Manel Juan

Manel Juan

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Manel Juan

Publications by authors named "Manel Juan"

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Targeting IRAK4 disrupts inflammatory pathways and delays tumor development in chronic lymphocytic leukemia.

Leukemia 2020 Jan 13;34(1):100-114. Epub 2019 Jun 13.

Experimental Therapeutics in Lymphoid Malignancies Group, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), CIBERONC, Barcelona, Spain.

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http://dx.doi.org/10.1038/s41375-019-0507-8DOI Listing
January 2020

CART manufacturing process and reasons for academy-pharma collaboration.

Immunol Lett 2020 01 25;217:39-48. Epub 2019 Oct 25.

Servei d'Immunologia, Hospital Clínic de Barcelona (HCB), University of Barcelona (UB), Banc de Sang i Teixits (BST) - HCB Immunotherapy Platform Barcelona, Spain; IDIBAPS, University of Barcelona (UB), Banc de Sang i Teixits (BST) - HCB Immunotherapy Platform Barcelona, Spain; University of Barcelona (UB), Banc de Sang i Teixits (BST) - HCB Immunotherapy Platform Barcelona, Spain; Hospital Sant Joan de Déu, University of Barcelona (UB), Banc de Sang i Teixits (BST) - HCB Immunotherapy Platform Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.imlet.2019.10.014DOI Listing
January 2020

Toll-like receptor 3 deficiency in autoimmune encephalitis post-herpes simplex encephalitis.

Neurol Neuroimmunol Neuroinflamm 2019 Nov 5;6(6). Epub 2019 Sep 5.

From the Neuroimmunology Program (T.A., M.P.-P., J.D.), Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clínic, Universitat de Barcelona, Barcelona, Spain; Pediatric Neuroimmunology Unit (T.A.), Neurology Department, Sant Joan de Déu (SJD) Children's Hospital, University of Barcelona, Barcelona, Spain; Clinical Immunology and Primary Immunodeficiencies Unit (B.J.B., A.D.-M., L.A., A.E.-S.), Pediatric Allergy and Clinical Immunology Department, Hospital Sant Joan de Déu, Institut de Recerca Sant Joan de Déu, Universitat de Barcelona, Spain; Clinical Immunology Unit (A.V., A.E.-S., R.R.-G., M.J., L.A.), Hospital Sant Joan de Déu-Hospital Clínic Barcelona, Barcelona, Spain; Laboratory of Immunogenetics of Human Diseases (R.P.d.D.), IdiPAZ Institute for Health Research, La Paz Hospital, Madrid, Spain; Innate Immunity Group (R.P.d.D.), IdiPAZ Institute for Health Research, La Paz Hospital, Madrid, Spain; Interdepartmental Group of Immunodeficiencies (R.P.d.D.), Madrid, Spain; Neurology Department (J.D.), University of Pennsylvania, Philadelphia; and Catalan Institute for Research and Advanced Studies (ICREA) (J.D.), Barcelona, Spain.

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http://dx.doi.org/10.1212/NXI.0000000000000611DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6773430PMC
November 2019

CAR-T Cell Therapy: A Door Is Open to Find Innumerable Possibilities of Treatments for Cancer Patients

Turk J Haematol 2018 11 6;35(4):217-228. Epub 2018 Sep 6.

Institut d’Investigacions Biomèdiques August Pi i Sunyer Hospital, Clinic of Hematology, Barcelona, Spain

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http://dx.doi.org/10.4274/tjh.2018.0196DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6256819PMC
November 2018

Frequency, symptoms, risk factors, and outcomes of autoimmune encephalitis after herpes simplex encephalitis: a prospective observational study and retrospective analysis.

Lancet Neurol 2018 09 23;17(9):760-772. Epub 2018 Jul 23.

Neuroimmunology Program, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clínic, University of Barcelona, Barcelona, Spain; Service of Neurology, Hospital Clínic, University of Barcelona, Barcelona, Spain; Department of Neurology, University of Pennsylvania, PA, USA; Catalan Institution for Research and Advanced Studies (ICREA), Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1016/S1474-4422(18)30244-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6128696PMC
September 2018

Severe BCG-osis Misdiagnosed as Multidrug-Resistant Tuberculosis in an IL-12Rβ1-Deficient Peruvian Girl.

J Clin Immunol 2018 08 23;38(6):712-716. Epub 2018 Jul 23.

Functional Unit of Clinical Immunology and Primary Immunodeficiencies, Hospital Sant Joan de Déu, University of Barcelona, Pediatric Research Institute Sant Joan de Déu, Barcelona, Spain.

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http://dx.doi.org/10.1007/s10875-018-0535-6DOI Listing
August 2018

B Regulatory Cells: Players in Pregnancy and Early Life.

Int J Mol Sci 2018 Jul 19;19(7). Epub 2018 Jul 19.

Functional Unit of Clinical Immunology and Primary Immunodeficiencies, Allergy and Clinical Immunology Department, Hospital Sant Joan de Déu, University of Barcelona, Pediatric Research Institute Sant Joan de Déu, 08950 Barcelona, Spain.

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http://dx.doi.org/10.3390/ijms19072099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6073150PMC
July 2018

Sirolimus as an alternative treatment in patients with granulomatous-lymphocytic lung disease and humoral immunodeficiency with impaired regulatory T cells.

Pediatr Allergy Immunol 2018 06 17;29(4):425-432. Epub 2018 Apr 17.

Allergy and Clinical Immunology Department, Institut de Recerca Pediàtrica Hospital Sant Joan de Déu, Esplugues de Llobregat, Spain.

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http://dx.doi.org/10.1111/pai.12890DOI Listing
June 2018

Detection of inflammatory monocytes but not mesenchymal stem/stromal cells in peripheral blood of patients with myelofibrosis.

Br J Haematol 2018 04 21;181(1):133-137. Epub 2017 Feb 21.

Josep Carreras Leukaemia Research Institute, Department of Biomedicine, School of Medicine, University of Barcelona, Barcelona, Spain.

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http://dx.doi.org/10.1111/bjh.14507DOI Listing
April 2018

Evans Syndrome as First Manifestation of Primary Immunodeficiency in Clinical Practice.

J Pediatr Hematol Oncol 2017 10;39(7):490-494

Departments of *Allergy and Clinical Immunology ‡Hematology and Oncology, Hospital Sant Joan de Dèu, Institut de Recerca Pediàtrica Hospital Sant Joan de Dèu, Esplugues de Llobregat §Immunology Department, Hospital Clinic-IDIBAPS, Universitat de Barcelona †Functional Unit of Clinical Immunology SJD-Clinic, Barcelona, Spain.

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http://dx.doi.org/10.1097/MPH.0000000000000880DOI Listing
October 2017

Immunological Changes in Blood of Newborns Exposed to Anti-TNF-α during Pregnancy.

Front Immunol 2017 21;8:1123. Epub 2017 Sep 21.

Allergy and Clinical Immunology Department, Hospital Sant Joan de Déu, Institut de Recerca Pediàtrica Hospital Sant Joan de Déu, Esplugues de Llobregat, Spain.

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http://dx.doi.org/10.3389/fimmu.2017.01123DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5613099PMC
September 2017

Detailed Characterization of Mesenchymal Stem/Stromal Cells from a Large Cohort of AML Patients Demonstrates a Definitive Link to Treatment Outcomes.

Stem Cell Reports 2017 06 18;8(6):1573-1586. Epub 2017 May 18.

Josep Carreras Leukemia Research Institute, Department of Biomedicine, School of Medicine, Universitat de Barcelona, Casanova 143, Barcelona 08036, Spain; Centro de Investigación Biomédica en Red-Oncología (CIBERONC), ISCIII, Madrid 28031, Spain; Instituciò Catalana de Recerca i Estudis Avançats (ICREA), Barcelona 08010, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2017.04.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5470078PMC
June 2017

Kinetic analysis of changes in T- and B-lymphocytes after anti-CD20 treatment in renal pathology.

Immunobiology 2017 04 17;222(4):620-630. Epub 2016 Nov 17.

Immunology Service, Hospital Clínic, Universitat de Barcelona, 08036, Barcelona, Spain; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIPABS), Barcelona, Spain; Facultat de Medicina, Universitat de Barcelona, 08036, Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.imbio.2016.11.011DOI Listing
April 2017

Characterization of the Highly Prevalent Regulatory CD24CD38 B-Cell Population in Human Cord Blood.

Front Immunol 2017 7;8:201. Epub 2017 Mar 7.

Allergy and Clinical Immunology Department, Hospital Sant Joan de Déu, Institut de Recerca Pediàtrica Hospital Sant Joan de Déu, Esplugues de Llobregat, Spain; Functional Unit of Clinical Immunology, Sant Joan de Déu-Hospital Clinic, Barcelona, Spain.

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http://journal.frontiersin.org/article/10.3389/fimmu.2017.00
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http://dx.doi.org/10.3389/fimmu.2017.00201DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5339297PMC
March 2017

DNA demethylation of inflammasome-associated genes is enhanced in patients with cryopyrin-associated periodic syndromes.

J Allergy Clin Immunol 2017 01 7;139(1):202-211.e6. Epub 2016 Jul 7.

Chromatin and Disease Group, Cancer Epigenetics and Biology Programme (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2016.05.016DOI Listing
January 2017

The inflammasome pathway in stable COPD and acute exacerbations.

ERJ Open Res 2016 Jul 11;2(3). Epub 2016 Jul 11.

Fundació Clinic per a la Recerca Biomèdica, Barcelona, Spain; CIBER Respiratory Diseases (CIBERES), Barcelona, Spain; Institut Respiratori, Hospital Clinic, Barcelona, Spain; Biomedic Research Institute August Pi i Sunyer (IDIBAPS), Barcelona, Spain.

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http://dx.doi.org/10.1183/23120541.00002-2016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5034597PMC
July 2016

Clues to management of neonatally diagnosed BTK deficiency.

Pediatr Allergy Immunol 2016 06 16;27(4):428-30. Epub 2016 Mar 16.

Department of Pediatric Allergy and Clinical Immunology, Hospital Sant Joan de Déu, Universitat de Barcelona, Barcelona, Spain.

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http://dx.doi.org/10.1111/pai.12549DOI Listing
June 2016

Jug r 2-reactive CD4(+) T cells have a dominant immune role in walnut allergy.

J Allergy Clin Immunol 2015 Oct 13;136(4):983-92.e7. Epub 2015 Mar 13.

Benaroya Research Institute at Virginia Mason, Seattle, Wash; Department of Medicine, University of Washington, Seattle, Wash. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2015.01.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4568181PMC
October 2015

Association of Polymorphisms in IRAK1, IRAK4 and MyD88, and Severe Invasive Pneumococcal Disease.

Pediatr Infect Dis J 2015 Sep;34(9):1008-13

From the *Pediatrics Department, †Pediatric Intensive Care Department, Hospital Sant Joan de Déu, Universitat de Barcelona; ‡Pediatric Allergy and Clinical Immunology Department, Hospital Sant Joan de Déu, Universitat de Barcelona, Sant Joan de Déu - Clínic Immunology Functional Unit; §Immunology Department, Hospital Clínic, IDIBAPS, Universitat de Barcelona, Sant Joan de Déu - Clínic Immunology Functional Unit; and ¶Microbiology Department, Hospital Sant Joan de Déu, Universitat de Barcelona, Barcelona, Spain.

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http://dx.doi.org/10.1097/INF.0000000000000779DOI Listing
September 2015

Massively parallel sequencing reveals maternal somatic IL2RG mosaicism in an X-linked severe combined immunodeficiency family.

J Allergy Clin Immunol 2013 Sep 15;132(3):741-743.e2. Epub 2013 May 15.

Immunology Department, Hospital Clínic, IDIBAPS, Universitat de Barcelona, Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2013.03.038DOI Listing
September 2013

Combined analysis of levels of serum B-cell activating factor and a proliferation-inducing ligand as predictor of disease progression in patients with chronic lymphocytic leukemia.

Leuk Lymphoma 2011 Nov 27;52(11):2064-8. Epub 2011 Jun 27.

Institute of Hematology and Oncology, Department of Hematology, University of Barcelona, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.

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http://www.tandfonline.com/doi/full/10.3109/10428194.2011.59
Publisher Site
http://dx.doi.org/10.3109/10428194.2011.591008DOI Listing
November 2011

CCL4L polymorphisms and CCL4/CCL4L serum levels are associated with psoriasis severity.

J Invest Dermatol 2011 Sep 26;131(9):1830-7. Epub 2011 May 26.

Laboratory of Immunobiology for Research and Application to Diagnosis, Tissue and Blood Bank (BST), Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol, Badalona, Barcelona, Spain.

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http://dx.doi.org/10.1038/jid.2011.127DOI Listing
September 2011

Association of an SNP with intrathymic transcription of TSHR and Graves' disease: a role for defective thymic tolerance.

Hum Mol Genet 2011 Sep 3;20(17):3415-23. Epub 2011 Jun 3.

Laboratory of Immunobiology for Research and Applications to Diagnostic, Banc de Sang i Teixits, Institut d'Investigacióen Ciències de Salut Germans Trias i Pujol, Badalona 08916, Catalonia, Spain.

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http://dx.doi.org/10.1093/hmg/ddr247DOI Listing
September 2011

Reassessing the role of HLA-DRB3 T-cell responses: evidence for significant expression and complementary antigen presentation.

Eur J Immunol 2010 Jan;40(1):91-102

Laboratory of Immunobiology Research and Applications to Diagnosis (LIRAD). Banc de Sang i Teixits, Badalona, Spain.

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http://dx.doi.org/10.1002/eji.200939225DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2830809PMC
January 2010

HIV transfer between CD4 T cells does not require LFA-1 binding to ICAM-1 and is governed by the interaction of HIV envelope glycoprotein with CD4.

Retrovirology 2008 Mar 31;5:32. Epub 2008 Mar 31.

Fundació irsiCaixa, Institut de Recerca en Ciències de la Salut Germans Trias i Pujol (IGTP), Hospital Germans Trias i Pujol, Universitat Autònoma de Barcelona, Badalona 08916, Barcelona, Catalonia, Spain.

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http://retrovirology.biomedcentral.com/articles/10.1186/1742
Publisher Site
http://dx.doi.org/10.1186/1742-4690-5-32DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2359761PMC
March 2008

Real-time PCR using fluorescent resonance emission transfer probes for HLA-B typing.

Hum Immunol 2006 Apr-May;67(4-5):374-85. Epub 2006 Apr 7.

Laboratory of Immunobiology Research and Applications to Diagnosis, Banc de Sang i Teixits, Barcelona, Spain.

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http://dx.doi.org/10.1016/j.humimm.2006.02.038DOI Listing
August 2006

Insulin alleles and autoimmune regulator (AIRE) gene expression both influence insulin expression in the thymus.

J Autoimmun 2005 Dec 24;25(4):312-8. Epub 2005 Oct 24.

Laboratory of Immunology for Research Applied to Diagnosis (LIRAD), Blood and Tissue Bank, Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol, Hospital Universitari Germans Trias i Pujol, Crtra. del Canyet s/n, 08916 Badalona, Spain.

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http://linkinghub.elsevier.com/retrieve/pii/S089684110500104
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http://dx.doi.org/10.1016/j.jaut.2005.08.006DOI Listing
December 2005

Multiple products derived from two CCL4 loci: high incidence of a new polymorphism in HIV+ patients.

J Immunol 2005 May;174(9):5655-64

Laboratory of Immunobiology for Research and Application to Diagnosis, Centre for Transfusion and Tissue Bank, Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol, Barcelona, Spain.

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http://dx.doi.org/10.4049/jimmunol.174.9.5655DOI Listing
May 2005

Development of a new HLA-DRB real-time PCR typing method.

Hum Immunol 2005 Jan;66(1):85-91

Laboratori d'Immunobiologia per a la Recerca i Aplicacions Diagnòstiques, Serveis Sanitaris de Referència--Centre de Transfusió i Banc de Teixits, Barcelona, Spain.

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http://dx.doi.org/10.1016/j.humimm.2004.08.178DOI Listing
January 2005

HLA-B27 genotyping by fluorescent resonance emission transfer (FRET) probes in real-time PCR.

Hum Immunol 2004 Aug;65(8):826-38

Laboratory of Immunobiology Research and Applications to Diagnosis (LIRAD), Serveis Sanitaris de Referència-Centre de Transfusió i Banc de Teixits (SSR-CTBT), Badalona, Barcelona, Spain.

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http://dx.doi.org/10.1016/j.humimm.2004.05.009DOI Listing
August 2004

Chemokines determine local lymphoneogenesis and a reduction of circulating CXCR4+ T and CCR7 B and T lymphocytes in thyroid autoimmune diseases.

J Immunol 2003 Jun;170(12):6320-8

Laboratory of Immunobiology for Research and Application to Diagnosis, Center for Transfusion and Tissue Bank, Badalona, Spain.

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http://dx.doi.org/10.4049/jimmunol.170.12.6320DOI Listing
June 2003

Frequency of antineutrophil cytoplasmic antibody in Graves' disease patients treated with methimazole.

J Clin Endocrinol Metab 2003 May;88(5):2141-6

Rheumatology Section, Hospital Universitari Germans Trias i Pujol, 08916 Badalona, Spain.

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http://dx.doi.org/10.1210/jc.2002-021383DOI Listing
May 2003