Malak Abedalthagafi

Malak Abedalthagafi

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Malak Abedalthagafi

Malak Abedalthagafi

Publications by authors named "Malak Abedalthagafi"

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New insights into the genomic landscape of meningiomas identified FGFR3 in a subset of patients with favorable prognoses.

Oncotarget 2019 Sep 17;10(53):5549-5559. Epub 2019 Sep 17.

Genomics Research Department, Saudi Human Genome Project, King Fahad Medical City and King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia.

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http://dx.doi.org/10.18632/oncotarget.27178DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6756861PMC
September 2019

Precision medicine of monogenic disorders: Lessons learned from the Saudi human genome.

Front Biosci (Landmark Ed) 2019 03 1;24:870-889. Epub 2019 Mar 1.

KACST, Riyadh, Saudi Arabia,

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March 2019

Immunogenetics of glioblastoma: the future of personalized patient management.

NPJ Precis Oncol 2018 4;2:27. Epub 2018 Dec 4.

Inova Neuroscience and Spine Institute, Inova Health Systems, Falls Church, VA USA.

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http://www.nature.com/articles/s41698-018-0070-1
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http://dx.doi.org/10.1038/s41698-018-0070-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6279755PMC
December 2018

Rare variant associated with Li-Fraumeni syndrome exhibits variable penetrance in a Saudi family.

NPJ Genom Med 2018 19;3:35. Epub 2018 Dec 19.

2Genomics Research Department, Saudi Human Genome Project, King Fahad Medical City and King Abdulaziz City for Science and Technology, Riyadh, 11525 Saudi Arabia.

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http://www.nature.com/articles/s41525-018-0074-3
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http://dx.doi.org/10.1038/s41525-018-0074-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300601PMC
December 2018

Constitutional mismatch repair-deficiency: current problems and emerging therapeutic strategies.

Oncotarget 2018 Oct 23;9(83):35458-35469. Epub 2018 Oct 23.

Genomics Research Department, Saudi Human Genome Project, King Fahad Medical City, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia.

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http://dx.doi.org/10.18632/oncotarget.26249DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6226037PMC
October 2018

A Jordanian biologist redefines success for women in science.

Nature 2018 08;560(7717):164

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http://dx.doi.org/10.1038/d41586-018-05891-7DOI Listing
August 2018

Craniopharyngioma: a roadmap for scientific translation.

Neurosurg Focus 2018 06;44(6):E12

1Center for Skull Base and Pituitary Surgery, Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts; and.

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http://dx.doi.org/10.3171/2018.3.FOCUS1861DOI Listing
June 2018

As a Saudi woman scientist, I'm tired of negative stereotypes.

Nature 2018 02;554(7693):405

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http://dx.doi.org/10.1038/d41586-018-02163-2DOI Listing
February 2018

A case of molecularly profiled extraneural medulloblastoma metastases in a child.

BMC Med Genet 2018 01 17;19(1):10. Epub 2018 Jan 17.

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Harvard Institute of Medicine, HIM-921F, 77 Avenue Louis Pasteur, Boston, MA, 02115, USA.

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http://dx.doi.org/10.1186/s12881-018-0526-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5772742PMC
January 2018

Osteoglycin promotes meningioma development through downregulation of NF2 and activation of mTOR signaling.

Cell Commun Signal 2017 09 18;15(1):34. Epub 2017 Sep 18.

Center for Skull Base and Pituitary Surgery, Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1186/s12964-017-0189-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5604305PMC
September 2017

Clinical Identification of Oncogenic Drivers and Copy-Number Alterations in Pituitary Tumors.

Endocrinology 2017 07;158(7):2284-2291

Center for Skull Base and Pituitary Surgery, Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115.

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http://dx.doi.org/10.1210/en.2016-1967DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5505210PMC
July 2017

Lymph node metastasis of presacral ependymoblastoma in a young child.

J Clin Neurosci 2017 Jun 17;40:64-66. Epub 2017 Feb 17.

Department of Pathology, Children's Mercy Hospital, Kansas City, MO, USA.

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http://dx.doi.org/10.1016/j.jocn.2017.01.029DOI Listing
June 2017

Genomic characterization of recurrent high-grade astroblastoma.

Cancer Genet 2016 Jul-Aug;209(7-8):321-30. Epub 2016 Jun 21.

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Center for Molecular Oncologic Pathology, Dana Farber Cancer Institute, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cancergen.2016.06.002DOI Listing
May 2017

Genomic landscape of intracranial meningiomas.

J Neurosurg 2016 09 15;125(3):525-35. Epub 2016 Jan 15.

Department of Neurosurgery, Brigham and Women's Hospital;

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http://dx.doi.org/10.3171/2015.6.JNS15591DOI Listing
September 2016

Cancer diagnostics: The journey from histomorphology to molecular profiling.

Oncotarget 2016 09;7(36):58696-58708

Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.18632/oncotarget.11061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5295463PMC
September 2016

Oncogenic PI3K mutations are as common as AKT1 and SMO mutations in meningioma.

Neuro Oncol 2016 05 28;18(5):649-55. Epub 2016 Jan 28.

Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts (M.A., P.H.M., R.B., M.L.L., S.H.R., R.D.F., K.L.L., A.H.L., S.S.); Department of Pathology, King Fahad Medical City, Riyadh, Saudi Arabia (M.A.); King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia (M.A.); Harvard Medical School, Boston, Massachusetts (M.A., A.A.A., D.D.-S., P.K.B., D.A.R., P.Y.W., O.A.-M., S.H.R., R.D.F., K.L.L., A.H.L., B.M.A., I.F.D., R.B., S.S.); Department of Neurosurgery, Brigham and Women's Hospital, Boston, Massachusetts (W.L.B., O.A.-M., I.F.D.); Department of Radiation Oncology, Brigham and Women's Hospital, Boston, Massachusetts (A.A.A., B.M.A.); Department of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts (P.K.A.); Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts (D.D.-S.); Center for Cancer Genomic Discovery, Dana-Farber Cancer Institute, Boston, Massachusetts (A.R.T., P.V.H.); Department of Neuro-Oncology, Massachusetts General Hospital, Boston, Massachusetts (P.K.B.); Center of Neuro-Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts (D.A.R., P.Y.W, R.B.); Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts (K.L.L., R.B.); Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA (S.S.).

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http://dx.doi.org/10.1093/neuonc/nov316DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4827048PMC
May 2016

Decreased FOXJ1 expression and its ciliogenesis programme in aggressive ependymoma and choroid plexus tumours.

J Pathol 2016 Mar;238(4):584-97

Department of Pathology, Division of Neuropathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1002/path.4682DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5364032PMC
March 2016

A prognostic cytogenetic scoring system to guide the adjuvant management of patients with atypical meningioma.

Neuro Oncol 2016 Feb 30;18(2):269-74. Epub 2015 Aug 30.

Department of Radiation Oncology, Dana-Farber/Brigham and Women's Cancer Center, Boston, Massachusetts (A.A.A., M.C.H., N.D.A., B.M.A.); Department of Pathology, Dana-Farber/Brigham and Women's Cancer Center, Boston, Massachusetts (M.A., K.L.L., A.H.L., S.S.); Department of Neurosurgery, Dana-Farber/Brigham and Women's Cancer Center, Boston, Massachusetts (W.L.B., O.A-M., I.F.D.); Center for Neuro-Oncology, Dana-Farber/Brigham and Women's Cancer Center, Boston, Massachusetts (E.Q.L., L.N., M.L.R., A.D.N., D.A.R., P.Y.W., R.B.).

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https://academic.oup.com/neuro-oncology/article-lookup/doi/1
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http://dx.doi.org/10.1093/neuonc/nov177DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4724184PMC
February 2016

Dramatic Response of BRAF V600E Mutant Papillary Craniopharyngioma to Targeted Therapy.

J Natl Cancer Inst 2016 Feb 23;108(2). Epub 2015 Oct 23.

Department of Medicine (PKB, RS), Department of Neurology (PKB, CMG), Department of Neurosurgery (GMS, PJ, BN, DPC, WTC, FGB), Department of Surgical Oncology (DTF), Department of Pathology (GG, DNL), Cancer Center (PKB, CMG, NN, DNL), Department of Radiology (JR) Massachusetts General Hospital, Harvard Medical School, Boston, MA; Broad Institute (ATW, GG), Department of Pathology, (MA, SS) and Department of Neurosurgery, Brigham and Women's Hospital (IFD), Boston, MA; Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA (DJP).

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http://dx.doi.org/10.1093/jnci/djv310DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4862417PMC
February 2016

Clinical implementation of integrated whole-genome copy number and mutation profiling for glioblastoma.

Neuro Oncol 2015 Oct 9;17(10):1344-55. Epub 2015 Mar 9.

Center for Molecular Oncologic Pathology, Dana-Farber Cancer Institute, Boston, Massachusetts (S.H.R., L.A.R., S.H., D.K., Y.J.K., K.L.L.); Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts (S.E.S., L.B., M.B., D.A.R., E.Q.L., M.L.R., A.D.N., L.N., S.R., L.M.D., D.C.L., P.K., B.J.R., P.Y.W., R.B., K.L.L.); Department of Neurosurgery, Brigham and Women's Hospital, Boston, Massachusetts (W.L.B., E.B.C, O.A.-M., M.D.J., A.J.G., I.F.D., E.A.C.); Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, Massachusetts (L.T.); Department of Radiation Oncology, Brigham and Women's Hospital, Boston, Massachusetts (M.H., A.A.A., N.D.A., B.M.A.); Department of Radiation Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts (M.H., A.A.A., N.D.A., B.M.A.); Harvard Radiation Oncology Program, Boston, Massachusetts (A.R.); Kravis Center for Molecular Oncology & Department of Epidemiology and Biostatistics, Memorial Sloan- Kettering Cancer Center, New York, New York (N.S.); Broad Institute, Cambridge, Massachusetts (R.B.); Department of Pathology, Boston Children's Hospital, Boston, Massachusetts (K.L.L.); Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts (S.H.R., A.D., J.B.C., M.A., S.S., R.D.F., N.I.L., A.H.L., K.L.L.)

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http://dx.doi.org/10.1093/neuonc/nov015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4578577PMC
October 2015

Extracranial growth of glioblastoma multiforme.

J Clin Neurosci 2015 Sep 5;22(9):1521-3. Epub 2015 May 5.

Department of Neurosurgery, Brigham and Women's Hospital, 15 Francis Street, Boston, MA 02115, USA; Center for Neuro-Oncology, Dana-Farber Cancer Institute, 5 Jimmy Fund Way, Boston, MA 02115, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09675868150018
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http://dx.doi.org/10.1016/j.jocn.2015.03.018DOI Listing
September 2015

Akt and Hippo Pathways in Ewing's Sarcoma Tumors and Their Prognostic Significance.

J Cancer 2015 22;6(10):1005-10. Epub 2015 Aug 22.

3. Department of Anatomic Pathology, Moffitt Cancer Center/University of South Florida, Tampa, Florida, United States.

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http://dx.doi.org/10.7150/jca.12703DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4565850PMC
September 2015

Myelodysplastic syndrome with progressive multifocal predominantly pontine demyelination.

Neurol Neuroimmunol Neuroinflamm 2015 Jun 12;2(3):e90. Epub 2015 Mar 12.

Department of Neurology (S.B., J.C.W., S.W.), Massachusetts General Hospital, Boston, MA; Department of Neurology (S.B., J.C.W., S.W., H.V.) and Department of Pathology (M.A.), Brigham and Women's Hospital, Boston, MA; and Harvard Medical School (S.B., J.C.W., M.A., S.W., H.V.), Boston, MA.

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http://dx.doi.org/10.1212/NXI.0000000000000090DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4360795PMC
June 2015

ARID1A and TERT promoter mutations in dedifferentiated meningioma.

Cancer Genet 2015 Jun 18;208(6):345-50. Epub 2015 Mar 18.

Division of Neuropathology, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cancergen.2015.03.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4882906PMC
June 2015

Cross-reactivity of the BRAF VE1 antibody with epitopes in axonemal dyneins leads to staining of cilia.

Mod Pathol 2015 Apr 21;28(4):596-606. Epub 2014 Nov 21.

1] Division of Neuropathology, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA [2] Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.

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http://www.nature.com/articles/modpathol2014150
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http://dx.doi.org/10.1038/modpathol.2014.150DOI Listing
April 2015

Adjuvant radiation therapy, local recurrence, and the need for salvage therapy in atypical meningioma.

Neuro Oncol 2014 Nov 2;16(11):1547-53. Epub 2014 Jun 2.

Harvard Radiation Oncology Program, Brigham and Women's Hospital, Boston, Massachusetts (A.A.A.); Dana-Farber/Brigham and Women's Cancer Center, Boston, Massachusetts (N.D.A., B.M.A.); Department of Biostatistics, Dana-Farber Cancer Institute, Boston, Massachusetts (P.C.); Department of Neurosurgery, Brigham and Women's Hospital, Boston, Massachusetts (E.B.C., A.J.G., M.D.J., O.A-M., I.F.D.); Center for Neuro-Oncology, Dana-Farber/Brigham and Women's Cancer Center, Boston, Massachusetts (P.Y.W., D.A.R., E.Q.L., L.N., M.L.R., R.B.); Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania (S.E.W.); Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts (S.H.R., S.S., M.A.).

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http://dx.doi.org/10.1093/neuonc/nou098DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4201070PMC
November 2014

Isolated cerebral mucormycosis of the basal ganglia.

Clin Neurol Neurosurg 2014 Sep 23;124:102-5. Epub 2014 Jun 23.

Department of Neurosurgery, Brigham and Women's Hospital, Boston, MA, United States. Electronic address:

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http://dx.doi.org/10.1016/j.clineuro.2014.06.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4256958PMC
September 2014

The alternative lengthening of telomere phenotype is significantly associated with loss of ATRX expression in high-grade pediatric and adult astrocytomas: a multi-institutional study of 214 astrocytomas.

Mod Pathol 2013 Nov 14;26(11):1425-32. Epub 2013 Jun 14.

1] Division of Neuropathology, Department of Pathology, University of California, San Francisco, San Francisco, CA, USA [2] Division of Surgical Pathology, Department of Pathology, University of California, San Francisco, San Francisco, CA, USA.

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http://dx.doi.org/10.1038/modpathol.2013.90DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6054791PMC
November 2013

Radiation-induced glioma following CyberKnife® treatment of metastatic renal cell carcinoma: a case report.

J Med Case Rep 2012 Sep 3;6:271. Epub 2012 Sep 3.

Pathology Department, Georgetown University Hospital, Washington, DC, 20007, USA.

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http://dx.doi.org/10.1186/1752-1947-6-271DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3469351PMC
September 2012

Gastrointestinal stromal tumour originating from the hepatic falciform ligament.

BMJ Case Rep 2012 Jul 10;2012. Epub 2012 Jul 10.

Department of Pathology, University of California San Francisco, Francisco, California, USA.

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http://dx.doi.org/10.1136/bcr-03-2012-6136DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4543157PMC
July 2012

Diagnostic evaluation of metastatic placental site trophoblastic tumor.

Obstet Gynecol 2009 Aug;114(2 Pt 2):465-8

Georgetown University Hospital, Washington, DC 20007, USA.

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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/AOG.0b013e31819db2feDOI Listing
August 2009

Asymptomatic diffuse "encephalitic" cerebral toxoplasmosis in a patient with chronic lymphocytic leukemia: case report and review of the literature.

Int J Clin Exp Pathol 2009 Mar 15;3(1):106-9. Epub 2009 Mar 15.

Department of Pathology, Georgetown University Hospital, Washington, DC 20007, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2776259PMC
March 2009

Primary retroperitoneal mucinous cystadenoma.

Saudi Med J 2009 Jan;30(1):146-9

Department of Pathology, Lombardi Comprehensive Cancer Center, Georgetown University Hospital 3900 Reservoir Road, NW, Washington, DC 20007, United States of Americal.

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January 2009