Publications by authors named "Manasa Geeta Rao"

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Development and validation of an LC-MS/MS method for the simultaneous determination of bedaquiline and rifabutin in human plasma.

J Pharm Biomed Anal 2019 Nov 16;176:112775. Epub 2019 Aug 16.

The University of Toledo, Department of Pediatrics, 3000 Arlington Ave., Toledo, OH 43614, USA; Professor The University of Toledo, Department of Pediatrics, Toledo, OH, USA.

This article describes the simultaneous determination of bedaquiline fumarate (TMC-207) and rifabutin in human plasma by stable isotope dilution tandem mass spectrometry. The methodology was developed for an investigation of potential drug-drug interactions of the two anti-tuberculosis drugs when given together to healthy human volunteers. Use of the two drugs in combination to treat disease caused by Mycobacterium tuberculosis is contemplated as the bacterium becomes resistant to many currently available drugs.
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http://dx.doi.org/10.1016/j.jpba.2019.07.023DOI Listing
November 2019
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