Manching Ku

Manching Ku

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Manching Ku

Manching Ku

Publications by authors named "Manching Ku"

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Deconstructive somatic cell nuclear transfer reveals novel regulatory T-cell subsets.

J Allergy Clin Immunol 2018 09 30;142(3):997-1000.e4. Epub 2018 May 30.

Division of Pediatric Hematology and Oncology, Department of Pediatric and Adolescent Medicine, Faculty of Medicine, University of Freiburg, Freiburg, Germany; The Scripps Research Institute, La Jolla, Calif. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2018.04.038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6561658PMC
September 2018

Regulatory T Cells Promote Apelin-Mediated Sprouting Angiogenesis in Type 2 Diabetes.

Cell Rep 2018 08;24(6):1610-1626

Department of Chemical Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong SAR, China; Li Ka Shing Institute of Health Sciences, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong SAR, China. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.07.019DOI Listing
August 2018

Nuclear transfer nTreg model reveals fate-determining TCR-β and novel peripheral nTreg precursors.

Proc Natl Acad Sci U S A 2016 Apr 4;113(16):E2316-25. Epub 2016 Apr 4.

Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037

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http://dx.doi.org/10.1073/pnas.1523664113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4843484PMC
April 2016

An epigenetic mechanism of resistance to targeted therapy in T cell acute lymphoblastic leukemia.

Nat Genet 2014 Apr 2;46(4):364-70. Epub 2014 Mar 2.

1] Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA. [2] Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA. [3] Center for Cancer Research, Massachusetts General Hospital, Boston, Massachusetts, USA. [4] Howard Hughes Medical Institute, Chevy Chase, Maryland, USA.

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http://www.nature.com/articles/ng.2913
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http://dx.doi.org/10.1038/ng.2913DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4086945PMC
April 2014

In silico abstraction of zinc finger nuclease cleavage profiles reveals an expanded landscape of off-target sites.

Nucleic Acids Res 2013 Oct 14;41(19):e181. Epub 2013 Aug 14.

Molecular Pathology Unit, Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA 02129, USA, Center for Computational and Integrative Biology, Massachusetts General Hospital, Charlestown, MA 02129, USA, Department of Pathology, Harvard Medical School, Boston, MA 02115, USA, Program in Biological and Biomedical Sciences, Harvard Medical School, Boston, MA 02115, USA, Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 01238, USA, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA and Howard Hughes Medical Institute, Chevy Chase, MD 02815, USA.

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http://dx.doi.org/10.1093/nar/gkt716DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3799455PMC
October 2013

SAM domain polymerization links subnuclear clustering of PRC1 to gene silencing.

Dev Cell 2013 Sep;26(6):565-77

Laboratory for Developmental Genetics, RIKEN Center for Integrative Medical Sciences (IMS-RCAI), 1-7-22 Suehiro, Tsurumi-ku, Yokohama 230-0045, Japan; CREST, Japan Science and Technology Agency, 1-7-22 Suehiro, Tsurumi-ku, Yokohama 230-0045, Japan; PREST, Japan Science and Technology Agency, 1-7-22 Suehiro, Tsurumi-ku, Yokohama 230-0045, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2013.08.016DOI Listing
September 2013

GC-rich sequence elements recruit PRC2 in mammalian ES cells.

PLoS Genet 2010 Dec 9;6(12):e1001244. Epub 2010 Dec 9.

Howard Hughes Medical Institute and Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America.

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https://dash.harvard.edu/bitstream/handle/1/4874826/3000368.
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http://dx.plos.org/10.1371/journal.pgen.1001244
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http://dx.doi.org/10.1371/journal.pgen.1001244DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3000368PMC
December 2010

Jarid2 and PRC2, partners in regulating gene expression.

Genes Dev 2010 Feb 1;24(4):368-80. Epub 2010 Feb 1.

Howard Hughes Medical Institute, New York University Medical School, New York, New York 10016, USA.

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http://dx.doi.org/10.1101/gad.1886410DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2816736PMC
February 2010

Chromatin profiling by directly sequencing small quantities of immunoprecipitated DNA.

Nat Methods 2010 Jan 29;7(1):47-9. Epub 2009 Nov 29.

Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.

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http://www.nature.com/doifinder/10.1038/nmeth.1404
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http://dx.doi.org/10.1038/nmeth.1404DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2862482PMC
January 2010

Dissecting direct reprogramming through integrative genomic analysis.

Nature 2008 Jul 28;454(7200):49-55. Epub 2008 May 28.

Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA.

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http://dx.doi.org/10.1038/nature07056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2754827PMC
July 2008

Control of phenotypic plasticity of smooth muscle cells by bone morphogenetic protein signaling through the myocardin-related transcription factors.

J Biol Chem 2007 Dec 17;282(51):37244-55. Epub 2007 Oct 17.

Molecular Cardiology Research Institute, Tufts-New England Medical Center, Boston, MA 02111, USA.

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http://dx.doi.org/10.1074/jbc.M708137200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3405982PMC
December 2007

In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state.

Nature 2007 Jul 6;448(7151):318-24. Epub 2007 Jun 6.

Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA.

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http://dx.doi.org/10.1038/nature05944DOI Listing
July 2007

OAZ regulates bone morphogenetic protein signaling through Smad6 activation.

J Biol Chem 2006 Feb 22;281(8):5277-87. Epub 2005 Dec 22.

Molecular Cardiology Research Institute, Tufts-New England Medical Center, Boston, MA 02111, USA.

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http://dx.doi.org/10.1074/jbc.M510004200DOI Listing
February 2006