Publications by authors named "Malcolm K Brenner"

195Publications

Transgenic CD8αβ co-receptor rescues endogenous TCR function in TCR-transgenic virus-specific T cells.

Authors:
Gagan Bajwa Inès Lanz Mara Cardenas Malcolm K Brenner Caroline Arber

J Immunother Cancer 2020 Nov;8(2)

Department of Oncology UNIL CHUV, Lausanne University Hospital, Ludwig Institute for Cancer Research, University of Lausanne, Lausanne, Switzerland

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November 2020

Modulating TNFα activity allows transgenic IL15-Expressing CLL-1 CAR T cells to safely eliminate acute myeloid leukemia.

Authors:
Pinar Ataca Atilla Mary K McKenna Haruko Tashiro Madhuwanti Srinivasan Feiyan Mo Norihiro Watanabe Brian Wesley Simons Alexandra McLean Stevens Michele S Redell Helen E Heslop Maksim Mamonkin Malcolm K Brenner Erden Atilla

J Immunother Cancer 2020 Sep;8(2)

Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, Texas, USA

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September 2020

Single-cell transcriptomics identifies multiple pathways underlying antitumor function of TCR- and CD8αβ-engineered human CD4 T cells.

Authors:
Jan A Rath Gagan Bajwa Benoit Carreres Elisabeth Hoyer Isabelle Gruber Melisa A Martínez-Paniagua Yi-Ru Yu Nazila Nouraee Fatemeh Sadeghi Mengfen Wu Tao Wang Michael Hebeisen Nathalie Rufer Navin Varadarajan Ping-Chih Ho Malcolm K Brenner David Gfeller Caroline Arber

Sci Adv 2020 Jul 3;6(27):eaaz7809. Epub 2020 Jul 3.

Department of Oncology UNIL-CHUV, Lausanne University Hospital, Ludwig Institute for Cancer Research, University of Lausanne, Lausanne, Switzerland.

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July 2020

The safety and clinical effects of administering a multiantigen-targeted T cell therapy to patients with multiple myeloma.

Authors:
Premal D Lulla Ifigeneia Tzannou Spyridoula Vasileiou George Carrum Carlos A Ramos Rammurti Kamble Tao Wang Mengfen Wu Mrinalini Bilgi Adrian P Gee Shivani Mukhi Betty Chung Linghua Wang Ayumi Watanabe Manik Kuvalekar Mira Jeong Yumei Li Shamika Ketkar Matthew French-Kim Bambi Grilley Malcolm K Brenner Helen E Heslop Juan F Vera Ann M Leen

Sci Transl Med 2020 Jul;12(554)

Center for Cell and Gene Therapy, Baylor College of Medicine, Texas Children's Hospital and Houston Methodist Hospital, Houston, TX 77030, USA.

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July 2020

Anti-CD30 CAR-T Cell Therapy in Relapsed and Refractory Hodgkin Lymphoma.

Authors:
Carlos A Ramos Natalie S Grover Anne W Beaven Premal D Lulla Meng-Fen Wu Anastasia Ivanova Tao Wang Thomas C Shea Cliona M Rooney Christopher Dittus Steven I Park Adrian P Gee Paul W Eldridge Kathryn L McKay Birju Mehta Catherine J Cheng Faith B Buchanan Bambi J Grilley Kaitlin Morrison Malcolm K Brenner Jonathan S Serody Gianpietro Dotti Helen E Heslop Barbara Savoldo

J Clin Oncol 2020 Nov 23;38(32):3794-3804. Epub 2020 Jul 23.

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC.

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November 2020

Tumor response and endogenous immune reactivity after administration of HER2 CAR T cells in a child with metastatic rhabdomyosarcoma.

Authors:
Meenakshi Hegde Sujith K Joseph Farzana Pashankar Christopher DeRenzo Khaled Sanber Shoba Navai Tiara T Byrd John Hicks Mina L Xu Claudia Gerken Mamta Kalra Catherine Robertson Huimin Zhang Ankita Shree Birju Mehta Olga Dakhova Vita S Salsman Bambi Grilley Adrian Gee Gianpietro Dotti Helen E Heslop Malcolm K Brenner Winfried S Wels Stephen Gottschalk Nabil Ahmed

Nat Commun 2020 07 15;11(1):3549. Epub 2020 Jul 15.

Texas Children's Cancer and Hematology Centers, Texas Children's Hospital, Baylor College of Medicine, Houston, TX, USA.

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July 2020

Engineered off-the-shelf therapeutic T cells resist host immune rejection.

Authors:
Feiyan Mo Norihiro Watanabe Mary K McKenna M John Hicks Madhuwanti Srinivasan Diogo Gomes-Silva Erden Atilla Tyler Smith Pinar Ataca Atilla Royce Ma David Quach Helen E Heslop Malcolm K Brenner Maksim Mamonkin

Nat Biotechnol 2021 Jan 13;39(1):56-63. Epub 2020 Jul 13.

Center for Cell and Gene Therapy, Baylor College of Medicine, Texas Children's Hospital and Houston Methodist Hospital, Houston, TX, USA.

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January 2021

Oncolytic Adenovirus Armed with BiTE, Cytokine, and Checkpoint Inhibitor Enables CAR T Cells to Control the Growth of Heterogeneous Tumors.

Authors:
Caroline E Porter Amanda Rosewell Shaw Youngrock Jung Tiffany Yip Patricia D Castro Vlad C Sandulache Andrew Sikora Stephen Gottschalk Michael M Ittman Malcolm K Brenner Masataka Suzuki

Mol Ther 2020 05 24;28(5):1251-1262. Epub 2020 Feb 24.

Department of Medicine, Baylor College of Medicine, Houston, TX, USA; Center for Cell and Gene Therapy, Baylor College of Medicine, Texas Children's Hospital, Houston Methodist Hospital, Houston, TX, USA. Electronic address:

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May 2020

T-Cell Receptor Stimulation Enhances the Expansion and Function of CD19 Chimeric Antigen Receptor-Expressing T Cells.

Authors:
Natalia Lapteva Margaret Gilbert Iulia Diaconu Lisa A Rollins Mina Al-Sabbagh Swati Naik Robert A Krance Tamara Tripic Manasa Hiregange Darshana Raghavan Olga Dakhova Rayne H Rouce Hao Liu Bilal Omer Barbara Savoldo Gianpietro Dotti Conrad Russel Cruz Keli Sharpe Melissa Gates Aaron Orozco April Durett Elizabeth Pacheco Adrian P Gee Carlos A Ramos Helen E Heslop Malcolm K Brenner Cliona M Rooney

Clin Cancer Res 2019 12 26;25(24):7340-7350. Epub 2019 Sep 26.

Center for Cell and Gene Therapy, Baylor College of Medicine, Houston Methodist Hospital, Texas Children's Hospital, Houston, Texas.

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December 2019

Allogeneic hematopoietic stem cell transplant for relapsed and refractory non-Hodgkin lymphoma in pediatric patients.

Authors:
Swati Naik Caridad A Martinez Bilal Omer Ghadir Sasa Khaled Yassine Carl E Allen Kala Kamdar Robert Orth Mengfen Wu Kathryn Leung Stephen Gottschalk Malcolm K Brenner Helen E Heslop Robert A Krance

Blood Adv 2019 09;3(18):2689-2695

Center for Cell and Gene Therapy, Texas Children's Hospital/Baylor College of Medicine/Houston Methodist Hospital, Houston, TX.

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September 2019

Tandem CAR T cells targeting HER2 and IL13Rα2 mitigate tumor antigen escape.

Authors:
Meenakshi Hegde Malini Mukherjee Zakaria Grada Antonella Pignata Daniel Landi Shoba A Navai Amanda Wakefield Kristen Fousek Kevin Bielamowicz Kevin Kh Chow Vita S Brawley Tiara T Byrd Simone Krebs Stephen Gottschalk Winfried S Wels Matthew L Baker Gianpietro Dotti Maksim Mamonkin Malcolm K Brenner Jordan S Orange Nabil Ahmed

J Clin Invest 2019 Jul 2;129(8):3464. Epub 2019 Jul 2.

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July 2019

Adoptive Cell Therapy for Acute Myeloid Leukemia and T-Cell Acute Lymphoblastic Leukemia.

Authors:
Premal D Lulla Maksim Mamonkin Malcolm K Brenner

Cancer J 2019 May/Jun;25(3):199-207

From the Center for Cell and Gene Therapy at Baylor College of Medicine; Houston Methodist Hospital; and Texas Children's Hospital, Houston, Texas.

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July 2020

Chimeric Antigen Receptors for T-Cell Malignancies.

Authors:
Lauren D Scherer Malcolm K Brenner Maksim Mamonkin

Front Oncol 2019 5;9:126. Epub 2019 Mar 5.

Texas Children's Hospital, Houston, TX, United States.

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March 2019

Adoptive Cell Therapy: ACT-Up or ACT-Out?

Authors:
Malcolm K Brenner

Mol Ther 2019 04 5;27(4):693-694. Epub 2019 Mar 5.

Center for Cell and Gene Therapy, Baylor College of Medicine, Houston Methodist Hospital and Texas Children's Hospital, Houston, TX, USA. Electronic address:

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April 2019

CD7 CAR T Cells for the Therapy of Acute Myeloid Leukemia.

Authors:
Diogo Gomes-Silva Erden Atilla Pinar Ataca Atilla Feiyan Mo Haruko Tashiro Madhuwanti Srinivasan Premal Lulla Rayne H Rouce Joaquim M S Cabral Carlos A Ramos Malcolm K Brenner Maksim Mamonkin

Mol Ther 2019 01 4;27(1):272-280. Epub 2018 Oct 4.

Center for Cell and Gene Therapy, Baylor College of Medicine, Texas Children's Hospital, Houston Methodist Hospital, Houston, TX 77030, USA; Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address:

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January 2019

In Vivo Fate and Activity of Second- versus Third-Generation CD19-Specific CAR-T Cells in B Cell Non-Hodgkin's Lymphomas.

Authors:
Carlos A Ramos Rayne Rouce Catherine S Robertson Amy Reyna Neeharika Narala Gayatri Vyas Birju Mehta Huimin Zhang Olga Dakhova George Carrum Rammurti T Kamble Adrian P Gee Zhuyong Mei Meng-Fen Wu Hao Liu Bambi Grilley Cliona M Rooney Helen E Heslop Malcolm K Brenner Barbara Savoldo Gianpietro Dotti

Mol Ther 2018 12 13;26(12):2727-2737. Epub 2018 Sep 13.

Center for Cell and Gene Therapy, Baylor College of Medicine, Houston Methodist Hospital and Texas Children's Hospital, Houston, TX 77030, USA; Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address:

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December 2018

EBV/LMP-specific T cells maintain remissions of T- and B-cell EBV lymphomas after allogeneic bone marrow transplantation.

Authors:
Lauren P McLaughlin Rayne Rouce Stephen Gottschalk Vicky Torrano George Carrum Meng-Fen Wu Fahmida Hoq Bambi Grilley Andrea M Marcogliese Patrick J Hanley Adrian P Gee Malcolm K Brenner Cliona M Rooney Helen E Heslop Catherine M Bollard

Blood 2018 11 27;132(22):2351-2361. Epub 2018 Sep 27.

Center for Cancer and Immunology Research, Children's National Health System and George Washington University, Washington, DC.

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November 2018

A Phase I/IIa Trial Using CD19-Targeted Third-Generation CAR T Cells for Lymphoma and Leukemia.

Authors:
Gunilla Enblad Hannah Karlsson Gustav Gammelgård Jessica Wenthe Tanja Lövgren Rose Marie Amini Kristina I Wikstrom Magnus Essand Barbara Savoldo Helene Hallböök Martin Höglund Gianpietro Dotti Malcolm K Brenner Hans Hagberg Angelica Loskog

Clin Cancer Res 2018 12 10;24(24):6185-6194. Epub 2018 Aug 10.

Department of Immunology, Genetics and Pathology, Uppsala University, Rudbeck Laboratory C11, Uppsala, Sweden.

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December 2018

Enhancing the Potency and Specificity of Engineered T Cells for Cancer Treatment.

Authors:
Sujita Sukumaran Norihiro Watanabe Pradip Bajgain Kanchana Raja Somala Mohammed William E Fisher Malcolm K Brenner Ann M Leen Juan F Vera

Cancer Discov 2018 08 7;8(8):972-987. Epub 2018 Jun 7.

Center for Cell and Gene Therapy, Baylor College of Medicine, Texas Children's Hospital and Houston Methodist Hospital, Houston, Texas.

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August 2018

Onward and upward for immuno-oncology.

Authors:
Malcolm K Brenner

Chin Clin Oncol 2018 04;7(2):18

Center for Cell and Gene Therapy, Baylor College of Medicine, Houston Methodist Hospital, Texas Children's Hospital, Houston, Texas, USA.

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April 2018