Publications by authors named "Malini Raghavan"

44Publications

HLA tapasin independence: broader peptide repertoire and HIV control.

Authors:
Arman A Bashirova Mathias Viard Vivek Naranbhai Alba Grifoni Wilfredo Garcia-Beltran Marjan Akdag Yuko Yuki Xiaojiang Gao Colm O'hUigin Malini Raghavan Steven Wolinsky Jay H Bream Priya Duggal Jeremy Martinson Nelson L Michael Gregory D Kirk Susan P Buchbinder David Haas James J Goedert Steven G Deeks Jacques Fellay Bruce Walker Philip Goulder Peter Cresswell Tim Elliott Alessandro Sette Jonathan Carlson Mary Carrington

Proc Natl Acad Sci U S A 2020 11 23;117(45):28232-28238. Epub 2020 Oct 23.

Basic Science Program, Frederick National Laboratory for Cancer Research, Frederick, MD 21702;

View Article and Find Full Text PDF
November 2020

Variations in MHC class I antigen presentation and immunopeptidome selection pathways.

Authors:
Anita J Zaitoua Amanpreet Kaur Malini Raghavan

F1000Res 2020 28;9. Epub 2020 Sep 28.

Department of Microbiology and Immunology, Michigan Medicine, University of Michigan, Ann Arbor, MI, USA.

View Article and Find Full Text PDF
September 2020

Calreticulin enhances the secretory trafficking of a misfolded α-1-antitrypsin.

Authors:
Harihar Milaganur Mohan Boning Yang Nicole A Dean Malini Raghavan

J Biol Chem 2020 Dec 25;295(49):16754-16772. Epub 2020 Sep 25.

Department of Microbiology and Immunology, Michigan Medicine, University of Michigan, Ann Arbor, Michigan, 48109 USA

View Article and Find Full Text PDF
December 2020

Concanamycin A counteracts HIV-1 Nef to enhance immune clearance of infected primary cells by cytotoxic T lymphocytes.

Authors:
Mark M Painter Gretchen E Zimmerman Madeline S Merlino Andrew W Robertson Valeri H Terry Xuefeng Ren Megan R McLeod Lyanne Gomez-Rodriguez Kirsten A Garcia Jolie A Leonard Kay E Leopold Andrew J Neevel Jay Lubow Eli Olson Alicja Piechocka-Trocha David R Collins Ashootosh Tripathi Malini Raghavan Bruce D Walker James H Hurley David H Sherman Kathleen L Collins

Proc Natl Acad Sci U S A 2020 09 8;117(38):23835-23846. Epub 2020 Sep 8.

Graduate Program in Immunology, University of Michigan, Ann Arbor, MI 48109;

View Article and Find Full Text PDF
September 2020

Polymorphisms of HLA-B: influences on assembly and immunity.

Authors:
Eli Olson Jie Geng Malini Raghavan

Curr Opin Immunol 2020 Jun 30;64:137-145. Epub 2020 Jun 30.

Department of Microbiology and Immunology, Michigan Medicine, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address:

View Article and Find Full Text PDF
June 2020

ER stress increases store-operated Ca entry (SOCE) and augments basal insulin secretion in pancreatic beta cells.

Authors:
Irina X Zhang Jianhua Ren Suryakiran Vadrevu Malini Raghavan Leslie S Satin

J Biol Chem 2020 04 16;295(17):5685-5700. Epub 2020 Mar 16.

Department of Pharmacology and Brehm Diabetes Research Center, University of Michigan Medical School, Ann Arbor, Michigan 48105

View Article and Find Full Text PDF
April 2020

A Calreticulin Tail: C-terminal Mutants of Calreticulin Allow Cancer Cells to Evade Phagocytosis.

Authors:
Amanpreet Kaur Malini Raghavan

Mol Cell 2020 02;77(4):683-685

Department of Microbiology and Immunology, Michigan Medicine, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address:

View Article and Find Full Text PDF
February 2020

The Endoplasmic Reticulum and Calcium Homeostasis in Pancreatic Beta Cells.

Authors:
Irina X Zhang Malini Raghavan Leslie S Satin

Endocrinology 2020 02;161(2)

Department of Pharmacology and Brehm Diabetes Research Center, University of Michigan, Ann Arbor, MI.

View Article and Find Full Text PDF
February 2020

CD8αα homodimers function as a coreceptor for KIR3DL1.

Authors:
Jie Geng Malini Raghavan

Proc Natl Acad Sci U S A 2019 09 16;116(36):17951-17956. Epub 2019 Aug 16.

Department of Microbiology and Immunology, Michigan Medicine, University of Michigan, Ann Arbor, MI 48109

View Article and Find Full Text PDF
September 2019

Strategies for the measurements of expression levels and half-lives of HLA class I allotypes.

Authors:
Malini Raghavan Brogan Yarzabek Anita J Zaitouna Sujatha Krishnakumar Daniel S Ramon

Hum Immunol 2019 Apr 5;80(4):221-227. Epub 2019 Feb 5.

Department of Laboratory Medicine and Pathology, Mayo Clinic, 5777 E. Mayo Blvd, Phoenix, AZ 85054, USA.

View Article and Find Full Text PDF
April 2019

Selected HLA-B allotypes are resistant to inhibition or deficiency of the transporter associated with antigen processing (TAP).

Authors:
Jie Geng Anita J Zaitouna Malini Raghavan

PLoS Pathog 2018 07 11;14(7):e1007171. Epub 2018 Jul 11.

Department of Microbiology and Immunology, Michigan Medicine, University of Michigan, Ann Arbor, Michigan, United States of America.

View Article and Find Full Text PDF
July 2018

Variations in HLA-B cell surface expression, half-life and extracellular antigen receptivity.

Authors:
Brogan Yarzabek Anita J Zaitouna Eli Olson Gayathri N Silva Jie Geng Aviva Geretz Rasmi Thomas Sujatha Krishnakumar Daniel S Ramon Malini Raghavan

Elife 2018 07 10;7. Epub 2018 Jul 10.

Department of Microbiology and Immunology, Michigan Medicine, University of Michigan, Michigan, United States.

View Article and Find Full Text PDF
July 2018

Empty conformers of HLA-B preferentially bind CD8 and regulate CD8 T cell function.

Authors:
Jie Geng John D Altman Sujatha Krishnakumar Malini Raghavan

Elife 2018 05 9;7. Epub 2018 May 9.

Department of Microbiology and Immunology, Michigan Medicine, University of Michigan, Ann Arbor, United States.

View Article and Find Full Text PDF
May 2018

Update on Gender Equity in Immunology, 2001 to 2016.

Authors:
Virginia Smith Shapiro Susan Kovats Michelle A Parent Sarah L Gaffen Catherine C Hedrick Pooja Jain Lisa K Denzin Malini Raghavan Robin Stephens

J Immunol 2016 11 17;197(10):3751-3753. Epub 2016 Oct 17.

Division of Infectious Diseases, Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX 77555-0435.

View Article and Find Full Text PDF
November 2016

The C-Terminal Acidic Region of Calreticulin Mediates Phosphatidylserine Binding and Apoptotic Cell Phagocytosis.

Authors:
Sanjeeva Joseph Wijeyesakere Sukhmani Kaur Bedi David Huynh Malini Raghavan

J Immunol 2016 05 1;196(9):3896-3909. Epub 2016 Apr 1.

Department of Microbiology and Immunology, University of Michigan School of Medicine, Ann Arbor MI 48109.

View Article and Find Full Text PDF
May 2016

Regulation of calreticulin-major histocompatibility complex (MHC) class I interactions by ATP.

Authors:
Sanjeeva Joseph Wijeyesakere Jessica K Gagnon Karunesh Arora Charles L Brooks Malini Raghavan

Proc Natl Acad Sci U S A 2015 Oct 29;112(41):E5608-17. Epub 2015 Sep 29.

Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109;

View Article and Find Full Text PDF
October 2015

Use of Functional Polymorphisms To Elucidate the Peptide Binding Site of TAP Complexes.

Authors:
Jie Geng Irina D Pogozheva Henry I Mosberg Malini Raghavan

J Immunol 2015 Oct 31;195(7):3436-48. Epub 2015 Aug 31.

Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109; and

View Article and Find Full Text PDF
October 2015

HLA-B polymorphisms and intracellular assembly modes.

Authors:
Malini Raghavan Jie Geng

Mol Immunol 2015 Dec 31;68(2 Pt A):89-93. Epub 2015 Jul 31.

Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

View Article and Find Full Text PDF
December 2015

Distinct assembly profiles of HLA-B molecules.

Authors:
Syed Monem Rizvi Nasir Salam Jie Geng Ying Qi Jay H Bream Priya Duggal Shehnaz K Hussain Jeremy Martinson Steven M Wolinsky Mary Carrington Malini Raghavan

J Immunol 2014 Jun 30;192(11):4967-76. Epub 2014 Apr 30.

Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109;

View Article and Find Full Text PDF
June 2014

Analyses of conformational states of the transporter associated with antigen processing (TAP) protein in a native cellular membrane environment.

Authors:
Jie Geng Sivaraj Sivaramakrishnan Malini Raghavan

J Biol Chem 2013 Dec 6;288(52):37039-47. Epub 2013 Nov 6.

From the Department of Microbiology and Immunology and.

View Article and Find Full Text PDF
December 2013

Glycan-dependent and -independent interactions contribute to cellular substrate recruitment by calreticulin.

Authors:
Sanjeeva J Wijeyesakere Syed M Rizvi Malini Raghavan

J Biol Chem 2013 Dec 7;288(49):35104-16. Epub 2013 Oct 7.

From the Department of Microbiology and Immunology, University of Michigan School Medical School, Ann Arbor, Michigan 48109.

View Article and Find Full Text PDF
December 2013

Calreticulin in the immune system: ins and outs.

Authors:
Malini Raghavan Sanjeeva J Wijeyesakere Larry Robert Peters Natasha Del Cid

Trends Immunol 2013 Jan 7;34(1):13-21. Epub 2012 Sep 7.

Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109-5620, USA.

View Article and Find Full Text PDF
January 2013

Assessment of roles for calreticulin in the cross-presentation of soluble and bead-associated antigens.

Authors:
Natasha Del Cid Lianjun Shen Janice Belleisle Malini Raghavan

PLoS One 2012 27;7(7):e41727. Epub 2012 Jul 27.

Graduate Program in Immunology, University of Michigan Medical School, Ann Arbor, Michigan, United States of America.

View Article and Find Full Text PDF
April 2013

Endoplasmic reticulum calcium depletion impacts chaperone secretion, innate immunity, and phagocytic uptake of cells.

Authors:
Larry Robert Peters Malini Raghavan

J Immunol 2011 Jul 13;187(2):919-31. Epub 2011 Jun 13.

Graduate Program in Immunology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

View Article and Find Full Text PDF
July 2011

Distinct functions for the glycans of tapasin and heavy chains in the assembly of MHC class I molecules.

Authors:
Syed Monem Rizvi Natasha Del Cid Lonnie Lybarger Malini Raghavan

J Immunol 2011 Feb 24;186(4):2309-20. Epub 2011 Jan 24.

Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

View Article and Find Full Text PDF
February 2011

Calreticulin is a thermostable protein with distinct structural responses to different divalent cation environments.

Authors:
Sanjeeva J Wijeyesakere Ari A Gafni Malini Raghavan

J Biol Chem 2011 Mar 22;286(11):8771-85. Epub 2010 Dec 22.

Department of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan 48109, USA.

View Article and Find Full Text PDF
March 2011

The polypeptide binding conformation of calreticulin facilitates its cell-surface expression under conditions of endoplasmic reticulum stress.

Authors:
Elise Jeffery Larry Robert Peters Malini Raghavan

J Biol Chem 2011 Jan 12;286(4):2402-15. Epub 2010 Nov 12.

Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA.

View Article and Find Full Text PDF
January 2011

Structure and function of major histocompatibility complex class I antigens.

Authors:
Xian C Li Malini Raghavan

Curr Opin Organ Transplant 2010 Aug;15(4):499-504

Harvard Medical School, Beth Israel-Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA.

View Article and Find Full Text PDF
August 2010

TAP-inhibitors from old world primate 1-herpesviruses and their use: WO2009008713.

Authors:
Malini Raghavan

Expert Opin Ther Pat 2010 Feb;20(2):277-82

University of Michigan Medical School, Department of Microbiology and Immunology, 5641 Medical Science Building II, Ann Arbor, MI 48109-5620, USA.

View Article and Find Full Text PDF
February 2010

Mechanisms of function of tapasin, a critical major histocompatibility complex class I assembly factor.

Authors:
Syed Monem Rizvi Malini Raghavan

Traffic 2010 Mar 3;11(3):332-47. Epub 2009 Dec 3.

Department of Microbiology and Immunology, University of Michigan Medical School, 5641 Medical Science Building II, Ann Arbor, MI 48109-5620, USA.

View Article and Find Full Text PDF
March 2010

Modes of calreticulin recruitment to the major histocompatibility complex class I assembly pathway.

Authors:
Natasha Del Cid Elise Jeffery Syed Monem Rizvi Ericca Stamper Larry Robert Peters William Clay Brown Chester Provoda Malini Raghavan

J Biol Chem 2010 Feb 3;285(7):4520-35. Epub 2009 Dec 3.

Department of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan 48109, USA.

View Article and Find Full Text PDF
February 2010

Assembly and intracellular trafficking of HLA-B*3501 and HLA-B*3503.

Authors:
Vilasack Thammavongsa Malinda Schaefer Tracey Filzen Kathleen L Collins Mary Carrington Naveen Bangia Malini Raghavan

Immunogenetics 2009 Dec;61(11-12):703-16

Department of Microbiology and Immunology, University of Michigan Medical School, 5641 Medical Science Building II, Ann Arbor, MI 48109-0620, USA.

View Article and Find Full Text PDF
December 2009

MHC class I assembly: out and about.

Authors:
Malini Raghavan Natasha Del Cid Syed Monem Rizvi Larry Robert Peters

Trends Immunol 2008 Sep;29(9):436-43

Department of Microbiology and Immunology, University of Michigan, Ann Arbor, MI 48109, USA.

View Article and Find Full Text PDF
September 2008

Direct peptide-regulatable interactions between MHC class I molecules and tapasin.

Authors:
Syed Monem Rizvi Malini Raghavan

Proc Natl Acad Sci U S A 2006 Nov 20;103(48):18220-5. Epub 2006 Nov 20.

Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109-0620, USA.

View Article and Find Full Text PDF
November 2006

Catalytic site modifications of TAP1 and TAP2 and their functional consequences.

Authors:
Christopher L Perria Vijayalakshmi Rajamanickam Philip E Lapinski Malini Raghavan

J Biol Chem 2006 Dec 26;281(52):39839-51. Epub 2006 Oct 26.

Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan 48109-0620, USA.

View Article and Find Full Text PDF
December 2006

HLA-B44 polymorphisms at position 116 of the heavy chain influence TAP complex binding via an effect on peptide occupancy.

Authors:
Vilasack Thammavongsa Gayatri Raghuraman Tracy M Filzen Kathleen L Collins Malini Raghavan

J Immunol 2006 Sep;177(5):3150-61

Graduate Program in Immunology, University of Michigan Medical School, Ann Arbor 48109-0620, USA.

View Article and Find Full Text PDF
September 2006

Identification of domain boundaries within the N-termini of TAP1 and TAP2 and their importance in tapasin binding and tapasin-mediated increase in peptide loading of MHC class I.

Authors:
Erik Procko Gayatri Raghuraman Don C Wiley Malini Raghavan Rachelle Gaudet

Immunol Cell Biol 2005 Oct;83(5):475-82

Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA.

View Article and Find Full Text PDF
October 2005

Polypeptide substrate recognition by calnexin requires specific conformations of the calnexin protein.

Authors:
Vilasack Thammavongsa Laura Mancino Malini Raghavan

J Biol Chem 2005 Sep 1;280(39):33497-505. Epub 2005 Aug 1.

Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan 48109-0620, USA.

View Article and Find Full Text PDF
September 2005

A rare transporter associated with antigen processing polymorphism overpresented in HLAlow colon cancer reveals the functional significance of the signature domain in antigen processing.

Authors:
Tianyu Yang Philip E Lapinski Haotian Zhao Qunmin Zhou Huiming Zhang Malini Raghavan Yang Liu Pan Zheng

Clin Cancer Res 2005 May;11(10):3614-23

Division of Cancer Immunology, Department of Pathology and Comprehensive Cancer Center, Graduate Program in Molecular, Cellular, and Developmental Biology, The Ohio State University, OncoImmune, Ltd., Columbus, Ohio, USA.

View Article and Find Full Text PDF
May 2005

A polypeptide binding conformation of calreticulin is induced by heat shock, calcium depletion, or by deletion of the C-terminal acidic region.

Authors:
Syed Monem Rizvi Laura Mancino Vilasack Thammavongsa Richard Louis Cantley Malini Raghavan

Mol Cell 2004 Sep;15(6):913-23

Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

View Article and Find Full Text PDF
September 2004

Nucleotide interactions with membrane-bound transporter associated with antigen processing proteins.

Authors:
Philip Edward Lapinski Gayatri Raghuraman Malini Raghavan

J Biol Chem 2003 Mar 25;278(10):8229-37. Epub 2002 Dec 25.

Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor 48109-0620, USA.

View Article and Find Full Text PDF
March 2003

Responses of herpes simplex virus type 1-infected cells to the presence of extracellular antibodies: gE-dependent glycoprotein capping and enhancement in cell-to-cell spread.

Authors:
Syed Monem Rizvi Malini Raghavan

J Virol 2003 Jan;77(1):701-8

Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor 48109-0620, USA.

View Article and Find Full Text PDF
January 2003

Tapasin interacts with the membrane-spanning domains of both TAP subunits and enhances the structural stability of TAP1 x TAP2 Complexes.

Authors:
Gayatri Raghuraman Philip Edward Lapinski Malini Raghavan

J Biol Chem 2002 Nov 3;277(44):41786-94. Epub 2002 Sep 3.

Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor 48109-0620, USA.

View Article and Find Full Text PDF
November 2002

Calreticulin recognizes misfolded HLA-A2 heavy chains.

Authors:
Laura Mancino Syed Monem Rizvi Philip Edward Lapinski Malini Raghavan

Proc Natl Acad Sci U S A 2002 Apr;99(9):5931-6

Department of Microbiology and Immunology and Immunology Graduate Program, University of Michigan Medical School, Ann Arbor, MI 48109-0620, USA.

View Article and Find Full Text PDF
April 2002