Publications by authors named "Malini Raghavan"

44Publications

Variations in MHC class I antigen presentation and immunopeptidome selection pathways.

F1000Res 2020 28;9. Epub 2020 Sep 28.

Department of Microbiology and Immunology, Michigan Medicine, University of Michigan, Ann Arbor, MI, USA.

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September 2020

Calreticulin enhances the secretory trafficking of a misfolded α-1-antitrypsin.

J Biol Chem 2020 Dec 25;295(49):16754-16772. Epub 2020 Sep 25.

Department of Microbiology and Immunology, Michigan Medicine, University of Michigan, Ann Arbor, Michigan, 48109 USA

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December 2020

Polymorphisms of HLA-B: influences on assembly and immunity.

Curr Opin Immunol 2020 Jun 30;64:137-145. Epub 2020 Jun 30.

Department of Microbiology and Immunology, Michigan Medicine, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address:

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June 2020

ER stress increases store-operated Ca entry (SOCE) and augments basal insulin secretion in pancreatic beta cells.

J Biol Chem 2020 04 16;295(17):5685-5700. Epub 2020 Mar 16.

Department of Pharmacology and Brehm Diabetes Research Center, University of Michigan Medical School, Ann Arbor, Michigan 48105

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April 2020

A Calreticulin Tail: C-terminal Mutants of Calreticulin Allow Cancer Cells to Evade Phagocytosis.

Mol Cell 2020 02;77(4):683-685

Department of Microbiology and Immunology, Michigan Medicine, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address:

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February 2020

The Endoplasmic Reticulum and Calcium Homeostasis in Pancreatic Beta Cells.

Endocrinology 2020 02;161(2)

Department of Pharmacology and Brehm Diabetes Research Center, University of Michigan, Ann Arbor, MI.

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February 2020

CD8αα homodimers function as a coreceptor for KIR3DL1.

Proc Natl Acad Sci U S A 2019 09 16;116(36):17951-17956. Epub 2019 Aug 16.

Department of Microbiology and Immunology, Michigan Medicine, University of Michigan, Ann Arbor, MI 48109

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September 2019

Strategies for the measurements of expression levels and half-lives of HLA class I allotypes.

Hum Immunol 2019 Apr 5;80(4):221-227. Epub 2019 Feb 5.

Department of Laboratory Medicine and Pathology, Mayo Clinic, 5777 E. Mayo Blvd, Phoenix, AZ 85054, USA.

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April 2019

Selected HLA-B allotypes are resistant to inhibition or deficiency of the transporter associated with antigen processing (TAP).

PLoS Pathog 2018 07 11;14(7):e1007171. Epub 2018 Jul 11.

Department of Microbiology and Immunology, Michigan Medicine, University of Michigan, Ann Arbor, Michigan, United States of America.

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July 2018

Variations in HLA-B cell surface expression, half-life and extracellular antigen receptivity.

Elife 2018 07 10;7. Epub 2018 Jul 10.

Department of Microbiology and Immunology, Michigan Medicine, University of Michigan, Michigan, United States.

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July 2018

Empty conformers of HLA-B preferentially bind CD8 and regulate CD8 T cell function.

Elife 2018 05 9;7. Epub 2018 May 9.

Department of Microbiology and Immunology, Michigan Medicine, University of Michigan, Ann Arbor, United States.

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May 2018

Update on Gender Equity in Immunology, 2001 to 2016.

J Immunol 2016 11 17;197(10):3751-3753. Epub 2016 Oct 17.

Division of Infectious Diseases, Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX 77555-0435.

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November 2016

The C-Terminal Acidic Region of Calreticulin Mediates Phosphatidylserine Binding and Apoptotic Cell Phagocytosis.

J Immunol 2016 05 1;196(9):3896-3909. Epub 2016 Apr 1.

Department of Microbiology and Immunology, University of Michigan School of Medicine, Ann Arbor MI 48109.

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May 2016

Regulation of calreticulin-major histocompatibility complex (MHC) class I interactions by ATP.

Proc Natl Acad Sci U S A 2015 Oct 29;112(41):E5608-17. Epub 2015 Sep 29.

Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109;

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October 2015

Use of Functional Polymorphisms To Elucidate the Peptide Binding Site of TAP Complexes.

J Immunol 2015 Oct 31;195(7):3436-48. Epub 2015 Aug 31.

Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109; and

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October 2015

HLA-B polymorphisms and intracellular assembly modes.

Mol Immunol 2015 Dec 31;68(2 Pt A):89-93. Epub 2015 Jul 31.

Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

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December 2015

Distinct assembly profiles of HLA-B molecules.

J Immunol 2014 Jun 30;192(11):4967-76. Epub 2014 Apr 30.

Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109;

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June 2014

Glycan-dependent and -independent interactions contribute to cellular substrate recruitment by calreticulin.

J Biol Chem 2013 Dec 7;288(49):35104-16. Epub 2013 Oct 7.

From the Department of Microbiology and Immunology, University of Michigan School Medical School, Ann Arbor, Michigan 48109.

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December 2013

Calreticulin in the immune system: ins and outs.

Trends Immunol 2013 Jan 7;34(1):13-21. Epub 2012 Sep 7.

Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109-5620, USA.

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January 2013

Assessment of roles for calreticulin in the cross-presentation of soluble and bead-associated antigens.

PLoS One 2012 27;7(7):e41727. Epub 2012 Jul 27.

Graduate Program in Immunology, University of Michigan Medical School, Ann Arbor, Michigan, United States of America.

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April 2013

Endoplasmic reticulum calcium depletion impacts chaperone secretion, innate immunity, and phagocytic uptake of cells.

J Immunol 2011 Jul 13;187(2):919-31. Epub 2011 Jun 13.

Graduate Program in Immunology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

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July 2011

Distinct functions for the glycans of tapasin and heavy chains in the assembly of MHC class I molecules.

J Immunol 2011 Feb 24;186(4):2309-20. Epub 2011 Jan 24.

Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

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February 2011

Calreticulin is a thermostable protein with distinct structural responses to different divalent cation environments.

J Biol Chem 2011 Mar 22;286(11):8771-85. Epub 2010 Dec 22.

Department of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan 48109, USA.

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March 2011

The polypeptide binding conformation of calreticulin facilitates its cell-surface expression under conditions of endoplasmic reticulum stress.

J Biol Chem 2011 Jan 12;286(4):2402-15. Epub 2010 Nov 12.

Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA.

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January 2011

Structure and function of major histocompatibility complex class I antigens.

Curr Opin Organ Transplant 2010 Aug;15(4):499-504

Harvard Medical School, Beth Israel-Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA.

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August 2010

TAP-inhibitors from old world primate 1-herpesviruses and their use: WO2009008713.

Authors:
Malini Raghavan

Expert Opin Ther Pat 2010 Feb;20(2):277-82

University of Michigan Medical School, Department of Microbiology and Immunology, 5641 Medical Science Building II, Ann Arbor, MI 48109-5620, USA.

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February 2010

Mechanisms of function of tapasin, a critical major histocompatibility complex class I assembly factor.

Traffic 2010 Mar 3;11(3):332-47. Epub 2009 Dec 3.

Department of Microbiology and Immunology, University of Michigan Medical School, 5641 Medical Science Building II, Ann Arbor, MI 48109-5620, USA.

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March 2010

Modes of calreticulin recruitment to the major histocompatibility complex class I assembly pathway.

J Biol Chem 2010 Feb 3;285(7):4520-35. Epub 2009 Dec 3.

Department of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan 48109, USA.

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February 2010

Assembly and intracellular trafficking of HLA-B*3501 and HLA-B*3503.

Immunogenetics 2009 Dec;61(11-12):703-16

Department of Microbiology and Immunology, University of Michigan Medical School, 5641 Medical Science Building II, Ann Arbor, MI 48109-0620, USA.

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December 2009

MHC class I assembly: out and about.

Trends Immunol 2008 Sep;29(9):436-43

Department of Microbiology and Immunology, University of Michigan, Ann Arbor, MI 48109, USA.

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September 2008

Direct peptide-regulatable interactions between MHC class I molecules and tapasin.

Proc Natl Acad Sci U S A 2006 Nov 20;103(48):18220-5. Epub 2006 Nov 20.

Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109-0620, USA.

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November 2006

Catalytic site modifications of TAP1 and TAP2 and their functional consequences.

J Biol Chem 2006 Dec 26;281(52):39839-51. Epub 2006 Oct 26.

Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan 48109-0620, USA.

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December 2006

HLA-B44 polymorphisms at position 116 of the heavy chain influence TAP complex binding via an effect on peptide occupancy.

J Immunol 2006 Sep;177(5):3150-61

Graduate Program in Immunology, University of Michigan Medical School, Ann Arbor 48109-0620, USA.

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September 2006

Polypeptide substrate recognition by calnexin requires specific conformations of the calnexin protein.

J Biol Chem 2005 Sep 1;280(39):33497-505. Epub 2005 Aug 1.

Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan 48109-0620, USA.

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September 2005

A rare transporter associated with antigen processing polymorphism overpresented in HLAlow colon cancer reveals the functional significance of the signature domain in antigen processing.

Clin Cancer Res 2005 May;11(10):3614-23

Division of Cancer Immunology, Department of Pathology and Comprehensive Cancer Center, Graduate Program in Molecular, Cellular, and Developmental Biology, The Ohio State University, OncoImmune, Ltd., Columbus, Ohio, USA.

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May 2005

Nucleotide interactions with membrane-bound transporter associated with antigen processing proteins.

J Biol Chem 2003 Mar 25;278(10):8229-37. Epub 2002 Dec 25.

Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor 48109-0620, USA.

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March 2003

Responses of herpes simplex virus type 1-infected cells to the presence of extracellular antibodies: gE-dependent glycoprotein capping and enhancement in cell-to-cell spread.

J Virol 2003 Jan;77(1):701-8

Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor 48109-0620, USA.

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January 2003

Tapasin interacts with the membrane-spanning domains of both TAP subunits and enhances the structural stability of TAP1 x TAP2 Complexes.

J Biol Chem 2002 Nov 3;277(44):41786-94. Epub 2002 Sep 3.

Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor 48109-0620, USA.

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November 2002

Calreticulin recognizes misfolded HLA-A2 heavy chains.

Proc Natl Acad Sci U S A 2002 Apr;99(9):5931-6

Department of Microbiology and Immunology and Immunology Graduate Program, University of Michigan Medical School, Ann Arbor, MI 48109-0620, USA.

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April 2002