Publications by authors named "Mandy Lawson"

12Publications

Discovery of AZD9833, a Potent and Orally Bioavailable Selective Estrogen Receptor Degrader and Antagonist.

Authors:
James S Scott Thomas A Moss Amber Balazs Bernard Barlaam Jason Breed Rodrigo J Carbajo Elisabetta Chiarparin Paul R J Davey Oona Delpuech Stephen Fawell David I Fisher Sladjana Gagrica Eric T Gangl Tyler Grebe Ryan D Greenwood Sudhir Hande Holia Hatoum-Mokdad Kara Herlihy Samantha Hughes Thomas A Hunt Hoan Huynh Sophie L M Janbon Tony Johnson Stefan Kavanagh Teresa Klinowska Mandy Lawson Andrew S Lister Stacey Marden Dermot F McGinnity Christopher J Morrow J Willem M Nissink Daniel H O'Donovan Bo Peng Radoslaw Polanski Darren S Stead Stephen Stokes Kumar Thakur Scott R Throner Michael J Tucker Jeffrey Varnes Haixia Wang David M Wilson Dedong Wu Ye Wu Bin Yang Wenzhan Yang

J Med Chem 2020 12 29;63(23):14530-14559. Epub 2020 Sep 29.

Advanced Drug Delivery, Pharmaceutical Sciences, R&D, Boston, Massachusetts, United States.

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December 2020

Tricyclic Indazoles-A Novel Class of Selective Estrogen Receptor Degrader Antagonists.

Authors:
James S Scott Andrew Bailey David Buttar Rodrigo J Carbajo Jon Curwen Paul R J Davey Robert D M Davies Sébastien L Degorce Craig Donald Eric Gangl Ryan Greenwood Sam D Groombridge Tony Johnson Scott Lamont Mandy Lawson Andrew Lister Christopher J Morrow Thomas A Moss Jennifer H Pink Radoslaw Polanski

J Med Chem 2019 02 30;62(3):1593-1608. Epub 2019 Jan 30.

Oncology IMED Biotech Unit , AstraZeneca, R&D Boston , 35 Gatehouse Drive , Waltham , Massachusetts 02451 , United States.

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February 2019

Combined Inhibition of mTOR and CDK4/6 Is Required for Optimal Blockade of E2F Function and Long-term Growth Inhibition in Estrogen Receptor-positive Breast Cancer.

Authors:
Chrysiis Michaloglou Claire Crafter Rasmus Siersbaek Oona Delpuech Jon O Curwen Larissa S Carnevalli Anna D Staniszewska Urszula M Polanska Azadeh Cheraghchi-Bashi Mandy Lawson Igor Chernukhin Robert McEwen Jason S Carroll Sabina C Cosulich

Mol Cancer Ther 2018 05 26;17(5):908-920. Epub 2018 Feb 26.

Bioscience, Oncology, IMED Biotech Unit, AstraZeneca, Cambridge United Kingdom.

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May 2018

Activating Mutations Differentially Affect the Efficacy of ER Antagonists.

Authors:
Weiyi Toy Hazel Weir Pedram Razavi Mandy Lawson Anne U Goeppert Anne Marie Mazzola Aaron Smith Joanne Wilson Christopher Morrow Wai Lin Wong Elisa De Stanchina Kathryn E Carlson Teresa S Martin Sharmeen Uddin Zhiqiang Li Sean Fanning John A Katzenellenbogen Geoffrey Greene José Baselga Sarat Chandarlapaty

Cancer Discov 2017 03 16;7(3):277-287. Epub 2016 Dec 16.

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.

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March 2017

AZD9496: An Oral Estrogen Receptor Inhibitor That Blocks the Growth of ER-Positive and ESR1-Mutant Breast Tumors in Preclinical Models.

Authors:
Hazel M Weir Robert H Bradbury Mandy Lawson Alfred A Rabow David Buttar Rowena J Callis Jon O Curwen Camila de Almeida Peter Ballard Michael Hulse Craig S Donald Lyman J L Feron Galith Karoutchi Philip MacFaul Thomas Moss Richard A Norman Stuart E Pearson Michael Tonge Gareth Davies Graeme E Walker Zena Wilson Rachel Rowlinson Steve Powell Claire Sadler Graham Richmond Brendon Ladd Ermira Pazolli Anne Marie Mazzola Celina D'Cruz Chris De Savi

Cancer Res 2016 06 28;76(11):3307-18. Epub 2016 Mar 28.

Oncology iMed, AstraZeneca R&D Boston, Gatehouse Drive, Waltham, Massachusetts.

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June 2016

Inhibition of PI3Kβ signaling with AZD8186 inhibits growth of PTEN-deficient breast and prostate tumors alone and in combination with docetaxel.

Authors:
Urs Hancox Sabina Cosulich Lyndsey Hanson Cath Trigwell Carol Lenaghan Rebecca Ellston Hannah Dry Claire Crafter Bernard Barlaam Martina Fitzek Paul D Smith Donald Ogilvie Celina D'Cruz Lillian Castriotta Stephen R Wedge Lara Ward Steve Powell Mandy Lawson Barry R Davies Elizabeth A Harrington Emily Foster Marie Cumberbatch Stephen Green Simon T Barry

Mol Cancer Ther 2015 Jan 14;14(1):48-58. Epub 2014 Nov 14.

Oncology Innovative Medicines, AstraZeneca, Alderley Park, Macclesfield, Cheshire, United Kingdom.

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January 2015

Discovery of AZD3199, An Inhaled Ultralong Acting β2 Receptor Agonist with Rapid Onset of Action.

Authors:
Michael J Stocks Lilian Alcaraz Andrew Bailey Roger Bonnert Elaine Cadogan Jadeen Christie John Dixon Stephen Connolly Anthony Cook Adrian Fisher Alice Flaherty Alexander Humphries Anthony Ingall Stephen Jordan Mandy Lawson Alex Mullen David Nicholls Stuart Paine Garry Pairaudeau Alan Young

ACS Med Chem Lett 2014 Apr 8;5(4):416-21. Epub 2014 Feb 8.

Department of Medicinal Chemistry, Department of Bioscience, and Department of Physical and Metabolic Sciences, AstraZeneca R&D Charnwood , Bakewell Road, Loughborough, Leicestershire LE11 5RH, U.K.

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April 2014

From libraries to candidate: the discovery of new ultra long-acting dibasic β₂-adrenoceptor agonists.

Authors:
Lilian Alcaraz Andrew Bailey Elaine Cadogan Stephen Connolly Robert Jewell Stephen Jordan Nicholas Kindon Andrew Lister Mandy Lawson Alexander Mullen Ian Dainty David Nicholls Stuart Paine Garry Pairaudeau Michael J Stocks Phillip Thorne Alan Young

Bioorg Med Chem Lett 2012 Jan 20;22(1):689-95. Epub 2011 Oct 20.

Department of Medicinal Chemistry, AstraZeneca R&D Charnwood, Bakewell Road, Loughborough, Leicestershire LE11 5RH, UK.

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January 2012

Design driven HtL: The discovery and synthesis of new high efficacy β₂-agonists.

Authors:
Michael J Stocks Lilian Alcaraz Andrew Bailey Roger Bonnert Elaine Cadogan Jadeen Christie Stephen Connolly Anthony Cook Adrian Fisher Alice Flaherty Stephen Hill Alexander Humphries Anthony Ingall Stephen Jordan Mandy Lawson Alex Mullen David Nicholls Stuart Paine Garry Pairaudeau Stephen St-Gallay Alan Young

Bioorg Med Chem Lett 2011 Jul 20;21(13):4027-31. Epub 2011 May 20.

Department of Medicinal Chemistry, AstraZeneca R&D Charnwood, Bakewell Road, Loughborough, Leicestershire LE11 5RH, UK.

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July 2011

Agonist-specific patterns of beta 2-adrenoceptor responses in human airway cells during prolonged exposure.

Authors:
Caroline Düringer Gunilla Grundström Eylem Gürcan Ian A Dainty Mandy Lawson Solange H Korn Anders Jerre Hanna Falk Håkansson Elisabet Wieslander Karin Fredriksson Carl Magnus Sköld Magnus Löfdahl Claes-Göran Löfdahl David J Nicholls David S Silberstein

Br J Pharmacol 2009 Sep 22;158(1):169-79. Epub 2009 Jun 22.

Astra Zeneca Research & Development, Lund, Sweden.

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September 2009

Discovery of potent and selective adamantane-based small-molecule P2X(7) receptor antagonists/interleukin-1beta inhibitors.

Authors:
Mark Furber Lilian Alcaraz Janice E Bent Armin Beyerbach Keith Bowers Martin Braddock Moya V Caffrey David Cladingboel John Collington David K Donald Malbinder Fagura Frank Ince Elizabeth C Kinchin Celine Laurent Mandy Lawson Timothy J Luker Michael M P Mortimore Austen D Pimm Robert J Riley Nicola Roberts Mark Robertson Jill Theaker Philip V Thorne Richard Weaver Peter Webborn Paul Willis

J Med Chem 2007 Nov 27;50(24):5882-5. Epub 2007 Oct 27.

Department of Medicinal Chemistry, AstraZeneca R&D Charnwood, Bakewell Road, Loughborough, Leics, U.K.

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November 2007

Hit-to-Lead studies: the discovery of potent adamantane amide P2X7 receptor antagonists.

Authors:
Andrew Baxter Janice Bent Keith Bowers Martin Braddock Steve Brough Malbinder Fagura Mandy Lawson Tom McInally Mike Mortimore Mark Robertson Richard Weaver Peter Webborn

Bioorg Med Chem Lett 2003 Nov;13(22):4047-50

AstraZeneca R&D Charnwood, Bakewell Road, Loughborough LE11 5RH, UK.

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November 2003