Publications by authors named "Maman Daou"

4 Publications

  • Page 1 of 1

[Malaria infection during pregnancy in Niamey, Niger].

Pan Afr Med J 2020 22;37:365. Epub 2020 Dec 22.

Unité de Paludologie-Entomologie Médicale, Centre de Recherche Médicale et Sanitaire, Niamey, République du Niger.

Introduction: malaria during pregnancy is a major public health problem in Africa. It can have serious consequences for mother, fetus and newborn. It is associated with high maternal and infant mortality rate. The purpose of our study was to determine the prevalence of plasmodium infection in pregnant women, describe their clinical signs and potential complications, analyze associated factors, and propose preventive measures.

Methods: we conducted a cross-sectional study at the Issaka Gazobi Maternity Ward (MIG), Niamey, from 1 June to 30 November 2017. Diagnosis was based on microscopic examination.

Results: two hundred and forty-nine (249) women were included in this study. The prevalence of plasmodium infection was 36.5% (IC95%; [30.6; 42.9]). Mean parasite density was 177 P/μl (SD: 121; [40; 800]). All infections were due to P. falciparum. Seventy-three point six percent (67/91) of infected women were asymptomatic. Only 26.4% (24/91) of them had uncomplicated malaria; 9.6% (6/91) had miscarriage; 38.4% of newborns were low birthweight; 26.51% (66/249) developed congenital malaria. Mortality rate was 1.1% (1/ 91). Intermittent preventive treatment (IPT) significantly protected patients against gestational malaria (p=0.01).

Conclusion: in Niger, P. falciparum infection very commonly affects pregnant women. It is most often asymptomatic but it can lead to uncomplicated or even severe malaria. Main consequences include abortion, low birth weight, intrauterine growth retardation, congenital malaria and maternal death. IPT and the use of long-lasting insecticide-treated mosquito nets (LLINs) can prevent infection.
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April 2021

[Epidemiological, clinical and evolutionary profile of patients with tuberculosis at the Regional Hospital of Maradi, Republic of the Niger].

Pan Afr Med J 2019 17;33:120. Epub 2019 Jun 17.

Service de Médecine Interne, Hôpital Général de Référence Niamey, Faculté des Sciences de la Santé de l'UAM de Niamey, Niamey, Niger.

Introduction: This study aimed to describe the epidemiological, clinical and evolutionary profile of patients treated for tuberculosis at the Regional Hospital of Maradi.

Methods: We conducted a retrospective, descriptive and analytical study of data from the medical records of patients treated for tuberculosis from 1 January 2015 to 31 December 2017.

Results: A total of 595 patients were followed (406 men, 68.24%, and 189 women, 31.76%) with a prevalence of 27,71%. The average age of patients was 42.3 ranging from 13 months to 85 years; 70.5% of these patients were from urban areas. Merchants represented 36.9% of the cases. Bacterial test was positive in 64.7% of cases. Functional signs included: coughing (99.5%), fever (79.5%), and chest pain. Pulmonary tuberculosis represented 78.7% of cases. Therapy was effective in 81.28% of cases. HIV prevalence was 13.6%, lethality 10.42% (40.4% of patients died from TB/HIV co-infection).

Conclusion: Tuberculosis is a scourge in low-income countries, with 10.42% of deaths. HIV/AIDS infection has negatively contributed to these deaths during the study period. The search for comorbidities in any patient with tuberculosis should be systematic in order to improve their global management.
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September 2019

Transfusional Malaria and Associated Factors at the National Blood Transfusion Center of Niamey-Niger.

J Trop Med 2019 1;2019:7290852. Epub 2019 Apr 1.

Centre de Recherche Médicale et Sanitaire, Niger.

Summary: . Transfusional malaria is an accidental transmission of via a blood transfusion. Its magnitude is underestimated and very little data on the assessment of this risk are available in Niger.

Objective: This study aimed to determine the prevalence of plasmodial infection of blood bags at the National Blood Transfusion Center of Niamey (NBTC).

Methodology: A cross-sectional study to diagnose infection by microscopy and Rapid Diagnostic Test (RDT) was carried out during the rainy season (September to November 2015). Blood grouping was performed by the BETH-VINCENT technique.

Results: One thousand three hundred and fifty-seven (1357) blood bags were collected. One hundred and fifty-seven (11.6%) of the donors were infected with by microscopy and 2.4% (9/369) by rapid diagnostic test. All infections were with (100%). The mean parasite density was 197 parasites/L (SD=281; [80: 2000]). There were no significant differences in infection prevalence between the ABO blood groups ( = 0.3) or the rhesus positivity (). There is also no significant difference in temporal ( = 0.1) and spatial ( = 0.6) distribution.

Conclusion: The transmission of transfusional malaria during the rainy season is a fact in Niger. Such risks were independent of the ABO blood type and positivity for the rhesus antigen. Pretransfusion diagnosis or posttransfusion therapy should be instituted to prevent it.
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April 2019

[Comparison of the therapeutic efficiency and of the tolerance of the artemether-lumefantrine and artesunate-amodiaquine combination in Niger].

Mali Med 2016 ;31(1):1-7

Faculté des Sciences de la Santé. UAM. BP: 10.896. Niamey-Niger.

Malaria is a major public health problem in Niger. The Global Fund to fight AIDS, Tuberculosis, and Malaria launched, in 2011, an initiative entitled "Affordable Medicines Facility - Malaria" or AMFm which aims to make artemisinin-based combination therapies (ACT) more available, more accessible and to eliminate the development of artemisinin resistance. It is in this context that we have conducted a randomized comparative double open-arm study of the efficacy and safety of artemether-lumefantrine (AL) and artesunate-amodiaquine (AM) in Gaya.

The objective of the study is to evaluate and then to compare the efficiency and tolerance to these two combinations. The study was modeled with the WHO 2003, 28 days protocol.

370 febrile patients were examined. 159 patients were included, where 79 (49.4%) were put in the AL arm and 81 (50.6%) were placed in the AM arm. The adequate clinical and parasitological response was 94.8% and 97.1% respectively for AL and AM. There was no statistical significant difference in efficiency between the two therapies . This difference in adverse effects was not statistically significant . Artemether-lumefantrine and artesunate-amodiaquine are two combinations with comparable efficacies and safety.
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January 2016