Dr. Maneesh Jain, Ph.D - University of Nebraska Medical Center - Assistnat Professor

Dr. Maneesh Jain

Ph.D

University of Nebraska Medical Center

Assistnat Professor

United States

Main Specialties: Oncology

Additional Specialties: Pancreatic Cancer, Antibodies, Mucins, Cancer Diagnosis, Tumor microenvironment.

Dr. Maneesh Jain, Ph.D - University of Nebraska Medical Center - Assistnat Professor

Dr. Maneesh Jain

Ph.D

Introduction

Primary Affiliation: University of Nebraska Medical Center - United States

Specialties:

Additional Specialties:

Publications

48Publications

1417Reads

2Profile Views

1502PubMed Central Citations

Genetic variants of mucins: unexplored conundrum.

Carcinogenesis 2017 07;38(7):671-679

Department of Biochemistry and Molecular Biology.

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http://dx.doi.org/10.1093/carcin/bgw120DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5862316PMC
July 2017
18 Reads
2 Citations
5.334 Impact Factor

Polyplex-mediated inhibition of chemokine receptor CXCR4 and chromatin-remodeling enzyme NCOA3 impedes pancreatic cancer progression and metastasis.

Biomaterials 2016 09 27;101:108-120. Epub 2016 May 27.

Center for Drug Delivery and Nanomedicine, Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, NE 68198.

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http://dx.doi.org/10.1016/j.biomaterials.2016.05.042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4921319PMC
September 2016
22 Reads
5 Citations
8.560 Impact Factor

Mucins and associated glycan signatures in colon adenoma-carcinoma sequence: Prospective pathological implication(s) for early diagnosis of colon cancer.

Cancer Lett 2016 May 16;374(2):304-14. Epub 2016 Feb 16.

Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, USA; Fred and Pamela Buffett Cancer Center, Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, USA. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2016.02.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4881851PMC
May 2016
41 Reads
12 Citations
5.621 Impact Factor

Pathobiological implications of mucin glycans in cancer: Sweet poison and novel targets.

Biochim Biophys Acta 2015 Dec 28;1856(2):211-25. Epub 2015 Aug 28.

Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198-5870, USA; Fred and Pamela Buffett Cancer Center, Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198-5870, USA; Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198-5870, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbcan.2015.08.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4663118PMC
December 2015
97 Reads
8 Citations

Genetically engineered mucin mouse models for inflammation and cancer.

Cancer Metastasis Rev 2015 Dec;34(4):593-609

Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, 68198-5870, USA.

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http://dx.doi.org/10.1007/s10555-015-9549-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4520780PMC
December 2015
4 Reads
4 Citations
7.234 Impact Factor

Mucin expression in endoscopic ultrasound-guided fine-needle aspiration specimens is a useful prognostic factor in pancreatic ductal adenocarcinoma.

Pancreas 2015 Jul;44(5):728-34

From the *Department of Human Pathology, Field of Oncology, Kagoshima University Graduate School of Medical and Dental Sciences; †National Sanatorium Hoshizuka-Keiaien, Kanoya; ‡Department of Digestive and Lifestyle Diseases, §Department of Radiology, ∥Department of Epidemiology and Preventive Medicine, ¶Department of Digestive Surgery, Breast and Thyroid Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan; and #Department of Biochemistry and Molecular Biology, Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE.

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http://dx.doi.org/10.1097/MPA.0000000000000362DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4464972PMC
July 2015
31 Reads
9 Citations
2.960 Impact Factor

Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver.

Nat Cell Biol 2015 Jun 18;17(6):816-26. Epub 2015 May 18.

1] Children's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medical College, New York, New York 10021, USA [2] Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.

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http://dx.doi.org/10.1038/ncb3169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5769922PMC
June 2015
140 Reads
322 Citations
19.680 Impact Factor

MicroRNAs (miRNAs) as biomarker(s) for prognosis and diagnosis of gastrointestinal (GI) cancers.

Curr Pharm Des 2014 ;20(33):5287-97

Department of Biochemistry and Molecular Biology, Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska, 68198-5870, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4113605PMC
http://dx.doi.org/10.2174/1381612820666140128213117DOI Listing
May 2015
63 Reads
18 Citations
3.452 Impact Factor

Antibody labeling with radioiodine and radiometals.

Methods Mol Biol 2014 ;1141:147-57

Department of Biochemistry and Molecular Biology, College of Medicine, University of Nebraska Medical Center, Omaha, NE, USA.

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http://dx.doi.org/10.1007/978-1-4939-0363-4_9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4095879PMC
May 2015
9 Reads

Emerging potential of natural products for targeting mucins for therapy against inflammation and cancer.

Cancer Treat Rev 2015 Mar 14;41(3):277-88. Epub 2015 Jan 14.

Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198, USA; Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE 68198, USA; Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ctrv.2015.01.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4469994PMC
March 2015
20 Reads
6 Citations
7.590 Impact Factor

Nano-immunoassay with improved performance for detection of cancer biomarkers.

Nanomedicine 2015 Jan 6;11(1):167-73. Epub 2014 Sep 6.

Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, NE, USA. Electronic address:

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http://dx.doi.org/10.1016/j.nano.2014.08.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4280309PMC
January 2015
8 Reads
5 Citations
6.160 Impact Factor

Mucins in lung cancer: diagnostic, prognostic, and therapeutic implications.

J Thorac Oncol 2015 Jan;10(1):19-27

*Department of Biochemistry and Molecular Biology, †Department of Pathology and Microbiology, ‡Eppley Institute for Research in Cancer and Allied Diseases, §Department of Internal Medicine, VA Nebraska-Western Iowa Health Care System, Omaha, Nebraska, and ‖Division of Oncology-Hematology, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska.

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http://dx.doi.org/10.1097/JTO.0000000000000404DOI Listing
January 2015
45 Reads
15 Citations
5.282 Impact Factor

Guggulsterone decreases proliferation and metastatic behavior of pancreatic cancer cells by modulating JAK/STAT and Src/FAK signaling.

Cancer Lett 2013 Dec 3;341(2):166-77. Epub 2013 Aug 3.

Department of Biochemistry and Molecular Biology, Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198-5870, USA.

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http://dx.doi.org/10.1016/j.canlet.2013.07.037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3825785PMC
December 2013
22 Reads
21 Citations
5.621 Impact Factor

Emerging trends for radioimmunotherapy in solid tumors.

Cancer Biother Radiopharm 2013 Nov 11;28(9):639-50. Epub 2013 Jul 11.

1 Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center , Omaha, Nebraska.

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http://dx.doi.org/10.1089/cbr.2013.1523DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3793648PMC
November 2013
5 Reads
7 Citations
1.381 Impact Factor

Analysis of tumor-associated mucin glycotopes by Western transfer methods.

Methods Mol Biol 2013 ;980:331-40

Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, USA.

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http://dx.doi.org/10.1007/978-1-62703-287-2_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3645295PMC
July 2013
5 Reads
1 Citation

Potentials of plasma NGAL and MIC-1 as biomarker(s) in the diagnosis of lethal pancreatic cancer.

PLoS One 2013 1;8(2):e55171. Epub 2013 Feb 1.

Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, Nebraska, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0055171PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3562325PMC
July 2013
13 Reads
16 Citations
3.234 Impact Factor

Pathobiological implications of MUC4 in non-small-cell lung cancer.

J Thorac Oncol 2013 Apr;8(4):398-407

Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, USA.

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http://dx.doi.org/10.1097/JTO.0b013e3182829e06DOI Listing
April 2013
33 Reads
11 Citations
5.282 Impact Factor

MUC4 potentiates invasion and metastasis of pancreatic cancer cells through stabilization of fibroblast growth factor receptor 1.

Carcinogenesis 2012 Oct 12;33(10):1953-64. Epub 2012 Jul 12.

Department of Biochemistry and Molecular Biology, University of Nebraska MedicalCenter, Omaha, NE 68198-5870, USA.

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https://academic.oup.com/carcin/article-lookup/doi/10.1093/c
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http://dx.doi.org/10.1093/carcin/bgs225DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3529557PMC
October 2012
18 Reads
25 Citations
5.334 Impact Factor

Early diagnosis of pancreatic cancer: challenges and new developments.

Biomark Med 2012 Oct;6(5):597-612

Department of Biochemistry & Molecular Biology, University of Nebraska Medical Center, Omaha, NE, USA.

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http://dx.doi.org/10.2217/bmm.12.69DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3546485PMC
October 2012
5 Reads
39 Citations
2.860 Impact Factor

Recent trends in antibody-based oncologic imaging.

Cancer Lett 2012 Feb 20;315(2):97-111. Epub 2011 Oct 20.

Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198, USA.

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http://dx.doi.org/10.1016/j.canlet.2011.10.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3249014PMC
February 2012
5 Reads
32 Citations
5.621 Impact Factor

Targeting the EGFR signaling pathway in cancer therapy.

Expert Opin Ther Targets 2012 Jan 12;16(1):15-31. Epub 2012 Jan 12.

University of Nebraska Medical Center, Department of Biochemistry and Molecular Biology, Omaha, NE 68198-5870, USA.

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http://dx.doi.org/10.1517/14728222.2011.648617DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3291787PMC
January 2012
9 Reads
105 Citations
5.140 Impact Factor

Monoclonal antibodies recognizing the non-tandem repeat regions of the human mucin MUC4 in pancreatic cancer.

PLoS One 2011 23;6(8):e23344. Epub 2011 Aug 23.

Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, Nebraska, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0023344PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3160300PMC
January 2012
12 Reads
6 Citations
3.234 Impact Factor

Mucins in the pathogenesis of breast cancer: implications in diagnosis, prognosis and therapy.

Biochim Biophys Acta 2011 Apr 26;1815(2):224-40. Epub 2011 Jan 26.

Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198, USA.

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http://dx.doi.org/10.1016/j.bbcan.2011.01.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3230300PMC
April 2011
17 Reads
31 Citations

Upregulation of MUC4 in cervical squamous cell carcinoma: pathologic significance.

Int J Gynecol Pathol 2009 Mar;28(2):127-33

Vincent Center for Reproductive Biology, Vincent Obstetrics and Gynecology Service, Massachusetts General Hospital, Boston, MA, USA.

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http://dx.doi.org/10.1097/PGP.0b013e318184f3e0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2932462PMC
March 2009
22 Reads
9 Citations
1.631 Impact Factor

Clinical potential of mucins in diagnosis, prognosis, and therapy of ovarian cancer.

Lancet Oncol 2008 Nov;9(11):1076-85

Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, Nebraska, USA.

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http://dx.doi.org/10.1016/S1470-2045(08)70277-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5600479PMC
November 2008
6 Reads
27 Citations
24.690 Impact Factor

MUC4 as a diagnostic marker in cancer.

Expert Opin Med Diagn 2008 Aug;2(8):891-910

University of Nebraska Medical Center, Eppley Institute for Research in Cancer, Department of Biochemistry and Molecular Biology, 984525 Nebraska Medical Center, Omaha, NE 68198-5870, USA +1 402 559 5455 ; +1 402 559 6650 ;

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http://dx.doi.org/10.1517/17530059.2.8.891DOI Listing
August 2008
24 Reads
5 Citations

A physiologically based pharmacokinetic (PBPK) model to characterize and predict the disposition of monoclonal antibody CC49 and its single chain Fv constructs.

Int Immunopharmacol 2008 Mar 26;8(3):401-13. Epub 2007 Nov 26.

Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, 986025 Nebraska Medical Center, Omaha, NE 68198-6025, USA.

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http://dx.doi.org/10.1016/j.intimp.2007.10.023DOI Listing
March 2008
9 Reads
19 Citations
2.472 Impact Factor

Engineering antibodies for clinical applications.

Trends Biotechnol 2007 Jul 21;25(7):307-16. Epub 2007 May 21.

Department of Biochemistry and Molecular Biology, Department of Pathology and Microbiology, Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198-5870, USA.

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http://dx.doi.org/10.1016/j.tibtech.2007.05.001DOI Listing
July 2007
16 Reads
22 Citations
11.960 Impact Factor

Cell-penetrating peptides and antibodies: a new direction for optimizing radioimmunotherapy.

Eur J Nucl Med Mol Imaging 2007 Jul;34(7):973-7

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http://dx.doi.org/10.1007/s00259-007-0395-4DOI Listing
July 2007
9 Reads
2 Citations
5.383 Impact Factor

Expression of TAG-72 in ovarian cancer and its correlation with tumor stage and patient prognosis.

Cancer Lett 2007 Jun 8;251(2):247-57. Epub 2007 Jan 8.

Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198-5870, USA.

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http://dx.doi.org/10.1016/j.canlet.2006.11.025DOI Listing
June 2007
23 Reads
10 Citations
5.621 Impact Factor

Optimization of radioimmunotherapy of solid tumors: biological impediments and their modulation.

Clin Cancer Res 2007 Mar 19;13(5):1374-82. Epub 2007 Feb 19.

Department of Biochemistry and Molecular Biology, Department of Pathology and Microbiology, Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska 68198-5870, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-06-2436DOI Listing
March 2007
7 Reads
17 Citations
8.722 Impact Factor

Aberrant expression of MUC4 in ovarian carcinoma: diagnostic significance alone and in combination with MUC1 and MUC16 (CA125).

Mod Pathol 2006 Oct 28;19(10):1386-94. Epub 2006 Jul 28.

Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198-5870, USA.

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http://dx.doi.org/10.1038/modpathol.3800646DOI Listing
October 2006
16 Reads
52 Citations
6.190 Impact Factor

Penetratin improves tumor retention of single-chain antibodies: a novel step toward optimization of radioimmunotherapy of solid tumors.

Cancer Res 2005 Sep;65(17):7840-6

Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, Nebraska 68198-5870, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-05-0662DOI Listing
September 2005
11 Reads
16 Citations
9.330 Impact Factor

Engineering and characterization of a divalent single-chain Fv angiotensin II fusion construct of the monoclonal antibody CC49.

Biochem Biophys Res Commun 2005 Apr;329(1):168-76

Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198, USA.

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http://dx.doi.org/10.1016/j.bbrc.2005.01.101DOI Listing
April 2005
14 Reads
2 Citations
2.300 Impact Factor

Pharmacokinetics and biodistribution of 177Lu-labeled multivalent single-chain Fv construct of the pancarcinoma monoclonal antibody CC49.

Eur J Nucl Med Mol Imaging 2005 Mar 2;32(3):264-73. Epub 2004 Oct 2.

Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, 68198, USA.

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http://link.springer.com/10.1007/s00259-004-1664-0
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http://dx.doi.org/10.1007/s00259-004-1664-0DOI Listing
March 2005
16 Reads
5 Citations
5.383 Impact Factor

The in vivo characteristics of genetically engineered divalent and tetravalent single-chain antibody constructs.

Nucl Med Biol 2005 Feb;32(2):157-64

Department of Biochemistry and Molecular Biology, Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198, USA.

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http://dx.doi.org/10.1016/j.nucmedbio.2004.11.003DOI Listing
February 2005
18 Reads
7 Citations
2.412 Impact Factor

Generation and characterization of anti-MUC4 monoclonal antibodies reactive with normal and cancer cells in humans.

J Histochem Cytochem 2004 Feb;52(2):253-61

Department of Biochemistry and Molecular Biology and Eppley Institute for Research in Cancer and Allied Disease, University of Nebraska Medical Center, Omaha, Nebraska 68198-4525, USA.

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http://dx.doi.org/10.1177/002215540405200213DOI Listing
February 2004
92 Reads
44 Citations
1.960 Impact Factor

Genetically engineered antibody fragments and PET imaging: a new era of radioimmunodiagnosis.

J Nucl Med 2003 Dec;44(12):1970-2

University of Nebraska Medical Center, Omaha, Nebraska 68198, USA.

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December 2003
1 Read
1 Citation
6.160 Impact Factor

Pharmacokinetics and biodistribution of genetically engineered antibodies.

Curr Opin Biotechnol 2002 Dec;13(6):603-8

Department of Biochemistry and Molecular Biology, Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA.

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http://dx.doi.org/10.1016/s0958-1669(02)00352-xDOI Listing
December 2002
12 Reads
29 Citations
7.120 Impact Factor

Top co-authors

Surinder K Batra
Surinder K Batra

University of Nebraska Medical Center

45
Sukhwinder Kaur
Sukhwinder Kaur

University of Nebraska Medical Center

16
Moorthy P Ponnusamy
Moorthy P Ponnusamy

University of Nebraska Medical Center

13
Satyanarayana Rachagani
Satyanarayana Rachagani

University of Nebraska Medical Center

8
Subhash C Chauhan
Subhash C Chauhan

University of Tennessee Health Science Center

7
Lynette M Smith
Lynette M Smith

University of Nebraska Medical Center

7
Muzafar A Macha
Muzafar A Macha

All India Institute of Medical Sciences

6
Sonny L Johansson
Sonny L Johansson

University of Nebraska Medical Center

6
Subhankar Chakraborty
Subhankar Chakraborty

University of Nebraska Medical Center

6
Sushil Kumar
Sushil Kumar

ICGEB

5