornelia M Ulrich Kana Wu Suminori Kono Dee W West Sonja I Berndt Stéphane Bezieau Hermann Brenner Peter T Campbell Andrew T Chan Jenny Chang-Claude Gerhard A Coetzee David V Conti David Duggan Jane C Figueiredo Barbara K Fortini Steven J Gallinger W James Gauderman Graham Giles Roger Green Robert Haile Tabitha A Harrison Michael Hoffmeister John L Hopper Thomas J Hudson Eric Jacobs Motoki Iwasaki Sun Ha Jee Mark Jenkins Wei-Hua Jia Amit Joshi Li Li Noralene M Lindor Keitaro Matsuo Victor Moreno Bhramar Mukherjee Polly A Newcomb John D Potter Leon Raskin Gad Rennert Stephanie Rosse Gianluca Severi Robert E Schoen Daniela Seminara Xiao-Ou Shu Martha L Slattery Shoichiro Tsugane Emily White Yong-Bing Xiang Brent W Zanke Wei Zheng Loic Le Marchand Graham Casey Stephen B Gruber Ulrike Peters

Nat Commun 2015 Jul 7;6:7138. Epub 2015 Jul 7.

Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98124, USA.

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http://dx.doi.org/10.1038/ncomms8138DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4967357PMC
July 2015

Molecular pathways: aspirin and Wnt signaling-a molecularly targeted approach to cancer prevention and treatment.

Clin Cancer Res 2015 Apr 11;21(7):1543-8. Epub 2014 Dec 11.

Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts. Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1158/1078-0432.CCR-14-0877DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4383688PMC
April 2015

Genetics of the serrated pathway to colorectal cancer.

Clin Transl Gastroenterol 2015 Apr 9;6:e84. Epub 2015 Apr 9.

Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/ctg.2015.12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4459531PMC
April 2015

Adrenomedullin is a therapeutic target in colorectal cancer.

Int J Cancer 2014 May 7;134(9):2041-50. Epub 2013 Nov 7.

Gastrointestinal Unit Massachusetts General Hospital, Harvard Medical School, Boston, MA; Department of Gastroenterology Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.

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http://dx.doi.org/10.1002/ijc.28542DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3929229PMC
May 2014

Case records of the Massachusetts General Hospital. Case 23-2012. A 59-year-old man with abdominal pain and weight loss.

N Engl J Med 2012 Jul;367(4):363-73

Department of Medicine, Massachusetts General Hospital, Boston, USA.

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http://dx.doi.org/10.1056/NEJMcpc1109275DOI Listing
July 2012

Oncogenic KRAS regulates BMP4 expression in colon cancer cell lines.

Am J Physiol Gastrointest Liver Physiol 2012 May 1;302(10):G1223-30. Epub 2012 Mar 1.

Gastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.

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http://www.physiology.org/doi/10.1152/ajpgi.00047.2011
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http://dx.doi.org/10.1152/ajpgi.00047.2011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3362092PMC
May 2012

Hereditary colon cancer syndromes.

Semin Oncol 2011 Aug;38(4):490-9

Gastrointestinal Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.

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http://dx.doi.org/10.1053/j.seminoncol.2011.05.003DOI Listing
August 2011

Hypoxic regulation of vascular endothelial growth factor through the induction of phosphatidylinositol 3-kinase/Rho/ROCK and c-Myc.

J Biol Chem 2006 May 16;281(20):13957-63. Epub 2006 Mar 16.

Gastrointestinal Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M511763200
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http://dx.doi.org/10.1074/jbc.M511763200DOI Listing
May 2006

Induction of interleukin-8 preserves the angiogenic response in HIF-1alpha-deficient colon cancer cells.

Nat Med 2005 Sep 28;11(9):992-7. Epub 2005 Aug 28.

Gastrointestinal Unit, Massachusetts General Hospital and Harvard Medical School, 50 Blossom Street, Boston, Massachusetts 02114, USA.

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http://dx.doi.org/10.1038/nm1294DOI Listing
September 2005

Inhibition of cell transformation by sulindac sulfide is confined to specific oncogenic pathways.

Cancer Lett 2002 Jan;175(1):89-94

Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2693486PMC
http://dx.doi.org/10.1016/s0304-3835(01)00716-9DOI Listing
January 2002