Manfred Gessler

Manfred Gessler

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Manfred Gessler

Publications by authors named "Manfred Gessler"

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The role of TCF3 as potential master regulator in blastemal Wilms tumors.

Int J Cancer 2019 03 13;144(6):1432-1443. Epub 2018 Nov 13.

Center for Bioinformatics, Saarland Informatics Campus, Saarland University, Saarbrücken, Germany.

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http://doi.wiley.com/10.1002/ijc.31834
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http://dx.doi.org/10.1002/ijc.31834DOI Listing
March 2019

Loss or oncogenic mutation of DROSHA impairs kidney development and function, but is not sufficient for Wilms tumor formation.

Int J Cancer 2019 03 3;144(6):1391-1400. Epub 2018 Dec 3.

Theodor-Boveri-Institute/Biocenter, Developmental Biochemistry, Wuerzburg University, Wuerzburg, Germany.

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http://dx.doi.org/10.1002/ijc.31952DOI Listing
March 2019

Cell-autonomous and redundant roles of Hey1 and HeyL in muscle stem cells: HeyL requires Hes1 to bind diverse DNA sites.

Development 2019 Feb 20;146(4). Epub 2019 Feb 20.

Laboratory of Molecular and Cellular Physiology, Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan

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http://dx.doi.org/10.1242/dev.163618DOI Listing
February 2019

Author Correction: The landscape of genomic alterations across childhood cancers.

Nature 2018 07;559(7714):E10

Hopp-Children's Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany.

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http://dx.doi.org/10.1038/s41586-018-0167-2DOI Listing
July 2018

ETV6-NTRK3 in congenital mesoblastic nephroma: A report of the SIOP/GPOH nephroblastoma study.

Pediatr Blood Cancer 2018 Apr 29;65(4). Epub 2017 Dec 29.

Kiel Pediatric Tumor Registry, Department of Pediatric Pathology, Christian-Albrechts-University Kiel, Kiel, Germany.

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http://doi.wiley.com/10.1002/pbc.26925
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http://dx.doi.org/10.1002/pbc.26925DOI Listing
April 2018

The landscape of genomic alterations across childhood cancers.

Nature 2018 03 28;555(7696):321-327. Epub 2018 Feb 28.

Hopp-Children's Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany.

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http://dx.doi.org/10.1038/nature25480DOI Listing
March 2018

Gene expression profiles of brain endothelial cells during embryonic development at bulk and single-cell levels.

Sci Signal 2017 07 11;10(487). Epub 2017 Jul 11.

Developmental Biochemistry, Theodor Boveri Institute (Biocenter), University of Wuerzburg, Wuerzburg D-97074, Germany.

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http://dx.doi.org/10.1126/scisignal.aag2476DOI Listing
July 2017

An essential developmental function for murine phosphoglycolate phosphatase in safeguarding cell proliferation.

Sci Rep 2016 10 12;6:35160. Epub 2016 Oct 12.

Institute of Pharmacology and Toxicology, University of Würzburg, Versbacher Strasse 9, D-97078 Würzburg, Germany.

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http://dx.doi.org/10.1038/srep35160DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5059750PMC
October 2016

Gain of 1q As a Prognostic Biomarker in Wilms Tumors (WTs) Treated With Preoperative Chemotherapy in the International Society of Paediatric Oncology (SIOP) WT 2001 Trial: A SIOP Renal Tumours Biology Consortium Study.

J Clin Oncol 2016 09 18;34(26):3195-203. Epub 2016 Jul 18.

Tasnim Chagtai, William Mifsud, Neil Sebire, Richard Dafydd Williams, and Kathy Pritchard-Jones, University College London Institute of Child Health, London; Sergey Popov, University Hospital of Wales; Gordan Vujanić, Cardiff University School of Medicine, Cardiff, United Kingdom; Christina Zill, Jenny Wegert, and Manfred Gessler, Wuerzburg University, Wuerzburg; Marcel Kool, German Cancer Research Center, Heidelberg; Norbert Graf, Saarland University Hospital, Homburg, Germany; Linda Dainese, Yves Le Bouc, Annick Blaise, and Aurore Coulomb, Sorbonne Universités; Linda Dainese, Yves Le Bouc, and Aurore Coulomb, Assistance Publique Hôpitaux de Paris-Hôpital Armand Trousseau, Paris; Christophe Bergeron, Centre Léon Bérard, Lyon, France; Suvi Savola, MRC-Holland; Harm van Tinteren, Netherlands Cancer Institute, Amsterdam; Godelieve A.M. Tytgat and Marry M. van den Heuvel-Eibrink, Princess Maxima Center for Pediatric Oncology/Hematology, Utrecht, the Netherlands; Peter F. Ambros and Leo Kager, Children's Cancer Research Institute; Leo Kager, St Anna Children's Hospital, Vienna, Austria; Maureen J. O'Sullivan, Our Lady's Children's Hospital, Dublin, Ireland; and Linda Holmquist Mengelbier and David Gisselsson, Lund University, Lund, Sweden.

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http://dx.doi.org/10.1200/JCO.2015.66.0001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5505170PMC
September 2016

The transcriptional repressor Hes1 attenuates inflammation by regulating transcription elongation.

Nat Immunol 2016 08 20;17(8):930-7. Epub 2016 Jun 20.

Institute for Immunology and School of Medicine, Tsinghua University, Beijing. China.

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http://dx.doi.org/10.1038/ni.3486DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4955730PMC
August 2016

Hey bHLH Proteins Interact with a FBXO45 Containing SCF Ubiquitin Ligase Complex and Induce Its Translocation into the Nucleus.

PLoS One 2015 12;10(6):e0130288. Epub 2015 Jun 12.

Developmental Biochemistry, Theodor-Boveri-Institute, Biocenter, University of Wuerzburg, Wuerzburg, Germany; Comprehensive Cancer Center Mainfranken, Wuerzburg University, Wuerzburg, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0130288PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4466309PMC
April 2016

Combining miRNA and mRNA Expression Profiles in Wilms Tumor Subtypes.

Int J Mol Sci 2016 Mar 30;17(4):475. Epub 2016 Mar 30.

Department of Human Genetics, Saarland University, 66421 Homburg/Saar, Germany.

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http://dx.doi.org/10.3390/ijms17040475DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4848931PMC
March 2016

Defective autophagy through epg5 mutation results in failure to reduce germ plasm and mitochondria.

FASEB J 2015 Oct 16;29(10):4145-61. Epub 2015 Jul 16.

*Physiological Chemistry, Developmental Biochemistry, Biocenter, University of Würzburg, Würzburg, Germany; Institut National de la Recherche Agronomique (INRA), Unité de Recherche 1037, Fish Physiology and Genomics, Rennes, France; and Comprehensive Cancer Centre, University Clinic Würzburg, Würzburg, Germany.

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http://dx.doi.org/10.1096/fj.14-265462DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4566938PMC
October 2015

Hey bHLH transcription factors.

Curr Top Dev Biol 2014 ;110:285-315

Developmental Biochemistry, Theodor-Boveri-Institute/Biocenter, Wuerzburg University, Wuerzburg, Germany; Comprehensive Cancer Center Mainfranken, Wuerzburg University, Wuerzburg, Germany. Electronic address:

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http://dx.doi.org/10.1016/B978-0-12-405943-6.00008-7DOI Listing
June 2015

Mechanisms of epigenetic and cell-type specific regulation of Hey target genes in ES cells and cardiomyocytes.

J Mol Cell Cardiol 2015 Feb 13;79:79-88. Epub 2014 Nov 13.

Developmental Biochemistry, Theodor Boveri Institute (Biocenter), University of Wuerzburg, Am Hubland, D-97074 Wuerzburg, Germany; Comprehensive Cancer Center Mainfranken, University of Wuerzburg, Am Hubland, D-97074 Wuerzburg, Germany; Comprehensive Heart Failure Center, University of Wuerzburg, Am Hubland, D-97074 Wuerzburg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.yjmcc.2014.11.004DOI Listing
February 2015

1q gain is a frequent finding in preoperatively treated Wilms tumors, but of limited prognostic value for risk stratification in the SIOP2001/GPOH trial.

Genes Chromosomes Cancer 2014 Nov 18;53(11):960-2. Epub 2014 Jul 18.

Kiel Paediatric Tumor Registry, Department of Paediatric Pathology, University of Kiel, Germany.

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http://dx.doi.org/10.1002/gcc.22203DOI Listing
November 2014

Mosaic variegated aneuploidy in mouse BubR1 deficient embryos and pregnancy loss in human.

Chromosome Res 2014 Sep 1;22(3):375-92. Epub 2014 Jul 1.

Department of Human Genetics, Biocenter, University of Würzburg, 97074, Würzburg, Germany.

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http://dx.doi.org/10.1007/s10577-014-9432-xDOI Listing
September 2014

Survival in patients with high-risk prostate cancer is predicted by miR-221, which regulates proliferation, apoptosis, and invasion of prostate cancer cells by inhibiting IRF2 and SOCS3.

Cancer Res 2014 May 7;74(9):2591-603. Epub 2014 Mar 7.

Authors' Affiliations: Department of Urology and Paediatric Urology, University Hospital Wuerzburg; IZKF Laboratory for Microarray Applications, University Hospital Wuerzburg; Departments of Physiological Chemistry I; Developmental Biochemistry, Biocenter; Comprehensive Cancer Center Mainfranken, University of Wuerzburg, Wuerzburg; Department of Pathology, University Hospital Goettingen, Goettingen, Germany; Department of Urology, University Hospital Bern, Inselspital, Bern, Switzerland; and Departments of Urology and Pathology, University Hospital Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1158/0008-5472.CAN-13-1606DOI Listing
May 2014

GATA-dependent regulatory switches establish atrioventricular canal specificity during heart development.

Nat Commun 2014 Apr 28;5:3680. Epub 2014 Apr 28.

Department of Anatomy, Embryology and Physiology, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105AZ Amsterdam, The Netherlands.

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http://dx.doi.org/10.1038/ncomms4680DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4015328PMC
April 2014

Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death.

Nat Genet 2013 Sep 21;45(9):1044-9. Epub 2013 Jul 21.

Department of Clinical and Experimental Cardiology, Heart Failure Research Center, Academic Medical Center, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1038/ng.2712DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3869788PMC
September 2013

COUP-TFII orchestrates venous and lymphatic endothelial identity by homo- or hetero-dimerisation with PROX1.

J Cell Sci 2013 Mar 23;126(Pt 5):1164-75. Epub 2013 Jan 23.

Department of Cardiovascular Sciences, Molecular and Vascular Biology Research Unit, Endothelial Cell Biology Unit, KU Leuven, B-3000 Leuven, Belgium.

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http://jcs.biologists.org/cgi/doi/10.1242/jcs.116293
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http://dx.doi.org/10.1242/jcs.116293DOI Listing
March 2013

Physiological notch signaling maintains bone homeostasis via RBPjk and Hey upstream of NFATc1.

PLoS Genet 2012 22;8(3):e1002577. Epub 2012 Mar 22.

Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1002577DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3310726PMC
September 2012

Multicenter study identified molecular blood-born protein signatures for Wilms Tumor.

Int J Cancer 2012 Aug 23;131(3):673-82. Epub 2011 Oct 23.

Department of Human Genetics, Medical School, Saarland University, 66421 Homburg, Germany.

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http://dx.doi.org/10.1002/ijc.26419DOI Listing
August 2012

Characterization of primary Wilms tumor cultures as an in vitro model.

Genes Chromosomes Cancer 2012 Jan 27;51(1):92-104. Epub 2011 Oct 27.

Developmental Biochemistry, Biocenter, University of Wuerzburg, Wuerzburg, Germany.

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http://dx.doi.org/10.1002/gcc.20936DOI Listing
January 2012

Retinoic acid pathway activity in Wilms tumors and characterization of biological responses in vitro.

Mol Cancer 2011 Nov 8;10:136. Epub 2011 Nov 8.

Developmental Biochemistry, Biocenter, University of Wuerzburg, Wuerzburg, Germany.

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http://dx.doi.org/10.1186/1476-4598-10-136DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3239322PMC
November 2011

Expression patterns of the mouse Spir-2 actin nucleator.

Gene Expr Patterns 2010 Oct-Dec;10(7-8):345-50. Epub 2010 Aug 17.

Bavarian Genome Research Network (BayGene), Institute of Functional Genomics, University of Regensburg, Franz-Josef-Strauß-Allee 11, 93053 Regensburg, Germany.

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http://dx.doi.org/10.1016/j.gep.2010.08.001DOI Listing
March 2011

Epithelial Notch signaling regulates interstitial fibrosis development in the kidneys of mice and humans.

J Clin Invest 2010 Nov 18;120(11):4040-54. Epub 2010 Oct 18.

Department of Medicine, Division of Nephrology, Albert Einstein College of Medicine, New York, New York 10461, USA.

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http://dx.doi.org/10.1172/JCI43025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2964979PMC
November 2010

Hey bHLH factors in cardiovascular development.

Pediatr Cardiol 2010 Apr 24;31(3):363-70. Epub 2009 Dec 24.

Developmental Biochemistry, Theodor-Boveri-Institut fuer Biowissenschaften/Biozentrum, Am Hubland, D-97074, Wuerzburg, Germany.

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http://dx.doi.org/10.1007/s00246-009-9609-9DOI Listing
April 2010

WTX inactivation is a frequent, but late event in Wilms tumors without apparent clinical impact.

Genes Chromosomes Cancer 2009 Dec;48(12):1102-11

Developmental Biochemistry, Biocenter, University of Wuerzburg, Germany.

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http://dx.doi.org/10.1002/gcc.20712DOI Listing
December 2009

Dll1 and Dll4: similar, but not the same.

Authors:
Manfred Gessler

Blood 2009 May;113(22):5375-6

Wuerzburg University.

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http://dx.doi.org/10.1182/blood-2009-02-205468DOI Listing
May 2009

Identification of the human homolog of the imprinted mouse Air non-coding RNA.

Genomics 2008 Dec 2;92(6):464-73. Epub 2008 Oct 2.

Ce-M-M-Research Center for Molecular Medicine of the Austrian Academy of Science, Vienna Biocenter, Dr. Bohr-Gasse 9/4, A1030 Vienna, Austria.

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http://dx.doi.org/10.1016/j.ygeno.2008.08.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2846268PMC
December 2008

Loss of Fat4 disrupts PCP signaling and oriented cell division and leads to cystic kidney disease.

Nat Genet 2008 Aug 6;40(8):1010-5. Epub 2008 Jul 6.

Samuel Lunenfeld Research Institute, Mt. Sinai Hospital, Toronto M5G 1X5, Canada.

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http://dx.doi.org/10.1038/ng.179DOI Listing
August 2008

New prognostic markers revealed by evaluation of genes correlated with clinical parameters in Wilms tumors.

Genes Chromosomes Cancer 2008 May;47(5):386-95

Department of Physiological Chemistry I, Biocenter, University of Wuerzburg, Am Hubland, Wuerzburg, Germany.

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http://dx.doi.org/10.1002/gcc.20544DOI Listing
May 2008

The rodent Four-jointed ortholog Fjx1 regulates dendrite extension.

Dev Biol 2007 Dec 4;312(1):461-70. Epub 2007 Oct 4.

Abteilung Molekularbiologie, Institut für Allgemeine Zoologie und Genetik, Westfälische Wilhelms-Universität Münster, D-48149 Münster, Germany.

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http://linkinghub.elsevier.com/retrieve/pii/S001216060701402
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http://dx.doi.org/10.1016/j.ydbio.2007.09.054DOI Listing
December 2007

Delta-Notch--and then? Protein interactions and proposed modes of repression by Hes and Hey bHLH factors.

Nucleic Acids Res 2007 22;35(14):4583-96. Epub 2007 Jun 22.

Physiological Chemistry I, Biocenter, Theodor-Boveri-Institute, University of Würzburg, Am Hubland, D-97074 Würzburg, Germany.

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https://academic.oup.com/nar/article-lookup/doi/10.1093/nar/
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http://dx.doi.org/10.1093/nar/gkm477DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1950541PMC
September 2007

Upregulation of soluble vascular endothelial growth factor receptor 1 contributes to angiogenesis defects in the placenta of alpha 2B-adrenoceptor deficient mice.

Circ Res 2007 Sep 2;101(7):682-91. Epub 2007 Aug 2.

Institute of Experimental and Clinical Pharmacology, University of Freiburg, Albertstrasse 25, 79104 Freiburg, Germany.

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http://dx.doi.org/10.1161/CIRCRESAHA.107.151563DOI Listing
September 2007

Combined loss of Hey1 and HeyL causes congenital heart defects because of impaired epithelial to mesenchymal transition.

Circ Res 2007 Mar 15;100(6):856-63. Epub 2007 Feb 15.

Department of Physiological Chemistry I, Biocenter, University of Würzburg, Würzburg, Germany.

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http://dx.doi.org/10.1161/01.RES.0000260913.95642.3bDOI Listing
March 2007

Loss of 11q and 16q in Wilms tumors is associated with anaplasia, tumor recurrence, and poor prognosis.

Genes Chromosomes Cancer 2007 Feb;46(2):163-70

Department of Physiological Chemistry I, Biocenter of the University of Wuerzburg, Am Hubland, Wuerzburg, Germany.

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http://dx.doi.org/10.1002/gcc.20397DOI Listing
February 2007

Hypoxia-mediated activation of Dll4-Notch-Hey2 signaling in endothelial progenitor cells and adoption of arterial cell fate.

Exp Cell Res 2007 Jan 19;313(1):1-9. Epub 2006 Sep 19.

Theodor-Boveri-Institute, Physiological Chemistry I, Biocenter of the University of Wurzburg, Am Hubland, 97074 Wuerzburg, Germany.

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http://dx.doi.org/10.1016/j.yexcr.2006.09.009DOI Listing
January 2007

Developmental patterning of the cardiac atrioventricular canal by Notch and Hairy-related transcription factors.

Development 2006 Nov 4;133(21):4381-90. Epub 2006 Oct 4.

Burnham Institute for Medical Research, 10901 N. Torrey Pines Road, La Jolla, CA 92037, USA.

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http://dev.biologists.org/cgi/doi/10.1242/dev.02607
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http://dx.doi.org/10.1242/dev.02607DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3619037PMC
November 2006

Target genes of the WNT/beta-catenin pathway in Wilms tumors.

Genes Chromosomes Cancer 2006 Jun;45(6):565-74

Physiological Chemistry I, Biozentrum, University of Wuerzburg, Germany.

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http://dx.doi.org/10.1002/gcc.20319DOI Listing
June 2006

Very-KIND is a novel nervous system specific guanine nucleotide exchange factor for Ras GTPases.

Gene Expr Patterns 2005 Dec 15;6(1):79-85. Epub 2005 Aug 15.

Institut für Medizinische Strahlenkunde und Zellforschung (MSZ), Universität Würzburg, Versbacher Str. 5, 97078 Würzburg, Germany.

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http://linkinghub.elsevier.com/retrieve/pii/S1567133X0500049
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http://dx.doi.org/10.1016/j.modgep.2005.04.015DOI Listing
December 2005

Expression of mouse dchs1, fjx1, and fat-j suggests conservation of the planar cell polarity pathway identified in Drosophila.

Dev Dyn 2005 Nov;234(3):747-55

University of Wuerzburg, Theodor-Boveri-Institute (Biocenter), Physiological Chemistry I, Am Hubland, Wuerzburg, Germany.

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http://doi.wiley.com/10.1002/dvdy.20515
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http://dx.doi.org/10.1002/dvdy.20515DOI Listing
November 2005

Fjx1: a notch-inducible secreted ligand with specific binding sites in developing mouse embryos and adult brain.

Dev Dyn 2005 Nov;234(3):602-12

University of Wuerzburg, Theodor-Boveri-Institute (Biocenter), Physiological Chemistry I, Am Hubland, Wuerzburg, Germany.

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http://dx.doi.org/10.1002/dvdy.20553DOI Listing
November 2005

All-trans retinoic acid treatment of Wilms tumor cells reverses expression of genes associated with high risk and relapse in vivo.

Oncogene 2005 Aug;24(33):5246-51

Physiological Chemistry I, Theodor-Boveri-Institute, Biocenter of the University of Wuerzburg, Wuerzburg 97074, Germany.

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http://dx.doi.org/10.1038/sj.onc.1208725DOI Listing
August 2005

Novel familial WT1 read-through mutation associated with Wilms tumor and slow progressive nephropathy.

Am J Kidney Dis 2005 Jun;45(6):1100-4

Physiological Chemistry I, Biozentrum, University of Wuerzburg, Germany.

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June 2005

Chibby, a novel antagonist of the Wnt pathway, is not involved in Wilms tumor development.

Cancer Lett 2005 Mar;220(1):115-20

Theodor-Boveri-Institut fuer Biowissenschaften, Physiologische Chemie I, Am Hubland, D-97074 Wuerzburg, Germany.

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http://dx.doi.org/10.1016/j.canlet.2004.08.001DOI Listing
March 2005

Transposable elements as a source of genetic innovation: expression and evolution of a family of retrotransposon-derived neogenes in mammals.

Gene 2005 Jan 25;345(1):101-11. Epub 2004 Dec 25.

Biofuture Research Group, Physiologische Chemie I, Biozentrum, University of Würzburg, am Hubland, D-97074 Würzburg, Germany.

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http://dx.doi.org/10.1016/j.gene.2004.11.022DOI Listing
January 2005

her7 and hey1, but not lunatic fringe show dynamic expression during somitogenesis in medaka (Oryzias latipes).

Gene Expr Patterns 2004 Sep;4(5):553-9

Department of Physiological Chemistry I, Biocenter, University of Wuerzburg, Am Hubland, 97074 Wuerzburg, Germany.

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http://dx.doi.org/10.1016/j.modgep.2004.02.003DOI Listing
September 2004

Phenotypic variability in Hey2 -/- mice and absence of HEY2 mutations in patients with congenital heart defects or Alagille syndrome.

Mamm Genome 2004 Sep;15(9):711-6

Theodor-Boveri-Institute (Biocenter), Physiological Chemistry I, University of Wuerzburg, D-97074, Am Hubland, Wuerzburg, Germany.

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http://dx.doi.org/10.1007/s00335-004-2389-xDOI Listing
September 2004

Cloning and expression analysis of the mouse stroma marker Snep encoding a novel nidogen domain protein.

Dev Dyn 2004 Jun;230(2):371-7

Theodor-Boveri-Institute, Physiological Chemistry I, University of Wuerzburg, Wuerzburg, Germany.

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http://dx.doi.org/10.1002/dvdy.20056DOI Listing
June 2004

Overlapping expression pattern of the actin organizers Spir-1 and formin-2 in the developing mouse nervous system and the adult brain.

Gene Expr Patterns 2004 May;4(3):249-55

Theodor-Boveri-Institut (Biozentrum), Universität Würzburg, Physiologische Chemie I, Am Hubland, 97074 Würzburg, Germany.

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http://dx.doi.org/10.1016/j.modgep.2003.11.006DOI Listing
May 2004

The Notch target genes Hey1 and Hey2 are required for embryonic vascular development.

Genes Dev 2004 Apr;18(8):901-11

Theodor-Boveri-Institut für Biowissenschaften (Biozentrum), Physiologische Chemie I, Universität Würzburg, 97074 Würzburg, Germany.

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http://dx.doi.org/10.1101/gad.291004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC395849PMC
April 2004

Identification of BOIP, a novel cDNA highly expressed during spermatogenesis that encodes a protein interacting with the orange domain of the hairy-related transcription factor HRT1/Hey1 in Xenopus and mouse.

Dev Dyn 2003 Dec;228(4):716-25

Institut de Recherche Interdisciplinaire en Biologie Humaine et Moléculaire (IRIBHM) and Institut de Biologie et de Médecine Moléculaires (IBMM), Université Libre de bruxelles, Gosselies, Belgium.

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http://dx.doi.org/10.1002/dvdy.10406DOI Listing
December 2003

Characterization of hey bHLH genes in teleost fish.

Dev Genes Evol 2003 Nov 31;213(11):541-53. Epub 2003 Oct 31.

Department of Physiological Chemistry I, Biocenter, University of Wuerzburg, Am Hubland, 97074 Wuerzburg, Germany.

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http://dx.doi.org/10.1007/s00427-003-0360-6DOI Listing
November 2003

Expression of Notch pathway genes in the embryonic mouse metanephros suggests a role in proximal tubule development.

Gene Expr Patterns 2003 Oct;3(5):595-8

Theodor-Boveri-Institute, Biozentrum, Physiological Chemistry I, University of Wuerzburg, Am Hubland, 97074, Wuerzburg, Germany.

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October 2003

Hey genes in cardiovascular development.

Trends Cardiovasc Med 2003 Aug;13(6):221-6

Physiological Chemistry I, Theodor-Boveri-Institute, University of Wuerzburg, Am Hubland, 97074 Wuerzburg, Germany.

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August 2003

Developmental expression and biochemical characterization of Emu family members.

Dev Biol 2002 Sep;249(2):204-18

Theodor-Boveri-Institute, Physiological Chemistry I, University of Wuerzburg, 97074, Wuerzburg, Germany.

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September 2002

Mouse gridlock: no aortic coarctation or deficiency, but fatal cardiac defects in Hey2 -/- mice.

Curr Biol 2002 Sep;12(18):1601-4

Theodor-Boveri-Institute of the University of Wuerzburg, Physiological Chemistry I, Am Hubland, D-97074 Wuerzburg, Germany.

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September 2002

Placental alpha(2)-adrenoceptors control vascular development at the interface between mother and embryo.

Nat Genet 2002 Jul 17;31(3):311-5. Epub 2002 Jun 17.

Institut für Pharmakologie und Toxikologie, Universität Würzburg, Versbacher Strasse 9, 97078 Würzburg, Germany.

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http://dx.doi.org/10.1038/ng919DOI Listing
July 2002