Publications by authors named "Mandeep Takhar"

40Publications

High-fat diet fuels prostate cancer progression by rewiring the metabolome and amplifying the MYC program.

Authors:
David P Labbé Giorgia Zadra Meng Yang Jaime M Reyes Charles Y Lin Stefano Cacciatore Ericka M Ebot Amanda L Creech Francesca Giunchi Michelangelo Fiorentino Habiba Elfandy Sudeepa Syamala Edward D Karoly Mohammed Alshalalfa Nicholas Erho Ashley Ross Edward M Schaeffer Ewan A Gibb Mandeep Takhar Robert B Den Jonathan Lehrer R Jeffrey Karnes Stephen J Freedland Elai Davicioni Daniel E Spratt Leigh Ellis Jacob D Jaffe Anthony V DʼAmico Philip W Kantoff James E Bradner Lorelei A Mucci Jorge E Chavarro Massimo Loda Myles Brown

Nat Commun 2019 09 25;10(1):4358. Epub 2019 Sep 25.

Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.

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September 2019

Discovery and preclinical evaluation of anti-miR-17 oligonucleotide RGLS4326 for the treatment of polycystic kidney disease.

Authors:
Edmund C Lee Tania Valencia Charles Allerson Annelie Schairer Andrea Flaten Matanel Yheskel Kara Kersjes Jian Li Sole Gatto Mandeep Takhar Steven Lockton Adam Pavlicek Michael Kim Tiffany Chu Randy Soriano Scott Davis John R Androsavich Salma Sarwary Tate Owen Julia Kaplan Kai Liu Graham Jang Steven Neben Philip Bentley Timothy Wright Vishal Patel

Nat Commun 2019 09 12;10(1):4148. Epub 2019 Sep 12.

Department of Internal Medicine and Division of Nephrology, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.

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September 2019

Development of a predictive model for stromal content in prostate cancer samples to improve signature performance.

Authors:
Nadia Boufaied Mandeep Takhar Claire Nash Nicholas Erho Tarek A Bismar Elai Davicioni Axel A Thomson

J Pathol 2019 12 16;249(4):411-424. Epub 2019 Oct 16.

Division of Urology and Cancer Research Program, McGill University Health Centre Research Institute, Quebec, Canada.

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December 2019

Biologic Significance of Magnetic Resonance Imaging Invisibility in Localized Prostate Cancer.

Authors:
Simpa S Salami Jeremy B Kaplan Srinivas Nallandhighal Mandeep Takhar Jeffrey J Tosoian Matthew Lee Junhee Yoon Daniel H Hovelson Komal R Plouffe Samuel D Kaffenberger Edward M Schaeffer R Jeffrey Karnes Tamara L Lotan Todd M Morgan Arvin K George Jeffrey S Montgomery Matthew S Davenport Sungyong You Scott A Tomlins Nicole E Curci Hyung L Kim Daniel E Spratt Aaron M Udager Ganesh S Palapattu

JCO Precis Oncol 2019 12;3. Epub 2019 Jun 12.

Michigan Medicine, Ann Arbor, MI.

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June 2019

Characterization of transcriptomic signature of primary prostate cancer analogous to prostatic small cell neuroendocrine carcinoma.

Authors:
Mohammed Alshalalfa Yang Liu Alexander W Wyatt Ewan A Gibb Harrison K Tsai Nicholas Erho Jonathan Lehrer Mandeep Takhar Varune R Ramnarine Colin C Collins Robert B Den Edward M Schaeffer Elai Davicioni Tamara L Lotan Tarek A Bismar

Int J Cancer 2019 12 10;145(12):3453-3461. Epub 2019 Jun 10.

Department of Pathology & Laboratory Medicine, Arnie Charbonneau Cancer Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.

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December 2019

African American Specific Gene Panel Predictive of Poor Prostate Cancer Outcome.

Authors:
Michelle I Echevarria Shivanshu Awasthi Chia-Ho Cheng Anders E Berglund Robert J Rounbehler Travis A Gerke Mandeep Takhar Elai Davicioni Eric A Klein Stephen J Freedland Ashley E Ross Edward M Schaeffer Robert B Den John L Cleveland Jong Y Park Walter Rayford Kosj Yamoah

J Urol 2019 08 8;202(2):247-255. Epub 2019 Jul 8.

H. Lee Moffitt Cancer Center and Research Institute , Tampa , Florida.

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August 2019

Impact of the SPOP Mutant Subtype on the Interpretation of Clinical Parameters in Prostate Cancer.

Authors:
Deli Liu Mandeep Takhar Mohammed Alshalalfa Nicholas Erho Jonathan Shoag Robert B Jenkins R Jeffrey Karnes Ashley E Ross Edward M Schaeffer Mark A Rubin Bruce Trock Eric A Klein Robert B Den Scott A Tomlins Daniel E Spratt Elai Davicioni Andrea Sboner Christopher E Barbieri

JCO Precis Oncol 2018 24;2018. Epub 2018 Jul 24.

Weill Cornell Medicine, NewYork-Presbyterian Hospital, New York, NY.

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July 2018

Multiparametric Magnetic Resonance Imaging Features Identify Aggressive Prostate Cancer at the Phenotypic and Transcriptomic Level.

Authors:
Alp Tuna Beksac Shivaram Cumarasamy Ugo Falagario Paige Xu Mandeep Takhar Mohamed Alshalalfa Akriti Gupta Sonya Prasad Alberto Martini Hari Thulasidass Richa Rai Mark Berger Stefanie Hectors Jennifer Jordan Elai Davicioni Sujit Nair Kenneth Haines Sara Lewis Ardeshir Rastinehad Kamlesh Yadav Isuru Jayaratna Bachir Taouli Ashutosh Tewari

J Urol 2018 12 3;200(6):1241-1249. Epub 2018 Jul 3.

Department of Urology, Icahn School of Medicine at Mount Sinai, New York, New York. Electronic address:

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December 2018

Distinct transcriptional repertoire of the androgen receptor in ETS fusion-negative prostate cancer.

Authors:
Anders E Berglund Robert J Rounbehler Travis Gerke Shivanshu Awasthi Chia-Ho Cheng Mandeep Takhar Elai Davicioni Mohammed Alshalalfa Nicholas Erho Eric A Klein Stephen J Freedland Ashley E Ross Edward M Schaeffer Bruce J Trock Robert B Den John L Cleveland Jong Y Park Jasreman Dhillon Kosj Yamoah

Prostate Cancer Prostatic Dis 2019 05 26;22(2):292-302. Epub 2018 Oct 26.

Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA.

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May 2019

Divergent Biological Response to Neoadjuvant Chemotherapy in Muscle-invasive Bladder Cancer.

Authors:
Roland Seiler Ewan A Gibb Natalie Q Wang Htoo Zarni Oo Hung-Ming Lam Kim E van Kessel Charlotte S Voskuilen Brian Winters Nicholas Erho Mandeep M Takhar James Douglas Funda Vakar-Lopez Simon J Crabb Bas W G van Rhijn Elisabeth E Fransen van de Putte Ellen C Zwarthoff George N Thalmann Elai Davicioni Joost L Boormans Marc Dall'Era Michiel S van der Heijden Jonathan L Wright Peter C Black

Clin Cancer Res 2019 08 17;25(16):5082-5093. Epub 2018 Sep 17.

Department of Urologic Sciences, University of British Columbia, Vancouver, British Columbia, Canada.

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August 2019

Tristetraprolin Is a Prognostic Biomarker for Poor Outcomes among Patients with Low-Grade Prostate Cancer.

Authors:
Robert J Rounbehler Anders E Berglund Travis Gerke Mandeep M Takhar Shivanshu Awasthi Weimin Li Elai Davicioni Nicholas G Erho Ashley E Ross Edward M Schaeffer Eric A Klein R Jeffrey Karnes Robert B Jenkins John L Cleveland Jong Y Park Kosj Yamoah

Cancer Epidemiol Biomarkers Prev 2018 11 14;27(11):1376-1383. Epub 2018 Aug 14.

Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida.

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November 2018

Development and Validation of a Prostate Cancer Genomic Signature that Predicts Early ADT Treatment Response Following Radical Prostatectomy.

Authors:
R Jeffrey Karnes Vidit Sharma Voleak Choeurng Hussam Al-Deen Ashab Nicholas Erho Mohammed Alshalalfa Bruce Trock Ashley Ross Kasra Yousefi Harrison Tsai Shuang G Zhao Jeffrey J Tosoian Zaid Haddad Mandeep Takhar S Laura Chang Daniel E Spratt Firas Abdollah Robert B Jenkins Eric A Klein Paul L Nguyen Adam P Dicker Robert B Den Elai Davicioni Felix Y Feng Tamara L Lotan Edward M Schaeffer

Clin Cancer Res 2018 08 14;24(16):3908-3916. Epub 2018 May 14.

Department of Urology, Feinberg School of Medicine, Northwestern University, Evanston, Illinois.

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August 2018

The long noncoding RNA landscape of neuroendocrine prostate cancer and its clinical implications.

Authors:
Varune Rohan Ramnarine Mohammed Alshalalfa Fan Mo Noushin Nabavi Nicholas Erho Mandeep Takhar Robert Shukin Sonal Brahmbhatt Alexander Gawronski Maxim Kobelev Mannan Nouri Dong Lin Harrison Tsai Tamara L Lotan R Jefferey Karnes Mark A Rubin Amina Zoubeidi Martin E Gleave Cenk Sahinalp Alexander W Wyatt Stanislav V Volik Himisha Beltran Elai Davicioni Yuzhuo Wang Colin C Collins

Gigascience 2018 06;7(6)

Vancouver Prostate Centre & Department of Urologic Sciences, University of British Columbia, Vancouver, BC, Canada.

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June 2018

Development and Validation of a 28-gene Hypoxia-related Prognostic Signature for Localized Prostate Cancer.

Authors:
Lingjian Yang Darren Roberts Mandeep Takhar Nicholas Erho Becky A S Bibby Niluja Thiruthaneeswaran Vinayak Bhandari Wei-Chen Cheng Syed Haider Amy M B McCorry Darragh McArt Suneil Jain Mohammed Alshalalfa Ashley Ross Edward Schaffer Robert B Den R Jeffrey Karnes Eric Klein Peter J Hoskin Stephen J Freedland Alastair D Lamb David E Neal Francesca M Buffa Robert G Bristow Paul C Boutros Elai Davicioni Ananya Choudhury Catharine M L West

EBioMedicine 2018 May 23;31:182-189. Epub 2018 Apr 23.

Translational Radiobiology Group, Division of Cancer Sciences, University of Manchester, Manchester Academic Health Science Centre, Christie Hospital, Manchester M20 4BX, UK; NIHR Manchester Biomedical Research Centre, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, UK. Electronic address:

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May 2018

Validation of a 10-gene molecular signature for predicting biochemical recurrence and clinical metastasis in localized prostate cancer.

Authors:
Hatem Abou-Ouf Mohammed Alshalalfa Mandeep Takhar Nicholas Erho Bryan Donnelly Elai Davicioni R Jeffrey Karnes Tarek A Bismar

J Cancer Res Clin Oncol 2018 May 6;144(5):883-891. Epub 2018 Mar 6.

Department of Pathology and Laboratory Medicine, University of Calgary, Cumming School of Medicine, Calgary, AB, Canada.

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May 2018

LSD1-Mediated Epigenetic Reprogramming Drives CENPE Expression and Prostate Cancer Progression.

Authors:
Yi Liang Musaddeque Ahmed Haiyang Guo Fraser Soares Junjie T Hua Shuai Gao Catherine Lu Christine Poon Wanting Han Jens Langstein Muhammad B Ekram Brian Li Elai Davicioni Mandeep Takhar Nicholas Erho R Jeffrey Karnes Dianne Chadwick Theodorus van der Kwast Paul C Boutros Cheryl H Arrowsmith Felix Y Feng Anthony M Joshua Amina Zoubeidi Changmeng Cai Housheng H He

Cancer Res 2017 10 15;77(20):5479-5490. Epub 2017 Sep 15.

Princess Margaret Cancer Centre/University Health Network, Toronto, Ontario, Canada.

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October 2017

Transcriptome Wide Analysis of Magnetic Resonance Imaging-targeted Biopsy and Matching Surgical Specimens from High-risk Prostate Cancer Patients Treated with Radical Prostatectomy: The Target Must Be Hit.

Authors:
Jan Philipp Radtke Mandeep Takhar David Bonekamp Claudia Kesch Nicholas Erho Marguerite du Plessis Christine Buerki Kaye Ong Elai Davicioni Markus Hohenfellner Boris A Hadaschik

Eur Urol Focus 2018 07 26;4(4):540-546. Epub 2017 Jan 26.

Department of Urology, University Hospital Heidelberg, Germany. Electronic address:

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July 2018

Androgen Receptor Deregulation Drives Bromodomain-Mediated Chromatin Alterations in Prostate Cancer.

Authors:
Alfonso Urbanucci Stefan J Barfeld Ville Kytölä Harri M Itkonen Ilsa M Coleman Daniel Vodák Liisa Sjöblom Xia Sheng Teemu Tolonen Sarah Minner Christoph Burdelski Kati K Kivinummi Annika Kohvakka Steven Kregel Mandeep Takhar Mohammed Alshalalfa Elai Davicioni Nicholas Erho Paul Lloyd R Jeffrey Karnes Ashley E Ross Edward M Schaeffer Donald J Vander Griend Stefan Knapp Eva Corey Felix Y Feng Peter S Nelson Fahri Saatcioglu Karen E Knudsen Teuvo L J Tammela Guido Sauter Thorsten Schlomm Matti Nykter Tapio Visakorpi Ian G Mills

Cell Rep 2017 06;19(10):2045-2059

Centre for Molecular Medicine Norway, Nordic European Molecular Biology Laboratory Partnership, Forskningsparken, University of Oslo, 21 0349 Oslo, Norway; Department of Molecular Oncology, Institute for Cancer Research, Oslo University Hospital, 0424 Oslo, Norway; PCUK Movember Centre of Excellence, CCRCB, Queen's University, Belfast BT7 1NN, Northern Ireland, UK. Electronic address:

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June 2017

PGCA: An algorithm to link protein groups created from MS/MS data.

Authors:
David Kepplinger Mandeep Takhar Mayu Sasaki Zsuzsanna Hollander Derek Smith Bruce McManus W Robert McMaster Raymond T Ng Gabriela V Cohen Freue

PLoS One 2017 31;12(5):e0177569. Epub 2017 May 31.

Department of Statistics, University of British Columbia, Vancouver, British Columbia, Canada.

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September 2017

Lipid degradation promotes prostate cancer cell survival.

Authors:
Harri M Itkonen Michael Brown Alfonso Urbanucci Gregory Tredwell Chung Ho Lau Stefan Barfeld Claire Hart Ingrid J Guldvik Mandeep Takhar Hannelore V Heemers Nicholas Erho Katarzyna Bloch Elai Davicioni Rita Derua Etienne Waelkens James L Mohler Noel Clarke Johan V Swinnen Hector C Keun Ole P Rekvig Ian G Mills

Oncotarget 2017 Jun;8(24):38264-38275

Prostate Cancer Research Group, Centre for Molecular Medicine Norway, University of Oslo, Oslo, Norway.

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June 2017