Mr. Maizbha Uddin Ahmed, M.Pharm - University of Dhaka - Assistant Professor

Mr. Maizbha Uddin Ahmed

M.Pharm

University of Dhaka

Assistant Professor

Dhaka, Dhaka | Bangladesh

Main Specialties: Pharmacology

Additional Specialties: Pharmacology, Pharmacogenomics, Pharmacogenetics


Top Author

Mr. Maizbha Uddin Ahmed, M.Pharm - University of Dhaka - Assistant Professor

Mr. Maizbha Uddin Ahmed

M.Pharm

Introduction

Antimicrobial resistance (AMR) is a global threat for the effective prevention and treatment of infectious diseases caused by multi-drug resistant (MDR) Gram-negative bacteria. Most dangerous of this pathogens are Pseudomonas aeruginosa, Acinetobacter baumannii, and Klebsiella pneumoniae. Infectious disease society of America (IDSA) has placed these three problematic pathogens on a hit list of the six top-priority dangerous MDR microorganisms. In 2013 the Centers for Disease Control and Prevention (CDC) escalated the antibiotic resistance threat level for these bacteria in the USA as being serious to urgent. Clinicians worldwide, including Australia (Australian Society for Infectious Diseases Gram-negative superbugs meeting, 2013), are increasingly confronted with the reality of infections with Gram-negative pathogens that are resistant to all antibiotics except polymyxins.
Polymyxins are used as the last-line therapy against Gram-negative superbugs. Current dosing recommendations of parenteral polymyxins are suboptimal, in particular for lung infections due to very limited access of polymyxins into the infection site. Moreover, nephrotoxicity is the dose-limiting factor and can occur in up to 60% of patients. Pulmonary delivery of polymyxins thus holds a great promise for treatment of lung infections with minimum systemic exposure. Unfortunately, there is a lack of information on the pharmacokinetics (PK) and pharmacodynamics (PD) for inhaled polymyxins. Worryingly, emergence of polymyxin resistance due to suboptimal use has been increasingly reported worldwide.
My research interest is to elucidate the toxicity and mechanism of disposition of polymyxins in lung epithelial cells using cutting-edge imaging techniques, metabolomics and experimental animal model. I am also interested in attenuation of polymyxin induced lung toxicity by co-administration of potential protective agents.

Primary Affiliation: University of Dhaka - Dhaka, Dhaka , Bangladesh

Specialties:

Additional Specialties:

Research Interests:


View Mr. Maizbha Uddin Ahmed’s Resume / CV

Metrics

Number of Publications

18

Publications

Number of Profile Views

378

Profile Views

Number of Article Reads

303

Reads

Number of PubMed Central Citations

32

PubMed Central Citations

Education

Mar 2015
Monash University
Doctor of Philosophy (3rd year)
Jun 2007
University of Dhaka
Master of Pharmacy
Jun 2006
University of Dhaka
Bachelor of Pharmacy

Publications

18Publications

303Reads

32PubMed Central Citations

DPYD*2A and MTHFR C677T predict toxicity and efficacy, respectively, in patients on chemotherapy with 5-fluorouracil for colorectal cancer.

Cancer Chemother Pharmacol 2018 Jan 13;81(1):119-129. Epub 2017 Nov 13.

Department of Clinical Pharmacy and Pharmacology, Faculty of Pharmacy, University of Dhaka, Dhaka, 1000, Bangladesh.

View Article
January 2018
17 Reads
2.770 Impact Factor

Gelofusine Ameliorates Colistin-Induced Nephrotoxicity.

Antimicrob Agents Chemother 2017 12 22;61(12). Epub 2017 Nov 22.

Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Melbourne, Victoria, Australia

View Article
December 2017
20 Reads
4.480 Impact Factor

Genetic variants of SULT1A1 and XRCC1 genes and risk of lung cancer in Bangladeshi population.

Tumour Biol 2017 Nov;39(11):1010428317729270

1 Department of Clinical Pharmacy and Pharmacology, Faculty of Pharmacy, University of Dhaka, Dhaka, Bangladesh.

View Article
November 2017
21 Reads
2.840 Impact Factor

Potential Toxicity of Polymyxins in Human Lung Epithelial Cells.

Antimicrob Agents Chemother 2017 06 24;61(6). Epub 2017 May 24.

Monash Biomedicine Discovery Institute, Department of Microbiology, Monash University, Victoria, Australia

View Article
June 2017
11 Reads
3 PubMed Central Citations(source)
4.480 Impact Factor

Association of BRCA1, BRCA2, RAD51, and HER2 gene polymorphisms with the breast cancer risk in the Bangladeshi population.

Breast Cancer 2017 Mar 11;24(2):229-237. Epub 2016 Apr 11.

Department of Clinical Pharmacy and Pharmacology, Faculty of Pharmacy, University of Dhaka, Dhaka, 1000, Bangladesh.

View Article
March 2017
22 Reads
2 PubMed Central Citations(source)
1.500 Impact Factor

Breast cancer risk in relation to TP53 codon 72 and CDH1 gene polymorphisms in the Bangladeshi women.

Tumour Biol 2016 Jun 14;37(6):7229-37. Epub 2015 Dec 14.

Department of Clinical Pharmacy and Pharmacology, Faculty of Pharmacy, University of Dhaka, Dhaka, 1000, Bangladesh.

View Article
June 2016
15 Reads
4 PubMed Central Citations(source)
2.840 Impact Factor

Effect of socio-economic status and estimation of lipid peroxidation and antioxidant in preeclamptic pregnant women: a case-control study.

Hypertens Pregnancy 2015 Feb;34(1):125-35

Department of Pharmacy, Southeast University , Banani, Dhaka , Bangladesh .

View Article
February 2015
9 Reads
3 PubMed Central Citations(source)
1.190 Impact Factor

Lung cancer risk in relation to TP53 codon 47 and codon 72 polymorphism in Bangladeshi population.

Tumour Biol 2014 Oct 18;35(10):10309-17. Epub 2014 Jul 18.

Department of Clinical Pharmacy and Pharmacology, Faculty of Pharmacy, University of Dhaka, Dhaka, 1000, Bangladesh.

View Article
October 2014
11 Reads
1 PubMed Central Citation(source)
2.840 Impact Factor

N-acetyltransferase 2 (NAT2) genotype as a risk factor for development of drug-induced liver injury relating to antituberculosis drug treatment in a mixed-ethnicity patient group.

Eur J Clin Pharmacol 2014 Sep 3;70(9):1079-86. Epub 2014 Jun 3.

Institute of Cellular Medicine, Newcastle University, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK.

View Article
September 2014
14 Reads
8 PubMed Central Citations(source)
2.970 Impact Factor

Association of CYP3A4, CYP3A5 polymorphisms with lung cancer risk in Bangladeshi population.

Tumour Biol 2014 Feb 2;35(2):1671-8. Epub 2013 Oct 2.

Department of Pharmacy, Noakhali Science and Technology University, Sonapur, Noakhali, 3814, Bangladesh.

View Article
February 2014
9 Reads
2 PubMed Central Citations(source)
2.840 Impact Factor

Comparative analysis of serum zinc, copper, manganese, iron, calcium, and magnesium level and complexity of interelement relations in generalized anxiety disorder patients.

Biol Trace Elem Res 2013 Jul 12;154(1):21-7. Epub 2013 Jun 12.

Department of Clinical Pharmacy and Pharmacology, Faculty of Pharmacy, University of Dhaka, Dhaka 1000, Bangladesh.

View Article
July 2013
16 Reads
3 PubMed Central Citations(source)
1.750 Impact Factor

Genotype-phenotype variability in human CYP3A locus in Nepalese people residing in Bangladesh.

Int J Clin Pharmacol Ther 2013 Mar;51(3):207-14

Department of Clinical Pharmacy and Pharmacology, University of Dhaka, Dhaka, Bangladesh.

View Article
March 2013
7 Reads
1.040 Impact Factor

Lung cancer risk in relation to nicotinic acetylcholine receptor, CYP2A6 and CYP1A1 genotypes in the Bangladeshi population.

Clin Chim Acta 2013 Feb 21;416:11-9. Epub 2012 Nov 21.

Department of Clinical Pharmacy and Pharmacology, Faculty of Pharmacy, University of Dhaka, Dhaka-1000, Bangladesh.

View Article
February 2013
14 Reads
4 PubMed Central Citations(source)
2.820 Impact Factor

Comparative pharmacokinetic and bioequivalence study of azithromycin 500 mg tablet in healthy Bangladeshi volunteers.

Int J Clin Pharmacol Ther 2012 06;50(6):452-8

Department of Clinical Pharmacy and Pharmacology, University of Dhaka, Bangladesh.

View Article
June 2012
22 Reads
1.040 Impact Factor

Pharmacokinetic and bioequivalence study of etoricoxib tablet in healthy Bangladeshi volunteers.

Arzneimittelforschung 2011 ;61(11):617-21

Department of Clinical Pharmacy and Pharmacology, University of Dhaka, Dhaka, Bangladesh.

View Article
January 2012
47 Reads
1 PubMed Central Citation(source)
0.510 Impact Factor

Genotypes and phenotypes of CYP3A in Bangladeshi population.

Clin Chim Acta 2011 Mar 27;412(7-8):531-6. Epub 2010 Nov 27.

Department of Clinical Pharmacy & Pharmacology, Faculty of Pharmacy, University of Dhaka, Dhaka 1000, Bangladesh.

View Article
March 2011
12 Reads
1 PubMed Central Citation(source)
2.820 Impact Factor