Publications


USP10 Is an Essential Deubiquitinase for Hematopoiesis and Inhibits Apoptosis of Long-Term Hematopoietic Stem Cells.
Stem Cell Reports 2016 Dec;7(6):1116-1129
Division of Virology, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-Dori, Niigata 951-8510, Japan. Electronic address:


RASAL3, a novel hematopoietic RasGAP protein, regulates the number and functions of NKT cells.
Eur J Immunol 2015 May 11;45(5):1512-23. Epub 2015 Mar 11.
Division of Virology, Niigata University Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan.

Protective effect of the long pentraxin PTX3 against histone-mediated endothelial cell cytotoxicity in sepsis.
Sci Signal 2014 Sep 16;7(343):ra88. Epub 2014 Sep 16.
Department of Quantitative Biology and Medicine, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo 153-8904, Japan.


Delayed emergence of oseltamivir-resistant seasonal influenza A (H1N1) and pandemic influenza A(H1N1)pdm09 viruses in Myanmar.
Influenza Other Respir Viruses 2013 Sep 5;7(5):766-71. Epub 2012 Nov 5.
Division of International Health (Public Health), Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan.

Immunoglobulin G4-related disease with several inflammatory foci.
Intern Med 2013 15;52(4):457-62. Epub 2013 Feb 15.
Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, Japan.

The proteomic profile of circulating pentraxin 3 (PTX3) complex in sepsis demonstrates the interaction with azurocidin 1 and other components of neutrophil extracellular traps.
Mol Cell Proteomics 2012 Jun 25;11(6):M111.015073. Epub 2012 Jan 25.
Department of Molecular Biology and Medicine, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo 153-8904, Japan.

Efficient palliative involved-field radiotherapy on highly progressive diffuse large B-cell primary gastric lymphoma with liver cirrhosis.
Clin J Gastroenterol 2012 Apr 11;5(2):164-9. Epub 2012 Mar 11.
Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, Asahimachi 1-757, Niigata, 951-8122, Japan.


Long pentraxin 3 (PTX3) expression and release by neutrophils in vitro and in ulcerative colitis.
Pathol Int 2011 May 17;61(5):290-7. Epub 2011 Mar 17.
Department of Cellular Function, Division of Cellular and Molecular Pathology, Niigata University Graduate School of Medical and Dental Sciences, Chuou-ku, Niigata, Japan.

The predominant expression of hepatocyte nuclear factor 4α (HNF4α) in thyroid transcription factor-1 (TTF-1)-negative pulmonary adenocarcinoma.
Histopathology 2011 Feb 23;58(3):467-76. Epub 2011 Feb 23.
Division of Cellular and Molecular Pathology, Niigata University Graduate School of Medical and Dental Sciences, Niigata University Hospital, Niigata, Japan.

Regulation by SIRPα of dendritic cell homeostasis in lymphoid tissues.
Blood 2010 Nov 3;116(18):3517-25. Epub 2010 Aug 3.
Laboratory of Biosignal Sciences, Institute for Molecular and Cellular Regulation, Gunma University, Gunma, Japan.

Antitumor effect after radiofrequency ablation of murine hepatoma is augmented by an active variant of CC Chemokine ligand 3/macrophage inflammatory protein-1alpha.
Cancer Res 2010 Aug 27;70(16):6556-65. Epub 2010 Jul 27.
Disease Control and Homeostasis, Graduate School of Medical Science, Cancer Research Institute, Kanazawa University, Kanazawa, Japan.

Endobronchial metastasis from adenocarcinoma of gastric cardia 7 years after potentially curable resection.
World J Gastrointest Surg 2010 Aug;2(8):270-4
Takaaki Hanyu, Tatsuo Kanda, Atsushi Matsuki, Kazuhito Yajima, Shin-ichi Kosugi, Katsuyoshi Hatakeyama, Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Asahimachi-dori 1-757, Niigata 951-8510, Japan.

Rare influenza A (H3N2) variants with reduced sensitivity to antiviral drugs.
Emerg Infect Dis 2010 Mar;16(3):493-6
Department of Public Health, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan.

Obesity and metabolic syndrome in histone demethylase JHDM2a-deficient mice.
Genes Cells 2009 Aug 15;14(8):991-1001. Epub 2009 Jul 15.
Metabolism and Endocrinology Division, Laboratory for Systems Biology and Medicine, Research Center for Advanced Science and Technology, University of Tokyo, Tokyo 153-8904, Japan.


COUP-TFII acts downstream of Wnt/beta-catenin signal to silence PPARgamma gene expression and repress adipogenesis.
Proc Natl Acad Sci U S A 2009 Apr 23;106(14):5819-24. Epub 2009 Mar 23.
Laboratory of Systems Biology and Medicine, Research Center for Advanced Science and Technology, University of Tokyo, 4-6-1, Komaba, Meguro-ku, Tokyo 153-8904, Japan.

Expression of liver X receptor alpha and lipid metabolism in granulocyte-macrophage colony-stimulating factor-induced human monocyte-derived macrophage.
Pathol Int 2009 Mar;59(3):152-60
Division of Cellular and Molecular Pathology, Department of Cellular Function, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.


Macrophage colony-stimulating factor is indispensable for repopulation and differentiation of Kupffer cells but not for splenic red pulp macrophages in osteopetrotic (op/op) mice after macrophage depletion.
Cell Tissue Res 2008 May 12;332(2):245-56. Epub 2008 Mar 12.
Department of Cellular Function, Division of Cellular and Molecular Pathology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, 951-8510, Japan,

Administration of high-dose intact immunoglobulin has an anti-resorption effect in a mouse model of reproductive failure.
Mol Hum Reprod 2007 Nov 31;13(11):807-14. Epub 2007 Aug 31.
Division of Immunobiology, Research Section of Pathophysiology, Institute for Genetic Medicine, Hokkaido University, Kita-15, Nishi-7, Kita-ku, Sapporo, Hokkaido, Japan.

Lipopolysaccharide induced expression of pentraxin 3 in human neutrophils and monocyte-derived macrophages.
Cell Immunol 2007 Aug 28;248(2):86-94. Epub 2007 Nov 28.
Division of Cellular and Molecular Pathology, Department of Cellular Function, Niigata University Graduate School of Medical and Dental Sciences, Asahimachi 1-757, Chuou-ku, Niigata 951-8510, Japan.

Expression of liver X receptor alpha in rat fetal tissues at different developmental stages.
J Histochem Cytochem 2007 Jun 6;55(6):641-9. Epub 2007 Mar 6.
Division of Cellular and Molecular Pathology, Department of Cellular Function, Niigata University Graduate School of Medical and Dental Sciences, Asahimachi-dori 1-757, 951-8510, Niigata, Japan.



High dose glucocorticoid hampers bone formation and resorption after bone marrow ablation in rat.
Microsc Res Tech 2006 Oct;69(10):839-46
Division of Orthopaedic Surgery, Department of Regenerative and Transplant Medicine, Niigata University Graduate School of Medical and Dental Sciences, Niigata City, Niigata 951-8510, Japan.


The PTEN/PI3K pathway governs normal vascular development and tumor angiogenesis.
Genes Dev 2005 Sep 17;19(17):2054-65. Epub 2005 Aug 17.
Department of Molecular Biology, Department of Microbiology, Department of Gastroenterology, Akita University School of Medicine, Akita 010-8543, Japan.

Augmentation of heme oxygenase-1 expression in the graft immediately after implantation in adult living-donor liver transplantation.
Transplantation 2005 Apr;79(8):977-80
Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8510, Japan.

Expression of the LXRalpha protein in human atherosclerotic lesions.
Arterioscler Thromb Vasc Biol 2005 Mar 29;25(3):622-7. Epub 2004 Dec 29.
Department of Systems Biology and Medicine, Research Center for Advanced Science and Technology, the University of Tokyo, Japan.

Important role for macrophages in induction of crescentic anti-GBM glomerulonephritis in WKY rats.
Nephrol Dial Transplant 2004 Dec;19(12):2997-3004
Department of Structural Pathology, Institute of Nephrology, Niigata University Graduate School of Medical and Dental Sciences, 757 Asahimachi-dori-1-bancho, Niigata 951-8510, Japan.

Effects of pranidipine, a novel calcium channel antagonist, on the progression of left ventricular dysfunction and remodeling in rats with heart failure.
Pharmacology 2004 Sep;72(1):26-32
Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Kamishin-ei-cho, Japan.




A novel method for viral display of ER membrane proteins on budded baculovirus.
Biochem Biophys Res Commun 2003 Aug;308(1):191-6
Department of Molecular Biology, Research Center for Advanced Science and Technology, The University of Tokyo, #35 4-6-1 Komaba, Meguro, Tokyo 153-8904, Japan.

Expression and localization of P1 promoter-driven hepatocyte nuclear factor-4alpha (HNF4alpha) isoforms in human and rats.
Nucl Recept 2003 Aug 8;1(1). Epub 2003 Aug 8.
Department of Cellular Function, Division of Cellular and Molecular Pathology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.


Deficiency of cathepsin S reduces atherosclerosis in LDL receptor-deficient mice.
J Clin Invest 2003 Mar;111(6):897-906
The Leducq Center for Cardiovascular Research, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.







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