Makoto Kadowaki

Makoto Kadowaki

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Makoto Kadowaki

Makoto Kadowaki

Publications by authors named "Makoto Kadowaki"

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The isoflavone puerarin induces Foxp3 regulatory T cells by augmenting retinoic acid production, thereby inducing mucosal immune tolerance in a murine food allergy model.

Biochem Biophys Res Commun 2019 Aug 22;516(3):626-631. Epub 2019 Jun 22.

Division of Gastrointestinal Pathophysiology, Institute of Natural Medicine, University of Toyama, Toyama, Japan.

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http://dx.doi.org/10.1016/j.bbrc.2019.06.051DOI Listing
August 2019

Regional variations in the number distribution of intrinsic myenteric neurons and coinnervated motor endplates on the striated muscles in the rat esophagus.

Auton Neurosci 2019 07 25;219:25-32. Epub 2019 Mar 25.

Division of Gastrointestinal Pathophysiology, Institute of Natural Medicine, University of Toyama, Toyama, Japan.

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http://dx.doi.org/10.1016/j.autneu.2019.03.004DOI Listing
July 2019

KampoDB, database of predicted targets and functional annotations of natural medicines.

Sci Rep 2018 07 25;8(1):11216. Epub 2018 Jul 25.

Department of Bioscience and Bioinformatics, Faculty of Computer Science and Systems Engineering, Kyushu Institute of Technology, 680-4 Kawazu, Iizuka, Fukuoka, 820-8502, Japan.

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http://dx.doi.org/10.1038/s41598-018-29516-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6060122PMC
July 2018

Peptidomic analysis of the venom of the solitary bee .

J Venom Anim Toxins Incl Trop Dis 2017 29;23:40. Epub 2017 Aug 29.

Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama, 930-0194 Japan.

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http://dx.doi.org/10.1186/s40409-017-0130-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5575948PMC
August 2017

PI3K p85α Subunit-deficient Macrophages Protect Mice from Acute Colitis due to the Enhancement of IL-10 Production.

Sci Rep 2017 07 21;7(1):6187. Epub 2017 Jul 21.

Division of Gastrointestinal Pathophysiology, Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama, 930-0194, Japan.

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http://dx.doi.org/10.1038/s41598-017-06464-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5522489PMC
July 2017

Induction of Regulatory T Cells as a Novel Mechanism Underlying the Therapeutic Action of Kakkonto, a Traditional Japanese Herbal Medicine, in a Murine Food Allergy Model.

Int Arch Allergy Immunol 2016 21;169(3):146-56. Epub 2016 Apr 21.

Division of Gastrointestinal Pathophysiology, Institute of Natural Medicine, University of Toyama, Toyama, Japan.

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http://dx.doi.org/10.1159/000445433DOI Listing
February 2017

Chemical constituents with anti-allergic activity from the root of Edulis Superba, a horticultural cultivar of Paeonia lactiflora.

J Nat Med 2016 Apr 30;70(2):234-40. Epub 2016 Jan 30.

Division of Pharmacognosy, Department of Medicinal Resources, Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama, 930-0194, Japan.

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http://dx.doi.org/10.1007/s11418-016-0966-4DOI Listing
April 2016

Review: Diverse pharmacological properties of Cinnamomum cassia: A review.

Pak J Pharm Sci 2015 Jul;28(4):1433-8

Division of Gastrointestinal Pathophysiology, Institute of Natural Medicine, University of Toyama, Sugitani, Toyama, Japan.

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July 2015

Shikonin, a constituent of Lithospermum erythrorhizon exhibits anti-allergic effects by suppressing orphan nuclear receptor Nr4a family gene expression as a new prototype of calcineurin inhibitors in mast cells.

Chem Biol Interact 2014 Dec 29;224:117-27. Epub 2014 Oct 29.

Division of Gastrointestinal Pathophysiology, Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.cbi.2014.10.021DOI Listing
December 2014

Arbutin, an intracellular hydroxyl radical scavenger, protects radiation-induced apoptosis in human lymphoma U937 cells.

Apoptosis 2014 Nov;19(11):1654-63

Department of Pathology, The 2nd Affiliated Hospital of Harbin Medical University, Nangang District, Harbin, 150081, China.

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http://dx.doi.org/10.1007/s10495-014-1032-xDOI Listing
November 2014

Nicotine suppresses acute colitis and colonic tumorigenesis associated with chronic colitis in mice.

Am J Physiol Gastrointest Liver Physiol 2014 Nov 25;307(10):G968-78. Epub 2014 Sep 25.

Division of Gastrointestinal Pathophysiology, Institute of Natural Medicine, University of Toyama, Toyama, Japan; and.

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http://dx.doi.org/10.1152/ajpgi.00346.2013DOI Listing
November 2014

Effect of Pakistani medicinal plants on IgE/antigen- and ionophore-induced mucosal mast cells degranulation.

Pak J Pharm Sci 2014 Jul;27(4 Suppl):1041-8

Division of Gastrointestinal Pathophysiology, Institute of Natural Medicine, University of Toyama, Toyama, Japan.

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July 2014

Isofraxidin, a potent reactive oxygen species (ROS) scavenger, protects human leukemia cells from radiation-induced apoptosis via ROS/mitochondria pathway in p53-independent manner.

Apoptosis 2014 Jun;19(6):1043-53

Department of Radiological Sciences, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Sugitani 2630, Toyama, 930-0194, Japan.

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http://dx.doi.org/10.1007/s10495-014-0984-1DOI Listing
June 2014

The molecular mechanisms and gene expression profiling for shikonin-induced apoptotic and necroptotic cell death in U937 cells.

Chem Biol Interact 2013 Sep 26;205(2):119-27. Epub 2013 Jun 26.

Department of Radiological Sciences, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.

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http://dx.doi.org/10.1016/j.cbi.2013.06.011DOI Listing
September 2013

TRPM2 contributes to antigen-stimulated Ca²⁺ influx in mucosal mast cells.

Pflugers Arch 2013 Jul 31;465(7):1023-30. Epub 2013 Jan 31.

Division of Gastrointestinal Pathophysiology, Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.

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http://link.springer.com/content/pdf/10.1007/s00424-013-1219
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http://link.springer.com/10.1007/s00424-013-1219-y
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http://dx.doi.org/10.1007/s00424-013-1219-yDOI Listing
July 2013

Oral tolerance induced by transfer of food antigens via breast milk of allergic mothers prevents offspring from developing allergic symptoms in a mouse food allergy model.

Clin Dev Immunol 2012 27;2012:721085. Epub 2012 Mar 27.

Division of Gastrointestinal Pathophysiology, Institute of Natural Medicine, University of Toyama, Sugitani, Toyama, Japan.

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http://dx.doi.org/10.1155/2012/721085DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3310277PMC
March 2013

Enhancement of CGRP sensory afferent innervation in the gut during the development of food allergy in an experimental murine model.

Biochem Biophys Res Commun 2013 Jan 19;430(3):895-900. Epub 2012 Dec 19.

Division of Gastrointestinal Pathophysiology, Institute of Natural Medicine, University of Toyama, Toyama 930-0194, Japan.

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http://dx.doi.org/10.1016/j.bbrc.2012.12.058DOI Listing
January 2013

Apoptotic cell death by the novel natural compound, cinobufotalin.

Chem Biol Interact 2012 Sep 8;199(3):154-60. Epub 2012 Aug 8.

Department of Radiological Sciences, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Sugitani 2630, Toyama 930-0194, Japan.

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http://dx.doi.org/10.1016/j.cbi.2012.07.005DOI Listing
September 2012

Sphingosine kinase-1-dependent and -independent inhibitory effects of zanthoxyli fructus to attenuate the activation of mucosal mast cells and ameliorate food allergies in mice.

Evid Based Complement Alternat Med 2012 7;2012:862743. Epub 2012 Jun 7.

Division of Gastrointestinal Pathophysiology, Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.

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http://dx.doi.org/10.1155/2012/862743DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3375181PMC
August 2012

Chemical inducers of heat shock proteins derived from medicinal plants and cytoprotective genes response.

Int J Hyperthermia 2012 ;28(1):1-8

Division of Gastrointestinal Pathophysiology, Institute of Natural Medicine, University of Toyama, Toyama, Japan.

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http://dx.doi.org/10.3109/02656736.2011.627408DOI Listing
May 2012

High-resolution multi-isotope imaging mass spectrometry enables visualisation of stem cell division and metabolism.

Chembiochem 2012 May 19;13(8):1103-6. Epub 2012 Apr 19.

Department of Cell Biology and Anatomy, Hamamatsu University, School of Medicine, 1-20-1 Handayama, Hamamatsu, Shizuoka 431-3192, Japan.

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http://dx.doi.org/10.1002/cbic.201200146DOI Listing
May 2012

TRPV1 expressing extrinsic primary sensory neurons play a protective role in mouse oxazolone-induced colitis.

Auton Neurosci 2012 Jan 19;166(1-2):72-6. Epub 2011 Aug 19.

Division of Gastroinstestinal Pathophysiology, Institute of Natural Medicine, University of Toyama, Toyama 930-0194, Japan.

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https://linkinghub.elsevier.com/retrieve/pii/S15660702110037
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http://dx.doi.org/10.1016/j.autneu.2011.07.008DOI Listing
January 2012

Suppression of phospholipase Cγ1 phosphorylation by cinnamaldehyde inhibits antigen-induced extracellular calcium influx and degranulation in mucosal mast cells.

Biochem Biophys Res Commun 2011 Dec 11;416(3-4):283-8. Epub 2011 Nov 11.

Division of Gastrointestinal Pathophysiology, Department of Bioscience, Institute of Natural Medicine, University of Toyama, Toyama 930-0194, Japan.

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http://linkinghub.elsevier.com/retrieve/pii/S0006291X1102013
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http://dx.doi.org/10.1016/j.bbrc.2011.11.014DOI Listing
December 2011

Rab5a regulates surface expression of FcεRI and functional activation in mast cells.

Biol Pharm Bull 2011 ;34(5):760-3

Division of Gastrointestinal Pathophysiology, Department of Bioscience, Institute of Natural Medicine, University of Toyama, Toyama, Japan.

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http://dx.doi.org/10.1248/bpb.34.760DOI Listing
September 2011

The inhibitory effect of ergosterol, a bioactive constituent of a traditional Japanese herbal medicine saireito on the activity of mucosal-type mast cells.

Biol Pharm Bull 2010 ;33(1):142-5

Division of Gastrointestinal Pathophysiology, Department of Bioscience, Institute of Natural Medicine, University of Toyama, Toyama, Japan.

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http://dx.doi.org/10.1248/bpb.33.142DOI Listing
June 2010

The traditional herbal medicine saireito exerts its inhibitory effect on murine oxazolone-induced colitis via the induction of Th1-polarized immune responses in the mucosal immune system of the colon.

Int Arch Allergy Immunol 2010 15;151(2):98-106. Epub 2009 Sep 15.

Division of Gastrointestinal Pathophysiology, Institute of Natural Medicine, Faculty of Medicine, University of Toyama, Toyama, Japan.

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http://dx.doi.org/10.1159/000235999DOI Listing
February 2010

Pentagalloylglucose down-regulates mast cell surface FcepsilonRI expression in vitro and in vivo.

FEBS Lett 2010 Jan;584(1):111-8

Division of Gastrointestinal Pathophysiology, Department of Bioscience, Institute of Natural Medicine, University of Toyama, Toyama, Japan.

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http://dx.doi.org/10.1016/j.febslet.2009.11.007DOI Listing
January 2010

Modulation of activation-induced cytidine deaminase by curcumin in Helicobacter pylori-infected gastric epithelial cells.

Helicobacter 2009 Dec;14(6):588-95

Department of Gastroenterology and Hematology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan.

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http://dx.doi.org/10.1111/j.1523-5378.2009.00724.xDOI Listing
December 2009

Non-pungent capsaicin analogs (capsinoids) increase metabolic rate and enhance thermogenesis via gastrointestinal TRPV1 in mice.

Biosci Biotechnol Biochem 2009 Dec 7;73(12):2690-7. Epub 2009 Dec 7.

Laboratory of Nutrition Chemistry, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Japan.

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http://dx.doi.org/10.1271/bbb.90555DOI Listing
December 2009

Effect of resveratrol on Helicobacter pylori-induced interleukin-8 secretion, reactive oxygen species generation and morphological changes in human gastric epithelial cells.

Biol Pharm Bull 2009 Nov;32(11):1931-5

Department of Gastroenterology and Hematology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Sugitani, Toyama 930-0194, Japan.

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http://dx.doi.org/10.1248/bpb.32.1931DOI Listing
November 2009

Therapeutic effect of kakkonto in a mouse model of food allergy with gastrointestinal symptoms.

Int Arch Allergy Immunol 2009 10;148(3):175-85. Epub 2008 Oct 10.

Division of Gastrointestinal Pathophysiology, Institute of Natural Medicine, University of Toyama, Toyama, Japan.

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http://dx.doi.org/10.1159/000161578DOI Listing
March 2009

Hyperactivity, memory deficit and anxiety-related behaviors in mice lacking the p85alpha subunit of phosphoinositide-3 kinase.

Brain Dev 2009 Jan 5;31(1):69-74. Epub 2008 Jun 5.

Division of Biofunctional Evaluation, Research Center for Ethnomedicine, Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 9300194, Japan.

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http://linkinghub.elsevier.com/retrieve/pii/S038776040800109
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http://dx.doi.org/10.1016/j.braindev.2008.04.006DOI Listing
January 2009

Bactericidal activity of medicinal plants, employed for the treatment of gastrointestinal ailments, against Helicobacter pylori.

J Ethnopharmacol 2009 Jan 8;121(2):286-91. Epub 2008 Nov 8.

Division of Gastrointestinal Pathophysiology, Institute of Natural Medicine, University of Toyama, Toyama 930-0194, Japan.

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http://dx.doi.org/10.1016/j.jep.2008.11.001DOI Listing
January 2009

IgE-induced degranulation of mucosal mast cells is negatively regulated via nicotinic acetylcholine receptors.

Biochem Biophys Res Commun 2008 Dec 10;377(1):321-5. Epub 2008 Oct 10.

Department of Bioscience, Division of Gastrointestinal Pathophysiology, Institute of Natural Medicine, University of Toyama, Sugitani, Toyama, Japan.

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http://dx.doi.org/10.1016/j.bbrc.2008.10.004DOI Listing
December 2008

Alteration of cholinergic, purinergic and sensory neurotransmission in the mouse colon of food allergy model.

Neurosci Lett 2008 Nov 11;445(3):195-8. Epub 2008 Sep 11.

Division of Gastrointestinal Pathophysiology, Institute of Natural Medicine, University of Toyama, Toyama 930-0194, Japan.

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http://dx.doi.org/10.1016/j.neulet.2008.09.014DOI Listing
November 2008

Learning deficits and agenesis of synapses and myelinated axons in phosphoinositide-3 kinase-deficient mice.

Neurosignals 2006-2007;15(6):293-306. Epub 2007 Sep 27.

Divisions of Biofunctional Evaluation, Research Center for Ethnomedicine, Institute of Natural Medicine, University of Toyama, Toyama, Japan.

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https://www.karger.com/Article/FullText/108936
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http://dx.doi.org/10.1159/000108936DOI Listing
July 2008

The pathophysiological roles of COX-1 and COX-2 in the intestinal smooth muscle contractility under the anaphylactic condition.

Biomed Res 2008 Apr;29(2):113-7

Division of Gastrointestinal Pathophysiology, Institute of Natural Medicine, University of Toyama, Toyama, Japan.

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http://dx.doi.org/10.2220/biomedres.29.113DOI Listing
April 2008

Distinct morphology of serotonin-containing enterochromaffin (EC) cells in the rat distal colon.

Arch Histol Cytol 2007 Nov;70(4):235-41

Department of Applied Biology, Kyoto Institute of Technology, Matsugasaki, Sakyo, Kyoto, Japan.

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http://dx.doi.org/10.1679/aohc.70.235DOI Listing
November 2007

Downregulation in aquaporin 4 and aquaporin 8 expression of the colon associated with the induction of allergic diarrhea in a mouse model of food allergy.

Life Sci 2007 Jun 16;81(2):115-20. Epub 2007 May 16.

Division of Gastroinstestinal Pathophysiology, Institute of Natural Medicine, University of Toyama, Toyama 930-0194, Japan.

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http://dx.doi.org/10.1016/j.lfs.2007.04.036DOI Listing
June 2007

Vagus nerve stimulation preferentially induces Fos expression in nitrergic neurons of rat esophagus.

Cell Tissue Res 2006 Jun 1;324(3):361-7. Epub 2006 Feb 1.

Department of Applied Biology, Kyoto Institute of Technology, Matsugasaki, Sakyo, Kyoto, 606-8585, Japan.

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http://dx.doi.org/10.1007/s00441-005-0124-xDOI Listing
June 2006

Calbindin is predominantly expressed in nitrergic neurons in rat esophagus.

Neurosci Lett 2006 Jun 4;401(1-2):174-7. Epub 2006 Apr 4.

Department of Applied Biology, Kyoto Institute of Technology, Matsugasaki, Sakyo, Kyoto 606-8585, Japan.

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http://dx.doi.org/10.1016/j.neulet.2006.03.019DOI Listing
June 2006

Combined determination with functional and morphological studies of origin of nerve fibers expressing transient receptor potential vanilloid 1 in the myenteric plexus of the rat jejunum.

Auton Neurosci 2004 Nov;116(1-2):11-8

Division of Gastrointestinal Pathophysiology, Department of Bioscience, Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930-0194, Japan.

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http://dx.doi.org/10.1016/j.autneu.2004.08.005DOI Listing
November 2004

Localization of neurokinin 1 receptor (NK1R) immunoreactivity in rat esophagus.

J Comp Neurol 2004 Oct;478(1):11-21

Department of Applied Biology, Kyoto Institute of Technology, Kyoto 606-8585, Japan.

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http://dx.doi.org/10.1002/cne.20169DOI Listing
October 2004

Characterization of in vitro gutlike organ formed from mouse embryonic stem cells.

Am J Physiol Cell Physiol 2004 Jun 11;286(6):C1344-52. Epub 2004 Feb 11.

Department of Physiology II, Nara Medical University, Kashihara, Nara 634-8521, Japan.

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http://dx.doi.org/10.1152/ajpcell.00392.2003DOI Listing
June 2004

A 5-HT4 agonist mosapride enhances rectorectal and rectoanal reflexes in guinea pigs.

Am J Physiol Gastrointest Liver Physiol 2003 Aug 30;285(2):G389-95. Epub 2003 Apr 30.

Dept. of Physiology II, Nara Medical Univ., 840 Shijo-cho, Kashihara, Nara 634-8521, Japan.

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http://dx.doi.org/10.1152/ajpgi.00085.2003DOI Listing
August 2003

Involvement of a purinergic pathway in the sympathetic regulation of motility in rat ileum.

Auton Neurosci 2003 Feb;104(1):10-6

Department of Physiology II, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8521, Japan.

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http://dx.doi.org/10.1016/s1566-0702(02)00257-6DOI Listing
February 2003

Adenosine A1 receptor blockade reverses experimental postoperative ileus in rat colon.

Eur J Pharmacol 2003 Jan;458(1-2):197-200

Pharmacological Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., 532-0031, Osaka, Japan.

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http://dx.doi.org/10.1016/s0014-2999(02)02766-8DOI Listing
January 2003

Integrative control of rectoanal reflex in guinea pigs through lumbar colonic nerves.

Am J Physiol Gastrointest Liver Physiol 2002 Jul;283(1):G148-56

First Department of Surgery, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8521, Japan.

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http://dx.doi.org/10.1152/ajpgi.00497.2001DOI Listing
July 2002

5-HT4 receptor enhances the propulsive power of the peristaltic reflex in the rat distal colon.

Auton Neurosci 2002 Jul;99(1):62-5

Department of Physiology II, Nara Medical University, Kashihara, Japan.

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http://dx.doi.org/10.1016/s1566-0702(02)00063-2DOI Listing
July 2002