Mr. Maizbha Uddin Ahmed, M.Pharm - University of Dhaka - Assistant Professor

Mr. Maizbha Uddin Ahmed

M.Pharm

University of Dhaka

Assistant Professor

Dhaka, Dhaka | Bangladesh

Main Specialties: Pharmacology

Additional Specialties: Pharmacology, Pharmacogenomics, Pharmacogenetics


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Mr. Maizbha Uddin Ahmed, M.Pharm - University of Dhaka - Assistant Professor

Mr. Maizbha Uddin Ahmed

M.Pharm

Introduction

Antimicrobial resistance (AMR) is a global threat for the effective prevention and treatment of infectious diseases caused by multi-drug resistant (MDR) Gram-negative bacteria. Most dangerous of this pathogens are Pseudomonas aeruginosa, Acinetobacter baumannii, and Klebsiella pneumoniae. Infectious disease society of America (IDSA) has placed these three problematic pathogens on a hit list of the six top-priority dangerous MDR microorganisms. In 2013 the Centers for Disease Control and Prevention (CDC) escalated the antibiotic resistance threat level for these bacteria in the USA as being serious to urgent. Clinicians worldwide, including Australia (Australian Society for Infectious Diseases Gram-negative superbugs meeting, 2013), are increasingly confronted with the reality of infections with Gram-negative pathogens that are resistant to all antibiotics except polymyxins.
Polymyxins are used as the last-line therapy against Gram-negative superbugs. Current dosing recommendations of parenteral polymyxins are suboptimal, in particular for lung infections due to very limited access of polymyxins into the infection site. Moreover, nephrotoxicity is the dose-limiting factor and can occur in up to 60% of patients. Pulmonary delivery of polymyxins thus holds a great promise for treatment of lung infections with minimum systemic exposure. Unfortunately, there is a lack of information on the pharmacokinetics (PK) and pharmacodynamics (PD) for inhaled polymyxins. Worryingly, emergence of polymyxin resistance due to suboptimal use has been increasingly reported worldwide.
My research interest is to elucidate the toxicity and mechanism of disposition of polymyxins in lung epithelial cells using cutting-edge imaging techniques, metabolomics and experimental animal model. I am also interested in attenuation of polymyxin induced lung toxicity by co-administration of potential protective agents.

Primary Affiliation: University of Dhaka - Dhaka, Dhaka , Bangladesh

Specialties:

Additional Specialties:

Research Interests:


View Mr. Maizbha Uddin Ahmed’s Resume / CV

Education

Mar 2015
Monash University
Doctor of Philosophy (3rd year)
Pharmacy and Pharmaceutical Sciences
Jun 2007
University of Dhaka
Master of Pharmacy
Clinical Pharmacy and Pharmacology
Jun 2006
University of Dhaka
Bachelor of Pharmacy
Pharmacy

Publications

18Publications

408Reads

456Profile Views

32PubMed Central Citations

DPYD*2A and MTHFR C677T predict toxicity and efficacy, respectively, in patients on chemotherapy with 5-fluorouracil for colorectal cancer.

Cancer Chemother Pharmacol 2018 01 13;81(1):119-129. Epub 2017 Nov 13.

Department of Clinical Pharmacy and Pharmacology, Faculty of Pharmacy, University of Dhaka, Dhaka, 1000, Bangladesh.

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http://dx.doi.org/10.1007/s00280-017-3478-3DOI Listing
January 2018
26 Reads
2.770 Impact Factor

Gelofusine Ameliorates Colistin-Induced Nephrotoxicity.

Antimicrob Agents Chemother 2017 12 22;61(12). Epub 2017 Nov 22.

Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Melbourne, Victoria, Australia

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http://dx.doi.org/10.1128/AAC.00985-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5700338PMC
December 2017
27 Reads
4.480 Impact Factor

Genetic variants of SULT1A1 and XRCC1 genes and risk of lung cancer in Bangladeshi population.

Tumour Biol 2017 Nov;39(11):1010428317729270

1 Department of Clinical Pharmacy and Pharmacology, Faculty of Pharmacy, University of Dhaka, Dhaka, Bangladesh.

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http://dx.doi.org/10.1177/1010428317729270DOI Listing
November 2017
27 Reads
2.840 Impact Factor

Potential Toxicity of Polymyxins in Human Lung Epithelial Cells.

Antimicrob Agents Chemother 2017 06 24;61(6). Epub 2017 May 24.

Monash Biomedicine Discovery Institute, Department of Microbiology, Monash University, Victoria, Australia

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http://dx.doi.org/10.1128/AAC.02690-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5444173PMC
June 2017
15 Reads
3 Citations
4.480 Impact Factor

Association of BRCA1, BRCA2, RAD51, and HER2 gene polymorphisms with the breast cancer risk in the Bangladeshi population.

Breast Cancer 2017 Mar 11;24(2):229-237. Epub 2016 Apr 11.

Department of Clinical Pharmacy and Pharmacology, Faculty of Pharmacy, University of Dhaka, Dhaka, 1000, Bangladesh.

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http://dx.doi.org/10.1007/s12282-016-0692-5DOI Listing
March 2017
24 Reads
2 Citations
1.505 Impact Factor

Breast cancer risk in relation to TP53 codon 72 and CDH1 gene polymorphisms in the Bangladeshi women.

Tumour Biol 2016 Jun 14;37(6):7229-37. Epub 2015 Dec 14.

Department of Clinical Pharmacy and Pharmacology, Faculty of Pharmacy, University of Dhaka, Dhaka, 1000, Bangladesh.

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http://link.springer.com/10.1007/s13277-015-4612-7
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http://dx.doi.org/10.1007/s13277-015-4612-7DOI Listing
June 2016
18 Reads
4 Citations
2.840 Impact Factor

Effect of socio-economic status and estimation of lipid peroxidation and antioxidant in preeclamptic pregnant women: a case-control study.

Hypertens Pregnancy 2015 Feb;34(1):125-35

Department of Pharmacy, Southeast University , Banani, Dhaka , Bangladesh .

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http://dx.doi.org/10.3109/10641955.2014.988349DOI Listing
February 2015
15 Reads
3 Citations
1.192 Impact Factor

Lung cancer risk in relation to TP53 codon 47 and codon 72 polymorphism in Bangladeshi population.

Tumour Biol 2014 Oct 18;35(10):10309-17. Epub 2014 Jul 18.

Department of Clinical Pharmacy and Pharmacology, Faculty of Pharmacy, University of Dhaka, Dhaka, 1000, Bangladesh.

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http://dx.doi.org/10.1007/s13277-014-2285-2DOI Listing
October 2014
18 Reads
1 Citation
2.840 Impact Factor

N-acetyltransferase 2 (NAT2) genotype as a risk factor for development of drug-induced liver injury relating to antituberculosis drug treatment in a mixed-ethnicity patient group.

Eur J Clin Pharmacol 2014 Sep 3;70(9):1079-86. Epub 2014 Jun 3.

Institute of Cellular Medicine, Newcastle University, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK.

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http://dx.doi.org/10.1007/s00228-014-1703-0DOI Listing
September 2014
19 Reads
8 Citations
2.970 Impact Factor

Association of CYP3A4, CYP3A5 polymorphisms with lung cancer risk in Bangladeshi population.

Tumour Biol 2014 Feb 2;35(2):1671-8. Epub 2013 Oct 2.

Department of Pharmacy, Noakhali Science and Technology University, Sonapur, Noakhali, 3814, Bangladesh.

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http://dx.doi.org/10.1007/s13277-013-1230-0DOI Listing
February 2014
12 Reads
2 Citations
2.840 Impact Factor

Comparative analysis of serum zinc, copper, manganese, iron, calcium, and magnesium level and complexity of interelement relations in generalized anxiety disorder patients.

Biol Trace Elem Res 2013 Jul 12;154(1):21-7. Epub 2013 Jun 12.

Department of Clinical Pharmacy and Pharmacology, Faculty of Pharmacy, University of Dhaka, Dhaka 1000, Bangladesh.

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http://dx.doi.org/10.1007/s12011-013-9723-7DOI Listing
July 2013
20 Reads
3 Citations
1.750 Impact Factor

Genotype-phenotype variability in human CYP3A locus in Nepalese people residing in Bangladesh.

Int J Clin Pharmacol Ther 2013 Mar;51(3):207-14

Department of Clinical Pharmacy and Pharmacology, University of Dhaka, Dhaka, Bangladesh.

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http://dx.doi.org/10.5414/CP201831DOI Listing
March 2013
12 Reads
1.044 Impact Factor

Lung cancer risk in relation to nicotinic acetylcholine receptor, CYP2A6 and CYP1A1 genotypes in the Bangladeshi population.

Clin Chim Acta 2013 Feb 21;416:11-9. Epub 2012 Nov 21.

Department of Clinical Pharmacy and Pharmacology, Faculty of Pharmacy, University of Dhaka, Dhaka-1000, Bangladesh.

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http://dx.doi.org/10.1016/j.cca.2012.11.011DOI Listing
February 2013
18 Reads
4 Citations
2.824 Impact Factor

Comparative pharmacokinetic and bioequivalence study of azithromycin 500 mg tablet in healthy Bangladeshi volunteers.

Int J Clin Pharmacol Ther 2012 06;50(6):452-8

Department of Clinical Pharmacy and Pharmacology, University of Dhaka, Bangladesh.

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June 2012
34 Reads
1.044 Impact Factor

Pharmacokinetic and bioequivalence study of etoricoxib tablet in healthy Bangladeshi volunteers.

Arzneimittelforschung 2011 ;61(11):617-21

Department of Clinical Pharmacy and Pharmacology, University of Dhaka, Dhaka, Bangladesh.

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http://dx.doi.org/10.1055/s-0031-1300564DOI Listing
January 2012
63 Reads
1 Citation
0.510 Impact Factor

Comparative pharmacokinetic and relative bioavailability study of coated and uncoated azithromycin powder for suspension in healthy Bangladeshi male volunteers.

Arzneimittelforschung 2011 ;61(10):594-8

Department of Clinical Pharmacy and Pharmacology, Faculty of Pharmacy, University of Dhaka, Dhaka, Bangladesh.

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http://dx.doi.org/10.1055/s-0031-1300558DOI Listing
January 2012
16 Reads
0.510 Impact Factor

Genotypes and phenotypes of CYP3A in Bangladeshi population.

Clin Chim Acta 2011 Mar 27;412(7-8):531-6. Epub 2010 Nov 27.

Department of Clinical Pharmacy & Pharmacology, Faculty of Pharmacy, University of Dhaka, Dhaka 1000, Bangladesh.

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http://dx.doi.org/10.1016/j.cca.2010.11.031DOI Listing
March 2011
16 Reads
1 Citation
2.824 Impact Factor