Magid Abou-Gharbia

Magid Abou-Gharbia

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Magid Abou-Gharbia

Magid Abou-Gharbia

Publications by authors named "Magid Abou-Gharbia"

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34Publications

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Novel compounds that reverse the disease phenotype in Type 2 Gaucher disease patient-derived cells.

Bioorg Med Chem Lett 2020 Jan 11;30(2):126806. Epub 2019 Nov 11.

Moulder Center for Drug Discovery Research, Department of Pharmaceutical Sciences, Temple University School of Pharmacy, 3307 N. Broad Street, Philadelphia, PA 19140, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2019.126806DOI Listing
January 2020

Novel inhibitors of Staphylococcus aureus RnpA that synergize with mupirocin.

Bioorg Med Chem Lett 2018 04 31;28(6):1127-1131. Epub 2018 Jan 31.

Moulder Center for Drug Discovery Research, Temple University School of Pharmacy, 3307 N. Broad Street, Philadelphia, PA, United States. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0960894X183003
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http://dx.doi.org/10.1016/j.bmcl.2018.01.022DOI Listing
April 2018

A Mitochondrial-targeted purine-based HSP90 antagonist for leukemia therapy.

Oncotarget 2017 Dec 11;8(68):112184-112198. Epub 2017 Dec 11.

Prostate Cancer Discovery and Development Program, The Wistar Institute, Philadelphia, PA, USA.

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http://dx.doi.org/10.18632/oncotarget.23097DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5762502PMC
December 2017

Nuclear Magnetic Resonance Structure of the Human Polyoma JC Virus Agnoprotein.

J Cell Biochem 2017 10 3;118(10):3268-3280. Epub 2017 May 3.

Université Paris Descartes, Sorbonne Paris Cité, Laboratoire de Cristallographie et RMN Biologiques, UMR 8015 CNRS, 4 av. de l'Observatoire, Paris, France.

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http://dx.doi.org/10.1002/jcb.25977DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5550335PMC
October 2017

Design, synthesis and SAR of new-di-substituted pyridopyrimidines as ATP-competitive dual PI3Kα/mTOR inhibitors.

Bioorg Med Chem Lett 2017 07 15;27(14):3117-3122. Epub 2017 May 15.

Moulder Center for Drug Discovery Research, Temple University, School of Pharmacy, 3307 N. Broad Street, Philadelphia, PA, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0960894X173052
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http://dx.doi.org/10.1016/j.bmcl.2017.05.044DOI Listing
July 2017

12/15-Lipoxygenase Inhibition Reverses Cognitive Impairment, Brain Amyloidosis, and Tau Pathology by Stimulating Autophagy in Aged Triple Transgenic Mice.

Biol Psychiatry 2017 01 4;81(2):92-100. Epub 2016 Jun 4.

Center for Translational Medicine, Lewis Katz School of Medicine, Philadelphia, Pennsylvania. Electronic address:

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http://dx.doi.org/10.1016/j.biopsych.2016.05.023DOI Listing
January 2017

Emerging From the Unknown: Structural and Functional Features of Agnoprotein of Polyomaviruses.

J Cell Physiol 2016 10 24;231(10):2115-27. Epub 2016 Feb 24.

Department of Neuroscience, Laboratory of Molecular Neurovirology, MERB-757, Temple University Lewis Katz School of Medicine, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1002/jcp.25329DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5217748PMC
October 2016

Heterocyclic chalcone activators of nuclear factor (erythroid-derived 2)-like 2 (Nrf2) with improved in vivo efficacy.

Bioorg Med Chem 2015 Sep 29;23(17):5352-9. Epub 2015 Jul 29.

Moulder Center for Drug Discovery Research, Temple University School of Pharmacy, 3307 N. Broad Street, Philadelphia, PA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2015.07.056DOI Listing
September 2015

Small-molecule inhibitors of Staphylococcus aureus RnpA-mediated RNA turnover and tRNA processing.

Antimicrob Agents Chemother 2015 Apr 20;59(4):2016-28. Epub 2015 Jan 20.

Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry Rochester, New York, USA

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http://dx.doi.org/10.1128/AAC.04352-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4356807PMC
April 2015

A novel assay platform for the detection of translation modulators of spermidine/spermine acetyltransferase.

Curr Pharm Des 2014 ;20(2):245-52

Department of Biochemistry and Fels Institute for Cancer Research, School of Medicine and 2 Moulder Center for Drug Discovery, School of Pharmacy, Temple University 3307 N. Broad Street, Philadelphia, PA 19140.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871977PMC
http://dx.doi.org/10.2174/13816128113199990035DOI Listing
October 2014

Discovery of innovative therapeutics: today's realities and tomorrow's vision. 2. Pharma's challenges and their commitment to innovation.

J Med Chem 2014 Jul 7;57(13):5525-53. Epub 2014 Feb 7.

Moulder Center for Drug Discovery Research, Temple University School of Pharmacy , 3307 North Broad Street, Philadelphia, Pennsylvania 19140, United States.

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http://dx.doi.org/10.1021/jm401564rDOI Listing
July 2014

Nuclear magnetic resonance structure revealed that the human polyomavirus JC virus agnoprotein contains an α-helix encompassing the Leu/Ile/Phe-rich domain.

J Virol 2014 Jun 26;88(12):6556-75. Epub 2014 Mar 26.

Department of Neuroscience, Laboratory of Molecular Neurovirology, Temple University School of Medicine, Philadelphia, Pennsylvania, USA

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http://dx.doi.org/10.1128/JVI.00146-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4054343PMC
June 2014

Essential roles of Leu/Ile/Phe-rich domain of JC virus agnoprotein in dimer/oligomer formation, protein stability and splicing of viral transcripts.

Virology 2013 Aug 6;443(1):161-76. Epub 2013 Jun 6.

Department of Neuroscience, Laboratory of Molecular Neurovirology, MERB-757, Temple University School of Medicine, 3500 N. Broad Street, Philadelphia, PA 19140, United States.

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http://dx.doi.org/10.1016/j.virol.2013.05.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3777628PMC
August 2013

Discovery of innovative therapeutics: today's realities and tomorrow's vision. 1. Criticisms faced by the pharmaceutical industry.

J Med Chem 2013 Jul 29;56(14):5659-72. Epub 2013 Apr 29.

Molder Center for Drug Discovery Research, Temple University School of Pharmacy , 3307 N. Broad Street, Philadelphia, Pennsylvania 18938, United States.

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http://dx.doi.org/10.1021/jm400330jDOI Listing
July 2013

Design and synthesis of 2-aminothiazole based antimicrobials targeting MRSA.

Bioorg Med Chem Lett 2012 Dec 3;22(24):7719-25. Epub 2012 Oct 3.

Temple University School of Pharmacy, Moulder Center for Drug Discovery Research, Philadelphia, PA, USA.

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http://dx.doi.org/10.1016/j.bmcl.2012.09.095DOI Listing
December 2012

A new and efficient synthetic route for the anxiolytic agent CL285032.

Bioorg Med Chem Lett 2011 Jan 5;21(1):259-61. Epub 2010 Nov 5.

Moulder Center for Drug Discovery Research, Temple University School of Pharmacy, 3307 N Broad Street, Philadelphia, PA 19140, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S0960894X100162
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http://dx.doi.org/10.1016/j.bmcl.2010.11.017DOI Listing
January 2011

Discovery of innovative small molecule therapeutics.

J Med Chem 2009 Jan;52(1):2-9

Center for Drug DiscoVery Research, School of Pharmacy, Temple UniVersity, 3307 North Broad Street, Philadelphia, Pennsylvania 19140, USA.

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http://dx.doi.org/10.1021/jm8012823DOI Listing
January 2009