Malcolm A Smith

Malcolm A Smith

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Malcolm A Smith

Malcolm A Smith

Publications by authors named "Malcolm A Smith"

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Preclinical activity of the antibody-drug conjugate denintuzumab mafodotin (SGN-CD19A) against pediatric acute lymphoblastic leukemia xenografts.

Pediatr Blood Cancer 2019 Aug 23;66(8):e27765. Epub 2019 Apr 23.

Children's Cancer Institute, School of Women's and Children's Health, UNSW Sydney, Sydney, New South Wales, Australia.

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http://dx.doi.org/10.1002/pbc.27765DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6588422PMC
August 2019

Will my child do better if she enrolls in a clinical trial?

Cancer 2018 10 6;124(20):3965-3968. Epub 2018 Oct 6.

Department of Medical Ethics and Health Policy, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.

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http://doi.wiley.com/10.1002/cncr.31722
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http://dx.doi.org/10.1002/cncr.31722DOI Listing
October 2018

Prospects for Minimal Residual Disease as a Surrogate Endpoint in Pediatric Acute Lymphoblastic Leukemia Clinical Trials.

JNCI Cancer Spectr 2018 Oct 19;2(4):pky070. Epub 2018 Dec 19.

Cancer Therapy Evaluation Program, Bethesda, MD.

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http://dx.doi.org/10.1093/jncics/pky070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6649735PMC
October 2018

Initial testing (stage 1) of M6620 (formerly VX-970), a novel ATR inhibitor, alone and combined with cisplatin and melphalan, by the Pediatric Preclinical Testing Program.

Pediatr Blood Cancer 2018 Feb 17;65(2). Epub 2017 Sep 17.

Cancer Therapy Evaluation Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, Maryland.

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http://dx.doi.org/10.1002/pbc.26825DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5876726PMC
February 2018

Remaining challenges in childhood cancer and newer targeted therapeutics.

Pediatr Clin North Am 2015 Feb 18;62(1):301-12. Epub 2014 Oct 18.

Office of Hematology and Oncology Products, OND, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, White Oak Building 22, Room 2202, 10903 New Hampshire Avenue, Silver Spring, MD 20993, USA.

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http://dx.doi.org/10.1016/j.pcl.2014.09.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4336187PMC
February 2015

Targetable kinase-activating lesions in Ph-like acute lymphoblastic leukemia.

N Engl J Med 2014 Sep;371(11):1005-15

From the Departments of Pathology (K.G.R., D.P.-T., Y.-L.Y., K. McCastlain, G.S., J.M., S.-C.C., J.C., N.S.-M., I.I., J.W., J.R.D., C.G.M.), Computational Biology and Bioinformatics (Y.L., J.B., M.R., E.H., P.G., P.N., G.W., X.C., J.Z.), Biostatistics (D.P., C.C.), Pharmaceutical Sciences (S.W.P., M.V.R., W.E.E.), and Oncology (C.-H.P., S.J.), the Pediatric Cancer Genome Project (Y.L., L.D., C.L., M.R., J.E., J.C., K.B., R.S.F., E.H., P.G., P.N., G.W., X.C., D.Y., B.V., H.M., M.V.R., W.E.E., E.M., R.K.W., J.R.D., J.Z., C.G.M.), and Cytogenetics Shared Resource (M.V.), St. Jude Children's Research Hospital, Memphis, TN; the University of New Mexico Cancer Center and School of Medicine, Albuquerque (R.C.H., I-M.C., C.L.W.); the Genome Institute at Washington University (L.D., C.L., R.S.F., E.M., R.K.W.), the Department of Genetics, Washington University School of Medicine (L.D., C.L., R.S.F., E.M., R.K.W.), and Siteman Cancer Center, Washington University (E.M., R.K.W.) - all in St. Louis; Epidemiology and Health Policy Research, College of Medicine, University of Florida, Gainesville (M.D.); the Research Institute at Nationwide Children's Hospital (S.R., A.S., J.M.G.-F.), the Department of Pathology, College of Medicine, Ohio State University (N.A.H.), and Ohio State University Comprehensive Cancer Center (G.M., C.D.B., K. Mrózek, J.K.) - all in Columbus, OH; the Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas (N.J.W.), Scott and White Hospitals and Clinics and Texas A&M Health Science Center, Temple (G.G.), the University of Texas Health Science Center San Antonio, San Antonio (M.F.-J.), and the Departments of Leukemia and Stem Cell Transplantation, Division of Cancer Medicine, University of Texas M.D. Anderson Cancer Center, Houston (S.M.K., M.K.) - all in Texas; Maine Children's Cancer Program, Scarborough (E.C.L.); New York University Cancer Institute, New York (W.L.C.), and the Department of Medicine (Oncology), Albert Einstein

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http://dx.doi.org/10.1056/NEJMoa1403088DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4191900PMC
September 2014

Lessons learned from adult clinical experience to inform evaluations of VEGF pathway inhibitors in children with cancer.

Authors:
Malcolm A Smith

Pediatr Blood Cancer 2014 Aug 24;61(8):1497-505. Epub 2014 Apr 24.

National Cancer Institute, Bethesda, Maryland.

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http://dx.doi.org/10.1002/pbc.25036DOI Listing
August 2014

Declining childhood and adolescent cancer mortality.

Cancer 2014 Aug 22;120(16):2497-506. Epub 2014 May 22.

Cancer Therapy Evaluation Program, National Cancer Institute, Bethesda, Maryland.

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http://dx.doi.org/10.1002/cncr.28748DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4136455PMC
August 2014

Sorafenib inhibits ABCG2 and overcomes irinotecan resistance--letter.

Authors:
Malcolm A Smith

Mol Cancer Ther 2014 Mar;13(3):763

Corresponding Author: Malcolm A. Smith, National Cancer Institute, 9609 Medical Center Drive, Room 5-W414, MSC 9737, Bethesda, MD 20892 (for U.S. Postal Service Delivery), Rockville, MD 20850 (for non-USPS courier delivery and campus visits).

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http://dx.doi.org/10.1158/1535-7163.MCT-13-0968DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4006365PMC
March 2014

Initial testing (Stage 1) of the antibody-maytansinoid conjugate, IMGN901 (Lorvotuzumab mertansine), by the pediatric preclinical testing program.

Pediatr Blood Cancer 2013 Nov 24;60(11):1860-7. Epub 2013 Jun 24.

Hematology-Oncology Division of Oncology, Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine and Abramson Family Cancer Research Institute, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1002/pbc.24647DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4260400PMC
November 2013

A proposal regarding reporting of in vitro testing results.

Clin Cancer Res 2013 Jun 11;19(11):2828-33. Epub 2013 Apr 11.

Cancer Therapy Evaluation Program, National Cancer Institute, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-13-0043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3741962PMC
June 2013

Initial testing of the MDM2 inhibitor RG7112 by the Pediatric Preclinical Testing Program.

Pediatr Blood Cancer 2013 Apr 2;60(4):633-41. Epub 2012 Jul 2.

Children's Cancer Institute Australia for Medical Research, University of New South Wales, Sydney, NSW, Australia.

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http://dx.doi.org/10.1002/pbc.24235DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3495996PMC
April 2013

Combination testing (Stage 2) of the Anti-IGF-1 receptor antibody IMC-A12 with rapamycin by the pediatric preclinical testing program.

Pediatr Blood Cancer 2012 May 31;58(5):729-35. Epub 2011 May 31.

A.I. duPont Hospital for Children, Nemours Center for Childhood Cancer Research, Wilmington, Delaware 19803, USA.

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http://dx.doi.org/10.1002/pbc.23157DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3166415PMC
May 2012

National Cancer Institute pediatric preclinical testing program: model description for in vitro cytotoxicity testing.

Pediatr Blood Cancer 2011 Feb 4;56(2):239-49. Epub 2010 Oct 4.

Cancer Center, School of Medicine, Texas Tech University Health Sciences Center, Lubbock, Texas 79430, USA.

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http://dx.doi.org/10.1002/pbc.22801DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3005554PMC
February 2011