Dr. Majid Asadi-Samani, PhD - Shahrekord University of Medical Sciences

Dr. Majid Asadi-Samani

PhD

Shahrekord University of Medical Sciences

Main Specialties: Allergy & Immunology, Biology, Biotechnology, Hematology & Oncology

Additional Specialties: Pharmacognosy

ORCID logohttps://orcid.org/0000-0001-5623-8729


Top Author

Dr. Majid Asadi-Samani, PhD - Shahrekord University of Medical Sciences

Dr. Majid Asadi-Samani

PhD

Introduction

Majid Asadi-Samani was born in Shahrekord, Chaharmahal va bakhtiari province, Iran on 22 May 1985. He graduated from Motahari High School in Saman of Chaharmahal va bakhtiari province, and from the University of Shahrekord with a Bachelor of Science in Cellular and Molecular Biology (Genetic Engineering) in Shahrekord. He remained at the University of Urmia to complete his Masters of Science degree in Plant Biology in Urmia and He ended his Ph.D. by research in Medical Immunology on Feb 2019. He is a biologist and expert in Biomedical Sciences.
As a researcher that has been worked at the Cellular and Molecular Research Center and the Medical Plants Research Center of Shahrekord University of Medical Sciences, he mainly completed his information around some desired issues especially in Phytomecine, Pharmacognosy, Immunology, and Cancer research.
He also was an activated one in scientific journals and so many various publishers which are focusing on his desired topics like Cancer. In addition, he is the Executive Manager of some reputed international journals and the Director of Nahalgostar Charmahal Co., which is a science-based company.
He has published more than 100 scientific papers in peer review international journals and greatly presented his works in more than 20 national and international congresses. He has two patents; 1- In vitro regeneration of Kelussia odoratissima Mozaff as a scarce and valuable medicinal plant; 2- Formulation of herbal medicine against influenza.
He is a member of Students Research Committee, Shahrekord University of Medical Sciences, Iran; a member of Young Researchers and Elite club, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran; an associate member of Iranian Society of Biology, the Iranian Society of Plant Physiology and the Iranian Medicinal Plants Society. In addition, he is a member of Iran's National Elites Foundation, so he has received some scholarships from this foundation.
He wishes to continue Post-Doc courses in other universities or institutes where he can vast his researches to all the people of the world for being cured and sharing them by other ones to make healthier world and future. He is going on prove and doing experiments on his future subjects, too.
His research interest:
His research interests are Biology, Phytomedicine, Pharmacognosy, Immunotoxicology, and Cancer.
He seeks to understand how local people use medicinal plants to treat diseases so that these plants can ultimately be used to prevent and treat human diseases. To this end, he has done much research on medicinal plants’ effects in various diseases.
Recently, he has focused on the effects of medicinal plants and their derivatives to can discover new anticancer drugs to prevent and treat cancer especially breast cancer and prostate cancer.

Primary Affiliation: Shahrekord University of Medical Sciences

Specialties:

Additional Specialties:

Research Interests:


View Dr. Majid Asadi-Samani’s Resume / CV

Education

Feb 2015
Cellular and Molecular Research Center
PhD of Immunology
Urmia University
MSc of Biology
biology

Experience

Feb 2012
Shahrekord University of Medical Science
Executive Manager of Journals

Publications

25Publications

332Reads

359Profile Views

49PubMed Central Citations

The effect of Fisch. & C.A.Mey extract on the viability and the proliferation of MDA-MB-231 cell line.

Biosci Rep 2019 01 11;39(1). Epub 2019 Jan 11.

Cellular and Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran

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http://dx.doi.org/10.1042/BSR20181538DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328893PMC
January 2019
10 Reads
2.637 Impact Factor

A screening to determine total phenol and flavonoid content of some Iran's medicinal plants grown in Chaharmahal va Bakhtyari province

INDIAN JOURNAL OF NATURAL PRODUCTS AND RESOURCES

The study of phytochemical compounds of plants grown in different regions can reveal their biological potentials for the identification and discovery of effective drugs. This study was conducted to investigate the total phenolic and flavonoid content of twenty Iranian medicinal plants. The plants were gathered from Chaharmahal va Bakhtyari and their aerial parts were used for extraction by maceration using ethanol 70 %. To determine total phenolic and flavonoid content of the extracts, the Folin-Ciocalteu method and the aluminum chloride colorimetric method were used respectively. Stachys inflate and Euphorbia szovitsii Fisch. & C.A. Mey. with 87.458 and 72.9644 mg GAE/g had the highest total phenolic content. Also, Urtica dioica (81.4945 mg RUT/g) and Satureja bachtiarica (41.5445 mg GAE/g) had the highest flavonoid content among the investigated plants. According to the result, all plants have different values of phenolic compounds. However, S. inflate, E. szovitsii, U. dioica and S. bachtiarica due to high values of phenolic and flavonoid contents can be considered as a potent resource of natural products for discovering antioxidant and anti-inflammatory drugs.

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December 2018

A screening of growth inhibitory activity of Iranian medicinal plants on prostate cancer cell lines.

Biomedicine (Taipei) 2018 Jun 28;8(2). Epub 2018 May 28.

Cellular and Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran.

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http://dx.doi.org/10.1051/bmdcn/2018080208DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5992925PMC
June 2018
6 Reads

Phytochemical evaluation and antibacterial effects of Medicago sativa, Onosma sericeum, Parietaria judaica L., Phlomis persica and Echinophora platyloba DC. on Enterococcus faecalis

Volume: 5 Issue: 1 Pages: 1941-1951

BIOMEDICAL RESEARCH AND THERAPY

Background: Since drug resistance has become one of the predominant problems of health worldwide, it is necessary to use new methods to combat drug-resistant bacteria. In this regard, medicinal plants are considered one of the richest sources to produce antibiotics. The aim of this study was to investigate the antibacterial effects as well as total phenolic and flavonoid contents of a number of medicinal plants collected from the Chaharmahal and Bakhtiari provinces of India, in order to investigate their potential use for the production of new antibiotics. Materials and Methods: In this experimental study, the maceration method was used to prepare hydroalcoholic extract of Medicago sativa, Onosma sericeum, Parietaria judaica L., Phlomis persica and Echinophora platyloba DC. The effect of these plants on Enterococcus faecalis (ATCC 29212) was investigated. To determine the antibacterial effect of the extracts, broth microdilution in a sterile 96-well plate was used according to the McFarland standard (105 CFU/ml). The total phenolic content was assayed by using the Folin-Ciocalteu colorimetric method and expressed in terms of gallic acid equivalent. The total flavonoid content was assayed by the aluminum chloride colorimetric method and expressed in terms of rutin equivalent. Results: Based on the results of this study, the 512, 256, 128, 32 and 32 mu g/ml doses were determined to be the minimum inhibitory concentrations (MICs), and the 1024, 1024, 512, 128 and 128 mu g/ml doses were derived as the minimum bactericidal concentration (MBCs) of M. sativa, O. Sericeum, P. judaica, P. persica and E. platyloba, respectively. E. faecalis and P. judaica contained the highest total phenolic content and flavonoid content, respectively. Conclusion: Given the comparatively higher antibacterial effect of P. persica and E. platyloba, as well as the presence of phenolic and flavonoid compounds in these plants, it is recommended that these plants be further investigated in feasibility studies for the production of new antibiotics.

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May 2018

REVIEW ON BOTANY, TRADITIONAL USES, PHYTOCHEMISTRY AND BIOLOGICAL ACTIVITIES OF EUPHORBIA MICROSCIADIA BOISS

Volume: 2 Issue: 4 Pages: 685-692

INTERNATIONAL JOURNAL OF HEALTH MEDICINE AND CURRENT RESEARCH-IJHMCR

Background: In traditional medicine, Euphorbia was used to treat inflammations, tumors, gout, back pain, sciatica, arthritis, pneumonia, intestinal parasites, gonorrhea, and skin diseases. The species of this genus that distribute in most regions worldwide studied to discover and produce effective medicines because they contain valuable active compounds. In this study, we provided available evidence regarding Euphorbia microsciadia Boiss. as one of the main species of this genus. 
Methods: For this purpose, we searched for relevant publications in scientific databases including PubMed, Web of Science, Google Scholar, Scopus, local herbal encyclopedias and textbooks. 
Results: Certain chemical compounds, including flavonoids and terpenoids, have been isolated from E. microsciadia. Recent pharmacological investigations have demonstrated that its extracts and active compounds have a wide spectrum of pharmacological effects, such as antimicrobial, antiviral, anticancer and immunomodulatory. 
Conclusion: This plant has a great potential and a broad spectrum of activities for treating different illnesses. Terpenes, as the main compounds of this plant, can be considered a potent source of natural compounds for discovering anticancer drugs.

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December 2017

Effects and mechanisms of medicinal plants on dopamine reward system to reduce complications of substance abuse: A systematic review

Volume: 15 Issue: 10 Pages: 202-207

WORLD FAMILY MEDICINE

Substance abuse is one of the problems that many countries are currently dealing with and it imposes several complications on our communities. The dopamine reward system is one of the regions of the brain that plays important roles in the pleasure and persistence of addiction. This review was conducted to investigate the effects and action mechanisms of medicinal plants on the dopaminergic review system in preventing substance abuse. The key words "dopamine*" in combination with "substance abuse", "drug abuse", "addiction" or "medicinal plant", "herb*", and "phyto*" were used to retrieve relevant publications indexed in the Institute for Scientific Information (ISI) and PubMed using the EndNote software. After examining the studies, we included 23 of them in final analysis. Medicinal plants and their derivatives can exhibit anti-addiction effects in substance use disorders mainly through influencing dopamine receptors (D1 and D2). They can also serve as appropriate alternatives to drugs and to help treat relapse due to stimulating the dopamine reward system. Because substance abuse is multifactorial, it should be taken into account that phytotherapy alone cannot be effective in treating it but instead a combination of different therapies should be adopted to fight it.

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December 2017

3 Citations

Effective Medicinal Plant in Cancer Treatment, Part 2: Review Study.

J Evid Based Complementary Altern Med 2017 Oct 31;22(4):982-995. Epub 2017 Mar 31.

5 Immunology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

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http://dx.doi.org/10.1177/2156587217696927DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5871268PMC
October 2017
26 Reads

The Application of Mir-183 Family and Mesenchymal Stem Cells: A Possibility for Restoring Hearing Loss

INDIAN JOURNAL OF OTOLOGY

Hearing loss as one of the most common disabilities approximately over 5% of the world's population - 360 million people - has disabling hearing loss (328 million adults and 32 million children). Recent developments in stem cell technology provide new opportunities for the treatment of deafness. miRNAs are essential factors of an extensively conserved posttranscriptional process controlling gene expression at mRNA level. Various biological processes such as growth and differentiation are regulated by miRNAs. In this review paper, we have discussed the application of the miR-183 family and mesenchymal stem cells as a possibility for restoring hearing loss. In this regards, the web of Science and PubMed databases were searched using the Endnote software for the publications about the application of miR-183 family and mesenchymal stem cells (MSCs) to study hearing loss published from 2000 to 2016. The miR-183 family (miR-183, miR-96, and miR-182) is expressed abundantly in sensory cells in the inner ear. miR-183 family is significant for the development and persistence of auditory neurons and hair cell. These four genes, i.e. Sox2, Notch1, Jag1, and Hes1, are potentially the targets of miR-183 family. In studies on animal models such as mouse and zebrafish, the time of Atoh1 expression in the hair cells was found to be the E12/5-E14/5 day, and miR-183 family was reported to begin to express on the E14/5 day. Use of human MSCs in differentiating into hair cells has been investigated, demonstrating that MSCs have neuroregenerative capacity. Cell therapy-targeting regeneration of the auditory neurons and hair cell may, therefore, be a powerful strategy to cure hearing loss that cannot be reversed by current therapies. A combination of the MSCs, specific growth factors and miR-183 cluster (96-182-183) can increase the potential to differentiate into the auditory neurons and hair cell.

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October 2017

Inhibition of Th1 and Th17 Cells by Medicinal Plants and Their Derivatives: A Systematic Review.

Phytother Res 2017 Aug 1;31(8):1128-1139. Epub 2017 Jun 1.

Cellular and Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran.

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http://dx.doi.org/10.1002/ptr.5837DOI Listing
August 2017
48 Reads
2.397 Impact Factor

Traditional uses of medicinal plants to prevent and treat diabetes; an updated review of ethnobotanical studies in Iran.

J Nephropathol 2017 Jul 15;6(3):118-125. Epub 2017 Jan 15.

Department of General Surgery, University of Michigan, Ann Arbor, Michigan, USA.

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http://dx.doi.org/10.15171/jnp.2017.20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5607970PMC
July 2017
12 Reads

Serum miRNAs as Biomarkers for the Diagnosis and Prognosis of Thyroid Cancer: A Comprehensive Review of the Literature.

Eur Thyroid J 2017 Jul 7;6(4):171-177. Epub 2017 Apr 7.

Cellular and Molecular Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran.

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http://dx.doi.org/10.1159/000468520DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5567107PMC
July 2017
1 Read

Phytotherapy of nephrotoxicity-induced by cancer drugs: an updated review.

J Nephropathol 2017 Jul 16;6(3):254-263. Epub 2017 Feb 16.

Department of Immunology, School of Medicine, Jundishapur University of Medical Sciences, Ahvaz, Iran.

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http://dx.doi.org/10.15171/jnp.2017.41DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5607991PMC
July 2017
1 Read

Ginkgo biloba in the treatment of tinnitus: An updated literature review.

Int Tinnitus J 2017 Jun 1;21(1):58-62. Epub 2017 Jun 1.

Institute of Pharmacy and Molecular Biotechnology, University of Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.5935/0946-5448.20170011DOI Listing
June 2017
5 Reads

A Review of Medicinal Plants for the Treatment of Earache and Tinnitus in Iran.

Int Tinnitus J 2017 Jun 1;21(1):44-49. Epub 2017 Jun 1.

Department of General Surgery, University of Michigan, Ann Arbor, MI, USA.

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http://dx.doi.org/10.5935/0946-5448.20170009DOI Listing
June 2017
9 Reads

Response to Comments by Dr Gholami on "A Systematic Review of Iran's Medicinal Plants With Anticancer Effects".

J Evid Based Complementary Altern Med 2017 Apr 8;22(2):360. Epub 2016 Jul 8.

1 Student Research Committee, Shahrekord University of Medical Sciences, Shahrekord, Iran.

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http://dx.doi.org/10.1177/2156587216636499DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5871182PMC
April 2017
3 Reads

Clinical relevance of Helicobacter pylori virulence factors in Iranian patients with gastrointestinal diseases.

Microb Pathog 2016 Nov 22;100:154-162. Epub 2016 Sep 22.

Cellular and Molecular Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran. Electronic address:

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http://dx.doi.org/10.1016/j.micpath.2016.09.016DOI Listing
November 2016
16 Reads
1 Citation
2.000 Impact Factor

A study on the association of diabetic dermopathy with nephropathy and retinopathy in patients with type 2 diabetes mellitus.

J Nephropathol 2016 Oct 26;5(4):139-143. Epub 2016 Jul 26.

Students Research Committee, Shahrekord University of Medical Sciences, Shahrekord, Iran.

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http://dx.doi.org/10.15171/jnp.2016.26DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5125061PMC
October 2016
2 Reads
2 Citations

Phytochemistry, pharmacology, and therapeutic uses of black seed (Nigella sativa).

Chin J Nat Med 2016 Oct 31;14(10):732-745. Epub 2016 Oct 31.

Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

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http://dx.doi.org/10.1016/S1875-5364(16)30088-7DOI Listing
October 2016
12 Reads

A mini-review on the most important effective medicinal plants to treat hypertension in ethnobotanical evidence of Iran.

J Nephropharmacol 2017 14;6(1):3-8. Epub 2016 Jun 14.

Student Research Committee, Medical Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5295656PMC
June 2016
1 Read

Oxidative stress and age-related changes in T cells: is thalassemia a model of accelerated immune system aging?

Cent Eur J Immunol 2016 20;41(1):116-24. Epub 2016 Jan 20.

Cellular and Molecular Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran.

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http://dx.doi.org/10.5114/ceji.2015.56973DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4829813PMC
April 2016
12 Reads
1 Citation
0.360 Impact Factor

A Systematic Review of Iran's Medicinal Plants With Anticancer Effects.

J Evid Based Complementary Altern Med 2016 Apr 21;21(2):143-53. Epub 2015 Aug 21.

Student Research Committee, Medical Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran

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http://dx.doi.org/10.1177/2156587215600873DOI Listing
April 2016
142 Reads
13 Citations

The role of medicinal plants in the treatment of diabetes: a systematic review.

Electron Physician 2016 Jan 15;8(1):1832-42. Epub 2016 Jan 15.

Student Research Committee, Medical Plant Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran.

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http://dx.doi.org/10.19082/1832DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4768936PMC
January 2016
4 Reads
4 Citations

The synergic effect of glycyrrhizic acid and low frequency electromagnetic field on angiogenesis in chick chorioallantoic membrane.

Avicenna J Phytomed 2015 May-Jun;5(3):174-81

Student's Research Committee, Shahrekord University of Medical Sciences, Shahrekord, Iran.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4469957PMC
June 2015
6 Reads
1 Citation

The chemical composition, botanical characteristic and biological activities of Borago officinalis: a review.

Asian Pac J Trop Med 2014 Sep;7S1:S22-8

Medical Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran. Electronic address:

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http://dx.doi.org/10.1016/S1995-7645(14)60199-1DOI Listing
September 2014
2 Reads
16 Citations
0.930 Impact Factor

Gundelia: a systematic review of medicinal and molecular perspective.

Pak J Biol Sci 2013 Nov;16(21):1238-47

Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran.

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November 2013
14 Reads
8 Citations

Top co-authors

Mahmoud Rafieian-Kopaei
Mahmoud Rafieian-Kopaei

Shahrekord University of Medical Sciences

6
Wesam Kooti
Wesam Kooti

Ahvaz Jundishapur University of Medical Sciences

4
Hedayatollah Shirzad
Hedayatollah Shirzad

Shahrekord University of Medical Sciences

4
Nader Bagheri
Nader Bagheri

School of Public Health

2
Morteza Hashemzadeh-Chaleshtori
Morteza Hashemzadeh-Chaleshtori

Shahrekord University of Medical Sciences

2
Tahra Luther
Tahra Luther

University of Michigan Comprehensive Cancer Center

2
Qian Yang
Qian Yang

College of Veterinary Medicine

2
Zahra Lorigooini
Zahra Lorigooini

Medical Plants Research Center

2
Nafiseh Esmaeili
Nafiseh Esmaeili

Tehran University of Medical Sciences

1