Malcolm Dunlop

Malcolm Dunlop

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Malcolm Dunlop

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Effects of common genetic variants associated with colorectal cancer risk on survival outcomes after diagnosis: A large population-based cohort study.

Int J Cancer 2019 Jul 4. Epub 2019 Jul 4.

Cancer Research UK Edinburgh Centre, Medical Research Council Institute of Genetics & Molecular Medicine, Western General Hospital, The University of Edinburgh, Edinburgh, United Kingdom.

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http://dx.doi.org/10.1002/ijc.32550DOI Listing
July 2019

Performance of prediction models on survival outcomes of colorectal cancer with surgical resection: A systematic review and meta-analysis.

Surg Oncol 2019 Jun 20;29:196-202. Epub 2019 May 20.

Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, The University of Edinburgh, Edinburgh, UK; Edinburgh Cancer Research Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK. Electronic address:

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http://dx.doi.org/10.1016/j.suronc.2019.05.014DOI Listing
June 2019

Association analyses identify 31 new risk loci for colorectal cancer susceptibility.

Nat Commun 2019 05 14;10(1):2154. Epub 2019 May 14.

Colon Cancer Genetics Group, Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, University of Edinburgh, Edinburgh, EH4 2XU, UK.

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http://www.nature.com/articles/s41467-019-09775-w
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http://dx.doi.org/10.1038/s41467-019-09775-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6517433PMC
May 2019

Higher Post-Operative Serum Vitamin D Level is Associated with Better Survival Outcome in Colorectal Cancer Patients.

Nutr Cancer 2019 Apr 4:1-8. Epub 2019 Apr 4.

l Discipline of Public Health and Primary Care, Institute of Population Health, Trinity College , University of Dublin , Dublin , Ireland.

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http://dx.doi.org/10.1080/01635581.2019.1597135DOI Listing
April 2019

Gene-environment interactions and colorectal cancer risk: An umbrella review of systematic reviews and meta-analyses of observational studies.

Int J Cancer 2018 Dec 11. Epub 2018 Dec 11.

Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, The University of Edinburgh, Edinburgh, United Kingdom.

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http://dx.doi.org/10.1002/ijc.32057DOI Listing
December 2018

Genome-wide scan of the effect of common nsSNPs on colorectal cancer survival outcome.

Br J Cancer 2018 10 21;119(8):988-993. Epub 2018 Aug 21.

Colon Cancer Genetics Group and Academic Coloproctology, Institute of Genetics and Molecular Medicine, University of Edinburgh and MRC Human Genetics Unit Western General Hospital Edinburgh, Edinburgh, EH4 2XU, UK.

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http://dx.doi.org/10.1038/s41416-018-0117-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6203849PMC
October 2018

Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels.

Authors:
Xia Jiang Paul F O'Reilly Hugues Aschard Yi-Hsiang Hsu J Brent Richards Josée Dupuis Erik Ingelsson David Karasik Stefan Pilz Diane Berry Bryan Kestenbaum Jusheng Zheng Jianan Luan Eleni Sofianopoulou Elizabeth A Streeten Demetrius Albanes Pamela L Lutsey Lu Yao Weihong Tang Michael J Econs Henri Wallaschofski Henry Völzke Ang Zhou Chris Power Mark I McCarthy Erin D Michos Eric Boerwinkle Stephanie J Weinstein Neal D Freedman Wen-Yi Huang Natasja M Van Schoor Nathalie van der Velde Lisette C P G M de Groot Anke Enneman L Adrienne Cupples Sarah L Booth Ramachandran S Vasan Ching-Ti Liu Yanhua Zhou Samuli Ripatti Claes Ohlsson Liesbeth Vandenput Mattias Lorentzon Johan G Eriksson M Kyla Shea Denise K Houston Stephen B Kritchevsky Yongmei Liu Kurt K Lohman Luigi Ferrucci Munro Peacock Christian Gieger Marian Beekman Eline Slagboom Joris Deelen Diana van Heemst Marcus E Kleber Winfried März Ian H de Boer Alexis C Wood Jerome I Rotter Stephen S Rich Cassianne Robinson-Cohen Martin den Heijer Marjo-Riitta Jarvelin Alana Cavadino Peter K Joshi James F Wilson Caroline Hayward Lars Lind Karl Michaëlsson Stella Trompet M Carola Zillikens Andre G Uitterlinden Fernando Rivadeneira Linda Broer Lina Zgaga Harry Campbell Evropi Theodoratou Susan M Farrington Maria Timofeeva Malcolm G Dunlop Ana M Valdes Emmi Tikkanen Terho Lehtimäki Leo-Pekka Lyytikäinen Mika Kähönen Olli T Raitakari Vera Mikkilä M Arfan Ikram Naveed Sattar J Wouter Jukema Nicholas J Wareham Claudia Langenberg Nita G Forouhi Thomas E Gundersen Kay-Tee Khaw Adam S Butterworth John Danesh Timothy Spector Thomas J Wang Elina Hyppönen Peter Kraft Douglas P Kiel

Nat Commun 2018 01 17;9(1):260. Epub 2018 Jan 17.

Institute for Aging Research, Hebrew SeniorLife, 1200 Centre Street, Boston, MA, 02131, USA.

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http://dx.doi.org/10.1038/s41467-017-02662-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5772647PMC
January 2018

Farming, Foreign Holidays, and Vitamin D in Orkney.

PLoS One 2016 17;11(5):e0155633. Epub 2016 May 17.

Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, Scotland.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0155633PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4871509PMC
July 2017

Validation of Recently Proposed Colorectal Cancer Susceptibility Gene Variants in an Analysis of Families and Patients-a Systematic Review.

Gastroenterology 2017 01 3;152(1):75-77.e4. Epub 2016 Oct 3.

Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK; Division of Pathology, The Institute of Cancer Research, London, UK. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2016.09.041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5860724PMC
January 2017

IgG Glycome in Colorectal Cancer.

Clin Cancer Res 2016 06 1;22(12):3078-86. Epub 2016 Feb 1.

Genos Glycoscience Research Laboratory, Zagreb, Croatia. Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia.

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http://dx.doi.org/10.1158/1078-0432.CCR-15-1867DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5860729PMC
June 2016

Five endometrial cancer risk loci identified through genome-wide association analysis.

Nat Genet 2016 06 2;48(6):667-674. Epub 2016 May 2.

Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.

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http://dx.doi.org/10.1038/ng.3562DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4907351PMC
June 2016

Modulation of genetic associations with serum urate levels by body-mass-index in humans.

Authors:
Jennifer E Huffman Eva Albrecht Alexander Teumer Massimo Mangino Karen Kapur Toby Johnson Zoltán Kutalik Nicola Pirastu Giorgio Pistis Lorna M Lopez Toomas Haller Perttu Salo Anuj Goel Man Li Toshiko Tanaka Abbas Dehghan Daniela Ruggiero Giovanni Malerba Albert V Smith Ilja M Nolte Laura Portas Amanda Phipps-Green Lora Boteva Pau Navarro Asa Johansson Andrew A Hicks Ozren Polasek Tõnu Esko John F Peden Sarah E Harris Federico Murgia Sarah H Wild Albert Tenesa Adrienne Tin Evelin Mihailov Anne Grotevendt Gauti K Gislason Josef Coresh Pio D'Adamo Sheila Ulivi Peter Vollenweider Gerard Waeber Susan Campbell Ivana Kolcic Krista Fisher Margus Viigimaa Jeffrey E Metter Corrado Masciullo Elisabetta Trabetti Cristina Bombieri Rossella Sorice Angela Döring Eva Reischl Konstantin Strauch Albert Hofman Andre G Uitterlinden Melanie Waldenberger H-Erich Wichmann Gail Davies Alan J Gow Nicola Dalbeth Lisa Stamp Johannes H Smit Mirna Kirin Ramaiah Nagaraja Matthias Nauck Claudia Schurmann Kathrin Budde Susan M Farrington Evropi Theodoratou Antti Jula Veikko Salomaa Cinzia Sala Christian Hengstenberg Michel Burnier Reedik Mägi Norman Klopp Stefan Kloiber Sabine Schipf Samuli Ripatti Stefano Cabras Nicole Soranzo Georg Homuth Teresa Nutile Patricia B Munroe Nicholas Hastie Harry Campbell Igor Rudan Claudia Cabrera Chris Haley Oscar H Franco Tony R Merriman Vilmundur Gudnason Mario Pirastu Brenda W Penninx Harold Snieder Andres Metspalu Marina Ciullo Peter P Pramstaller Cornelia M van Duijn Luigi Ferrucci Giovanni Gambaro Ian J Deary Malcolm G Dunlop James F Wilson Paolo Gasparini Ulf Gyllensten Tim D Spector Alan F Wright Caroline Hayward Hugh Watkins Markus Perola Murielle Bochud W H Linda Kao Mark Caulfield Daniela Toniolo Henry Völzke Christian Gieger Anna Köttgen Veronique Vitart

PLoS One 2015 26;10(3):e0119752. Epub 2015 Mar 26.

Medical Research Council (MRC) Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine (IGMM), University of Edinburgh, Edinburgh, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0119752PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4374966PMC
March 2016

Meta-analysis of genome-wide association studies identifies common susceptibility polymorphisms for colorectal and endometrial cancer near SH2B3 and TSHZ1.

Authors:
Timothy H T Cheng Deborah Thompson Jodie Painter Tracy O'Mara Maggie Gorman Lynn Martin Claire Palles Angela Jones Daniel D Buchanan Aung Ko Win John Hopper Mark Jenkins Noralane M Lindor Polly A Newcomb Steve Gallinger David Conti Fred Schumacher Graham Casey Graham G Giles Paul Pharoah Julian Peto Angela Cox Anthony Swerdlow Fergus Couch Julie M Cunningham Ellen L Goode Stacey J Winham Diether Lambrechts Peter Fasching Barbara Burwinkel Hermann Brenner Hiltrud Brauch Jenny Chang-Claude Helga B Salvesen Vessela Kristensen Hatef Darabi Jingmei Li Tao Liu Annika Lindblom Per Hall Magdalena Echeverry de Polanco Monica Sans Angel Carracedo Sergi Castellvi-Bel Augusto Rojas-Martinez Samuel Aguiar Jnr Manuel R Teixeira Alison M Dunning Joe Dennis Geoffrey Otton Tony Proietto Elizabeth Holliday John Attia Katie Ashton Rodney J Scott Mark McEvoy Sean C Dowdy Brooke L Fridley Henrica M J Werner Jone Trovik Tormund S Njolstad Emma Tham Miriam Mints Ingo Runnebaum Peter Hillemanns Thilo Dörk Frederic Amant Stefanie Schrauwen Alexander Hein Matthias W Beckmann Arif Ekici Kamila Czene Alfons Meindl Manjeet K Bolla Kyriaki Michailidou Jonathan P Tyrer Qin Wang Shahana Ahmed Catherine S Healey Mitul Shah Daniela Annibali Jeroen Depreeuw Nada A Al-Tassan Rebecca Harris Brian F Meyer Nicola Whiffin Fay J Hosking Ben Kinnersley Susan M Farrington Maria Timofeeva Albert Tenesa Harry Campbell Robert W Haile Shirley Hodgson Luis Carvajal-Carmona Jeremy P Cheadle Douglas Easton Malcolm Dunlop Richard Houlston Amanda Spurdle Ian Tomlinson

Sci Rep 2015 12 1;5:17369. Epub 2015 Dec 1.

Molecular and Population Genetics Laboratory, Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK.

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http://dx.doi.org/10.1038/srep17369DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4664893PMC
December 2015

Obesity, Aspirin, and Risk of Colorectal Cancer in Carriers of Hereditary Colorectal Cancer: A Prospective Investigation in the CAPP2 Study.

J Clin Oncol 2015 Nov 17;33(31):3591-7. Epub 2015 Aug 17.

Mohammad Movahedi, Beheshti University of Medical Sciences, Tehran, Iran; Mohammad Movahedi and D. Timothy Bishop, University of Leeds, Leeds; Diana Eccles, University of Southampton, Southampton; D. Gareth Evans, St Mary's Hospital, Manchester; Eamonn R. Maher, University of Birmingham, Birmingham; Malcolm G. Dunlop, Western General Hospital, Edinburgh; Shirley V. Hodgson, St George's Hospital; Lucy Side, University College London; Huw J.W. Thomas, St Mark's Hospital, Imperial College, London; Patrick J. Morrison, Queens University Belfast, Belfast City Hospital Health and Social Care Trust, Belfast; Victoria Murday, Yorkhill Hospital, Glasgow; John Burn and John C. Mathers, Newcastle University, Newcastle upon Tyne, United Kingdom; Finlay Macrae, Royal Melbourne Hospital, Melbourne, Victoria; Rodney J. Scott, John Hunter Hospital, New Lambton, New South Wales, Australia; Jukka-Pekka Mecklin, Jyväskylä Central Hospital, Jyväskylä, Finland; Gabriela Moeslein, HELIOS St Josefs Hospital, Bochum-Linden, Germany; Sylviane Olschwang, Institut Paoli Calmettes, Marseille, France; Lucio Bertario, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy; Marie-Luise Bisgaard, University of Copenhagen, Hvidovre, Denmark; Judy W.C. Ho, Queen Mary Hospital, Hong Kong, Special Administrative Region, People's Republic of China; Annika Lindblom, Karolinska Institutet, Stockholm, Sweden; Jan Lubinski, International Hereditary Cancer Centre, Szczecin, Poland; Raj S. Ramesar, University of Cape Town, South Africa; and Hans F. Vasen, Netherlands Foundation of the Detection of Hereditary Tumours and Leiden University, Leiden, the Netherlands.

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http://dx.doi.org/10.1200/JCO.2014.58.9952DOI Listing
November 2015

Inflammatory bowel disease associates with proinflammatory potential of the immunoglobulin G glycome.

Inflamm Bowel Dis 2015 Jun;21(6):1237-47

*Genos Glycoscience Research Laboratory, Zagreb, Croatia; †Gastrointestinal Unit, Centre for Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom; ‡Centre for Population Health Sciences, University of Edinburgh, Edinburgh, United Kingdom; §Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and Medical Research Council Human Genetics Unit, Edinburgh, United Kingdom; ‖Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia; ¶Novosibirsk State University, Novosibirsk, Russia; and **Department of Biochemistry and Molecular Biology, University of Zagreb, Faculty of Pharmacy and Biochemistry, Zagreb, Croatia.

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http://dx.doi.org/10.1097/MIB.0000000000000372DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4450892PMC
June 2015

Reply to F.J.S. Conway et Al.

J Clin Oncol 2015 Jan 8;33(2):224-5. Epub 2014 Dec 8.

Institute of Genetics and Molecular Medicine, and Centre for Population Health Sciences, University of Edinburgh, and Western General Hospital Edinburgh, Edinburgh, United Kingdom.

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http://dx.doi.org/10.1200/JCO.2014.59.3319DOI Listing
January 2015

Plasma vitamin D concentration influences survival outcome after a diagnosis of colorectal cancer.

J Clin Oncol 2014 Aug 7;32(23):2430-9. Epub 2014 Jul 7.

Lina Zgaga, Susan M. Farrington, Farhat V.N. Din, Li Yin Ooi, Dominik Glodzik, Albert Tenesa, Harry Campbell, and Malcolm G. Dunlop, University of Edinburgh and Western General Hospital; Evropi Theodoratou and Harry Campbell, University of Edinburgh, Edinburgh; Albert Tenesa, University of Edinburgh, Roslin; Susan Johnston, Glasgow Royal Infirmary, Glasgow, United Kingdom; Lina Zgaga, Trinity College Dublin, Dublin, Ireland.

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http://dx.doi.org/10.1200/JCO.2013.54.5947DOI Listing
August 2014

Re: Role of the oxidative DNA damage repair gene OGG1 in colorectal tumorigenesis.

J Natl Cancer Inst 2014 Apr 26;106(5). Epub 2014 Apr 26.

Affiliations of authors: Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton, Surrey, UK (BK, RSH); Department of Medicine I, University Hospital Dresden, Dresden, Germany (SB); Department of Gastroenterology, Hospital Clínic, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Institut d'Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona, Barcelona, Catalonia, Spain (SCB); Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and Medical Research Council (MRC) Human Genetics Unit, Edinburgh, UK (MGD, SMF); German Cancer Research Center, Heidelberg, Germany (AF, KH); Department of Internal Medicine I, Hospital Schleswig-Holstein, Kiel, Germany (JH); Leeds Cancer Research UK Centre, Section of Epidemiology and Biostatistics, Leeds Institute of Cancer Studies and Pathology, St James's University Hospital, Leeds, UK (EN, DTB); Molecular and Population Genetics Laboratory, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK (CP, IT); Department of Genetics, Portugese Oncology Institute, Porto, Portugal (MP, MRT); Galician Public Foundation of Genomic Medicine, Centro de Investigación Biomédica en Rad de Enfermedades Rares, Genomics Medicine Group, Hospital Clínico, Santiago de Compostela, University of Santiago de Compostela, Galicia, Spain (CRP); Department of General and Thoraci Surgery, University Hospital Schleswig-Holstein, Kiel, Germany (CS); University of Gronigen, University Medical Centre Gronigen, Department of Genetics, Gronigen, The Netherlands (HW, RMWH); Department of Clinical Genetics, Erasmus Medical Center, Rotterdam, The Netherlands (RMWH); Leiden Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands (TW).

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http://dx.doi.org/10.1093/jnci/dju086DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4677263PMC
April 2014

Associations between dietary and lifestyle risk factors and colorectal cancer in the Scottish population.

Eur J Cancer Prev 2014 Jan;23(1):8-17

aDepartment of Environmental and Occupational Medicine, Liberty Safe Work Research Centre, University of Aberdeen, Aberdeen bCentre for Population Health Sciences, College of Medicine and Veterinary Medicine cColon Cancer Genetics Group, Institute of Genetics and Molecular Medicine dSchool of Informatics, College of Science and Engineering, University of Edinburgh eSchool of Nursing, Midwifery & Social Care, Faculty of Health, Life and Social Sciences, Edinburgh Napier University fSouth East Scotland Genetic Service, Western General Hospital, Edinburgh, UK.

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http://dx.doi.org/10.1097/CEJ.0b013e3283639fb8DOI Listing
January 2014

Germline variants and advanced colorectal adenomas: adenoma prevention with celecoxib trial genome-wide association study.

Clin Cancer Res 2013 Dec 1;19(23):6430-7. Epub 2013 Oct 1.

Authors' Affiliations: Department of Surgery, Division of Surgical Oncology, Center for Genomic Medicine, Channing Laboratory, Brigham and Women's Hospital, Boston, Massachusetts; Genome Center and Department of Biochemistry and Molecular Medicine, University of California, Davis, California; Department of Epidemiology and Statistics, Memorial Sloan-Kettering Cancer Center, New York; RIKEN Center for Genomic Medicine, Tokyo, Japan; Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and MRC Human Genetics Unit, Edinburgh; Section of Cancer Genetics, Institute of Cancer Research, Sutton, United Kingdom; Ludwig Colon Cancer Initiative Laboratory, Ludwig Institute for Cancer Research, Royal Melbourne Hospital, Parkville; Genetic and Molecular Epidemiology Laboratories, and Familial Cancer laboratory, Queensland Institute of Medical Research, Brisbane; Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, East Melbourne, Australia; and Department of Medicine, University of Chicago, Chicago, Illinois.

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http://dx.doi.org/10.1158/1078-0432.CCR-13-0550DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4037290PMC
December 2013

Inference of identity by descent in population isolates and optimal sequencing studies.

Eur J Hum Genet 2013 Oct 30;21(10):1140-5. Epub 2013 Jan 30.

MRC Institute of Genetics and Molecular Medicine (MRC IGMM), MRC Human Genetics Unit, University of Edinburgh, Western General Hospital, Edinburgh, UK.

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http://dx.doi.org/10.1038/ejhg.2012.307DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3778345PMC
October 2013

Long term effect of surgery and radiotherapy for colorectal cancer on defecatory function and quality of life.

Eur J Oncol Nurs 2013 Oct 27;17(5):570-7. Epub 2013 Feb 27.

Edinburgh Cancer Centre, Lothian University Hospitals Division, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, Scotland, UK. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S14623889130001
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http://dx.doi.org/10.1016/j.ejon.2013.01.010DOI Listing
October 2013

Genome-wide association analyses identify 18 new loci associated with serum urate concentrations.

Authors:
Anna Köttgen Eva Albrecht Alexander Teumer Veronique Vitart Jan Krumsiek Claudia Hundertmark Giorgio Pistis Daniela Ruggiero Conall M O'Seaghdha Toomas Haller Qiong Yang Toshiko Tanaka Andrew D Johnson Zoltán Kutalik Albert V Smith Julia Shi Maksim Struchalin Rita P S Middelberg Morris J Brown Angelo L Gaffo Nicola Pirastu Guo Li Caroline Hayward Tatijana Zemunik Jennifer Huffman Loic Yengo Jing Hua Zhao Ayse Demirkan Mary F Feitosa Xuan Liu Giovanni Malerba Lorna M Lopez Pim van der Harst Xinzhong Li Marcus E Kleber Andrew A Hicks Ilja M Nolte Asa Johansson Federico Murgia Sarah H Wild Stephan J L Bakker John F Peden Abbas Dehghan Maristella Steri Albert Tenesa Vasiliki Lagou Perttu Salo Massimo Mangino Lynda M Rose Terho Lehtimäki Owen M Woodward Yukinori Okada Adrienne Tin Christian Müller Christopher Oldmeadow Margus Putku Darina Czamara Peter Kraft Laura Frogheri Gian Andri Thun Anne Grotevendt Gauti Kjartan Gislason Tamara B Harris Lenore J Launer Patrick McArdle Alan R Shuldiner Eric Boerwinkle Josef Coresh Helena Schmidt Michael Schallert Nicholas G Martin Grant W Montgomery Michiaki Kubo Yusuke Nakamura Toshihiro Tanaka Patricia B Munroe Nilesh J Samani David R Jacobs Kiang Liu Pio D'Adamo Sheila Ulivi Jerome I Rotter Bruce M Psaty Peter Vollenweider Gerard Waeber Susan Campbell Olivier Devuyst Pau Navarro Ivana Kolcic Nicholas Hastie Beverley Balkau Philippe Froguel Tõnu Esko Andres Salumets Kay Tee Khaw Claudia Langenberg Nicholas J Wareham Aaron Isaacs Aldi Kraja Qunyuan Zhang Philipp S Wild Rodney J Scott Elizabeth G Holliday Elin Org Margus Viigimaa Stefania Bandinelli Jeffrey E Metter Antonio Lupo Elisabetta Trabetti Rossella Sorice Angela Döring Eva Lattka Konstantin Strauch Fabian Theis Melanie Waldenberger H-Erich Wichmann Gail Davies Alan J Gow Marcel Bruinenberg Ronald P Stolk Jaspal S Kooner Weihua Zhang Bernhard R Winkelmann Bernhard O Boehm Susanne Lucae Brenda W Penninx Johannes H Smit Gary Curhan Poorva Mudgal Robert M Plenge Laura Portas Ivana Persico Mirna Kirin James F Wilson Irene Mateo Leach Wiek H van Gilst Anuj Goel Halit Ongen Albert Hofman Fernando Rivadeneira Andre G Uitterlinden Medea Imboden Arnold von Eckardstein Francesco Cucca Ramaiah Nagaraja Maria Grazia Piras Matthias Nauck Claudia Schurmann Kathrin Budde Florian Ernst Susan M Farrington Evropi Theodoratou Inga Prokopenko Michael Stumvoll Antti Jula Markus Perola Veikko Salomaa So-Youn Shin Tim D Spector Cinzia Sala Paul M Ridker Mika Kähönen Jorma Viikari Christian Hengstenberg Christopher P Nelson James F Meschia Michael A Nalls Pankaj Sharma Andrew B Singleton Naoyuki Kamatani Tanja Zeller Michel Burnier John Attia Maris Laan Norman Klopp Hans L Hillege Stefan Kloiber Hyon Choi Mario Pirastu Silvia Tore Nicole M Probst-Hensch Henry Völzke Vilmundur Gudnason Afshin Parsa Reinhold Schmidt John B Whitfield Myriam Fornage Paolo Gasparini David S Siscovick Ozren Polašek Harry Campbell Igor Rudan Nabila Bouatia-Naji Andres Metspalu Ruth J F Loos Cornelia M van Duijn Ingrid B Borecki Luigi Ferrucci Giovanni Gambaro Ian J Deary Bruce H R Wolffenbuttel John C Chambers Winfried März Peter P Pramstaller Harold Snieder Ulf Gyllensten Alan F Wright Gerjan Navis Hugh Watkins Jacqueline C M Witteman Serena Sanna Sabine Schipf Malcolm G Dunlop Anke Tönjes Samuli Ripatti Nicole Soranzo Daniela Toniolo Daniel I Chasman Olli Raitakari W H Linda Kao Marina Ciullo Caroline S Fox Mark Caulfield Murielle Bochud Christian Gieger

Nat Genet 2013 Feb 23;45(2):145-54. Epub 2012 Dec 23.

Renal Division, Freiburg University Hospital, Freiburg, Germany.

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http://dx.doi.org/10.1038/ng.2500DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3663712PMC
February 2013

Evidence of inbreeding depression on human height.

PLoS Genet 2012 19;8(7):e1002655. Epub 2012 Jul 19.

Centre for Population Health Sciences, University of Edinburgh, Edinburgh, Scotland, United Kingdom.

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http://dx.doi.org/10.1371/journal.pgen.1002655DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3400549PMC
January 2013

Aspirin inhibits mTOR signaling, activates AMP-activated protein kinase, and induces autophagy in colorectal cancer cells.

Gastroenterology 2012 Jun 6;142(7):1504-15.e3. Epub 2012 Mar 6.

Colon Cancer Genetics Group and Academic Coloproctology, Institute of Genetics and Molecular Medicine, University of Edinburgh and Medical Research Council Human Genetics Unit, Western General Hospital Edinburgh, United Kingdom.

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http://dx.doi.org/10.1053/j.gastro.2012.02.050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3682211PMC
June 2012

Investigation of the effects of DNA repair gene polymorphisms on the risk of colorectal cancer.

Mutagenesis 2012 Mar;27(2):219-23

Molecular and Population Genetics Laboratory and Oxford NIHR Comprehensive Biomedical Research Centre, Nuffield Department of Clinical Medicine, Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK.

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http://dx.doi.org/10.1093/mutage/ger070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4610049PMC
March 2012

In vitro stability of APC gene sequences and the influence of DNA repair status.

Mutagenesis 2012 Mar;27(2):233-8

Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and MRC Human Genetics Unit, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK.

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http://dx.doi.org/10.1093/mutage/ger069DOI Listing
March 2012

The interleukin-6 receptor as a target for prevention of coronary heart disease: a mendelian randomisation analysis.

Authors:
Daniel I Swerdlow Michael V Holmes Karoline B Kuchenbaecker Jorgen E L Engmann Tina Shah Reecha Sofat Yiran Guo Christina Chung Anne Peasey Roman Pfister Simon P Mooijaart Helen A Ireland Maarten Leusink Claudia Langenberg Ka Wah Li Jutta Palmen Philip Howard Jackie A Cooper Fotios Drenos John Hardy Michael A Nalls Yun Rose Li Gordon Lowe Marlene Stewart Suzette J Bielinski Julian Peto Nicholas J Timpson John Gallacher Malcolm Dunlop Richard Houlston Ian Tomlinson Ioanna Tzoulaki Jian'an Luan Jolanda M A Boer Nita G Forouhi N Charlotte Onland-Moret Yvonne T van der Schouw Renate B Schnabel Jaroslav A Hubacek Ruzena Kubinova Migle Baceviciene Abdonas Tamosiunas Andrzej Pajak Roman Topor-Madry Sofia Malyutina Damiano Baldassarre Bengt Sennblad Elena Tremoli Ulf de Faire Luigi Ferrucci Stefania Bandenelli Toshiko Tanaka James F Meschia Andrew Singleton Gerjan Navis Irene Mateo Leach Stephan J L Bakker Ron T Gansevoort Ian Ford Stephen E Epstein Mary Susan Burnett Joe M Devaney J Wouter Jukema Rudi G J Westendorp Gert Jan de Borst Yolanda van der Graaf Pim A de Jong Anke-Hilse Mailand-van der Zee Olaf H Klungel Anthonius de Boer Pieter A Doevendans Jeffrey W Stephens Charles B Eaton Jennifer G Robinson JoAnn E Manson F Gerry Fowkes Timonthy M Frayling Jackie F Price Peter H Whincup Richard W Morris Debbie A Lawlor George Davey Smith Yoav Ben-Shlomo Susan Redline Leslie A Lange Meena Kumari Nick J Wareham W M Monique Verschuren Emelia J Benjamin John C Whittaker Anders Hamsten Frank Dudbridge J A Chris Delaney Andrew Wong Diana Kuh Rebecca Hardy Berta Almoguera Castillo John J Connolly Pim van der Harst Eric J Brunner Michael G Marmot Christina L Wassel Steve E Humphries Philippa J Talmud Mika Kivimaki Folkert W Asselbergs Mikhail Voevoda Martin Bobak Hynek Pikhart James G Wilson Hakon Hakonarson Alex P Reiner Brendan J Keating Naveed Sattar Aroon D Hingorani Juan Pablo Casas

Lancet 2012 Mar 14;379(9822):1214-24. Epub 2012 Mar 14.

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http://dx.doi.org/10.1016/S0140-6736(12)60110-XDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3316968PMC
March 2012

Cigarette smoke extract (CSE) delays NOD2 expression and affects NOD2/RIPK2 interactions in intestinal epithelial cells.

PLoS One 2011 12;6(9):e24715. Epub 2011 Sep 12.

Gastrointestinal Unit, Molecular Medicine Centre, Western General Hospital, University of Edinburgh, Edinburgh, Scotland, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0024715PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3171477PMC
February 2012

c-Src dependency of NSAID-induced effects on NF-κB-mediated apoptosis in colorectal cancer cells.

Carcinogenesis 2011 Jul 5;32(7):1069-77. Epub 2011 May 5.

Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, UK.

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http://dx.doi.org/10.1093/carcin/bgr077DOI Listing
July 2011

Effect of aspirin and NSAIDs on risk and survival from colorectal cancer.

Gut 2010 Dec 15;59(12):1670-9. Epub 2010 Sep 15.

Colon Cancer Genetics Group and Academic Coloproctology, Institute of Genetics and Molecular Medicine, University of Edinburgh and MRC Human Genetics Unit, Western General Hospital, Edinburgh EH4 2XU, UK.

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http://dx.doi.org/10.1136/gut.2009.203000DOI Listing
December 2010

MLH1 Differential allelic expression in mutation carriers and controls.

Ann Hum Genet 2010 Nov 23;74(6):479-88. Epub 2010 Sep 23.

Institute of Human Genetics, University of Newcastle, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1111/j.1469-1809.2010.00603.xDOI Listing
November 2010

Ten common genetic variants associated with colorectal cancer risk are not associated with survival after diagnosis.

Clin Cancer Res 2010 Jul 13;16(14):3754-9. Epub 2010 Jul 13.

Colon Cancer Genetics Group and Academic Coloproctology, Institute of Genetics and Molecular Medicine, Western General Hospital Edinburgh, University of Edinburgh and MRC Human Genetics Unit, Edinburgh, United Kingdom.

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http://dx.doi.org/10.1158/1078-0432.CCR-10-0439DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2906703PMC
July 2010

Comprehensive assessment of variation at the transforming growth factor beta type 1 receptor locus and colorectal cancer predisposition.

Proc Natl Acad Sci U S A 2010 Apr 5;107(17):7858-62. Epub 2010 Apr 5.

Molecular and Population Genetics Laboratory, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, United Kingdom.

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http://dx.doi.org/10.1073/pnas.1002816107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2867909PMC
April 2010

Association between common mtDNA variants and all-cause or colorectal cancer mortality.

Carcinogenesis 2010 Feb 27;31(2):296-301. Epub 2009 Nov 27.

Public Health Sciences, College of Medicine and Veterinary Medicine, University of Edinburgh, Edinburgh, UK.

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http://dx.doi.org/10.1093/carcin/bgp237DOI Listing
February 2010

Nucleolar targeting of RelA(p65) is regulated by COMMD1-dependent ubiquitination.

Cancer Res 2010 Jan;70(1):139-49

Colon Cancer Genetics Group, University of Edinburgh Cancer Research Centre and MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, United Kingdom.

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http://dx.doi.org/10.1158/0008-5472.CAN-09-1397DOI Listing
January 2010

MUTYH-associated polyposis and colorectal cancer.

Surg Oncol Clin N Am 2009 Oct;18(4):599-610

Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and MRC Human Genetics Unit, Western General Hospital, Edinburgh EH4 2XU, UK.

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http://dx.doi.org/10.1016/j.soc.2009.08.003DOI Listing
October 2009

New insights into the aetiology of colorectal cancer from genome-wide association studies.

Nat Rev Genet 2009 Jun;10(6):353-8

Colon Cancer Genetics Group, University of Edinburgh, Western General Hospital, Edinburgh, UK.

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http://dx.doi.org/10.1038/nrg2574DOI Listing
June 2009

Modification of the associations between lifestyle, dietary factors and colorectal cancer risk by APC variants.

Carcinogenesis 2008 Sep 28;29(9):1774-80. Epub 2008 Mar 28.

Public Health Sciences, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, UK.

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http://dx.doi.org/10.1093/carcin/bgn082DOI Listing
September 2008

A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3.

Nat Genet 2008 May 30;40(5):623-30. Epub 2008 Mar 30.

Molecular and Population Genetics Laboratory, London Research Institute, Cancer Research UK, London WC2A 3PX, UK.

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http://dx.doi.org/10.1038/ng.111DOI Listing
May 2008