Publications by authors named "Manfred Schwab"

63Publications

Stronger prognostic power of the CpG island methylator phenotype than methylation of individual genes in neuroblastomas.

Jpn J Clin Oncol 2013 Jun 25;43(6):641-5. Epub 2013 Apr 25.

Division of Epigenomics, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan.

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June 2013

Instability at the FRA8I common fragile site disrupts the genomic integrity of the KIAA0146, CEBPD and PRKDC genes in colorectal cancer.

Cancer Lett 2013 Aug 16;336(1):85-95. Epub 2013 Apr 16.

Division of Tumor Genetics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.

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August 2013

1p36 tumor suppression--a matter of dosage?

Cancer Res 2012 Dec 20;72(23):6079-88. Epub 2012 Nov 20.

Division of Tumor Genetics B030, German Cancer Research Center, Heidelberg, Germany.

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December 2012

Genomic rearrangements at the FRA2H common fragile site frequently involve non-homologous recombination events across LTR and L1(LINE) repeats.

Hum Genet 2012 Aug 5;131(8):1345-59. Epub 2012 Apr 5.

Division of Tumor Genetics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.

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August 2012

ABCC multidrug transporters in childhood neuroblastoma: clinical and biological effects independent of cytotoxic drug efflux.

J Natl Cancer Inst 2011 Aug 28;103(16):1236-51. Epub 2011 Jul 28.

Experimental Therapeutics and Molecular Diagnostics Program, Children's Cancer Institute Australia for Medical Research, Lowy Cancer Research Centre, University of New South Wales, P.O. Box 81, Randwick, NSW 2031, Australia.

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August 2011

CAMTA1, a 1p36 tumor suppressor candidate, inhibits growth and activates differentiation programs in neuroblastoma cells.

Cancer Res 2011 Apr 8;71(8):3142-51. Epub 2011 Mar 8.

Division of Tumor Genetics B030, Clinical Cooperation Unit Pediatric Oncology G340, German Cancer Research Center, Bioquant, Heidelberg, Germany.

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April 2011

Regulation of BIRC5 and its isoform BIRC5-2B in neuroblastoma.

Cancer Lett 2009 Nov 3;285(1):99-107. Epub 2009 Jun 3.

Department of Tumor Genetics, German Cancer Research Center, Heidelberg, Germany.

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November 2009

Heterogeneity of the MYCN oncogene in neuroblastoma.

Clin Cancer Res 2009 Mar 10;15(6):2085-90. Epub 2009 Mar 10.

Department of Pediatric Oncology and Hematology, Children's Hospital, University of Cologne, Cologne, Germany.

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March 2009

Genetic variation of Aflatoxin B1 aldehyde reductase genes (AFAR) in human tumour cells.

Cancer Lett 2008 Dec 26;272(1):160-6. Epub 2008 Aug 26.

Division of Tumour Genetics B030, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany.

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December 2008

Generation and characterization of novel local and metastatic human neuroblastoma variants.

Neoplasia 2008 Aug;10(8):816-27

Department of Cell Research and Immunology, George S Wise Faculty of Life Sciences, Tel-Aviv University, Tel-Aviv, Israel.

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August 2008

Cathepsin D protects human neuroblastoma cells from doxorubicin-induced cell death.

Carcinogenesis 2008 Oct 19;29(10):1869-77. Epub 2008 Jun 19.

Department of Tumor Genetics B030, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.

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October 2008

Suppression of polyploidy by the BRCA2 protein.

Cancer Lett 2007 Nov 7;257(1):65-72. Epub 2007 Aug 7.

Department of Tumor Genetics B030, German Cancer Research Centre, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.

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November 2007

Novel aphidicolin-inducible common fragile site FRA9G maps to 9p22.2, within the C9orf39 gene.

Genes Chromosomes Cancer 2007 Nov;46(11):991-9

Division of Tumor Genetics, German Cancer Research Center, Im Neuenheimer Feld, Heidelberg, Germany.

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November 2007

Cloning of genetically tagged chromosome break sequences reveals new fragile sites at 6p21 and 13q22.

Int J Cancer 2007 Jun;120(11):2359-67

Division of Tumour Genetics, German Cancer Research Center, DKFZ, Im Neuenheimer Feld 280, Heidelberg, Germany.

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June 2007

Allelic variants of CAMTA1 and FLJ10737 within a commonly deleted region at 1p36 in neuroblastoma.

Eur J Cancer 2007 Feb 11;43(3):607-16. Epub 2007 Jan 11.

Division of Tumour Genetics B030, German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.

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February 2007

Targeted MYCN expression affects cytotoxic potential of chemotherapeutic drugs in neuroblastoma cells.

Cancer Lett 2007 May 4;250(1):17-24. Epub 2006 Dec 4.

Division of Tumour Genetics, German Cancer Research Center, DKFZ, Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany.

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May 2007

Classification of neuroblastoma patients by published gene-expression markers reveals a low sensitivity for unfavorable courses of MYCN non-amplified disease.

Cancer Lett 2007 Jun 28;250(2):250-67. Epub 2006 Nov 28.

Children's Hospital, Department of Pediatric Oncology and Hematology and Center for Molecular Medicine Cologne (CMMC), University of Cologne, Kerpener Strasse 62, D-50924 Cologne, Germany.

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June 2007

Common fragile site FRA11G and rare fragile site FRA11B at 11q23.3 encompass distinct genomic regions.

Genes Chromosomes Cancer 2007 Jan;46(1):98-106

Division of Tumour Genetics, German Cancer Research Center, 69120 Heidelberg, Germany.

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January 2007

Increased WSB1 copy number correlates with its over-expression which associates with increased survival in neuroblastoma.

Genes Chromosomes Cancer 2006 Sep;45(9):856-62

Oncogenomics Section, Pediatric Oncology Branch, Advanced Technology Center, National Cancer Institute, 8717 Grovemont Circle, Gaithersburg, MD 20877, USA.

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September 2006

Marked and independent prognostic significance of the CpG island methylator phenotype in neuroblastomas.

Cancer Lett 2007 Mar 6;247(2):253-8. Epub 2006 Jun 6.

Carcinogenesis Division, National Cancer Center Research Institute, University of Tokyo Graduate School of Medicine, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan.

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March 2007

Characterization and development of a peptide (p160) with affinity for neuroblastoma cells.

J Nucl Med 2006 Jun;47(6):981-8

Clinical Cooperation Unit Nuclear Medicine, German Cancer Research Center (DKFZ) and University of Heidelberg, Heidelberg, Germany.

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June 2006

FRA1E common fragile site breaks map within a 370kilobase pair region and disrupt the dihydropyrimidine dehydrogenase gene (DPYD).

Cancer Lett 2007 Feb 23;246(1-2):82-91. Epub 2006 Mar 23.

Division of Tumour Genetics, German Cancer Research Center, DKFZ, Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany.

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February 2007

Low-frequency common fragile sites: link to neuropsychiatric disorders?

Cancer Lett 2006 Jan 17;232(1):58-69. Epub 2005 Nov 17.

Division of Tumor Genetics, German Cancer Research Center, DKFZ, Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany.

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January 2006

The neurobeachin gene spans the common fragile site FRA13A.

Hum Genet 2006 Jan 22;118(5):551-8. Epub 2005 Oct 22.

Division of Tumor Genetics, German Cancer Research Center, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany.

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January 2006

Fragilome: determining the role of fragile sites in human disease.

Authors:
Manfred Schwab

Cancer Lett 2006 Jan 18;232(1):1-3. Epub 2005 Oct 18.

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January 2006

Preclinical evaluation of the breast cancer cell-binding peptide, p160.

Clin Cancer Res 2005 Sep;11(18):6705-12

Clinical Cooperation Unit Nuclear Medicine, German Cancer Research Center, University of Heidelberg, Germany.

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September 2005

Inferring a tumor progression model for neuroblastoma from genomic data.

J Clin Oncol 2005 Oct 6;23(29):7322-31. Epub 2005 Sep 6.

Oncogenomics Section, Pediatric Oncology Branch, Advanced Technology Center, National Cancer Institute, Gaithersburg, MD, USA.

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October 2005

Common fragile sites and cancer: targeted cloning by insertional mutagenesis.

Ann N Y Acad Sci 2004 Dec;1028:14-27

Division of Tumor Genetics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany.

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December 2004

cDNA array-CGH profiling identifies genomic alterations specific to stage and MYCN-amplification in neuroblastoma.

BMC Genomics 2004 Sep 20;5:70. Epub 2004 Sep 20.

Oncogenomics Section, Pediatric Oncology Branch, Advanced Technology Center, National Cancer Institute, 8717 Grovemont Circle, Gaithersburg, MD 20877, USA.

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September 2004

Increased rates of spontaneous sister chromatid exchange in lymphocytes of BRCA2+/- carriers of familial breast cancer clusters.

Cancer Lett 2004 Jul;210(1):85-94

Deutsches Krebsforschungszentrum, Abteilung Tumorgenetik B030, Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany.

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July 2004

MYCN in neuronal tumours.

Authors:
Manfred Schwab

Cancer Lett 2004 Feb;204(2):179-87

Department of Tumour Genetics-B030, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, Heidelberg D-69120, Germany.

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February 2004

Enhanced expression of MYCN leads to centrosome hyperamplification after DNA damage in neuroblastoma cells.

Oncogene 2004 Jan;23(4):1005-9

Department of Biochemistry and Molecular Oncology, Institute of Basic Medical Sciences, University of Tsukuba, 1-1-1, Tennoudai, Tsukuba Science City, Ibaraki 305-8575, Japan.

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January 2004

Neuroblastoma: biology and molecular and chromosomal pathology.

Lancet Oncol 2003 Aug;4(8):472-80

Division of Tumour Genetics, German Cancer Research Centre, Heidelberg, Germany.

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August 2003

Aflatoxin B1 aldehyde reductase (AFAR) genes cluster at 1p35-1p36.1 in a region frequently altered in human tumour cells.

Oncogene 2003 Jul;22(30):4765-73

Division of Tumour Genetics B030, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany.

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July 2003

Yaf2 inhibits Myc biological function.

Cancer Lett 2003 Apr;193(2):171-6

Division of Cytogenetics-H0400, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany.

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April 2003

Ataxin-2 promotes apoptosis of human neuroblastoma cells.

Oncogene 2003 Jan;22(3):401-11

Department of Cytogenetics (H0400), German Cancer Research Center, Heidelberg, Germany.

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January 2003

Preferential integration of a transfected marker gene into spontaneously expressed fragile sites of a breast cancer cell line.

Cancer Lett 2003 Jan;189(2):207-19

Abteilung Zytogenetik H-0400, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany.

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January 2003

Arginine-glycine-aspartic acid (RGD)-peptide binds to both tumor and tumor-endothelial cells in vivo.

Cancer Res 2002 Sep;62(18):5139-43

Department for Cytogenetics H0400, German Cancer Research Center, Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany.

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September 2002

Genetic parameters of neuroblastomas.

Cancer Lett 2002 Oct;184(2):127-47

Department of Cytogenetics (H0400), German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.

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October 2002

Amplified MYCN in human neuroblastoma: paradigm for the translation of molecular genetics to clinical oncology.

Authors:
Manfred Schwab

Ann N Y Acad Sci 2002 Jun;963:63-73

Division of Cytogenetics, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany.

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June 2002

BRCA2: a genetic risk factor for breast cancer.

Cancer Lett 2002 Jan;175(1):1-8

Deutsches Krebsforschungszentrum, Abteilung Zytogenetik H-0400, Im Neuenheimer Feld 280, D-69120, Heidelberg, Germany.

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January 2002

MYCN Amplification in Neuroblastoma: a Paradigm for the Clinical Use of an Oncogene.

Authors:
Manfred Schwab

Pathol Oncol Res 1997 ;3(1):3-7

German Cancer Research Center, Division of Cytogenetics, Heidelberg, Germany.

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January 1997