Mahdad Noursadeghi

Mahdad Noursadeghi

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Mahdad Noursadeghi

Mahdad Noursadeghi

Publications by authors named "Mahdad Noursadeghi"

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70Publications

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Quantitative Interferon Gamma Release Assay and Tuberculin Skin Test Results to Predict Incident Tuberculosis: A Prospective Cohort Study.

Authors:
Rishi K Gupta Marc Lipman Charlotte Jackson Alice Sitch Jo Southern Francis Drobniewski Jonathan J Deeks Chuen-Yan Tsou Chris Griffiths Jennifer Davidson Colin Campbell Oliver Stirrup Mahdad Noursadeghi Heinke Kunst Pranab Haldar Ajit Lalvani Ibrahim Abubakar

Am J Respir Crit Care Med 2019 Dec 11. Epub 2019 Dec 11.

University College London, 4919, Institute for Global Health, London, United Kingdom of Great Britain and Northern Ireland.

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http://dx.doi.org/10.1164/rccm.201905-0969OCDOI Listing
December 2019

Spatial heterogeneity of the T cell receptor repertoire reflects the mutational landscape in lung cancer.

Authors:
Kroopa Joshi Marc Robert de Massy Mazlina Ismail James L Reading Imran Uddin Annemarie Woolston Emine Hatipoglu Theres Oakes Rachel Rosenthal Thomas Peacock Tahel Ronel Mahdad Noursadeghi Virginia Turati Andrew J S Furness Andrew Georgiou Yien Ning Sophia Wong Assma Ben Aissa Mariana Werner Sunderland Mariam Jamal-Hanjani Selvaraju Veeriah Nicolai J Birkbak Gareth A Wilson Crispin T Hiley Ehsan Ghorani José Afonso Guerra-Assunção Javier Herrero Tariq Enver Sine R Hadrup Allan Hackshaw Karl S Peggs Nicholas McGranahan Charles Swanton Sergio A Quezada Benny Chain

Nat Med 2019 10 7;25(10):1549-1559. Epub 2019 Oct 7.

Division of Infection and Immunity, University College London, London, UK.

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http://dx.doi.org/10.1038/s41591-019-0592-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6890490PMC
October 2019

Assessing the Impact of Sample Heterogeneity on Transcriptome Analysis of Human Diseases Using MDP Webtool.

Authors:
André N A Gonçalves Melissa Lever Pedro S T Russo Bruno Gomes-Correia Alysson H Urbanski Gabriele Pollara Mahdad Noursadeghi Vinicius Maracaja-Coutinho Helder I Nakaya

Front Genet 2019 24;10:971. Epub 2019 Oct 24.

Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil.

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http://dx.doi.org/10.3389/fgene.2019.00971DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6822058PMC
October 2019

Relative Contributions of Extracellular and Internalized Bacteria to Early Macrophage Proinflammatory Responses to Streptococcus pneumoniae.

Authors:
Jimstan Periselneris Giuseppe Ercoli Tracey Pollard Suneeta Chimalapati Emilie Camberlein Gabriella Szylar Catherine Hyams Gillian Tomlinson Fernanda C Petersen R Andres Floto Mahdad Noursadeghi Jeremy S Brown

mBio 2019 09 24;10(5). Epub 2019 Sep 24.

Centre for Inflammation and Tissue Repair, UCL Respiratory, Division of Medicine, University College Medical School, Rayne Institute, London, United Kingdom

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http://dx.doi.org/10.1128/mBio.02144-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6759765PMC
September 2019

Spatial Network Mapping of Pulmonary Multidrug-Resistant Tuberculosis Cavities Using RNA Sequencing.

Authors:
Keertan Dheda Laura Lenders Shashikant Srivastava Gesham Magombedze Helen Wainwright Prithvi Raj Stephen J Bush Gabriele Pollara Rachelle Steyn Malika Davids Anil Pooran Timothy Pennel Anthony Linegar Ruth McNerney Loven Moodley Jotam G Pasipanodya Carolin T Turner Mahdad Noursadeghi Robin M Warren Edward Wakeland Tawanda Gumbo

Am J Respir Crit Care Med 2019 Aug;200(3):370-380

1Centre for Lung Infection and Immunity, Division of Pulmonology, Department of Medicine and UCT Lung Institute and South African MRC/UCT Centre for the Study of Antimicrobial Resistance, University of Cape Town, Cape Town, South Africa.

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https://www.atsjournals.org/doi/10.1164/rccm.201807-1361OC
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http://dx.doi.org/10.1164/rccm.201807-1361OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6680310PMC
August 2019

Microinvasion by Streptococcus pneumoniae induces epithelial innate immunity during colonisation at the human mucosal surface.

Authors:
Caroline M Weight Cristina Venturini Sherin Pojar Simon P Jochems Jesús Reiné Elissavet Nikolaou Carla Solórzano Mahdad Noursadeghi Jeremy S Brown Daniela M Ferreira Robert S Heyderman

Nat Commun 2019 07 16;10(1):3060. Epub 2019 Jul 16.

Division of Infection and Immunity, University College London, London, UK.

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http://dx.doi.org/10.1038/s41467-019-11005-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6635362PMC
July 2019

Blood transcriptomic stratification of short-term risk in contacts of tuberculosis.

Authors:
Jennifer Roe Cristina Venturini Rishi K Gupta Celine Gurry Benjamin M Chain Yuxin Sun Jo Southern Charlotte Jackson Marc C Lipman Robert F Miller Adrian R Martineau Ibrahim Abubakar Mahdad Noursadeghi

Clin Infect Dis 2019 Mar 28. Epub 2019 Mar 28.

Division of Infection & Immunity, University College London, United Kingdom.

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https://academic.oup.com/cid/advance-article/doi/10.1093/cid
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http://dx.doi.org/10.1093/cid/ciz252DOI Listing
March 2019

Cyclosporine H Overcomes Innate Immune Restrictions to Improve Lentiviral Transduction and Gene Editing In Human Hematopoietic Stem Cells.

Authors:
Carolina Petrillo Lucy G Thorne Giulia Unali Giulia Schiroli Anna M S Giordano Francesco Piras Ivan Cuccovillo Sarah J Petit Fatima Ahsan Mahdad Noursadeghi Simon Clare Pietro Genovese Bernhard Gentner Luigi Naldini Greg J Towers Anna Kajaste-Rudnitski

Cell Stem Cell 2018 12 8;23(6):820-832.e9. Epub 2018 Nov 8.

San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, MI 20132, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2018.10.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292841PMC
December 2018

Enhancement of cutaneous immunity during aging by blocking p38 mitogen-activated protein (MAP) kinase-induced inflammation.

Authors:
Milica Vukmanovic-Stejic Emma S Chambers Mayte Suárez-Fariñas Daisy Sandhu Judilyn Fuentes-Duculan Neil Patel Elaine Agius Katie E Lacy Carolin T Turner Anis Larbi Veronique Birault Mahdad Noursadeghi Neil A Mabbott Malcolm H A Rustin James G Krueger Arne N Akbar

J Allergy Clin Immunol 2018 09 17;142(3):844-856. Epub 2017 Nov 17.

Division of Infection and Immunity, University College London, London, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2017.10.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6127037PMC
September 2018

Cohort study protocol: Bioresource in Adult Infectious Diseases (BioAID).

Authors:
Laura J Shallcross Alexander Mentzer Saadia Rahman Graham S Cooke Shiranee Sriskandan Mahdad Noursadeghi

Wellcome Open Res 2018 8;3:97. Epub 2018 Aug 8.

Division of Infection and Immunity, UCL, London, UK.

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https://wellcomeopenresearch.org/articles/3-97/v1
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http://dx.doi.org/10.12688/wellcomeopenres.14690.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6171553PMC
August 2018

HIV gp120 in the Lungs of Antiretroviral Therapy-treated Individuals Impairs Alveolar Macrophage Responses to Pneumococci.

Authors:
Paul J Collini Martin A Bewley Mohamed Mohasin Helen M Marriott Robert F Miller Anna-Maria Geretti Apostolos Beloukas Athanasios Papadimitropoulos Robert C Read Mahdad Noursadeghi David H Dockrell

Am J Respir Crit Care Med 2018 06;197(12):1604-1615

1 The Florey Institute for Host-Pathogen Interactions and Department of Infection, Immunity & Cardiovascular Disease, University of Sheffield Medical School, Sheffield, United Kingdom.

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http://dx.doi.org/10.1164/rccm.201708-1755OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6006400PMC
June 2018

Tissue Metabolic Changes Drive Cytokine Responses to Mycobacterium tuberculosis.

Authors:
Ekta Lachmandas Ana B Rios-Miguel Valerie A C M Koeken Eva van der Pasch Vinod Kumar Vasiliki Matzaraki Yang Li Marije Oosting Leo A B Joosten Richard A Notebaart Mahdad Noursadeghi Mihai G Netea Reinout van Crevel Gabriele Pollara

J Infect Dis 2018 06;218(1):165-170

Division of Infection and Immunity, University College London, United Kingdom.

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http://dx.doi.org/10.1093/infdis/jiy173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5989606PMC
June 2018

Pathogenesis of HIV-1 and Mycobacterium tuberculosis co-infection.

Authors:
Lucy C K Bell Mahdad Noursadeghi

Nat Rev Microbiol 2018 02 7;16(2):80-90. Epub 2017 Nov 7.

Division of Infection & Immunity, Cruciform Building, University College London, WC1E 6BT, London, UK.

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http://www.nature.com/doifinder/10.1038/nrmicro.2017.128
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http://dx.doi.org/10.1038/nrmicro.2017.128DOI Listing
February 2018

Quantitative Characterization of the T Cell Receptor Repertoire of Naïve and Memory Subsets Using an Integrated Experimental and Computational Pipeline Which Is Robust, Economical, and Versatile.

Authors:
Theres Oakes James M Heather Katharine Best Rachel Byng-Maddick Connor Husovsky Mazlina Ismail Kroopa Joshi Gavin Maxwell Mahdad Noursadeghi Natalie Riddell Tabea Ruehl Carolin T Turner Imran Uddin Benny Chain

Front Immunol 2017 12;8:1267. Epub 2017 Oct 12.

Division of Infection and Immunity, University College London, London, United Kingdom.

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http://dx.doi.org/10.3389/fimmu.2017.01267DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5643411PMC
October 2017

Validation of Immune Cell Modules in Multicellular Transcriptomic Data.

Authors:
Gabriele Pollara Matthew J Murray James M Heather Rachel Byng-Maddick Naomi Guppy Matthew Ellis Carolin T Turner Benjamin M Chain Mahdad Noursadeghi

PLoS One 2017 3;12(1):e0169271. Epub 2017 Jan 3.

Division of Infection & Immunity, University College London, London, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0169271PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5207692PMC
August 2017

Tumor Necrosis Factor (TNF) Bioactivity at the Site of an Acute Cell-Mediated Immune Response Is Preserved in Rheumatoid Arthritis Patients Responding to Anti-TNF Therapy.

Authors:
Rachel Byng-Maddick Carolin T Turner Gabriele Pollara Matthew Ellis Naomi J Guppy Lucy C K Bell Michael R Ehrenstein Mahdad Noursadeghi

Front Immunol 2017 4;8:932. Epub 2017 Aug 4.

Division of Infection and Immunity, University College London, London, United Kingdom.

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http://dx.doi.org/10.3389/fimmu.2017.00932DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5543043PMC
August 2017

A G1-like state allows HIV-1 to bypass SAMHD1 restriction in macrophages.

Authors:
Petra Mlcochova Katherine A Sutherland Sarah A Watters Cosetta Bertoli Rob Am de Bruin Jan Rehwinkel Stuart J Neil Gina M Lenzi Baek Kim Asim Khwaja Matthew C Gage Christiana Georgiou Alexandra Chittka Simon Yona Mahdad Noursadeghi Greg J Towers Ravindra K Gupta

EMBO J 2017 03 25;36(5):604-616. Epub 2017 Jan 25.

Division of Infection and Immunity, University College London, London, UK

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http://dx.doi.org/10.15252/embj.201696025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5331754PMC
March 2017

Cell-type-specific modulation of innate immune signalling by vitamin D in human mononuclear phagocytes.

Authors:
Rhiannon Kundu Aikaterini Theodoraki Carolin T Haas Yanjing Zhang Benjamin Chain Janos Kriston-Vizi Mahdad Noursadeghi Bernard Khoo

Immunology 2017 Jan 3;150(1):55-63. Epub 2016 Oct 3.

Endocrinology, Division of Medicine, University College London, London, UK.

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http://dx.doi.org/10.1111/imm.12669DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5167305PMC
January 2017

Blood transcriptomic diagnosis of pulmonary and extrapulmonary tuberculosis.

Authors:
Jennifer K Roe Niclas Thomas Eliza Gil Katharine Best Evdokia Tsaliki Stephen Morris-Jones Sian Stafford Nandi Simpson Karolina D Witt Benjamin Chain Robert F Miller Adrian Martineau Mahdad Noursadeghi

JCI Insight 2016 Oct 6;1(16):e87238. Epub 2016 Oct 6.

Division of Infection and Immunity, University College London, London, United Kingdom.

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http://dx.doi.org/10.1172/jci.insight.87238DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5053151PMC
October 2016

Cell-type deconvolution with immune pathways identifies gene networks of host defense and immunopathology in leprosy.

Authors:
Megan S Inkeles Rosane Mb Teles Delila Pouldar Priscila R Andrade Cressida A Madigan David Lopez Mike Ambrose Mahdad Noursadeghi Euzenir N Sarno Thomas H Rea Maria T Ochoa M Luisa Iruela-Arispe William R Swindell Tom Hm Ottenhoff Annemieke Geluk Barry R Bloom Matteo Pellegrini Robert L Modlin

JCI Insight 2016 09 22;1(15):e88843. Epub 2016 Sep 22.

Division of Dermatology, David Geffen School of Medicine at UCLA, California, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5033757PMC
http://dx.doi.org/10.1172/jci.insight.88843DOI Listing
September 2016

A Linear Epitope in the N-Terminal Domain of CCR5 and Its Interaction with Antibody.

Authors:
Benny Chain Jack Arnold Samia Akthar Michael Brandt David Davis Mahdad Noursadeghi Thabo Lapp Changhua Ji Surya Sankuratri Yanjing Zhang Lata Govada Emmanuel Saridakis Naomi Chayen

PLoS One 2015 1;10(6):e0128381. Epub 2015 Jun 1.

Computational and Systems Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0128381PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4451072PMC
April 2016

Does tuberculosis threaten our ageing populations?

Authors:
Rachel Byng-Maddick Mahdad Noursadeghi

BMC Infect Dis 2016 Mar 11;16:119. Epub 2016 Mar 11.

Division of Infection and Immunity, University College London, Cruciform Building, Gower Street, London, WC1E 6BT, UK.

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http://dx.doi.org/10.1186/s12879-016-1451-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4787032PMC
March 2016

In Vivo Molecular Dissection of the Effects of HIV-1 in Active Tuberculosis.

Authors:
Lucy C K Bell Gabriele Pollara Mellissa Pascoe Gillian S Tomlinson Rannakoe J Lehloenya Jennifer Roe Richard Meldau Robert F Miller Alan Ramsay Benjamin M Chain Keertan Dheda Mahdad Noursadeghi

PLoS Pathog 2016 Mar 17;12(3):e1005469. Epub 2016 Mar 17.

Division of Infection and Immunity, University College London, London, United Kingdom.

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http://dx.doi.org/10.1371/journal.ppat.1005469DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4795555PMC
March 2016

Diagnostic 'omics' for active tuberculosis.

Authors:
Carolin T Haas Jennifer K Roe Gabriele Pollara Meera Mehta Mahdad Noursadeghi

BMC Med 2016 Mar 23;14:37. Epub 2016 Mar 23.

Division of Infection and Immunity, University College London, Cruciform Building, Gower Street, London, WC1E 6BT, UK.

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http://dx.doi.org/10.1186/s12916-016-0583-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4804573PMC
March 2016

Transcriptional Profiling of Endobronchial Ultrasound-Guided Lymph Node Samples Aids Diagnosis of Mediastinal Lymphadenopathy.

Authors:
Gillian S Tomlinson Niclas Thomas Benjamin M Chain Katharine Best Nandi Simpson Georgia Hardavella James Brown Angshu Bhowmik Neal Navani Samuel M Janes Robert F Miller Mahdad Noursadeghi

Chest 2016 Feb 12;149(2):535-544. Epub 2016 Jan 12.

Department of Infection and Immunity, University College London, London, England.

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http://journal.publications.chestnet.org/data/Journals/CHEST
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http://linkinghub.elsevier.com/retrieve/pii/S001236921500126
Publisher Site
http://dx.doi.org/10.1378/chest.15-0647DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4740456PMC
February 2016

Dynamic Perturbations of the T-Cell Receptor Repertoire in Chronic HIV Infection and following Antiretroviral Therapy.

Authors:
James M Heather Katharine Best Theres Oakes Eleanor R Gray Jennifer K Roe Niclas Thomas Nir Friedman Mahdad Noursadeghi Benjamin Chain

Front Immunol 2015 11;6:644. Epub 2016 Jan 11.

Division of Infection and Immunity, University College London , London , UK.

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http://dx.doi.org/10.3389/fimmu.2015.00644DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4707277PMC
January 2016

Identification of Therapeutic Targets of Inflammatory Monocyte Recruitment to Modulate the Allogeneic Injury to Donor Cornea.

Authors:
Thabo Lapp Sarah S Zaher Carolin T Haas David L Becker Chris Thrasivoulou Benjamin M Chain Daniel F P Larkin Mahdad Noursadeghi

Invest Ophthalmol Vis Sci 2015 Nov;56(12):7250-9

Division of Infection and Immunity University College London, London, United Kingdom.

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http://dx.doi.org/10.1167/iovs.15-16941DOI Listing
November 2015

Are the public getting the message about antimicrobial resistance?

Authors:
Laura J Shallcross Michelle Berin Jennifer Roe Mahdad Noursadeghi

Arch Public Health 2015 12;73:55. Epub 2015 Nov 12.

UCL Infection and Immunity, Cruciform Building, Gower Street, London, WC1E 6BT UK.

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http://dx.doi.org/10.1186/s13690-015-0108-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4642666PMC
November 2015

elCID: An electronic Clinical Infection Database to support integrated clinical services and research in infectious diseases.

Authors:
Michael Marks Gabriele Pollara David Miller Sonia Bhatt Carl Reynolds Vanya Gant Mahdad Noursadeghi

J Infect 2015 Sep 17;71(3):402-405. Epub 2015 Apr 17.

Department of Microbiology, University College London Hospital, 235 Euston Road, London, UK.

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http://dx.doi.org/10.1016/j.jinf.2015.04.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4868136PMC
September 2015

Towards host-directed therapies for tuberculosis.

Authors:
Alimuddin Zumla Markus Maeurer Jeremiah Chakaya Michael Hoelscher Francine Ntoumi Roxana Rustomjee Cristina Vilaplana Dorothy Yeboah-Manu Voahangy Rasolof Paula Munderi Nalini Singh Eleni Aklillu Nesri Padayatchi Eusebio Macete Nathan Kapata Modest Mulenga Gibson Kibiki Sayoki Mfinanga Thomas Nyirenda Leonard Maboko Alberto Garcia-Basteiro Niaina Rakotosamimanana Matthew Bates Peter Mwaba Klaus Reither Sebastien Gagneux Sarah Edwards Elirehema Mfinanga Salim Abdulla Pere-Joan Cardona James B W Russell Vanya Gant Mahdad Noursadeghi Paul Elkington Maryline Bonnet Clara Menendez Tandakha N Dieye Bassirou Diarra Almoustapha Maiga Abraham Aseffa Shreemanta Parida Christian Wejse Eskild Petersen Pontiano Kaleebu Matt Oliver Gill Craig Tumena Corrah Leopold Tientcheu Martin Antonio Martin Rao Timothy D McHugh Aziz Sheikh Giuseppe Ippolito Gita Ramjee Stefan H E Kaufmann Gavin Churchyard Andrie Steyn Martin Grobusch Ian Sanne Neil Martinson Rajhmun Madansein Robert J Wilkinson Bongani Mayosi Marco Schito Robert S Wallis

Nat Rev Drug Discov 2015 Aug 17;14(8):511-2. Epub 2015 Jul 17.

Aurum Institute, Johannesburg, South Africa.

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http://dx.doi.org/10.1038/nrd4696DOI Listing
August 2015

Cerebrospinal fluid cytokine profiles predict risk of early mortality and immune reconstitution inflammatory syndrome in HIV-associated cryptococcal meningitis.

Authors:
Joseph N Jarvis Graeme Meintjes Tihana Bicanic Viviana Buffa Louise Hogan Stephanie Mo Gillian Tomlinson Pascale Kropf Mahdad Noursadeghi Thomas S Harrison

PLoS Pathog 2015 Apr 8;11(4):e1004754. Epub 2015 Apr 8.

Research Centre for Infection and Immunity, Division of Clinical Sciences, St. George's University of London, London, United Kingdom.

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http://dx.doi.org/10.1371/journal.ppat.1004754DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4390200PMC
April 2015

Importance of bacterial replication and alveolar macrophage-independent clearance mechanisms during early lung infection with Streptococcus pneumoniae.

Authors:
Emilie Camberlein Jonathan M Cohen Ricardo José Catherine J Hyams Robin Callard Suneeta Chimalapati Jose Yuste Lindsey A Edwards Helina Marshall Nico van Rooijen Mahdad Noursadeghi Jeremy S Brown

Infect Immun 2015 Mar 12;83(3):1181-9. Epub 2015 Jan 12.

Centre for Inflammation and Tissue Repair, Department of Medicine, University College Medical School, Rayne Institute, London, United Kingdom

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http://dx.doi.org/10.1128/IAI.02788-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4333471PMC
March 2015

Paradoxical reactions and immune reconstitution inflammatory syndrome in tuberculosis.

Authors:
Lucy C K Bell Ronan Breen Robert F Miller Mahdad Noursadeghi Marc Lipman

Int J Infect Dis 2015 Mar;32:39-45

Centre for Respiratory Medicine, Royal Free London NHS Foundation Trust, University College London, London, UK.

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http://dx.doi.org/10.1016/j.ijid.2014.12.030DOI Listing
March 2015

TLR-mediated inflammatory responses to Streptococcus pneumoniae are highly dependent on surface expression of bacterial lipoproteins.

Authors:
Gillian Tomlinson Suneeta Chimalapati Tracey Pollard Thabo Lapp Jonathan Cohen Emilie Camberlein Sian Stafford Jimstan Periselneris Christine Aldridge Waldemar Vollmer Capucine Picard Jean-Laurent Casanova Mahdad Noursadeghi Jeremy Brown

J Immunol 2014 Oct 29;193(7):3736-45. Epub 2014 Aug 29.

Centre for Inflammation and Tissue Repair, Division of Medicine, University College Medical School, Rayne Institute, London WC1E 6JF, United Kingdom;

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http://dx.doi.org/10.4049/jimmunol.1401413DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4170674PMC
October 2014

Characterizing the genetic basis of innate immune response in TLR4-activated human monocytes.

Authors:
Sarah Kim Jessica Becker Matthias Bechheim Vera Kaiser Mahdad Noursadeghi Nadine Fricker Esther Beier Sven Klaschik Peter Boor Timo Hess Andrea Hofmann Stefan Holdenrieder Jens R Wendland Holger Fröhlich Gunther Hartmann Markus M Nöthen Bertram Müller-Myhsok Benno Pütz Veit Hornung Johannes Schumacher

Nat Commun 2014 Oct 20;5:5236. Epub 2014 Oct 20.

1] Institute of Human Genetics, University of Bonn, Bonn 53127, Germany [2] Department of Genomics, Life &Brain Center, University of Bonn, Bonn 53127, Germany.

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http://dx.doi.org/10.1038/ncomms6236DOI Listing
October 2014

Interactions between HIV-1 and the cell-autonomous innate immune system.

Authors:
Greg J Towers Mahdad Noursadeghi

Cell Host Microbe 2014 Jul;16(1):10-8

Division of Infection and Immunity, University College London, London W1CE 6BT, UK.

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http://dx.doi.org/10.1016/j.chom.2014.06.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4096382PMC
July 2014

Regulation of CYP27B1 and CYP24A1 hydroxylases limits cell-autonomous activation of vitamin D in dendritic cells.

Authors:
Rhiannon Kundu Benjamin M Chain Anna K Coussens Bernard Khoo Mahdad Noursadeghi

Eur J Immunol 2014 Jun 10;44(6):1781-90. Epub 2014 Apr 10.

Division of Infection and Immunity, University College London, London, UK.

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http://dx.doi.org/10.1002/eji.201344157DOI Listing
June 2014

HIV-1 infection of macrophages dysregulates innate immune responses to Mycobacterium tuberculosis by inhibition of interleukin-10.

Authors:
Gillian S Tomlinson Lucy C K Bell Naomi F Walker Jhen Tsang Jeremy S Brown Ronan Breen Marc Lipman David R Katz Robert F Miller Benjamin M Chain Paul T G Elkington Mahdad Noursadeghi

J Infect Dis 2014 Apr 21;209(7):1055-65. Epub 2013 Nov 21.

Infection and Immunity, University College London.

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https://academic.oup.com/jid/article-lookup/doi/10.1093/infd
Publisher Site
http://dx.doi.org/10.1093/infdis/jit621DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3952672PMC
April 2014

Vpx complementation of 'non-macrophage tropic' R5 viruses reveals robust entry of infectious HIV-1 cores into macrophages.

Authors:
Petra Mlcochova Sarah A Watters Greg J Towers Mahdad Noursadeghi Ravindra K Gupta

Retrovirology 2014 Mar 21;11:25. Epub 2014 Mar 21.

Department of Infection, University College London, London, UK.

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http://dx.doi.org/10.1186/1742-4690-11-25DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3997928PMC
March 2014

HIV-1 evades innate immune recognition through specific cofactor recruitment.

Authors:
Jane Rasaiyaah Choon Ping Tan Adam J Fletcher Amanda J Price Caroline Blondeau Laura Hilditch David A Jacques David L Selwood Leo C James Mahdad Noursadeghi Greg J Towers

Nature 2013 Nov 6;503(7476):402-405. Epub 2013 Nov 6.

University College London, Medical Research Council Centre for Medical Molecular Virology, Division of Infection and Immunity, University College London, 90 Gower St, London WC1E 6BT, United Kingdom.

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http://dx.doi.org/10.1038/nature12769DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3928559PMC
November 2013

The clinical and ecological impact of childhood pneumococcal vaccination.

Authors:
Eliza Gil Mahdad Noursadeghi Jeremy S Brown

Br J Hosp Med (Lond) 2013 Apr;74(4):212-6

Respiratory Medicine Department, University College, London, UK.

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http://dx.doi.org/10.12968/hmed.2013.74.4.212DOI Listing
April 2013

The immune system as a biomonitor: explorations in innate and adaptive immunity.

Authors:
Niclas Thomas James Heather Gabriel Pollara Nandi Simpson Theres Matjeka John Shawe-Taylor Mahdad Noursadeghi Benjamin Chain

Interface Focus 2013 Apr;3(2):20120099

Division of Infection and Immunity, University College London, Gower Street, London WC1E 6BT, UK.

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http://dx.doi.org/10.1098/rsfs.2012.0099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3638490PMC
April 2013

Needles and the damage done: reasons for admission and financial costs associated with injecting drug use in a Central London Teaching Hospital.

Authors:
Michael Marks Emily Pollock Margaret Armstrong Stephen Morris-Jones Michael Kidd Philip Gothard Mahdad Noursadeghi Justin F Doherty

J Infect 2013 Jan 12;66(1):95-102. Epub 2012 Oct 12.

Hospital for Tropical Diseases, University College London Hospital, United Kingdom.

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http://dx.doi.org/10.1016/j.jinf.2012.10.004DOI Listing
January 2013

Streptococcus pneumoniae capsular serotype invasiveness correlates with the degree of factor H binding and opsonization with C3b/iC3b.

Authors:
Catherine Hyams Krzysztof Trzcinski Emilie Camberlein Daniel M Weinberger Suneeta Chimalapati Mahdad Noursadeghi Marc Lipsitch Jeremy S Brown

Infect Immun 2013 Jan 12;81(1):354-63. Epub 2012 Nov 12.

Centre for Inflammation and Tissue Repair, Division of Medicine, University College Medical School, Rayne Institute, London, United Kingdom.

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http://iai.asm.org/content/early/2012/11/09/IAI.00862-12.ful
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3536142PMC
January 2013

Adherent human alveolar macrophages exhibit a transient pro-inflammatory profile that confounds responses to innate immune stimulation.

Authors:
Gillian S Tomlinson Helen Booth Sarah J Petit Elspeth Potton Greg J Towers Robert F Miller Benjamin M Chain Mahdad Noursadeghi

PLoS One 2012 29;7(6):e40348. Epub 2012 Jun 29.

Infection and Immunity, University College London, London, United Kingdom.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3386998PMC
November 2012

Innate immune interferon responses to human immunodeficiency virus-1 infection.

Authors:
Rose Hughes Greg Towers Mahdad Noursadeghi

Rev Med Virol 2012 Jul 22;22(4):257-66. Epub 2012 Feb 22.

Division of Infection and Immunity, MRC Centre for Medical Molecular Virology, University College London, London, UK.

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http://dx.doi.org/10.1002/rmv.1708DOI Listing
July 2012

Chemical toxicity to keratinocytes triggers dendritic cell activation via an IL-1α path.

Authors:
Theres Matjeka Vicki Summerfield Mahdad Noursadeghi Benjamin M Chain

J Allergy Clin Immunol 2012 Jan 23;129(1):247-50.e1-3. Epub 2011 Sep 23.

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http://dx.doi.org/10.1016/j.jaci.2011.08.018DOI Listing
January 2012

HIV-1 capsid-cyclophilin interactions determine nuclear import pathway, integration targeting and replication efficiency.

Authors:
Torsten Schaller Karen E Ocwieja Jane Rasaiyaah Amanda J Price Troy L Brady Shoshannah L Roth Stéphane Hué Adam J Fletcher KyeongEun Lee Vineet N KewalRamani Mahdad Noursadeghi Richard G Jenner Leo C James Frederic D Bushman Greg J Towers

PLoS Pathog 2011 Dec 8;7(12):e1002439. Epub 2011 Dec 8.

Division of Infection and Immunity, University College London Medical Research Council Centre for Medical Molecular Virology, London, United Kingdom.

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http://dx.doi.org/10.1371/journal.ppat.1002439DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3234246PMC
December 2011

Transcriptional profiling of innate and adaptive human immune responses to mycobacteria in the tuberculin skin test.

Authors:
Gillian S Tomlinson Tamaryn J Cashmore Paul T G Elkington John Yates Rannakoe J Lehloenya Jhen Tsang Michael Brown Robert F Miller Keertan Dheda David R Katz Benjamin M Chain Mahdad Noursadeghi

Eur J Immunol 2011 Nov 30;41(11):3253-60. Epub 2011 Aug 30.

Infection and Immunity, University College London, London, UK.

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http://dx.doi.org/10.1002/eji.201141841DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3258543PMC
November 2011

Kaposi's sarcoma-associated herpesvirus vFLIP and human T cell lymphotropic virus type 1 Tax oncogenic proteins activate IkappaB kinase subunit gamma by different mechanisms independent of the physiological cytokine-induced pathways.

Authors:
Akira Shimizu Mehdi Baratchian Yasu Takeuchi David Escors Douglas Macdonald Tracey Barrett Claire Bagneris Mary Collins Mahdad Noursadeghi

J Virol 2011 Jul 18;85(14):7444-8. Epub 2011 May 18.

Infection & Immunity, University College London, Cruciform Building, Gower Street, London WC1E 6BT, United Kingdom.

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http://dx.doi.org/10.1128/JVI.02337-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3126584PMC
July 2011

DC priming by M. vaccae inhibits Th2 responses in contrast to specific TLR2 priming and is associated with selective activation of the CREB pathway.

Authors:
Nina Le Bert Benjamin M Chain Graham Rook Mahdad Noursadeghi

PLoS One 2011 Apr 1;6(4):e18346. Epub 2011 Apr 1.

Infection and Immunity, University College London, London, United Kingdom.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3069967PMC
April 2011

Error, reproducibility and sensitivity: a pipeline for data processing of Agilent oligonucleotide expression arrays.

Authors:
Benjamin Chain Helen Bowen John Hammond Wilfried Posch Jane Rasaiyaah Jhen Tsang Mahdad Noursadeghi

BMC Bioinformatics 2010 Jun 24;11:344. Epub 2010 Jun 24.

Division of infection and Immunity, UCL, London, UK.

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http://dx.doi.org/10.1186/1471-2105-11-344DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2909218PMC
June 2010

Targeted delivery of antigen processing inhibitors to antigen presenting cells via mannose receptors.

Authors:
Eun-Ang Raiber Calogero Tulone Yanjing Zhang Luisa Martinez-Pomares Emily Steed Anna M Sponaas Jean Langhorne Mahdad Noursadeghi Benjamin M Chain Alethea B Tabor

ACS Chem Biol 2010 May;5(5):461-476

Dept of Chemistry, UCL, London, UK.

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http://dx.doi.org/10.1021/cb100008pDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4163654PMC
May 2010

HIV-1 infection of macrophages is dependent on evasion of innate immune cellular activation.

Authors:
Jhen Tsang Benjamin M Chain Robert F Miller Benjamin L J Webb Wendy Barclay Greg J Towers David R Katz Mahdad Noursadeghi

AIDS 2009 Nov;23(17):2255-63

Division of Infection and Immunity, University College London, London, UK.

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http://dx.doi.org/10.1097/QAD.0b013e328331a4ceDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2873676PMC
November 2009

Transcriptional and functional defects of dendritic cells derived from the MUTZ-3 leukaemia line.

Authors:
Jane Rasaiyaah Mahdad Noursadeghi Paul Kellam Benjamin Chain

Immunology 2009 Jul;127(3):429-41

Division of Infection and Immunity, University College London, London, UK.

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http://doi.wiley.com/10.1111/j.1365-2567.2008.03018.x
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http://dx.doi.org/10.1111/j.1365-2567.2008.03018.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2712111PMC
July 2009

Cyclophilin A levels dictate infection efficiency of human immunodeficiency virus type 1 capsid escape mutants A92E and G94D.

Authors:
Laura M J Ylinen Torsten Schaller Amanda Price Adam J Fletcher Mahdad Noursadeghi Leo C James Greg J Towers

J Virol 2009 Feb 10;83(4):2044-7. Epub 2008 Dec 10.

Medical Research Council Centre for Medical Molecular Virology, University College London, United Kingdom.

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http://dx.doi.org/10.1128/JVI.01876-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2643744PMC
February 2009

Genome-wide innate immune responses in HIV-1-infected macrophages are preserved despite attenuation of the NF-kappa B activation pathway.

Authors:
Mahdad Noursadeghi Jhen Tsang Robert F Miller Sarah Straschewski Paul Kellam Benjamin M Chain David R Katz

J Immunol 2009 Jan;182(1):319-28

Infection and Immunity, University College London, London, United Kingdom.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2637478PMC
http://dx.doi.org/10.4049/jimmunol.182.1.319DOI Listing
January 2009

HIV blocking antibodies following immunisation with chimaeric peptides coding a short N-terminal sequence of the CCR5 receptor.

Authors:
Benjamin M Chain Mahdad Noursadeghi Michelle Gardener Jhen Tsang Edward Wright

Vaccine 2008 Oct 31;26(45):5752-9. Epub 2008 Aug 31.

Division of Infection and Immunity, Windeyer Building, UCL, 46 Cleveland St., London W1T 4JF, UK.

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http://dx.doi.org/10.1016/j.vaccine.2008.08.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2670972PMC
October 2008

Comment on "Transcription factor FOXO3a mediates apoptosis in HIV-1-infected macrophages".

Authors:
Mahdad Noursadeghi Jhen Tsang Robert F Miller David R Katz

J Immunol 2008 Jun;180(12):7783; author reply 7783-4

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http://dx.doi.org/10.4049/jimmunol.180.12.7783DOI Listing
June 2008

vFLIP from KSHV inhibits anoikis of primary endothelial cells.

Authors:
Sofia Efklidou Ranbir Bailey Nigel Field Mahdad Noursadeghi Mary K Collins

J Cell Sci 2008 Feb 22;121(Pt 4):450-7. Epub 2008 Jan 22.

Infection and Immunity, University College London, Windeyer Building, London, UK.

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http://dx.doi.org/10.1242/jcs.022343DOI Listing
February 2008

Quantitative imaging assay for NF-kappaB nuclear translocation in primary human macrophages.

Authors:
Mahdad Noursadeghi Jhen Tsang Thomas Haustein Robert F Miller Benjamin M Chain David R Katz

J Immunol Methods 2008 Jan 20;329(1-2):194-200. Epub 2007 Nov 20.

Department of Immunology & Molecular Pathology, University College London, Windeyer Building, 46 Cleveland Street, W1T 4JF London, UK.

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http://dx.doi.org/10.1016/j.jim.2007.10.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2225449PMC
January 2008

Cytomegalovirus ileitis associated with goblet cell carcinoid tumour of the appendix.

Authors:
Siew C Ng Mahdad Noursadeghi Axel von Herbay Carolynne Vaizey Maxton C Pitcher Katie L Flanagan

J Infect 2007 Mar 16;54(3):e153-6. Epub 2006 Oct 16.

Department of Gastroenterology, Northwick Park Hospital, Harrow, Middlesex HA1 3UJ, UK.

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http://dx.doi.org/10.1016/j.jinf.2006.09.010DOI Listing
March 2007

HIV-1 infection of mononuclear phagocytic cells: the case for bacterial innate immune deficiency in AIDS.

Authors:
Mahdad Noursadeghi David R Katz Robert F Miller

Lancet Infect Dis 2006 Dec;6(12):794-804

Department of Immunology and Molecular Pathology, University College London, UK.

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http://dx.doi.org/10.1016/S1473-3099(06)70656-9DOI Listing
December 2006

Tuberculous pericardial effusion after coronary artery bypass graft.

Authors:
Sampurna M Tuladhar Mahdad Noursadeghi Joseph J Boyle Jon S Friedland Philip Hornick

Ann Thorac Surg 2006 Oct;82(4):1519-21

Department of Cardiac Surgery, Hammersmith Hospital, London, United Kingdom.

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http://dx.doi.org/10.1016/j.athoracsur.2006.02.059DOI Listing
October 2006

Bacterial disease in HIV-infected patients: the blind spot of highly active antiretroviral therapy?

Authors:
Mahdad Noursadeghi Andrew Ustianowski Ali Elgalib Robert Miller

J Acquir Immune Defic Syndr 2006 Apr;41(4):532-5

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http://dx.doi.org/10.1097/01.qai.0000209912.17695.e5DOI Listing
April 2006

Kikuchi's disease: a rare cause of meningitis?

Authors:
Mahdad Noursadeghi Nayef Aqel Geoffrey Pasvol

Clin Infect Dis 2005 Oct 9;41(8):e80-2. Epub 2005 Sep 9.

Department of Infection and Tropical Medicine, Northwick Park Hospital, Middlesex, United Kingdom.

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http://dx.doi.org/10.1086/444563DOI Listing
October 2005

Clinical value of C-reactive protein measurements in HIV-positive patients.

Authors:
Mahdad Noursadeghi Robert F Miller

Int J STD AIDS 2005 Jun;16(6):438-41

Patrick Manson Unit, University College London Hospitals Trust, London, UK.

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http://dx.doi.org/10.1258/0956462054094006DOI Listing
June 2005

Pathology of bone marrow in human herpes virus-8 (HHV8)-associated multicentric Castleman disease.

Authors:
Chris M Bacon Robert F Miller Mahdad Noursadeghi Christopher McNamara Ming-Qing Du Ahmet Dogan

Br J Haematol 2004 Dec;127(5):585-91

Department of Histopathology, Royal Free and University College Medical School, London, UK.

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http://dx.doi.org/10.1111/j.1365-2141.2004.05230.xDOI Listing
December 2004

Production of granulocyte colony-stimulating factor in the nonspecific acute phase response enhances host resistance to bacterial infection.

Authors:
Mahdad Noursadeghi Maria C M Bickerstaff Jeff Herbert David Moyes Jonathan Cohen Mark B Pepys

J Immunol 2002 Jul;169(2):913-9

Center for Amyloidosis and Acute Phase Proteins, Department of Medicine, Royal Free and University College Medical School, London, United Kingdom.

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http://dx.doi.org/10.4049/jimmunol.169.2.913DOI Listing
July 2002

Increased susceptibility of C1q-deficient mice to Salmonella enterica serovar Typhimurium infection.

Authors:
Joanna Warren Pietro Mastroeni Gordon Dougan Mahdad Noursadeghi Jonathan Cohen Mark J Walport Marina Botto

Infect Immun 2002 Feb;70(2):551-7

Rheumatology Section, Division of Medicine, Department of Biochemistry, Imperial College School of Medicine London, University of Cambridge, Cambridge, United Kingdom.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC127690PMC
http://dx.doi.org/10.1128/iai.70.2.551-557.2002DOI Listing
February 2002