Magnus Ingelman-Sundberg

Magnus Ingelman-Sundberg

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Magnus Ingelman-Sundberg

Magnus Ingelman-Sundberg

Publications by authors named "Magnus Ingelman-Sundberg"

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Evaluation of current regulation and guidelines of pharmacogenomic drug labels; opportunities for improvements.

Clin Pharmacol Ther 2019 Nov 12. Epub 2019 Nov 12.

Department of Physiology and Pharmacology, Section of Pharmacogenetics, Karolinska Institutet, Biomedicum 5B, SE-171 77, Stockholm, Sweden.

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http://dx.doi.org/10.1002/cpt.1720DOI Listing
November 2019

Development of the PGx-Passport: A Panel of Actionable Germline Genetic Variants for Pre-Emptive Pharmacogenetic Testing.

Clin Pharmacol Ther 2019 Oct 12;106(4):866-873. Epub 2019 Jun 12.

Department of Clinical Pharmacy and Toxicology, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1002/cpt.1489DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6771671PMC
October 2019

CYP3A5 is unlikely to mediate anticancer drug resistance in hepatocellular carcinoma.

Pharmacogenomics 2019 Oct;20(15):1085-1092

Department of Physiology & Pharmacology, Karolinska Institutet, Biomedicum 5B, SE-171 77 Stockholm, Sweden.

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http://dx.doi.org/10.2217/pgs-2019-0094DOI Listing
October 2019

Impact of CYP2C19 genotype on sertraline exposure in 1200 Scandinavian patients.

Neuropsychopharmacology 2019 Oct 24. Epub 2019 Oct 24.

Center for Psychopharmacology, Diakonhjemmet Hospital, Oslo, Norway.

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http://dx.doi.org/10.1038/s41386-019-0554-xDOI Listing
October 2019

One non-believer: Response to "Obviously Nine Believers: Actionable Germline Genetic Variants for Pre-emptive Pharmacogenetic Testing".

Basic Clin Pharmacol Toxicol 2019 Oct 31. Epub 2019 Oct 31.

Department of Clinical Pharmacy & Toxicology, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1111/bcpt.13336DOI Listing
October 2019

Mechanisms of chronic fialuridine hepatotoxicity as revealed in primary human hepatocyte spheroids.

Toxicol Sci 2019 Aug 27. Epub 2019 Aug 27.

Section of Pharmacogenetics, Department of Physiology and Pharmacology, Karolinska Institutet, SE-171 77, Stockholm, Sweden.

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https://academic.oup.com/toxsci/article/171/2/385/5555426
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http://dx.doi.org/10.1093/toxsci/kfz195DOI Listing
August 2019

3D Primary Hepatocyte Culture Systems for Analyses of Liver Diseases, Drug Metabolism, and Toxicity: Emerging Culture Paradigms and Applications.

Biotechnol J 2019 Jul 20;14(7):e1800347. Epub 2019 May 20.

Department of Physiology and Pharmacology, Section of Pharmacogenetics, Biomedicum 5B, Karolinska Institutet, SE-171 77, Stockholm, Sweden.

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http://dx.doi.org/10.1002/biot.201800347DOI Listing
July 2019

Novel genetic and epigenetic factors of importance for inter-individual differences in drug disposition, response and toxicity.

Pharmacol Ther 2019 05 22;197:122-152. Epub 2019 Jan 22.

Department of Physiology and Pharmacology, Section of Pharmacogenetics, Biomedicum 5B, Karolinska Institutet, SE-171 77 Stockholm, Sweden. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01637258193000
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http://dx.doi.org/10.1016/j.pharmthera.2019.01.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6527860PMC
May 2019

Effect of CYP2D6 genotype on exposure and efficacy of risperidone and aripiprazole: a retrospective, cohort study.

Lancet Psychiatry 2019 May 15;6(5):418-426. Epub 2019 Apr 15.

Section of Pharmacogenetics, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1016/S2215-0366(19)30088-4DOI Listing
May 2019

Prediction of drug response and adverse drug reactions: From twin studies to Next Generation Sequencing.

Eur J Pharm Sci 2019 Mar 23;130:65-77. Epub 2019 Jan 23.

Department of Physiology and Pharmacology, Section of Pharmacogenetics, Karolinska Institutet, SE-171 77 Stockholm, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.ejps.2019.01.024DOI Listing
March 2019

Inter-individual differences in the susceptibility of primary human hepatocytes towards drug-induced cholestasis are compound and time dependent.

Toxicol Lett 2018 Oct 18;295:187-194. Epub 2018 Jun 18.

KaLy-Cell, 20A rue du Général Leclerc, 67115 Plobsheim, France; Université de Bourgogne Franche-Comté, EA 4267 PEPITE, France. Electronic address:

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http://dx.doi.org/10.1016/j.toxlet.2018.06.1069DOI Listing
October 2018

Human liver spheroids in chemically defined conditions for studies of gene-drug, drug-drug and disease-drug interactions.

Pharmacogenomics 2018 09 25;19(14):1133-1138. Epub 2018 Jul 25.

Department of Physiology & Pharmacology, Section of Pharmacogenetics, Karolinska Institutet, SE-171 77 Stockholm, Sweden.

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http://dx.doi.org/10.2217/pgs-2018-0096DOI Listing
September 2018

Current Statistical Metrics Are Pragmatic Measures to Compare the Predictive Quality of Preclinical Assays.

Toxicol Sci 2018 09;165(1):4-5

Section of Pharmacogenetics, Department of Physiology and Pharmacology, Karolinska Institutet, SE-171 77 Stockholm, Sweden.

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http://dx.doi.org/10.1093/toxsci/kfy160DOI Listing
September 2018

Human hepatic 3D spheroids as a model for steatosis and insulin resistance.

Sci Rep 2018 09 24;8(1):14297. Epub 2018 Sep 24.

Section of Pharmacogenetics, Department of Physiology and Pharmacology, Karolinska Institutet, SE-17177, Stockholm, Sweden.

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http://dx.doi.org/10.1038/s41598-018-32722-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155201PMC
September 2018

Functional characterization of CYP2D7 gene variants.

Pharmacogenomics 2018 08 24;19(12):931-936. Epub 2018 Jul 24.

Department of Physiology & Pharmacology, Karolinska Institutet, 17165 Stockholm, Sweden.

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http://dx.doi.org/10.2217/pgs-2018-0065DOI Listing
August 2018

Novel copy-number variations in pharmacogenes contribute to interindividual differences in drug pharmacokinetics.

Genet Med 2018 06 26;20(6):622-629. Epub 2017 Oct 26.

Hereditary Endocrine Cancer Group, Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.

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http://dx.doi.org/10.1038/gim.2017.156DOI Listing
June 2018

Prediction of Drug-Induced Hepatotoxicity Using Long-Term Stable Primary Hepatic 3D Spheroid Cultures in Chemically Defined Conditions.

Toxicol Sci 2018 06;163(2):655-665

Section of Pharmacogenetics, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm SE-171 77, Sweden.

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http://dx.doi.org/10.1093/toxsci/kfy058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5974779PMC
June 2018

How to Consider Rare Genetic Variants in Personalized Drug Therapy.

Clin Pharmacol Ther 2018 05 5;103(5):745-748. Epub 2018 Jan 5.

Department of Physiology and Pharmacology, Section of Pharmacogenetics, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1002/cpt.976DOI Listing
May 2018

Impact of CYP2C19 Genotype on Escitalopram Exposure and Therapeutic Failure: A Retrospective Study Based on 2,087 Patients.

Am J Psychiatry 2018 05 12;175(5):463-470. Epub 2018 Jan 12.

From the Section of Pharmacogenetics, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm; the Department of Physiology, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia; the Center for Psychopharmacology, Diakonhjemmet Hospital, Oslo; and the Department of Pharmaceutical Biosciences, School of Pharmacy, University of Oslo, Oslo.

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http://dx.doi.org/10.1176/appi.ajp.2017.17050550DOI Listing
May 2018

Integrating rare genetic variants into pharmacogenetic drug response predictions.

Hum Genomics 2018 05 25;12(1):26. Epub 2018 May 25.

Department of Physiology and Pharmacology, Section of Pharmacogenetics, Karolinska Institutet, SE-171 77, Stockholm, Sweden.

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http://dx.doi.org/10.1186/s40246-018-0157-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5968569PMC
May 2018

Pharmacoepigenetics and Toxicoepigenetics: Novel Mechanistic Insights and Therapeutic Opportunities.

Annu Rev Pharmacol Toxicol 2018 01 13;58:161-185. Epub 2017 Oct 13.

Pharmacogenetics Section, Department of Physiology and Pharmacology, Karolinska Institutet, SE-171 77 Stockholm, Sweden; email:

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http://dx.doi.org/10.1146/annurev-pharmtox-010617-053021DOI Listing
January 2018

Pharmacogenomic Biomarkers for Improved Drug Therapy-Recent Progress and Future Developments.

AAPS J 2017 11 27;20(1). Epub 2017 Nov 27.

Department of Physiology and Pharmacology, Section of Pharmacogenetics, Karolinska Institutet, SE-171 77, Stockholm, Sweden.

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http://dx.doi.org/10.1208/s12248-017-0161-xDOI Listing
November 2017

Pitfalls and Opportunities for Epigenomic Analyses Focused on Disease Diagnosis, Prognosis, and Therapy.

Trends Pharmacol Sci 2017 09 15;38(9):765-770. Epub 2017 Jun 15.

Department of Physiology and Pharmacology, Section of Pharmacogenetics, Karolinska Institutet, SE-171 77 Stockholm, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.tips.2017.05.007DOI Listing
September 2017

Transcriptional, Functional, and Mechanistic Comparisons of Stem Cell-Derived Hepatocytes, HepaRG Cells, and Three-Dimensional Human Hepatocyte Spheroids as Predictive In Vitro Systems for Drug-Induced Liver Injury.

Drug Metab Dispos 2017 04 30;45(4):419-429. Epub 2017 Jan 30.

Section of Pharmacogenetics, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden (C.C.B., V.M.L., S.U.V., T.B.A., M.I.-S.); Cardiovascular and Metabolic Diseases, Innovative Medicines and Early Development Biotech Unit, AstraZeneca, Mölndal, Sweden (H.P., T.B.A.); and CXR Biosciences Ltd., Dundee, United Kingdom (R.D.).

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http://dx.doi.org/10.1124/dmd.116.074369DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5363699PMC
April 2017

Rare genetic variants in cellular transporters, metabolic enzymes, and nuclear receptors can be important determinants of interindividual differences in drug response.

Genet Med 2017 01 21;19(1):20-29. Epub 2016 Apr 21.

Section of Pharmacogenetics, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1038/gim.2016.33DOI Listing
January 2017

The role of microRNAs in liver injury at the crossroad between hepatic cell death and regeneration.

Biochem Biophys Res Commun 2017 01 24;482(3):399-407. Epub 2016 Oct 24.

Department of Physiology and Pharmacology, Section of Pharmacogenetics, Karolinska Institute, Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.bbrc.2016.10.084DOI Listing
January 2017

Novel 3D Culture Systems for Studies of Human Liver Function and Assessments of the Hepatotoxicity of Drugs and Drug Candidates.

Chem Res Toxicol 2016 12 23;29(12):1936-1955. Epub 2016 Sep 23.

Section of Pharmacogenetics, Department of Physiology and Pharmacology, Karolinska Institutet , SE-17177 Stockholm, Sweden.

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http://dx.doi.org/10.1021/acs.chemrestox.6b00150DOI Listing
December 2016

The Importance of Patient-Specific Factors for Hepatic Drug Response and Toxicity.

Int J Mol Sci 2016 Oct 12;17(10). Epub 2016 Oct 12.

Section of Pharmacogenetics, Department of Physiology and Pharmacology, Karolinska Institutet, SE-17177 Stockholm, Sweden.

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http://dx.doi.org/10.3390/ijms17101714DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5085745PMC
October 2016

Hepatic 3D spheroid models for the detection and study of compounds with cholestatic liability.

Sci Rep 2016 10 19;6:35434. Epub 2016 Oct 19.

Department of Physiology and Pharmacology, Section of Pharmacogenetics, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1038/srep35434DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5069690PMC
October 2016

Single base resolution analysis of 5-hydroxymethylcytosine in 188 human genes: implications for hepatic gene expression.

Nucleic Acids Res 2016 08 29;44(14):6756-69. Epub 2016 Apr 29.

Section of Pharmacogenetics, Department of Physiology and Pharmacology, Karolinska Institutet, Nanna Svartz väg 2, 17177 Stockholm, Sweden.

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http://dx.doi.org/10.1093/nar/gkw316DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5001587PMC
August 2016

The CYP2W1 enzyme: regulation, properties and activation of prodrugs.

Drug Metab Rev 2016 08 3;48(3):369-78. Epub 2016 Jun 3.

a Section of Pharmacogenetics, Department of Physiology and Pharmacology , Karolinska Institutet , Stockholm , Sweden.

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http://dx.doi.org/10.1080/03602532.2016.1188939DOI Listing
August 2016

Requirements for comprehensive pharmacogenetic genotyping platforms.

Pharmacogenomics 2016 06 1;17(8):917-24. Epub 2016 Jun 1.

Section of Pharmacogenetics, Department of Physiology & Pharmacology, Karolinska Institutet, SE-17177 Stockholm, Sweden.

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http://dx.doi.org/10.2217/pgs-2016-0023DOI Listing
June 2016

Developmental regulation and induction of cytochrome P450 2W1, an enzyme expressed in colon tumors.

PLoS One 2015 6;10(4):e0122820. Epub 2015 Apr 6.

Department of Physiology and Pharmacology, Section of Pharmacogenetics, Karolinska Institutet, Stockholm, Sweden.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0122820PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4386763PMC
April 2016

Role of cytochrome P450 2C8*3 (CYP2C8*3) in paclitaxel metabolism and paclitaxel-induced neurotoxicity.

Pharmacogenomics 2015 26;16(9):929-37. Epub 2015 Jun 26.

Section of Pharmacogenetics, Department of Physiology & Pharmacology, Karolinska Institutet, SE 171 77 Stockholm, Sweden.

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http://dx.doi.org/10.2217/pgs.15.46DOI Listing
April 2016

What do animal experiments tell us that in vitro systems cannot? The Human Toxome Project.

Regul Toxicol Pharmacol 2016 Mar 26;75:1-4. Epub 2015 Sep 26.

Department of Physiology and Pharmacology, Section of Pharmacogenetics, Karolinska Institutet, 171 77 Stockholm, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.yrtph.2015.09.027DOI Listing
March 2016

Precision Medicine and Rare Genetic Variants.

Trends Pharmacol Sci 2016 Feb 17;37(2):85-86. Epub 2015 Dec 17.

Karolinska Institutet, Department of Physiology and Pharmacology, Section of Pharmacogenetics, Stockholm, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.tips.2015.10.006DOI Listing
February 2016

Membrane topology and search for potential redox partners of colon cancer-specific cytochrome P450 2W1.

FEBS Lett 2016 Feb 2;590(3):330-9. Epub 2016 Feb 2.

Section of Pharmacogenetics, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1002/1873-3468.12063DOI Listing
February 2016

Genetic variation in the human cytochrome P450 supergene family.

Pharmacogenet Genomics 2015 Dec;25(12):584-94

aKobe University Hospital, Kobe, Japan bSection of Pharmacogenetics, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1097/FPC.0000000000000172DOI Listing
December 2015

Interview with Magnus Ingelman-Sundberg.

Trends Pharmacol Sci 2015 Feb 23;36(2):65-7. Epub 2014 Dec 23.

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http://dx.doi.org/10.1016/j.tips.2014.11.007DOI Listing
February 2015

Stem cell-derived systems in toxicology assessment.

Stem Cells Dev 2015 Jun 31;24(11):1284-96. Epub 2015 Mar 31.

19Division of Toxicology, Leiden Academic Centre for Drug Research, Leiden University, Leiden, the Netherlands.

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http://dx.doi.org/10.1089/scd.2014.0540DOI Listing
June 2015

Interview with Magnus Ingelman-Sundberg.

Trends Pharmacol Sci 2015 Feb 23;36(2):65-7. Epub 2014 Dec 23.

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http://dx.doi.org/10.1016/j.tips.2014.11.007DOI Listing
February 2015

Long-term chronic toxicity testing using human pluripotent stem cell-derived hepatocytes.

Drug Metab Dispos 2014 Sep 30;42(9):1401-6. Epub 2014 Jun 30.

Systems Biology Research Center, School of Bioscience, University of Skövde, Skövde, Sweden (G.H., P.S., J.S.); Department of Clinical Chemistry and Transfusion Medicine, Institute of Biomedicine, University of Gothenburg, Gothenburg, Sweden (G.H.); Department of Discovery Safety, Drug Safety and Metabolism, AstraZeneca R&D, Mölndal, Sweden (A.-K.S.); Section of Pharmacogenetics, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden (I.B., T.B.A., M.I.-S.); Department of Bioscience, Cardiovascular and Metabolic Diseases, AstraZeneca R&D, Mölndal, Sweden (A.S.); NovaHep AB, Gothenburg, Sweden (P.B.); Department of Drug Metabolism and Pharmacokinetics, AstraZeneca R&D, Mölndal, Sweden (T.B.A.); and Cellectis AB, Gothenburg, Sweden (P.S., P.B., J.E.).

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http://dx.doi.org/10.1124/dmd.114.059154DOI Listing
September 2014

Epigenetic mechanisms of importance for drug treatment.

Trends Pharmacol Sci 2014 Aug 1;35(8):384-96. Epub 2014 Jul 1.

Pharmacogenetics Section, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.tips.2014.05.004DOI Listing
August 2014

High CYP2A6 enzyme activity as measured by a caffeine test and unique distribution of CYP2A6 variant alleles in Ethiopian population.

OMICS 2014 Jul 31;18(7):446-53. Epub 2013 Dec 31.

1 Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska University Hospital , Karolinska Institutet, Stockholm, Sweden .

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http://dx.doi.org/10.1089/omi.2013.0140DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4086241PMC
July 2014

The expression of CYP2W1 in colorectal primary tumors, corresponding lymph node metastases and liver metastases.

Acta Oncol 2014 Jul 13;53(7):885-91. Epub 2014 Mar 13.

Center of Surgical Gastroenterology, Karolinska University Hospital , Stockholm , Sweden.

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http://dx.doi.org/10.3109/0284186X.2014.887224DOI Listing
July 2014

Potential role of epigenetic mechanisms in the regulation of drug metabolism and transport.

Drug Metab Dispos 2013 Oct 5;41(10):1725-31. Epub 2013 Aug 5.

Department of Physiology and Pharmacology, Section of Pharmacogenetics, Karolinska Institutet, Stockholm, Sweden (M.I.-S.); Department of Pharmaceutical Sciences, University of Connecticut, Storrs, Connecticut (X.-B.Z., L.P.); Interdepartmental Molecular Toxicology Program and the Department of Pathology and Laboratory Medicine, University of California, Los Angeles, California (O.H., S.B.); Department of Biochemistry and Molecular Medicine, University of California at Davis School of Medicine, Sacramento, California (A.-M.Y.); and Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan (Y.O.).

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http://dx.doi.org/10.1124/dmd.113.053157DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3781370PMC
October 2013

CYP2W1 polymorphism: functional aspects and relation to risk for colorectal cancer.

Pharmacogenomics 2013 Oct;14(13):1615-22

Department of Molecular Medicine & Surgery, Karolinska Institutet & Karolinska University Hospital, SE-171 76 Stockholm, Sweden.

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https://www.futuremedicine.com/doi/10.2217/pgs.13.136
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http://dx.doi.org/10.2217/pgs.13.136DOI Listing
October 2013

Update on allele nomenclature for human cytochromes P450 and the Human Cytochrome P450 Allele (CYP-allele) Nomenclature Database.

Methods Mol Biol 2013 ;987:251-9

Section for Pharmacogenetics, Department of Physiology and Pharmacology, Karolinska Institute, Stockholm, Sweden.

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http://dx.doi.org/10.1007/978-1-62703-321-3_21DOI Listing
August 2013

Sex difference in formation of propofol metabolites: a replication study.

Basic Clin Pharmacol Toxicol 2013 Aug 20;113(2):126-31. Epub 2013 May 20.

Section of Pharmacogenetics, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1111/bcpt.12070DOI Listing
August 2013

An integrated in vitro model for simultaneous assessment of drug uptake, metabolism, and efflux.

Mol Pharm 2013 Aug 15;10(8):3152-63. Epub 2013 Jul 15.

Section of Pharmacogenetics, Department of Physiology and Pharmacology, Karolinska Institutet , 171 77 Stockholm, Sweden.

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http://dx.doi.org/10.1021/mp400202dDOI Listing
August 2013

Colon cancer-specific cytochrome P450 2W1 converts duocarmycin analogues into potent tumor cytotoxins.

Clin Cancer Res 2013 Jun 15;19(11):2952-61. Epub 2013 Apr 15.

Department of Physiology and Pharmacology, Section of Pharmacogenetics, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1158/1078-0432.CCR-13-0238DOI Listing
June 2013

3D organotypic cultures of human HepaRG cells: a tool for in vitro toxicity studies.

Toxicol Sci 2013 May 1;133(1):67-78. Epub 2013 Feb 1.

Section of Pharmacogenetics, Department of Physiology and Pharmacology, Karolinska Institutet, 171 77 Stockholm, Sweden.

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https://academic.oup.com/toxsci/article-lookup/doi/10.1093/t
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http://dx.doi.org/10.1093/toxsci/kft021DOI Listing
May 2013

In-solution hybrid capture of bisulfite-converted DNA for targeted bisulfite sequencing of 174 ADME genes.

Nucleic Acids Res 2013 Apr 15;41(6):e72. Epub 2013 Jan 15.

Section of Pharmacogenetics, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm 17177, Sweden.

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https://academic.oup.com/nar/article/41/6/e72/2902438
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http://dx.doi.org/10.1093/nar/gks1467DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3616706PMC
April 2013

Strong effects of environmental factors on prevalence and course of major depressive disorder are not moderated by 5-HTTLPR polymorphisms in a large Dutch sample.

J Affect Disord 2013 Mar 27;146(1):91-9. Epub 2012 Sep 27.

Department of Psychiatry, Neuroscience Campus Amsterdam and EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.jad.2012.08.044DOI Listing
March 2013

Characterization of human cytochrome P450s involved in the bioactivation of clozapine.

Drug Metab Dispos 2013 Mar 7;41(3):651-8. Epub 2013 Jan 7.

Division of Molecular Toxicology, Leiden/Amsterdam Center for Drug Research, Faculty of Sciences, Vrije Universiteit, De Boelelaan 1083, 1081 HV Amsterdam, The Netherlands.

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http://dx.doi.org/10.1124/dmd.112.050484DOI Listing
March 2013

Hepatic differentiation and maturation of human embryonic stem cells cultured in a perfused three-dimensional bioreactor.

Stem Cells Dev 2013 Feb 2;22(4):581-94. Epub 2012 Nov 2.

Section of Pharmacogenetics, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1089/scd.2012.0202DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3564470PMC
February 2013

Institutional profile: Karolinska Institutet.

Pharmacogenomics 2012 Dec;13(16):1887-91

Karolinska Institutet, Department of Laboratory Medicine, Clinical Pharmacology, Karolinska University Hospital Huddinge, Stockholm, Sweden.

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http://dx.doi.org/10.2217/pgs.12.176DOI Listing
December 2012

DNA methylation dynamics in the hepatic CYP3A4 gene promoter.

Biochimie 2012 Nov 31;94(11):2338-44. Epub 2012 Jul 31.

Section of Pharmacogenetics, Department of Physiology and Pharmacology, Karolinska Institutet, SE-171 77 Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.biochi.2012.07.013DOI Listing
November 2012

Epigenetic-dependent regulation of drug transport and metabolism: an update.

Pharmacogenomics 2012 Sep;13(12):1373-85

Section of Pharmacogenetics, Department of Physiology & Pharmacology, Karolinska Institutet, SE-171 77 Stockholm, Sweden.

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September 2012

The expression of CYP2W1: a prognostic marker in colon cancer.

Anticancer Res 2012 Sep;32(9):3869-74

Department of 1Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.

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September 2012

Influence of sex on propofol metabolism, a pilot study: implications for propofol anesthesia.

Eur J Clin Pharmacol 2012 Apr 18;68(4):397-406. Epub 2011 Oct 18.

Section of Pharmacogenetics, Department of Physiology and Pharmacology, Karolinska Institutet, SE-171 77, Stockholm, Sweden.

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http://dx.doi.org/10.1007/s00228-011-1132-2DOI Listing
April 2012

Omeprazole limited sampling strategies to predict area under the concentration-time curve ratios: implications for cytochrome P450 2C19 and 3A phenotyping.

Eur J Clin Pharmacol 2012 Apr 19;68(4):407-13. Epub 2011 Oct 19.

Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego (UCSD), 9500 Gilman Drive, MC 0714, La Jolla, CA 92093-0714, USA.

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http://dx.doi.org/10.1007/s00228-011-1136-yDOI Listing
April 2012

Amidoxime reductase system containing cytochrome b5 type B (CYB5B) and MOSC2 is of importance for lipid synthesis in adipocyte mitochondria.

J Biol Chem 2012 Feb 27;287(9):6307-17. Epub 2011 Dec 27.

Section of Pharmacogenetics, Department of Physiology and Pharmacology, Karolinska Institutet, SE-17177 Stockholm.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3307252PMC
February 2012

The ligands of estrogen receptor α regulate cytochrome P4502C9 (CYP2C9) expression.

J Pharmacol Exp Ther 2011 Jul 14;338(1):302-9. Epub 2011 Apr 14.

Department of Physiology and Pharmacology, Section of Pharmacogenetics, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1124/jpet.110.175075DOI Listing
July 2011

Databases in the area of pharmacogenetics.

Hum Mutat 2011 May 5;32(5):526-31. Epub 2011 Apr 5.

Section of Pharmacogenetics, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3352027PMC
May 2011

Genetic polymorphism and toxicology--with emphasis on cytochrome p450.

Toxicol Sci 2011 Mar 13;120(1):1-13. Epub 2010 Dec 13.

Section of Pharmacogenetics, Department of Physiology and Pharmacology, Karolinska Institutet, 171 77 Stockholm, Sweden.

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http://dx.doi.org/10.1093/toxsci/kfq374DOI Listing
March 2011

Pharmacogenomic biomarkers: new tools in current and future drug therapy.

Trends Pharmacol Sci 2011 Feb 22;32(2):72-81. Epub 2010 Dec 22.

Department of Physiology and Pharmacology, Section of Pharmacogenetics, Karolinska Institute, 171 77 Stockholm, Sweden.

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February 2011