Manfred B Lutz

Manfred B Lutz

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Manfred B Lutz

Manfred B Lutz

Publications by authors named "Manfred B Lutz"

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Tolerogenic Transcriptional Signatures of Steady-State and Pathogen-Induced Dendritic Cells.

Front Immunol 2018 28;9:333. Epub 2018 Feb 28.

Institute for Virology and Immunobiology, University of Würzburg, Würzburg, Germany.

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http://dx.doi.org/10.3389/fimmu.2018.00333DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5835767PMC
March 2019

GM-CSF Monocyte-Derived Cells and Langerhans Cells As Part of the Dendritic Cell Family.

Front Immunol 2017 23;8:1388. Epub 2017 Oct 23.

Department of Dermatology, Venereology and Allergology, Medical University of Innsbruck, Innsbruck, Austria.

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http://dx.doi.org/10.3389/fimmu.2017.01388DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5660299PMC
October 2017

Phenotypically resembling myeloid derived suppressor cells are increased in children with HIV and exposed/infected with Mycobacterium tuberculosis.

Eur J Immunol 2017 01 16;47(1):107-118. Epub 2016 Dec 16.

Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences/SAMRC Centre for Tuberculosis Research/DST and NRF Centre of Excellence for Biomedical TB Research, Faculty of Medicine and Health Sciences, Stellenbosch University, Stellenbosch, South Africa.

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http://dx.doi.org/10.1002/eji.201646658DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5233566PMC
January 2017

Sialoadhesin promotes neuroinflammation-related disease progression in two mouse models of CLN disease.

Glia 2016 May 17;64(5):792-809. Epub 2016 Jan 17.

Department of Neurology, Developmental Neurobiology, University Hospital Wuerzburg, Wuerzburg, Germany.

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http://dx.doi.org/10.1002/glia.22962DOI Listing
May 2016

Induction of CD4(+) Regulatory and Polarized Effector/helper T Cells by Dendritic Cells.

Authors:
Manfred B Lutz

Immune Netw 2016 Feb 25;16(1):13-25. Epub 2016 Feb 25.

Institute of Virology and Immunobiology, University of Würzburg, 97078 Würzburg, Germany.

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http://dx.doi.org/10.4110/in.2016.16.1.13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4770096PMC
February 2016

Still Alive and Kicking: In-Vitro-Generated GM-CSF Dendritic Cells!

Immunity 2016 Jan;44(1):1-2

Department of Dermatology & Venereology, Medical University of Innsbruck, 6020 Innsbruck, Austria.

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http://dx.doi.org/10.1016/j.immuni.2015.12.013DOI Listing
January 2016

Deficiency of HIF1α in Antigen-Presenting Cells Aggravates Atherosclerosis and Type 1 T-Helper Cell Responses in Mice.

Arterioscler Thromb Vasc Biol 2015 Nov 24;35(11):2316-25. Epub 2015 Sep 24.

From the Institute of Clinical Biochemistry and Pathobiochemistry, University Hospital Würzburg (S.M.C., M.K., C.C., A.Z.), Rudolf Virchow Center (H.D.M., M.B., H.M.H.), Institute of Virology and Immunobiology (M.B.L.), and Division of Hepatology, Medical Clinic II, University Hospital Würzburg (H.M.H.), University of Würzburg, Würzburg, Germany; Department of Pathology, Maastricht University Medical Centre, Cardiovascular Research Institute Maastricht, Maastricht, The Netherlands (J.C.S., T.L.T.); Joslin Diabetes Center, Harvard Medical School, Boston, MA (C.C.-F., S.K.); Experimental and Molecular Pediatric Cardiology, German Heart Center Munich, TU Munich, Munich, Germany (F.V., A.G.); Department of Vascular and Endovascular Surgery, Klinikum Rechts der Isar der Technischen Universität München, Munich, Germany (J.P.); and Department of Pathology, Amsterdam Medical Centre, Amsterdam, The Netherlands (M.J.D.).

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http://dx.doi.org/10.1161/ATVBAHA.115.306171DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4618712PMC
November 2015

In vitro-generated MDSCs prevent murine GVHD by inducing type 2 T cells without disabling antitumor cytotoxicity.

Blood 2015 Aug 16;126(9):1138-48. Epub 2015 Jul 16.

Department of Pediatrics and Adolescent Medicine, University Medical Center Ulm Ulm, Germany;

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http://dx.doi.org/10.1182/blood-2015-01-624163DOI Listing
August 2015

TCAIM decreases T cell priming capacity of dendritic cells by inhibiting TLR-induced Ca2+ influx and IL-2 production.

J Immunol 2015 Apr 6;194(7):3136-46. Epub 2015 Mar 6.

Institute of Medical Immunology, Charite University Medicine, Berlin 13353, Germany; Berlin Brandenburg Center for Regenerative Therapies, Charite University Medicine, Berlin 13353, Germany;

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http://dx.doi.org/10.4049/jimmunol.1400713DOI Listing
April 2015

Immature dendritic cells convert anergic nonregulatory T cells into Foxp3- IL-10+ regulatory T cells by engaging CD28 and CTLA-4.

Eur J Immunol 2015 Feb 2;45(2):480-91. Epub 2014 Dec 2.

Institute of Virology and Immunobiology, University of Würzburg, Würzburg, Germany.

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http://dx.doi.org/10.1002/eji.201444991DOI Listing
February 2015

Dendritic cell subset distributions in the aorta in healthy and atherosclerotic mice.

PLoS One 2014 14;9(2):e88452. Epub 2014 Feb 14.

Institute of Clinical Biochemistry and Pathobiocchemistry, University Hospital Würzburg, Würzburg, Germany ; Department of Vascular Surgery, Klinikum rechts der Isar der Technischen Universität München, Munich, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0088452PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3925240PMC
October 2014

EmTIP, a T-Cell immunomodulatory protein secreted by the tapeworm Echinococcus multilocularis is important for early metacestode development.

PLoS Negl Trop Dis 2014 2;8(1):e2632. Epub 2014 Jan 2.

University of Würzburg, Institute for Hygiene and Microbiology, Würzburg, Germany.

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http://dx.doi.org/10.1371/journal.pntd.0002632DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3879249PMC
September 2014

Cathepsin B in antigen-presenting cells controls mediators of the Th1 immune response during Leishmania major infection.

PLoS Negl Trop Dis 2014 Sep 25;8(9):e3194. Epub 2014 Sep 25.

Institute for Molecular Infection Biology, University of Würzburg, Würzburg, Germany.

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http://dx.doi.org/10.1371/journal.pntd.0003194DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4177854PMC
September 2014

Development and validation of a fully GMP-compliant production process of autologous, tumor-lysate-pulsed dendritic cells.

Cytotherapy 2014 Jul 13;16(7):946-64. Epub 2014 May 13.

Laboratory of Pediatric Immunology, Department of Microbiology and Immunology, KU Leuven, Belgium (on behalf of the HGG-Immuno Network).

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http://dx.doi.org/10.1016/j.jcyt.2014.02.017DOI Listing
July 2014

Dendritic cells generated with Flt3L and exposed to apoptotic cells lack induction of T cell anergy and Foxp3⁺ regulatory T cell conversion in vitro.

Immunobiology 2014 Mar 24;219(3):230-40. Epub 2013 Oct 24.

Institute of Virology and Immunobiology, University of Wuerzburg, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01712985130018
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http://dx.doi.org/10.1016/j.imbio.2013.10.006DOI Listing
March 2014

Immunogenic and tolerogenic effects of the chimeric IL-2-diphtheria toxin cytocidal agent Ontak on CD25 cells.

Oncoimmunology 2014 17;3:e28223. Epub 2014 Mar 17.

Department of Dermatology; University Hospital Erlangen; Erlangen, Germany.

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http://dx.doi.org/10.4161/onci.28223DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4091105PMC
March 2014

The nature of activatory and tolerogenic dendritic cell-derived signal 2.

Front Immunol 2014 6;5:42. Epub 2014 Feb 6.

Department of Biotechnology and Bioscience, University of Milano-Bicocca , Milan , Italy.

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http://dx.doi.org/10.3389/fimmu.2014.00042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3915285PMC
February 2014

Increased frequency of myeloid-derived suppressor cells during active tuberculosis and after recent mycobacterium tuberculosis infection suppresses T-cell function.

Am J Respir Crit Care Med 2013 Sep;188(6):724-32

1 Division of Molecular Biology and Human Genetics, MRC Centre for Molecular and Cellular Biology, DST/NRF Centre of Excellence for Biomedical TB Research, and.

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http://dx.doi.org/10.1164/rccm.201302-0249OCDOI Listing
September 2013

The nature of activatory and tolerogenic dendritic cell-derived signal 2.

Front Immunol 2013 16;4:198. Epub 2013 Jul 16.

Department of Biotechnology and Bioscience, University of Milano-Bicocca , Milan, Italy.

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http://dx.doi.org/10.3389/fimmu.2013.00198DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3712195PMC
July 2013

How quantitative differences in dendritic cell maturation can direct T1/T2-cell polarization.

Authors:
Manfred B Lutz

Oncoimmunology 2013 Feb;2(2):e22796

Institute of Virology and Immunobiology; University of Würzburg; Würzburg, Germany.

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http://dx.doi.org/10.4161/onci.22796DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3601159PMC
February 2013

Role of dendritic cell maturity/costimulation for generation, homeostasis, and suppressive activity of regulatory T cells.

Front Immunol 2011 27;2:39. Epub 2011 Sep 27.

Institute of Virology and Immunobiology, University of Wuerzburg Wuerzburg, Germany.

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http://dx.doi.org/10.3389/fimmu.2011.00039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3342346PMC
August 2012

Therapeutic potential of semi-mature dendritic cells for tolerance induction.

Authors:
Manfred B Lutz

Front Immunol 2012 18;3:123. Epub 2012 May 18.

Institute of Virology and Immunobiology, University of Wuerzburg Wuerzburg, Germany.

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http://dx.doi.org/10.3389/fimmu.2012.00123DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3355325PMC
August 2012

Buy one, get one free: additional functions of GM-CSF in DC maturation.

Authors:
Manfred B Lutz

Eur J Immunol 2012 Jan;42(1):35-8

Institute of Virology and Immunobiology, University of Würzburg, Würzburg, Germany.

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http://dx.doi.org/10.1002/eji.201142271DOI Listing
January 2012

Similar inflammatory DC maturation signatures induced by TNF or Trypanosoma brucei antigens instruct default Th2-cell responses.

Eur J Immunol 2011 Dec 3;41(12):3479-94. Epub 2011 Nov 3.

Institute of Virology and Immunobiology, University of Wuerzburg, Wuerzburg, Germany.

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http://dx.doi.org/10.1002/eji.201141631DOI Listing
December 2011

Neuromelanin is an immune stimulator for dendritic cells in vitro.

BMC Neurosci 2011 Nov 15;12:116. Epub 2011 Nov 15.

University of Würzburg, Institute of Virology and Immunobiology, Würzburg, Germany.

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http://dx.doi.org/10.1186/1471-2202-12-116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3225309PMC
November 2011

Revisiting the tolerogenicity of epidermal Langerhans cells.

Immunol Cell Biol 2010 May-Jun;88(4):381-6. Epub 2010 Mar 9.

Institute of Virology and Immunobiology, University of Wuerzburg, Wuerzburg, Germany.

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http://dx.doi.org/10.1038/icb.2010.17DOI Listing
August 2010

Subsets, expansion and activation of myeloid-derived suppressor cells.

Med Microbiol Immunol 2010 Aug 8;199(3):273-81. Epub 2010 Apr 8.

Institute of Virology and Immunobiology, University of Würzburg, Versbacherstrasse 7, Würzburg, Germany.

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http://dx.doi.org/10.1007/s00430-010-0151-4DOI Listing
August 2010

Immobilized chemokine fields and soluble chemokine gradients cooperatively shape migration patterns of dendritic cells.

Immunity 2010 May 13;32(5):703-13. Epub 2010 May 13.

Hofschneider Group Leukocyte Migration, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany.

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http://dx.doi.org/10.1016/j.immuni.2010.04.017DOI Listing
May 2010

Gr-1 antibody induces STAT signaling, macrophage marker expression and abrogation of myeloid-derived suppressor cell activity in BM cells.

Eur J Immunol 2009 Dec;39(12):3538-51

Institute of Virology and Immunobiology, University of Wuerzburg, Germany.

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http://dx.doi.org/10.1002/eji.200939530DOI Listing
December 2009

Myeloid-derived suppressor cell activation by combined LPS and IFN-gamma treatment impairs DC development.

Eur J Immunol 2009 Oct;39(10):2865-76

Department of Dermatology, University Hospital Erlangen, Erlangen, Germany.

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http://dx.doi.org/10.1002/eji.200939486DOI Listing
October 2009

Induction of peripheral CD4+ T-cell tolerance and CD8+ T-cell cross-tolerance by dendritic cells.

Eur J Immunol 2009 Sep;39(9):2325-30

Institute for Virology and Immunobiology, University of Würzburg, Würzburg, Germany.

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http://dx.doi.org/10.1002/eji.200939548DOI Listing
September 2009

An improved method to generate equine dendritic cells from peripheral blood mononuclear cells: divergent maturation programs by IL-4 and LPS.

Immunobiology 2008 3;213(9-10):751-8. Epub 2008 Sep 3.

Department of Dermatology, University Hospital Erlangen, Germany.

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http://dx.doi.org/10.1016/j.imbio.2008.07.024DOI Listing
February 2009

Production of IL-12, IL-23 and IL-27p28 by bone marrow-derived conventional dendritic cells rather than macrophages after LPS/TLR4-dependent induction by Salmonella Enteritidis.

Immunobiology 2007 9;212(9-10):739-50. Epub 2007 Nov 9.

Institute of Immunology, College of Veterinary Medicine, An den Tierkliniken 11, 04103, Leipzig, Germany.

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http://dx.doi.org/10.1016/j.imbio.2007.09.004DOI Listing
March 2008

Factors influencing the generation of murine dendritic cells from bone marrow: the special role of fetal calf serum.

Immunobiology 2007 8;212(9-10):855-62. Epub 2007 Nov 8.

Institute for Virology and Immunobiology, University of Wuerzburg, 97078, Wuerzburg, Germany.

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http://dx.doi.org/10.1016/j.imbio.2007.09.001DOI Listing
March 2008

Suppression of mature dendritic cell function by regulatory T cells in vivo is abrogated by CD40 licensing.

J Immunol 2008 Feb;180(3):1405-13

Department of Dermatology, University Hospital Erlangen, Erlangen, Germany.

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http://dx.doi.org/10.4049/jimmunol.180.3.1405DOI Listing
February 2008

TLR9 cooperates with TLR4 to increase IL-12 release by murine dendritic cells.

Mol Immunol 2008 Jan 27;45(1):244-52. Epub 2007 Jun 27.

Department of Dermatology, University Hospital Erlangen, Germany.

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http://dx.doi.org/10.1016/j.molimm.2007.02.021DOI Listing
January 2008

Targeting HIV-1 Gag into the defective ribosomal product pathway enhances MHC class I antigen presentation and CD8+ T cell activation.

J Immunol 2008 Jan;180(1):372-82

Institute of Clinical and Molecular Virology, Department of Dermatology, University Hospital of Erlangen, Germany.

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http://dx.doi.org/10.4049/jimmunol.180.1.372DOI Listing
January 2008

Skin-derived dendritic cells can mediate deletional tolerance of class I-restricted self-reactive T cells.

J Immunol 2007 Oct;179(7):4535-41

Department of Microbiology and Immunology, University of Melbourne, Parkville, Australia.

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http://dx.doi.org/10.4049/jimmunol.179.7.4535DOI Listing
October 2007

The mast cell mediator PGD2 suppresses IL-12 release by dendritic cells leading to Th2 polarized immune responses in vivo.

Immunobiology 2006 7;211(6-8):463-72. Epub 2006 Jul 7.

Department of Dermatology, University of Erlangen-Nuremberg, Erlangen, Germany.

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http://dx.doi.org/10.1016/j.imbio.2006.05.020DOI Listing
December 2006

Non-invasive imaging of dendritic cell migration in vivo.

Immunobiology 2006 3;211(6-8):587-97. Epub 2006 Jul 3.

Department of Dermatology, University Hospital Erlangen, Hartmannstr. 14, 91052 Erlangen, Germany.

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http://dx.doi.org/10.1016/j.imbio.2006.05.011DOI Listing
December 2006

In vivo magnetic resonance imaging of dendritic cell migration into the draining lymph nodes of mice.

Eur J Immunol 2006 Sep;36(9):2544-55

Department of Dermatology, University of Erlangen, Erlangen, Germany.

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http://dx.doi.org/10.1002/eji.200535742DOI Listing
September 2006

IL-3 in dendritic cell development and function: a comparison with GM-CSF and IL-4.

Authors:
Manfred B Lutz

Immunobiology 2004 ;209(1-2):79-87

Department of Dermatology, University Hospital Erlangen, Hartmannstr. 14, 91052 Erlangen, Germany.

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http://dx.doi.org/10.1016/j.imbio.2004.03.001DOI Listing
May 2005

IL-4 supports the generation of a dendritic cell subset from murine bone marrow with altered endocytosis capacity.

J Leukoc Biol 2005 Apr 23;77(4):535-43. Epub 2004 Dec 23.

Department of Dermatology, University Hospital Erlangen, Germany.

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http://dx.doi.org/10.1189/jlb.0804473DOI Listing
April 2005

Simultaneous induction of CD4 T cell tolerance and CD8 T cell immunity by semimature dendritic cells.

J Immunol 2005 Apr;174(7):3941-7

Institute for Immunology, Ludwig-Maximilians-Universität München, Munich, Germany.

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http://dx.doi.org/10.4049/jimmunol.174.7.3941DOI Listing
April 2005

Prevention and treatment of experimental autoimmune encephalomyelitis by soluble CD83.

J Exp Med 2004 Aug;200(3):345-51

Department of Dermatology, Hartmannstasse 14, University Hospital Erlangen, 91052 Erlangen, Germany.

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http://dx.doi.org/10.1084/jem.20030973DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2211980PMC
August 2004

Molecular cloning of human dectin-2.

J Invest Dermatol 2004 Jun;122(6):1522-4

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http://dx.doi.org/10.1111/j.0022-202X.2004.22602.xDOI Listing
June 2004

The cyclin-dependent kinase inhibitors p27Kip1 and p21Cip1 are not essential in T cell anergy.

Eur J Immunol 2003 Nov;33(11):3154-63

Department of Dermatology, University of Erlangen, Erlangen, Germany.

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http://dx.doi.org/10.1002/eji.200323960DOI Listing
November 2003

Developmental stages of myeloid dendritic cells in mouse bone marrow.

Int Immunol 2003 Apr;15(4):515-24

Department of Immunology, Erasmus MC, University Medical Center, PO Box 1738, 3000 DR Rotterdam, The Netherlands. t.nikolic@erasmusmc

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http://dx.doi.org/10.1093/intimm/dxg050DOI Listing
April 2003

Differential functions of IL-4 receptor types I and II for dendritic cell maturation and IL-12 production and their dependency on GM-CSF.

J Immunol 2002 Oct;169(7):3574-80

Department of Dermatology and Institute of Clinical Microbiology, Immunology, and Hygiene, University of Erlangen-Nuremberg, Erlangen, Germany.

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http://dx.doi.org/10.4049/jimmunol.169.7.3574DOI Listing
October 2002

Immature, semi-mature and fully mature dendritic cells: which signals induce tolerance or immunity?

Trends Immunol 2002 Sep;23(9):445-9

University of Erlangen, Department of Dermatology, Hartmannstr. 14, 91052 Erlangen, Germany.

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September 2002