Publications by authors named "Manel Juan"

70Publications

Deep diving in the PACIFIC: Practical issues in stage III non-small cell lung cancer to avoid shipwreck.

World J Clin Oncol 2020 Nov;11(11):898-917

Department of Radiation Oncology, Hospital Universitario Quirónsalud Madrid, Hospital La Luz, Universidad Europea de Madrid, Madrid 28028, Spain.

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November 2020

Manufacturing and Management of CAR T-Cell Therapy in "COVID-19's Time": Central Versus Point of Care Proposals.

Front Immunol 2020 15;11:573179. Epub 2020 Oct 15.

Department of Immunology, Centre de Diagnòstic Biomèdic, Hospital Clínic de Barcelona, Barcelona, Spain.

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December 2020

Purification, Culture, and CD19-CAR Lentiviral Transduction of Adult and Umbilical Cord Blood NK Cells.

Curr Protoc Immunol 2020 12;131(1):e108

Cell Therapy, Stem Cells and Tissues Group, Osakidetza, Basque Centre for Blood Transfusion and Human Tissues, Galdakao, Spain.

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December 2020

CAR T cells targeting options in the fight against multiple myeloma.

Panminerva Med 2020 Sep 21. Epub 2020 Sep 21.

Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, Forlì-Cesena, Italy.

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September 2020

[CAR-T immunotherapy in pediatric hemato-oncology… present and future].

An Pediatr (Barc) 2020 Jul 8;93(1):1-3. Epub 2020 Jun 8.

Hospital Sant Joan de Déu, Plataforma de Inmunoterapia Celular SJD-Clínic, Barcelona, España; Institut de Recerca Hospital Sant Joan de Déu de Barcelona (IRP-HSJD), Barcelona, España.

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July 2020

Single-cycle rituximab-induced immunologic changes in children: Enhanced in neuroimmunologic disease?

Neurol Neuroimmunol Neuroinflamm 2020 07 6;7(4). Epub 2020 May 6.

From the Clinical Immunology and Primary Immunodeficiencies Unit (A.D.-M., A.E.-S., A.G.-G., L.A.), Pediatric Allergy and Clinical Immunology Department (A.D.-M., Y.G., M.P., A.E.-S., A.G.-G., A.M.P., L.A.), Hospital Sant Joan de Déu, Barcelona, Spain; Institut de Recerca Sant Joan de Déu (A.D.-M., Y.G., M.P., A.E.-S., J.A., A.G.-G., A.M.P., L.A.), Barcelona, Spain; Clinical Immunology Unit Hospital Sant Joan de Déu-Hospital Clínic (A.D.-M., A.V., M.P., M.J., A.E.-S., A.G.-G., A.M.P., L.A.), Barcelona, Spain; Universitat de Barcelona (J.A., L.A., M.J.), Spain; Immunology Department (A.V., M.J.), Biomedical Diagnostics Center, Hospital Clinic-IDIBAPS, Barcelona, Spain; Pediatric Neuroimmunology Unit (C.M.-A., T.A.), Neurology Department, Hospital Sant Joan de Déu, University of Barcelona, Barcelona, Spain; Neuroimmunology Program (T.A.), Institut D'Investigacions Biomèdiques (IDIBAPS), Hospital Clinic, University of Barcelona, Barcelona, Spain; Pediatric Rheumatology Division (J.A.), Hospital Sant Joan de Déu, Barcelona, Spain; and Pediatric Nephrology Department (Á.M.), Hospital Sant Joan de Déu, Barcelona, Spain.

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July 2020

CART manufacturing process and reasons for academy-pharma collaboration.

Immunol Lett 2020 01 25;217:39-48. Epub 2019 Oct 25.

Servei d'Immunologia, Hospital Clínic de Barcelona (HCB), University of Barcelona (UB), Banc de Sang i Teixits (BST) - HCB Immunotherapy Platform Barcelona, Spain; IDIBAPS, University of Barcelona (UB), Banc de Sang i Teixits (BST) - HCB Immunotherapy Platform Barcelona, Spain; University of Barcelona (UB), Banc de Sang i Teixits (BST) - HCB Immunotherapy Platform Barcelona, Spain; Hospital Sant Joan de Déu, University of Barcelona (UB), Banc de Sang i Teixits (BST) - HCB Immunotherapy Platform Barcelona, Spain. Electronic address:

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January 2020

Toll-like receptor 3 deficiency in autoimmune encephalitis post-herpes simplex encephalitis.

Neurol Neuroimmunol Neuroinflamm 2019 11 5;6(6). Epub 2019 Sep 5.

From the Neuroimmunology Program (T.A., M.P.-P., J.D.), Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clínic, Universitat de Barcelona, Barcelona, Spain; Pediatric Neuroimmunology Unit (T.A.), Neurology Department, Sant Joan de Déu (SJD) Children's Hospital, University of Barcelona, Barcelona, Spain; Clinical Immunology and Primary Immunodeficiencies Unit (B.J.B., A.D.-M., L.A., A.E.-S.), Pediatric Allergy and Clinical Immunology Department, Hospital Sant Joan de Déu, Institut de Recerca Sant Joan de Déu, Universitat de Barcelona, Spain; Clinical Immunology Unit (A.V., A.E.-S., R.R.-G., M.J., L.A.), Hospital Sant Joan de Déu-Hospital Clínic Barcelona, Barcelona, Spain; Laboratory of Immunogenetics of Human Diseases (R.P.d.D.), IdiPAZ Institute for Health Research, La Paz Hospital, Madrid, Spain; Innate Immunity Group (R.P.d.D.), IdiPAZ Institute for Health Research, La Paz Hospital, Madrid, Spain; Interdepartmental Group of Immunodeficiencies (R.P.d.D.), Madrid, Spain; Neurology Department (J.D.), University of Pennsylvania, Philadelphia; and Catalan Institute for Research and Advanced Studies (ICREA) (J.D.), Barcelona, Spain.

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November 2019

Targeting IRAK4 disrupts inflammatory pathways and delays tumor development in chronic lymphocytic leukemia.

Leukemia 2020 01 13;34(1):100-114. Epub 2019 Jun 13.

Experimental Therapeutics in Lymphoid Malignancies Group, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), CIBERONC, Barcelona, Spain.

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January 2020

CAR-T Cell Therapy: A Door Is Open to Find Innumerable Possibilities of Treatments for Cancer Patients

Turk J Haematol 2018 11 6;35(4):217-228. Epub 2018 Sep 6.

Institut d’Investigacions Biomèdiques August Pi i Sunyer Hospital, Clinic of Hematology, Barcelona, Spain

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November 2018

Frequency, symptoms, risk factors, and outcomes of autoimmune encephalitis after herpes simplex encephalitis: a prospective observational study and retrospective analysis.

Lancet Neurol 2018 09 23;17(9):760-772. Epub 2018 Jul 23.

Neuroimmunology Program, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clínic, University of Barcelona, Barcelona, Spain; Service of Neurology, Hospital Clínic, University of Barcelona, Barcelona, Spain; Department of Neurology, University of Pennsylvania, PA, USA; Catalan Institution for Research and Advanced Studies (ICREA), Barcelona, Spain. Electronic address:

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September 2018

Severe BCG-osis Misdiagnosed as Multidrug-Resistant Tuberculosis in an IL-12Rβ1-Deficient Peruvian Girl.

J Clin Immunol 2018 08 23;38(6):712-716. Epub 2018 Jul 23.

Functional Unit of Clinical Immunology and Primary Immunodeficiencies, Hospital Sant Joan de Déu, University of Barcelona, Pediatric Research Institute Sant Joan de Déu, Barcelona, Spain.

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August 2018

B Regulatory Cells: Players in Pregnancy and Early Life.

Int J Mol Sci 2018 Jul 19;19(7). Epub 2018 Jul 19.

Functional Unit of Clinical Immunology and Primary Immunodeficiencies, Allergy and Clinical Immunology Department, Hospital Sant Joan de Déu, University of Barcelona, Pediatric Research Institute Sant Joan de Déu, 08950 Barcelona, Spain.

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July 2018

Immunological Changes in Blood of Newborns Exposed to Anti-TNF-α during Pregnancy.

Front Immunol 2017 21;8:1123. Epub 2017 Sep 21.

Allergy and Clinical Immunology Department, Hospital Sant Joan de Déu, Institut de Recerca Pediàtrica Hospital Sant Joan de Déu, Esplugues de Llobregat, Spain.

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September 2017

Evans Syndrome as First Manifestation of Primary Immunodeficiency in Clinical Practice.

J Pediatr Hematol Oncol 2017 10;39(7):490-494

Departments of *Allergy and Clinical Immunology ‡Hematology and Oncology, Hospital Sant Joan de Dèu, Institut de Recerca Pediàtrica Hospital Sant Joan de Dèu, Esplugues de Llobregat §Immunology Department, Hospital Clinic-IDIBAPS, Universitat de Barcelona †Functional Unit of Clinical Immunology SJD-Clinic, Barcelona, Spain.

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October 2017

Detailed Characterization of Mesenchymal Stem/Stromal Cells from a Large Cohort of AML Patients Demonstrates a Definitive Link to Treatment Outcomes.

Stem Cell Reports 2017 06 18;8(6):1573-1586. Epub 2017 May 18.

Josep Carreras Leukemia Research Institute, Department of Biomedicine, School of Medicine, Universitat de Barcelona, Casanova 143, Barcelona 08036, Spain; Centro de Investigación Biomédica en Red-Oncología (CIBERONC), ISCIII, Madrid 28031, Spain; Instituciò Catalana de Recerca i Estudis Avançats (ICREA), Barcelona 08010, Spain. Electronic address:

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June 2017

Characterization of the Highly Prevalent Regulatory CD24CD38 B-Cell Population in Human Cord Blood.

Front Immunol 2017 7;8:201. Epub 2017 Mar 7.

Allergy and Clinical Immunology Department, Hospital Sant Joan de Déu, Institut de Recerca Pediàtrica Hospital Sant Joan de Déu, Esplugues de Llobregat, Spain; Functional Unit of Clinical Immunology, Sant Joan de Déu-Hospital Clinic, Barcelona, Spain.

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March 2017

Detection of inflammatory monocytes but not mesenchymal stem/stromal cells in peripheral blood of patients with myelofibrosis.

Br J Haematol 2018 04 21;181(1):133-137. Epub 2017 Feb 21.

Josep Carreras Leukaemia Research Institute, Department of Biomedicine, School of Medicine, University of Barcelona, Barcelona, Spain.

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April 2018

Kinetic analysis of changes in T- and B-lymphocytes after anti-CD20 treatment in renal pathology.

Immunobiology 2017 04 17;222(4):620-630. Epub 2016 Nov 17.

Immunology Service, Hospital Clínic, Universitat de Barcelona, 08036, Barcelona, Spain; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIPABS), Barcelona, Spain; Facultat de Medicina, Universitat de Barcelona, 08036, Barcelona, Spain. Electronic address:

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April 2017

The inflammasome pathway in stable COPD and acute exacerbations.

ERJ Open Res 2016 Jul 11;2(3). Epub 2016 Jul 11.

Fundació Clinic per a la Recerca Biomèdica, Barcelona, Spain; CIBER Respiratory Diseases (CIBERES), Barcelona, Spain; Institut Respiratori, Hospital Clinic, Barcelona, Spain; Biomedic Research Institute August Pi i Sunyer (IDIBAPS), Barcelona, Spain.

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July 2016

DNA demethylation of inflammasome-associated genes is enhanced in patients with cryopyrin-associated periodic syndromes.

J Allergy Clin Immunol 2017 01 7;139(1):202-211.e6. Epub 2016 Jul 7.

Chromatin and Disease Group, Cancer Epigenetics and Biology Programme (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain. Electronic address:

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January 2017

Clues to management of neonatally diagnosed BTK deficiency.

Pediatr Allergy Immunol 2016 06 16;27(4):428-30. Epub 2016 Mar 16.

Department of Pediatric Allergy and Clinical Immunology, Hospital Sant Joan de Déu, Universitat de Barcelona, Barcelona, Spain.

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June 2016

Association of Polymorphisms in IRAK1, IRAK4 and MyD88, and Severe Invasive Pneumococcal Disease.

Pediatr Infect Dis J 2015 Sep;34(9):1008-13

From the *Pediatrics Department, †Pediatric Intensive Care Department, Hospital Sant Joan de Déu, Universitat de Barcelona; ‡Pediatric Allergy and Clinical Immunology Department, Hospital Sant Joan de Déu, Universitat de Barcelona, Sant Joan de Déu - Clínic Immunology Functional Unit; §Immunology Department, Hospital Clínic, IDIBAPS, Universitat de Barcelona, Sant Joan de Déu - Clínic Immunology Functional Unit; and ¶Microbiology Department, Hospital Sant Joan de Déu, Universitat de Barcelona, Barcelona, Spain.

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September 2015

Jug r 2-reactive CD4(+) T cells have a dominant immune role in walnut allergy.

J Allergy Clin Immunol 2015 Oct 13;136(4):983-92.e7. Epub 2015 Mar 13.

Benaroya Research Institute at Virginia Mason, Seattle, Wash; Department of Medicine, University of Washington, Seattle, Wash. Electronic address:

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October 2015

Combined analysis of levels of serum B-cell activating factor and a proliferation-inducing ligand as predictor of disease progression in patients with chronic lymphocytic leukemia.

Leuk Lymphoma 2011 Nov 27;52(11):2064-8. Epub 2011 Jun 27.

Institute of Hematology and Oncology, Department of Hematology, University of Barcelona, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.

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November 2011

Association of an SNP with intrathymic transcription of TSHR and Graves' disease: a role for defective thymic tolerance.

Hum Mol Genet 2011 Sep 3;20(17):3415-23. Epub 2011 Jun 3.

Laboratory of Immunobiology for Research and Applications to Diagnostic, Banc de Sang i Teixits, Institut d'Investigacióen Ciències de Salut Germans Trias i Pujol, Badalona 08916, Catalonia, Spain.

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September 2011

CCL4L polymorphisms and CCL4/CCL4L serum levels are associated with psoriasis severity.

J Invest Dermatol 2011 Sep 26;131(9):1830-7. Epub 2011 May 26.

Laboratory of Immunobiology for Research and Application to Diagnosis, Tissue and Blood Bank (BST), Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol, Badalona, Barcelona, Spain.

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September 2011

Reassessing the role of HLA-DRB3 T-cell responses: evidence for significant expression and complementary antigen presentation.

Eur J Immunol 2010 Jan;40(1):91-102

Laboratory of Immunobiology Research and Applications to Diagnosis (LIRAD). Banc de Sang i Teixits, Badalona, Spain.

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January 2010

HIV transfer between CD4 T cells does not require LFA-1 binding to ICAM-1 and is governed by the interaction of HIV envelope glycoprotein with CD4.

Retrovirology 2008 Mar 31;5:32. Epub 2008 Mar 31.

Fundació irsiCaixa, Institut de Recerca en Ciències de la Salut Germans Trias i Pujol (IGTP), Hospital Germans Trias i Pujol, Universitat Autònoma de Barcelona, Badalona 08916, Barcelona, Catalonia, Spain.

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March 2008

Real-time PCR using fluorescent resonance emission transfer probes for HLA-B typing.

Hum Immunol 2006 Apr-May;67(4-5):374-85. Epub 2006 Apr 7.

Laboratory of Immunobiology Research and Applications to Diagnosis, Banc de Sang i Teixits, Barcelona, Spain.

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August 2006

Insulin alleles and autoimmune regulator (AIRE) gene expression both influence insulin expression in the thymus.

J Autoimmun 2005 Dec 24;25(4):312-8. Epub 2005 Oct 24.

Laboratory of Immunology for Research Applied to Diagnosis (LIRAD), Blood and Tissue Bank, Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol, Hospital Universitari Germans Trias i Pujol, Crtra. del Canyet s/n, 08916 Badalona, Spain.

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December 2005

Multiple products derived from two CCL4 loci: high incidence of a new polymorphism in HIV+ patients.

J Immunol 2005 May;174(9):5655-64

Laboratory of Immunobiology for Research and Application to Diagnosis, Centre for Transfusion and Tissue Bank, Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol, Barcelona, Spain.

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May 2005

Development of a new HLA-DRB real-time PCR typing method.

Hum Immunol 2005 Jan;66(1):85-91

Laboratori d'Immunobiologia per a la Recerca i Aplicacions Diagnòstiques, Serveis Sanitaris de Referència--Centre de Transfusió i Banc de Teixits, Barcelona, Spain.

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January 2005

HLA-B27 genotyping by fluorescent resonance emission transfer (FRET) probes in real-time PCR.

Hum Immunol 2004 Aug;65(8):826-38

Laboratory of Immunobiology Research and Applications to Diagnosis (LIRAD), Serveis Sanitaris de Referència-Centre de Transfusió i Banc de Teixits (SSR-CTBT), Badalona, Barcelona, Spain.

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August 2004

Frequency of antineutrophil cytoplasmic antibody in Graves' disease patients treated with methimazole.

J Clin Endocrinol Metab 2003 May;88(5):2141-6

Rheumatology Section, Hospital Universitari Germans Trias i Pujol, 08916 Badalona, Spain.

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May 2003