Publications by authors named "Maiken Nedergaard"

100Publications

Glymphatic failure as a final common pathway to dementia.

Science 2020 10;370(6512):50-56

Center for Translational Neuromedicine, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.

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http://dx.doi.org/10.1126/science.abb8739DOI Listing
October 2020

Circadian control of brain glymphatic and lymphatic fluid flow.

Nat Commun 2020 09 2;11(1):4411. Epub 2020 Sep 2.

Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, NY, 14642, USA.

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http://dx.doi.org/10.1038/s41467-020-18115-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7468152PMC
September 2020

A community-based transcriptomics classification and nomenclature of neocortical cell types.

Nat Neurosci 2020 Aug 24. Epub 2020 Aug 24.

Allen Institute for Brain Science, Seattle, WA, USA.

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http://dx.doi.org/10.1038/s41593-020-0685-8DOI Listing
August 2020

Defining novel functions for cerebrospinal fluid in ALS pathophysiology.

Acta Neuropathol Commun 2020 08 20;8(1):140. Epub 2020 Aug 20.

UK Dementia Research Institute at University of Edinburgh, Edinburgh, UK.

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http://dx.doi.org/10.1186/s40478-020-01018-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7439665PMC
August 2020

Twists and turns of ocular glymphatic clearance - new study reveals surprising findings in glaucoma.

Acta Ophthalmol 2020 Jul 24. Epub 2020 Jul 24.

Center for Basic and Translational Neuroscience, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1111/aos.14524DOI Listing
July 2020

A three-dimensional, population-based average of the C57BL/6 mouse brain from DAPI-stained coronal slices.

Sci Data 2020 07 13;7(1):235. Epub 2020 Jul 13.

Center for Translational Neuromedicine, Faculty of Health and Medical Sciences, University of Copenhagen, 2200, Copenhagen, Denmark.

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http://dx.doi.org/10.1038/s41597-020-0570-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7359299PMC
July 2020

Human Glial Progenitor Cells Effectively Remyelinate the Demyelinated Adult Brain.

Cell Rep 2020 May;31(7):107658

Center for Translational Neuromedicine and the Department of Neurology, University of Rochester Medical Center, Rochester, NY 14642, USA; Center for Translational Neuromedicine, University of Copenhagen, Copenhagen, Denmark; Neuroscience Center, Rigshospitalet, Copenhagen, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2020.107658DOI Listing
May 2020

The Brain's Glymphatic System: Current Controversies.

Trends Neurosci 2020 Jul 15;43(7):458-466. Epub 2020 May 15.

Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, NY 14642, USA; Center for Translational Neuromedicine, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.tins.2020.04.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7331945PMC
July 2020

Interstitial ions: A key regulator of state-dependent neural activity?

Prog Neurobiol 2020 10 13;193:101802. Epub 2020 May 13.

Center for Translational Neuromedicine, Faculty of Health and Medical Sciences, University of Copenhagen, 2200, Copenhagen, Denmark; Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, NY, 14642, United States. Electronic address:

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http://dx.doi.org/10.1016/j.pneurobio.2020.101802DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7331944PMC
October 2020

Mechanisms of cognitive dysfunction in CKD.

Nat Rev Nephrol 2020 Aug 31;16(8):452-469. Epub 2020 Mar 31.

Department of Translational Medical Sciences, University of Campania "Luigi Vanvitelli", Naples, Italy.

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http://dx.doi.org/10.1038/s41581-020-0266-9DOI Listing
August 2020

Inflammation in acquired hydrocephalus: pathogenic mechanisms and therapeutic targets.

Nat Rev Neurol 2020 May 9;16(5):285-296. Epub 2020 Mar 9.

Departments of Neurosurgery, Pediatrics, and Cellular & Molecular Physiology and Yale-Rockefeller NIH Centers for Mendelian Genomics, Yale School of Medicine, New Haven, CT, USA.

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http://dx.doi.org/10.1038/s41582-020-0321-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7375440PMC
May 2020

Meningeal Lymphangiogenesis and Enhanced Glymphatic Activity in Mice with Chronically Implanted EEG Electrodes.

J Neurosci 2020 03 11;40(11):2371-2380. Epub 2020 Feb 11.

Center for Translational Neuromedicine, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark,

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http://dx.doi.org/10.1523/JNEUROSCI.2223-19.2020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7083292PMC
March 2020

Aquaporin 1 and the Na/K/2Cl cotransporter 1 are present in the leptomeningeal vasculature of the adult rodent central nervous system.

Fluids Barriers CNS 2020 Feb 11;17(1):15. Epub 2020 Feb 11.

Center for Translational Neuromedicine, Division of Glial Disease and Therapeutics, University of Copenhagen, 2200, Copenhagen, Denmark.

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http://dx.doi.org/10.1186/s12987-020-0176-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7014736PMC
February 2020

Editorial: Sleep and Mood Disorders.

Front Psychiatry 2019 16;10:981. Epub 2020 Jan 16.

Laboratory Teaching Center, School of Forensic Medicine, China Medical University, Shenyang, China.

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http://dx.doi.org/10.3389/fpsyt.2019.00981DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6977539PMC
January 2020

Glymphatic System Impairment in Alzheimer's Disease and Idiopathic Normal Pressure Hydrocephalus.

Trends Mol Med 2020 Mar 18;26(3):285-295. Epub 2020 Jan 18.

Departments of Neurosurgery, Pediatrics, and Cellular and Molecular Physiology; and Yale-Rockefeller National Institutes of Health (NIH) Centers for Mendelian Genomics, Yale School of Medicine, New Haven, CT 06510, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molmed.2019.11.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7489754PMC
March 2020

Gabor domain optical coherence microscopy combined with laser scanning confocal fluorescence microscopy.

Biomed Opt Express 2019 Dec 14;10(12):6242-6257. Epub 2019 Nov 14.

The Institute of Optics, University of Rochester, Wilmot Building, Rochester, New York 14627, USA.

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http://dx.doi.org/10.1364/BOE.10.006242DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6913392PMC
December 2019

Glial cells in schizophrenia: a unified hypothesis.

Lancet Psychiatry 2020 03 6;7(3):272-281. Epub 2019 Nov 6.

Center for Translational Neuromedicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, NY, USA.

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http://dx.doi.org/10.1016/S2215-0366(19)30302-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7267935PMC
March 2020

State-Dependent Changes in Brain Glycogen Metabolism.

Adv Neurobiol 2019 ;23:269-309

Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1007/978-3-030-27480-1_9DOI Listing
December 2019

Astrocytes in chronic pain and itch.

Nat Rev Neurosci 2019 11 19;20(11):667-685. Epub 2019 Sep 19.

Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, NY, USA.

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http://dx.doi.org/10.1038/s41583-019-0218-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6874831PMC
November 2019

In Vivo Imaging of Cerebrospinal Fluid Transport through the Intact Mouse Skull using Fluorescence Macroscopy.

J Vis Exp 2019 07 29(149). Epub 2019 Jul 29.

Center for Translational Neuromedicine, University of Rochester Medical Center; Center for Translational Neuromedicine, University of Copenhagen;

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http://dx.doi.org/10.3791/59774DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7001880PMC
July 2019

Cortex-wide Changes in Extracellular Potassium Ions Parallel Brain State Transitions in Awake Behaving Mice.

Cell Rep 2019 07;28(5):1182-1194.e4

Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, NY 14642, USA; Center for Translational Neuromedicine, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen N, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.06.082DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6790006PMC
July 2019

Longitudinal shear waves for elastic characterization of tissues in optical coherence elastography.

Biomed Opt Express 2019 Jul 1;10(7):3699-3718. Epub 2019 Jul 1.

Dept. of Electrical & Computer Engineering, University of Rochester, Rochester, NY 14627, USA.

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http://dx.doi.org/10.1364/BOE.10.003699DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6640829PMC
July 2019

Astrocytic connexin 43 potentiates myelin injury in ischemic white matter disease.

Theranostics 2019 9;9(15):4474-4493. Epub 2019 Jun 9.

Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.

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http://dx.doi.org/10.7150/thno.31942DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6599652PMC
August 2020

Cellular Control of Brain Capillary Blood Flow: In Vivo Imaging Veritas.

Trends Neurosci 2019 08 26;42(8):528-536. Epub 2019 Jun 26.

Center for Translational Neuromedicine, University of Rochester Medical Center, Elmwood Avenue 601, Rochester, NY 14642, USA; Center for Translational Neuromedicine, Faculty of Medical and Health Sciences, University of Copenhagen, Denmark, Blegdamsvej 3B, 2200 Copenhagen N, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.tins.2019.05.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7386067PMC
August 2019

Astrocytic Endocannabinoids Mediate Hippocampal Transient Heterosynaptic Depression.

Neurochem Res 2020 Jan 28;45(1):100-108. Epub 2019 Jun 28.

Division of Glia Disease and Therapeutics, Dept. of Neurosurgery, Center for Translational Neuromedicine, School of Medicine and Dentistry, University of Rochester, Rochester, NY, 14642, USA.

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http://dx.doi.org/10.1007/s11064-019-02834-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6934934PMC
January 2020

Dysregulated Glial Differentiation in Schizophrenia May Be Relieved by Suppression of SMAD4- and REST-Dependent Signaling.

Cell Rep 2019 06;27(13):3832-3843.e6

Center for Translational Neuromedicine and Department of Neurology, University of Rochester Medical Center, Rochester, NY 14642, USA; Center for Neuroscience, University of Copenhagen Faculty of Health and Medical Sciences, 2200 Copenhagen N, Denmark; Neuroscience Center, Rigshospitalet, Copenhagen, Denmark. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22111247193072
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http://dx.doi.org/10.1016/j.celrep.2019.05.088DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6700735PMC
June 2019

Hydraulic resistance of periarterial spaces in the brain.

Fluids Barriers CNS 2019 Jun 20;16(1):19. Epub 2019 Jun 20.

Department of Mechanical Engineering, University of Rochester, Rochester, NY, 14627, USA.

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http://dx.doi.org/10.1186/s12987-019-0140-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6585017PMC
June 2019

Impaired Glymphatic Transport in Spontaneously Hypertensive Rats.

J Neurosci 2019 08 17;39(32):6365-6377. Epub 2019 Jun 17.

Center for Translational Neuromedicine, University of Copenhagen, Copenhagen N, Denmark, 2200,

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http://dx.doi.org/10.1523/JNEUROSCI.1974-18.2019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6687896PMC
August 2019

Adrenergic receptor antagonism induces neuroprotection and facilitates recovery from acute ischemic stroke.

Proc Natl Acad Sci U S A 2019 05 16;116(22):11010-11019. Epub 2019 May 16.

Laboratory for Neuron-Glia Circuitry, RIKEN Center for Brain Science, 351-0198 Wako, Saitama, Japan;

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http://dx.doi.org/10.1073/pnas.1817347116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6561179PMC
May 2019

Dexmedetomidine enhances glymphatic brain delivery of intrathecally administered drugs.

J Control Release 2019 06 5;304:29-38. Epub 2019 May 5.

Center for Translational Neuromedicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, NY, USA.

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http://dx.doi.org/10.1016/j.jconrel.2019.05.005DOI Listing
June 2019

PDGF-B Is Required for Development of the Glymphatic System.

Cell Rep 2019 03;26(11):2955-2969.e3

Center for Translational Neuromedicine, University of Rochester, Rochester, NY 14642, USA; Department of Experimental Medical Science, Lund University, 221 84 Lund, Sweden; Wallenberg Center for Molecular Medicine, Lund University, 221 84 Lund, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.02.050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447074PMC
March 2019

Increased glymphatic influx is correlated with high EEG delta power and low heart rate in mice under anesthesia.

Sci Adv 2019 02 27;5(2):eaav5447. Epub 2019 Feb 27.

Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, NY 14642, USA.

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http://dx.doi.org/10.1126/sciadv.aav5447DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6392807PMC
February 2019

Vascular dysfunction-The disregarded partner of Alzheimer's disease.

Alzheimers Dement 2019 01;15(1):158-167

Department of Physiology and Neuroscience, Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA; Alzheimer's Disease Research Center, Keck School of Medicine at the University of Southern California, Los Angeles, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jalz.2018.07.222DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338083PMC
January 2019

Cisterna Magna Injection in Rats to Study Glymphatic Function.

Methods Mol Biol 2019 ;1938:97-104

Department of Experimental Medical Science and Wallenberg Center for Molecular Medicine, Lund University, Lund, Sweden.

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http://link.springer.com/10.1007/978-1-4939-9068-9_7
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http://dx.doi.org/10.1007/978-1-4939-9068-9_7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6800144PMC
July 2019

Flow of cerebrospinal fluid is driven by arterial pulsations and is reduced in hypertension.

Nat Commun 2018 11 19;9(1):4878. Epub 2018 Nov 19.

Department of Mechanical Engineering, University of Rochester, Rochester, NY, 14627, USA.

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http://dx.doi.org/10.1038/s41467-018-07318-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6242982PMC
November 2018

The glymphatic pathway in neurological disorders.

Lancet Neurol 2018 11;17(11):1016-1024

Centre for Translational Neuromedicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, NY, USA; Department of Neuroscience, University of Rochester Medical Center, Rochester, NY, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S14744422183031
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http://dx.doi.org/10.1016/S1474-4422(18)30318-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261373PMC
November 2018

Cerebral Metabolic Changes During Sleep.

Curr Neurol Neurosci Rep 2018 07 16;18(9):57. Epub 2018 Jul 16.

Center for Translational Neuromedicine, Division of Glial Disease and Therapeutics, Faculty of Health and Medical Sciences, University of Copenhagen, Nørre Allé 14, 2200, Copenhagen N, Denmark.

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http://dx.doi.org/10.1007/s11910-018-0868-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6688614PMC
July 2018

Cannula Implantation into the Cisterna Magna of Rodents.

J Vis Exp 2018 05 23(135). Epub 2018 May 23.

Center for Translational Neuromedicine, Division of Glial Therapeutics, University of Copenhagen; Center for Translational Neuromedicine, Division of Glial Therapeutics, University of Rochester Medical Center.

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http://dx.doi.org/10.3791/57378DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6101354PMC
May 2018

Interstitial ion homeostasis and acid-base balance are maintained in oedematous brain of mice with acute toxic liver failure.

Neurochem Int 2018 09 14;118:286-291. Epub 2018 May 14.

Department of Neurotoxicology, Mossakowski Medical Research Centre, Polish Academy of Sciences, 5 Pawińskiego St, 02-106 Warsaw, Poland. Electronic address:

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http://dx.doi.org/10.1016/j.neuint.2018.05.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6688610PMC
September 2018

Beneficial effects of low alcohol exposure, but adverse effects of high alcohol intake on glymphatic function.

Sci Rep 2018 02 2;8(1):2246. Epub 2018 Feb 2.

Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester, Rochester, NY, 14642, USA.

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http://dx.doi.org/10.1038/s41598-018-20424-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5797082PMC
February 2018

Fluorescent Ca indicators directly inhibit the Na,K-ATPase and disrupt cellular functions.

Sci Signal 2018 01 30;11(515). Epub 2018 Jan 30.

Center for Translational Neuromedicine, Departments of Neurosurgery and Neurology, University of Rochester Medical Center, Rochester, NY 14642, USA.

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http://dx.doi.org/10.1126/scisignal.aal2039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6190706PMC
January 2018

Physiology of Astroglia.

Physiol Rev 2018 01;98(1):239-389

The University of Manchester , Manchester , United Kingdom ; Achúcarro Basque Center for Neuroscience, IKERBASQUE, Basque Foundation for Science , Bilbao , Spain ; Department of Neuroscience, University of the Basque Country UPV/EHU and CIBERNED, Leioa, Spain ; Center for Basic and Translational Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen , Copenhagen , Denmark ; and Center for Translational Neuromedicine, University of Rochester Medical Center , Rochester, New York.

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http://dx.doi.org/10.1152/physrev.00042.2016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6050349PMC
January 2018

The Glymphatic System in Central Nervous System Health and Disease: Past, Present, and Future.

Annu Rev Pathol 2018 01;13:379-394

Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, New York 14642, USA; email: ,

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http://www.annualreviews.org/doi/10.1146/annurev-pathol-0512
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http://dx.doi.org/10.1146/annurev-pathol-051217-111018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5803388PMC
January 2018

Voluntary running enhances glymphatic influx in awake behaving, young mice.

Neurosci Lett 2018 Jan 25;662:253-258. Epub 2017 Oct 25.

Center for Translational Neuromedicine, University of Copenhagen, 2200 Copenhagen, Denmark; Center for Translational Neuromedicine, Division of Glial Disease and Therapeutics, University of Rochester Medical Center, Rochester, New York 14642, USA.

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http://dx.doi.org/10.1016/j.neulet.2017.10.035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5696653PMC
January 2018

Brain energetics during the sleep-wake cycle.

Curr Opin Neurobiol 2017 12 9;47:65-72. Epub 2017 Oct 9.

Center for Basic and Translational Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Center for Translational Neuromedicine, University of Rochester Medical School, Rochester, NY 14640, USA.

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http://dx.doi.org/10.1016/j.conb.2017.09.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5732842PMC
December 2017

Anesthesia with Dexmedetomidine and Low-dose Isoflurane Increases Solute Transport via the Glymphatic Pathway in Rat Brain When Compared with High-dose Isoflurane.

Anesthesiology 2017 12;127(6):976-988

From the Department of Anesthesiology, Yale School of Medicine, New Haven, Connecticut (H.B., H.L.); Center for Translational Neuromedicine, University of Rochester, Rochester, New York (F.D., Q.S., M.N.); Department of Anesthesiology, Stony Brook Medicine, Stony Brook, New York (E.A.-B., R.M., S.P.); National Institute on Drug Abuse, Intramural Research Program, Baltimore, Maryland (E.A.S., H.L.).

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http://dx.doi.org/10.1097/ALN.0000000000001888DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5685871PMC
December 2017

Understanding the functions and relationships of the glymphatic system and meningeal lymphatics.

J Clin Invest 2017 Sep 1;127(9):3210-3219. Epub 2017 Sep 1.

Center for Brain Immunology and Glia, Department of Neuroscience, School of Medicine, University of Virginia, Charlottesville, Virginia, USA.

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http://dx.doi.org/10.1172/JCI90603DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5669566PMC
September 2017

Do Evolutionary Changes in Astrocytes Contribute to the Computational Power of the Hominid Brain?

Neurochem Res 2017 Sep 19;42(9):2577-2587. Epub 2017 Aug 19.

Center for Translational Neuromedicine, University of Rochester Medical School, Rochester, NY, USA.

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http://dx.doi.org/10.1007/s11064-017-2363-0DOI Listing
September 2017

Perivascular spaces, glymphatic dysfunction, and small vessel disease.

Clin Sci (Lond) 2017 Sep 10;131(17):2257-2274. Epub 2017 Aug 10.

Department of Neurosurgery, Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, NY 14642, U.S.A.

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http://dx.doi.org/10.1042/CS20160381DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5567781PMC
September 2017

Human iPSC Glial Mouse Chimeras Reveal Glial Contributions to Schizophrenia.

Cell Stem Cell 2017 08 20;21(2):195-208.e6. Epub 2017 Jul 20.

Department of Neurology and Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, NY 14642, USA; Center for Neuroscience, University of Copenhagen Faculty of Health and Medical Sciences, 2200 Copenhagen N, Denmark; Neuroscience Center, Rigshospitalet, 2100 Copenhagen, Denmark. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S19345909173023
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http://dx.doi.org/10.1016/j.stem.2017.06.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5576346PMC
August 2017

Quantitative Gd-DOTA uptake from cerebrospinal fluid into rat brain using 3D VFA-SPGR at 9.4T.

Magn Reson Med 2018 03 19;79(3):1568-1578. Epub 2017 Jun 19.

Department of Anesthesiology, Yale School of Medicine, New Haven, Connecticut, USA.

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http://dx.doi.org/10.1002/mrm.26779DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5736474PMC
March 2018

Cerebrospinal and interstitial fluid transport via the glymphatic pathway modeled by optimal mass transport.

Neuroimage 2017 05 18;152:530-537. Epub 2017 Mar 18.

Department of Applied Mathematics and Statistics, Stony Brook University, Stony Brook, NY 11790, USA; Department of Computer Science, Stony Brook University, Stony Brook, NY 11790, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuroimage.2017.03.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5490081PMC
May 2017

Does Global Astrocytic Calcium Signaling Participate in Awake Brain State Transitions and Neuronal Circuit Function?

Neurochem Res 2017 Jun 16;42(6):1810-1822. Epub 2017 Feb 16.

Center for Basic and Translational Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, Building 24.2, Blegdamsvej 3B, 2200, Copenhagen N, Denmark.

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http://dx.doi.org/10.1007/s11064-017-2195-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5451293PMC
June 2017

Focal Solute Trapping and Global Glymphatic Pathway Impairment in a Murine Model of Multiple Microinfarcts.

J Neurosci 2017 03 10;37(11):2870-2877. Epub 2017 Feb 10.

Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, New York 14642,

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http://dx.doi.org/10.1523/JNEUROSCI.2112-16.2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354332PMC
March 2017

Erratum to: Glymphatic distribution of CSF-derived apoE into brain is isoform specific and suppressed during sleep deprivation.

Mol Neurodegener 2017 01 12;12(1). Epub 2017 Jan 12.

Center for Translational Neuromedicine, Division of Glial Disease and Therapeutics, Department of Neurosurgery, University of Rochester Medical Center, University of Rochester, Rochester, NY, 14642, USA.

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http://dx.doi.org/10.1186/s13024-016-0147-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5234150PMC
January 2017

Direct comparison of microglial dynamics and inflammatory profile in photothrombotic and arterial occlusion evoked stroke.

Neuroscience 2017 02 18;343:483-494. Epub 2016 Dec 18.

Division of Glia Disease and Therapeutics, Center for Translational Neuromedicine, University of Rochester Medical School, Rochester, NY 14640, USA.

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http://dx.doi.org/10.1016/j.neuroscience.2016.12.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5523105PMC
February 2017

Glymphatic distribution of CSF-derived apoE into brain is isoform specific and suppressed during sleep deprivation.

Mol Neurodegener 2016 12 8;11(1):74. Epub 2016 Dec 8.

Center for Translational Neuromedicine, Division of Glial Disease and Therapeutics, Department of Neurosurgery, University of Rochester Medical Center, University of Rochester, Rochester, NY, 14642, USA.

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http://dx.doi.org/10.1186/s13024-016-0138-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5146863PMC
December 2016

A Novel Model of Transient Occlusion of the Middle Cerebral Artery in Awake Mice.

J Nat Sci 2016 ;2(2)

Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, NY 14642, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5074053PMC
January 2016

NKCC1 up-regulation contributes to early post-traumatic seizures and increased post-traumatic seizure susceptibility.

Brain Struct Funct 2017 04 1;222(3):1543-1556. Epub 2016 Sep 1.

Department of Surgery, Texas A&M University Health Science Center, College of Medicine, Temple, TX, 76504, USA.

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http://dx.doi.org/10.1007/s00429-016-1292-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5368191PMC
April 2017

Erythrocytes Are Oxygen-Sensing Regulators of the Cerebral Microcirculation.

Neuron 2016 Aug 4;91(4):851-862. Epub 2016 Aug 4.

Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, NY 14642, USA; Center for Basic and Translational Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2016.07.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5405863PMC
August 2016

Glymphatic clearance controls state-dependent changes in brain lactate concentration.

J Cereb Blood Flow Metab 2017 Jun 1;37(6):2112-2124. Epub 2016 Jan 1.

1 Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester, Rochester, NY, USA.

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http://dx.doi.org/10.1177/0271678X16661202DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5464705PMC
June 2017

Sulforhodamine 101, a widely used astrocyte marker, can induce cortical seizure-like activity at concentrations commonly used.

Sci Rep 2016 07 26;6:30433. Epub 2016 Jul 26.

Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, New York 14642, USA.

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http://dx.doi.org/10.1038/srep30433DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4960645PMC
July 2016

The homeostatic astroglia emerges from evolutionary specialization of neural cells.

Philos Trans R Soc Lond B Biol Sci 2016 08;371(1700)

Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, NY 14642, USA Center for Basic and Translational Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen 2200, Denmark

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http://rstb.royalsocietypublishing.org/content/royptb/371/17
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http://dx.doi.org/10.1098/rstb.2015.0428DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4938028PMC
August 2016

Impairment of the glymphatic system after diabetes.

J Cereb Blood Flow Metab 2017 Apr 1;37(4):1326-1337. Epub 2016 Jan 1.

1 Departments of Neurology, Henry Ford Health System, Detroit, MI, USA.

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http://dx.doi.org/10.1177/0271678X16654702DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5453454PMC
April 2017

Suppression of glymphatic fluid transport in a mouse model of Alzheimer's disease.

Neurobiol Dis 2016 09 24;93:215-25. Epub 2016 May 24.

Center for Translational Neuromedicine, Division of Glial Disease and Therapeutics, Department of Neurosurgery, University of Rochester Medical Center, Rochester, NY 14642, USA. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2016.05.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4980916PMC
September 2016

Changes in the composition of brain interstitial ions control the sleep-wake cycle.

Science 2016 Apr;352(6285):550-5

Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, NY 14642, USA. Center for Basic and Translational Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen 2200, Denmark.

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http://dx.doi.org/10.1126/science.aad4821DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5441687PMC
April 2016

Optimal-mass-transfer-based estimation of glymphatic transport in living brain.

Proc SPIE Int Soc Opt Eng 2015 Feb 20;9413. Epub 2015 Mar 20.

Dept. of Computer Sciences and Applied Mathematics/Statistics, Stony Brook University, Stony Brook, New York 11790.

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http://dx.doi.org/10.1117/12.2076289DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4752194PMC
February 2015

Purinergic receptor P2RY12-dependent microglial closure of the injured blood-brain barrier.

Proc Natl Acad Sci U S A 2016 Jan 11;113(4):1074-9. Epub 2016 Jan 11.

Center for Translational Neuromedicine, University of Rochester Medical School, Rochester, NY 14642; Center for Translational Neuromedicine, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark

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http://dx.doi.org/10.1073/pnas.1520398113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4743790PMC
January 2016

Cerebral microcirculatory failure after subarachnoid hemorrhage is reversed by hyaluronidase.

J Cereb Blood Flow Metab 2016 09 14;36(9):1537-52. Epub 2015 Oct 14.

Center for Translational Neuromedicine, Division of Glial Disease and Therapeutics, University of Rochester Medical Center, Rochester, NY, USA Department of Neurological Surgery, University of Rochester Medical Center, Rochester, NY, USA.

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http://dx.doi.org/10.1177/0271678X15608389DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5012515PMC
September 2016

Distinct functional states of astrocytes during sleep and wakefulness: Is norepinephrine the master regulator?

Curr Sleep Med Rep 2015 Mar 29;1(1):1-8. Epub 2015 Jan 29.

Center for Translational Neuromedicine, University of Rochester Medical School, Rochester, NY 14642, USA.

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http://dx.doi.org/10.1007/s40675-014-0004-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4659506PMC
March 2015

Implications of the discovery of brain lymphatic pathways.

Lancet Neurol 2015 Oct;14(10):977-9

Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, NY, USA; Center for Basic and Translational Neuroscience, University of Copenhagen, Copenhagen, Denmark. Electronic address:

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http://dx.doi.org/10.1016/S1474-4422(15)00221-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4655610PMC
October 2015

A Distinct Population of Microglia Supports Adult Neurogenesis in the Subventricular Zone.

J Neurosci 2015 Aug;35(34):11848-61

Center for Translational Neuromedicine, University of Rochester Medical School, Rochester, New York 14642, and Center for Basic and Translational Neuroscience, University of Copenhagen, 2200N Copenhagen, Denmark

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http://dx.doi.org/10.1523/JNEUROSCI.1217-15.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4549398PMC
August 2015

Brain maturation in neonatal rodents is impeded by sevoflurane anesthesia.

Anesthesiology 2015 Sep;123(3):557-68

From the Department of Anesthesiology, Stony Brook Medicine, Stony Brook, New York (R.M., H.L., Z.J., H.B.); Department of Applied Mathematics and Statistics (T.F.), Stony Brook University, Stony Brook, New York; Cold Spring Harbor Laboratory, Cold Spring Harbor, New York (J.-H.P., G.E.); and Department of Neurosurgery, Rochester University, Rochester, New York (M.N.).

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http://dx.doi.org/10.1097/ALN.0000000000000762DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4543401PMC
September 2015

Modeling cognition and disease using human glial chimeric mice.

Glia 2015 Aug 24;63(8):1483-93. Epub 2015 May 24.

Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, New York.

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http://dx.doi.org/10.1002/glia.22862DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4527525PMC
August 2015

Filtering the muddied waters of brain edema.

Trends Neurosci 2015 Jun 22;38(6):333-5. Epub 2015 May 22.

Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, NY 14642, USA.

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http://dx.doi.org/10.1016/j.tins.2015.04.009DOI Listing
June 2015