Man-Sun Sy

Man-Sun Sy

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Man-Sun Sy

Man-Sun Sy

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Melanoma migration is promoted by prion protein via Akt-hsp27 signaling axis.

Biochem Biophys Res Commun 2020 Mar 20;523(2):375-381. Epub 2019 Dec 20.

Affiliated Cancer Hospital & Institute of Guangzhou Medical University, State Key Laboratory of Respiratory Diseases, 78 Hengzhigang Road, Guangzhou, 510095, China. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2019.12.042DOI Listing
March 2020

Prion dimer is heterogenous and is modulated by multiple negative and positive motifs.

Biochem Biophys Res Commun 2019 02 29;509(2):570-576. Epub 2018 Dec 29.

Wuhan Institute of Virology, Chinese Academy of Sciences, State Key Laboratory of Virology, 44 Xiao Hong Shan Zhong Qu, Wuhan, 430071, China; Affiliated Cancer Hospital & Institute of Guangzhou Medical University, 78 Heng Zhi Gang Road, Guangzhou, 510095, China. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2018.12.113DOI Listing
February 2019

CD2-Associated Protein Contributes to Hepatitis C, Virus Propagation and Steatosis by Disrupting Insulin Signaling.

Hepatology 2018 11;68(5):1710-1725

Center for Molecular Virology, Wuhan Institute of Virology, State Key Laboratory of Virology, Chinese Academy of Sciences, Wuhan, China.

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http://dx.doi.org/10.1002/hep.30073DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6220802PMC
November 2018

Prion protein is required for tumor necrosis factor α (TNFα)-triggered nuclear factor κB (NF-κB) signaling and cytokine production.

J Biol Chem 2017 11 12;292(46):18747-18759. Epub 2017 Sep 12.

From the Wuhan Institute of Virology, Chinese Academy of Sciences, State Key Laboratory of Virology, 44 Xiao Hong Shan Zhong Qu, Wuhan 430071, China,

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http://dx.doi.org/10.1074/jbc.M117.787283DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5704461PMC
November 2017

Cellular Prion Protein Mediates Pancreatic Cancer Cell Survival and Invasion through Association with and Enhanced Signaling of Notch1.

Am J Pathol 2016 11 14;186(11):2945-2956. Epub 2016 Sep 14.

Department of Pathology, Case Western Reserve University, Cleveland, Ohio; Department of Pathology, University Hospitals Case Medical Center, Cleveland, Ohio. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2016.07.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6667968PMC
November 2016

Polyglutamine Tract Expansion Increases S-Nitrosylation of Huntingtin and Ataxin-1.

PLoS One 2016;11(9):e0163359. Epub 2016 Sep 22.

Cell Biology Program, Department of Molecular Biology and Microbiology, Case Western Reserve University, Cleveland, OH, 44106, United States of America.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5033456PMC
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0163359PLOS
September 2016

Glycan-deficient PrP stimulates VEGFR2 signaling via glycosaminoglycan.

Cell Signal 2016 Jun 19;28(6):652-62. Epub 2016 Mar 19.

Center for Molecular Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, State Key Laboratory of Virology, Wuhan Brain Hospital, 44 Xiao Hong Shan Zhong Qu, Wuhan 430071, China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S08986568163006
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http://dx.doi.org/10.1016/j.cellsig.2016.03.010DOI Listing
June 2016

Glycosylphosphatidylinositol Anchor Modification Machinery Deficiency Is Responsible for the Formation of Pro-Prion Protein (PrP) in BxPC-3 Protein and Increases Cancer Cell Motility.

J Biol Chem 2016 Feb 18;291(8):3905-17. Epub 2015 Dec 18.

the State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Hubei Collaborative Innovation Center for Industrial Fermentation, 44 Xiao Hong Shan Zhong Qu, Wuhan 430071, China

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http://www.jbc.org/content/291/8/3905.full.pdf
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http://www.jbc.org/lookup/doi/10.1074/jbc.M115.705830
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http://dx.doi.org/10.1074/jbc.M115.705830DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4759170PMC
February 2016

Anti-lubricin monoclonal antibodies created using lubricin-knockout mice immunodetect lubricin in several species and in patients with healthy and diseased joints.

PLoS One 2015 2;10(2):e0116237. Epub 2015 Feb 2.

Howard Hughes Medical Institute and Department of Genetics, Case Western Reserve University, School of Medicine, Cleveland, OH, United States of America; Howard Hughes Medical Institute and Orthopaedics Research Laboratories, Boston Children's Hospital, and Departments of Genetics and Orthopaedic Surgery, Harvard Medical School, Boston, MA, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0116237PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4314068PMC
October 2015

A panel of monoclonal antibodies against the prion protein proves that there is no prion protein in human pancreatic ductal epithelial cells.

Virol Sin 2014 Aug 14;29(4):228-36. Epub 2014 Aug 14.

State Key Laboratory of Virology and Department of Molecular Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, 430071, China.

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http://link.springer.com/content/pdf/10.1007/s12250-014-3480
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http://link.springer.com/10.1007/s12250-014-3480-4
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http://dx.doi.org/10.1007/s12250-014-3480-4DOI Listing
August 2014

Small protease sensitive oligomers of PrPSc in distinct human prions determine conversion rate of PrP(C).

PLoS Pathog 2012 2;8(8):e1002835. Epub 2012 Aug 2.

National Prion Disease Surveillance Center, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.

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http://dx.doi.org/10.1371/journal.ppat.1002835DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3410855PMC
December 2012

Protease-sensitive conformers in broad spectrum of distinct PrPSc structures in sporadic Creutzfeldt-Jakob disease are indicator of progression rate.

PLoS Pathog 2011 Sep 8;7(9):e1002242. Epub 2011 Sep 8.

Department of Pathology, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.

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http://dx.doi.org/10.1371/journal.ppat.1002242DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3169556PMC
September 2011

A multistage pathway for human prion protein aggregation in vitro: from multimeric seeds to β-oligomers and nonfibrillar structures.

J Am Chem Soc 2011 Jun 17;133(22):8586-93. Epub 2011 May 17.

Physical and Life Sciences Directorate, Lawrence Livermore National Laboratory, Livermore, California 94550, USA.

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http://dx.doi.org/10.1021/ja1117446DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505822PMC
June 2011

Pro-prion binds filamin A, facilitating its interaction with integrin beta1, and contributes to melanomagenesis.

J Biol Chem 2010 Sep 21;285(39):30328-39. Epub 2010 Jul 21.

Department of Pathology, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA.

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http://dx.doi.org/10.1074/jbc.M110.147413DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2943319PMC
September 2010

Role of the highly conserved middle region of prion protein (PrP) in PrP-lipid interaction.

Biochemistry 2010 Sep;49(37):8169-76

Department of Molecular and Cellular Biochemistry, The Ohio State University, Columbus, Ohio 43210, USA.

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http://dx.doi.org/10.1021/bi101146vDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2950782PMC
September 2010

Paradoxical role of prion protein aggregates in redox-iron induced toxicity.

PLoS One 2010 Jul 6;5(7):e11420. Epub 2010 Jul 6.

Department of Pathology, Case Western Reserve University, Cleveland, Ohio, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0011420PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2897850PMC
July 2010

The fatal attraction between pro-prion and filamin A: prion as a marker in human cancers.

Biomark Med 2010 Jun;4(3):453-64

Department of Pathology, School of Medicine, Case Western Reserve University, 2103 Cornell Road, Cleveland, OH 44106, USA.

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http://dx.doi.org/10.2217/bmm.10.14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2925173PMC
June 2010

Residues at P2-P1 positions of epsilon- and zeta-cleavage sites are important in formation of beta-amyloid peptide.

Neurobiol Dis 2009 Dec 27;36(3):453-60. Epub 2009 Aug 27.

Department of Pathobiology, College of Veterinary Medicine, The University of Tennessee, 2407 River Drive, Knoxville, TN 37996, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S096999610900229
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http://dx.doi.org/10.1016/j.nbd.2009.08.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3520095PMC
December 2009

The saga of prion: to cut or not to cut.

Authors:
Man-Sun Sy

Cell Res 2009 Sep 3;19(9):1039-40. Epub 2009 Sep 3.

Department of Pathology, School of Medicine, Case Western Reserve University, 2103 Cornell Rd., Cleveland, OH 44106, USA.

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http://dx.doi.org/10.1038/cr.2009.102DOI Listing
September 2009

Ligand binding promotes prion protein aggregation--role of the octapeptide repeats.

FEBS J 2008 Nov;275(22):5564-75

Department of Pathology, Case Western Reserve University, Cleveland, OH 44106-7288, USA.

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http://dx.doi.org/10.1111/j.1742-4658.2008.06680.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2648294PMC
November 2008

Binding of recombinant but not endogenous prion protein to DNA causes DNA internalization and expression in mammalian cells.

J Biol Chem 2008 Sep 11;283(37):25446-54. Epub 2008 Jul 11.

Department of Pathology, School of Medicine, Case Western Reserve University, 2103 Cornell Road, Cleveland, OH 44120, USA.

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http://dx.doi.org/10.1074/jbc.M800814200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2533082PMC
September 2008

Normal cellular prion protein with a methionine at position 129 has a more exposed helix 1 and is more prone to aggregate.

Biochem Biophys Res Commun 2008 Apr 12;368(4):875-81. Epub 2008 Feb 12.

Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland Clinic Research Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA.

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http://dx.doi.org/10.1016/j.bbrc.2008.01.172DOI Listing
April 2008

Cyclodextrins inhibit replication of scrapie prion protein in cell culture.

J Virol 2007 Oct 15;81(20):11195-207. Epub 2007 Aug 15.

School of Biomolecular and Biomedical Science, University College Dublin, Belfield Campus, Dublin 4, Ireland.

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http://dx.doi.org/10.1128/JVI.02559-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2045541PMC
October 2007

Normal cellular prion protein is a ligand of selectins: binding requires Le(X) but is inhibited by sLe(X).

Biochem J 2007 Sep;406(2):333-41

Institute of Pathology, School of Medicine, Case Western Reserve University, Cleveland, OH 44107-1712, U.S.A.

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http://dx.doi.org/10.1042/BJ20061857DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1948967PMC
September 2007

Human prion proteins with pathogenic mutations share common conformational changes resulting in enhanced binding to glycosaminoglycans.

Proc Natl Acad Sci U S A 2007 May 24;104(18):7546-51. Epub 2007 Apr 24.

Department of Pathology, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA.

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http://dx.doi.org/10.1073/pnas.0610827104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1863438PMC
May 2007

Aggregation of prion protein with insertion mutations is proportional to the number of inserts.

Biochem J 2007 Apr;403(2):343-51

Department of Pathology, School of Medicine, Case Western Reserve University, 10900 Euclid Ave., Cleveland, OH 44120, USA.

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http://dx.doi.org/10.1042/BJ20061592DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1874237PMC
April 2007

Novel single chain antibodies to the prion protein identified by phage display.

Virology 2007 Feb 25;358(1):166-77. Epub 2006 Sep 25.

School of Biological Sciences, The University of Reading, Reading, RG6 6AJ, UK.

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http://dx.doi.org/10.1016/j.virol.2006.08.023DOI Listing
February 2007

Altered prion protein glycosylation in the aging mouse brain.

J Neurochem 2007 Feb 27;100(3):841-54. Epub 2006 Nov 27.

National University Medical Institutes, Departments of Biochemistry, National University of Singapore, Singapore.

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http://dx.doi.org/10.1111/j.1471-4159.2006.04268.xDOI Listing
February 2007

Prion proteins with insertion mutations have altered N-terminal conformation and increased ligand binding activity and are more susceptible to oxidative attack.

J Biol Chem 2006 Apr 14;281(16):10698-705. Epub 2006 Feb 14.

Department of Pathology, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44120, USA.

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http://dx.doi.org/10.1074/jbc.M511819200DOI Listing
April 2006

KDEL-tagged anti-prion intrabodies impair PrP lysosomal degradation and inhibit scrapie infectivity.

Biochem Biophys Res Commun 2005 Dec 2;338(4):1791-7. Epub 2005 Nov 2.

Department of Neuroscience and Laboratory of Clinical Biochemistry, University of Tor Vergata, Via Montpellier 1, 00133 Rome, Italy.

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http://dx.doi.org/10.1016/j.bbrc.2005.10.146DOI Listing
December 2005

Characterization of the F198S prion protein mutation: enhanced glycosylation and defective refolding.

J Alzheimers Dis 2005 Apr;7(2):159-71; discussion 173-80

Department of Physiology and Biophysics, Howard University College of Medicine, Washington, DC 20059, USA.

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http://dx.doi.org/10.3233/jad-2005-7209DOI Listing
April 2005

Trapping prion protein in the endoplasmic reticulum impairs PrPC maturation and prevents PrPSc accumulation.

J Biol Chem 2005 Jan 28;280(1):685-94. Epub 2004 Oct 28.

Department of Neuroscience, University of Tor Vergata, Via Montpellier 1, 00133 Roma, Italy.

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http://www.jbc.org/content/280/1/685.full.pdf
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http://www.jbc.org/cgi/doi/10.1074/jbc.M407360200
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http://dx.doi.org/10.1074/jbc.M407360200DOI Listing
January 2005

Calpain and other cytosolic proteases can contribute to the degradation of retro-translocated prion protein in the cytosol.

J Biol Chem 2005 Jan 2;280(1):317-25. Epub 2004 Nov 2.

Department of Molecular and Cellular Biochemistry, The Ohio State University, Columbus, Ohio 43210, USA.

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http://dx.doi.org/10.1074/jbc.M410649200DOI Listing
January 2005

Biochemical fingerprints of prion diseases: scrapie prion protein in human prion diseases that share prion genotype and type.

J Neurochem 2005 Jan;92(1):132-42

Division of Neuropathology, Case Western Reserve University, Cleveland, Ohio 44120, USA.

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http://dx.doi.org/10.1111/j.1471-4159.2004.02859.xDOI Listing
January 2005

Genetic mapping of activity determinants within cellular prion proteins: N-terminal modules in PrPC offset pro-apoptotic activity of the Doppel helix B/B' region.

J Biol Chem 2004 Dec 29;279(53):55443-54. Epub 2004 Sep 29.

Centre for Research in Neurodegenerative Diseases, Tanz Neuroscience Building, 6 Queen's Park Crescent West, University of Toronto, Toronto, Ontario M5S 3H2, Canada.

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http://dx.doi.org/10.1074/jbc.M404794200DOI Listing
December 2004

Polymorphisms of the PRNP gene in Chinese populations and the identification of a novel insertion mutation.

Eur J Hum Genet 2004 Oct;12(10):867-70

CJD Surveillance Unit, Modern Virology Research Center, College of Life Sciences, Wuhan University, Wuhan, Hubei 430072, People's Republic of China.

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http://dx.doi.org/10.1038/sj.ejhg.5201245DOI Listing
October 2004

Epitope scanning reveals gain and loss of strain specific antibody binding epitopes associated with the conversion of normal cellular prion to scrapie prion.

J Neurochem 2004 Sep;90(5):1205-17

Institute of Pathology, School of Medicine, Case Western Reserve University, Cleveland, Ohio 10900, USA.

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http://dx.doi.org/10.1111/j.1471-4159.2004.02582.xDOI Listing
September 2004

Interaction of Doppel with the full-length laminin receptor precursor protein.

Arch Biochem Biophys 2004 Aug;428(2):165-9

Institute of Microbiology, Chinese Academy of Science, Beijing 100080, People's Republic of China.

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http://dx.doi.org/10.1016/j.abb.2004.06.003DOI Listing
August 2004

Prion protein is ubiquitinated after developing protease resistance in the brains of scrapie-infected mice.

J Pathol 2004 May;203(1):603-8

Institute of Pathology, Case Western Reserve University School of Medicine, 10900 Euclid Avenue, Cleveland, OH 44106, USA.

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http://dx.doi.org/10.1002/path.1555DOI Listing
May 2004

An engineered PrPsc-like molecule from the chimera of mammalian prion protein and yeast Ure2p prion-inducing domain.

Acta Biochim Biophys Sin (Shanghai) 2004 Feb;36(2):128-32

Institute of Microbiology, the Chinese Academy of Sciences, Beijing 100080, China.

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http://dx.doi.org/10.1093/abbs/36.2.128DOI Listing
February 2004

Identification of novel proteinase K-resistant C-terminal fragments of PrP in Creutzfeldt-Jakob disease.

J Biol Chem 2003 Oct 12;278(42):40429-36. Epub 2003 Aug 12.

Institute of Pathology, Case Western Reserve University, Cleveland, Ohio 44106, USA.

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http://dx.doi.org/10.1074/jbc.M308550200DOI Listing
October 2003

Mapping the functional domain of the prion protein.

Eur J Biochem 2003 Aug;270(16):3368-76

Department of Biology and Biochemistry, University of Bath, UK.

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http://dx.doi.org/10.1046/j.1432-1033.2003.03717.xDOI Listing
August 2003

Guanidine hydrochloride extraction and detection of prion proteins in mouse and hamster prion diseases by ELISA.

J Pathol 2003 Apr;199(4):534-41

Institute of Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA.

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http://dx.doi.org/10.1002/path.1294DOI Listing
April 2003

Molecular analysis of iatrogenic scrapie in Italy.

J Gen Virol 2003 Apr;84(Pt 4):1047-52

Department of Neurological and Visual Sciences, University of Verona, Piazzale L. A. Scuro, 10, 37134 Verona, Italy.

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http://dx.doi.org/10.1099/vir.0.18774-0DOI Listing
April 2003

Anti-prion antibodies for prophylaxis following prion exposure in mice.

Neurosci Lett 2003 Jan;336(3):185-7

Department of Psychiatry, New York University School of Medicine, Millhauser Laboratory, 550 First Avenue, New York, NY 10016, USA.

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http://dx.doi.org/10.1016/s0304-3940(02)01192-8DOI Listing
January 2003

Intercellular transfer of the cellular prion protein.

J Biol Chem 2002 Dec 30;277(49):47671-8. Epub 2002 Sep 30.

Division of Neuropathology, Institute of Pathology, Case Western Reserve University, Cleveland, Ohio 44106, USA.

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http://dx.doi.org/10.1074/jbc.M207458200DOI Listing
December 2002

Cell-surface prion protein interacts with glycosaminoglycans.

Biochem J 2002 Nov;368(Pt 1):81-90

Institute of Pathology, Case Western Reserve University School of Medicine, 10900 Euclid Avenue, Cleveland, OH 44106-1712, USA.

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http://dx.doi.org/10.1042/BJ20020773DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1222984PMC
November 2002

Heterogeneity of normal prion protein in two- dimensional immunoblot: presence of various glycosylated and truncated forms.

J Neurochem 2002 Jun;81(5):1092-101

Institute of Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106-1712, USA.

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http://dx.doi.org/10.1046/j.1471-4159.2002.00909.xDOI Listing
June 2002

Human prion diseases.

Med Clin North Am 2002 May;86(3):551-71, vi-vii

Division of Neuropathology, Institute of Pathology, and Cancer Research Center, Room 933 Biomedical Research Building, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44120-1712, USA.

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http://dx.doi.org/10.1016/s0025-7125(02)00004-4DOI Listing
May 2002