Publications by authors named "Maggie C U Cheang"

38Publications

A Four-gene Decision Tree Signature Classification of Triple-negative Breast Cancer: Implications for Targeted Therapeutics.

Mol Cancer Ther 2019 01 10;18(1):204-212. Epub 2018 Oct 10.

Cancer Bioinformatics, Cancer Centre at Guy's Hospital, King's College London, London, United Kingdom.

View Article and Find Full Text PDF
January 2019

Defining breast cancer intrinsic subtypes by quantitative receptor expression.

Oncologist 2015 May 23;20(5):474-82. Epub 2015 Apr 23.

Lineberger Comprehensive Cancer Center and Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, USA; Clinical Trials and Statistics Unit at The Institute of Cancer Research, London, United Kingdom; Servicio de Oncología Médica, Instituto de Investigacion Sanitaria Hospital Universitario Gregorio Marañón, Facultad de Medicina, Universidad Complutense, Madrid, Spain; Department of Pathology, University of British Columbia, Vancouver, British Columbia, Canada; Translation Genomics Unit, Vall d´Hebron Institute of Oncology, Barcelona, Spain; British Columbia Cancer Agency, Vancouver, British Columbia, Canada; Department of Medical Oncology, Hospital General Universitario de Elche, Alicante, Spain; Department of Medical Oncology, Instituto Valenciano de Oncologia, Valencia, Spain; National Cancer Institute of Canada Clinical Trials Group, Kingston, Ontario, Canada; Department of Medical Oncology, Hospital Universitario Virgen del Rocio, Seville, Spain; Department of Medical Oncology, Complejo Hospitalario Universitario A Coruña, Coruña, Spain; Department of Medical Oncology, Hospital Universitario Virgen de la Victoria, Málaga, Spain; GEICAM, Madrid, Spain; Sunnybrook Odette Cancer Centre, University of Toronto, Toronto, Ontario, Canada; McMaster University, Hamilton, Ontario, Canada; Department of Oncology, Tom Baker Cancer Centre, University of Calgary, Calgary, Alberta, Canada; Department of Pathology, University of Utah Health Sciences Center, Salt Lake City, Utah, USA; Department of Medicine, Washington University, St. Louis, Missouri, USA; Department of Oncology, Hospital of Prato, Istituto Toscani Tumori, Florence, Italy

View Article and Find Full Text PDF
May 2015

Genomic Complexity Profiling Reveals That HORMAD1 Overexpression Contributes to Homologous Recombination Deficiency in Triple-Negative Breast Cancers.

Cancer Discov 2015 May 13;5(5):488-505. Epub 2015 Mar 13.

Breakthrough Breast Cancer Research Unit, King's College London, London, United Kingdom. Department of Research Oncology, King's Health Partners AHSC, Life Sciences and Medicine, King's College London, London, United Kingdom. The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, United Kingdom.

View Article and Find Full Text PDF
May 2015

Radiation-induced gene signature predicts pathologic complete response to neoadjuvant chemotherapy in breast cancer patients.

Radiat Res 2014 Feb 14;181(2):193-207. Epub 2014 Feb 14.

a Department of Radiation Oncology, Leo W. Jenkins Cancer Center, The Brody School of Medicine at East Carolina University, Greenville, North Carolina 27834.

View Article and Find Full Text PDF
February 2014

Research-based PAM50 subtype predictor identifies higher responses and improved survival outcomes in HER2-positive breast cancer in the NOAH study.

Clin Cancer Res 2014 Jan;20(2):511-21

Authors' Affiliations: Translational Genomics Group, Vall d'Hebron Institute of Oncology; Department of Medicine, Universitat Autònoma de Barcelona, Barcelona; Hospital Clinico Universitario, Valencia, Spain; Oncologia Medica, San Raffaele Cancer Centre, Milan, Italy; Roche, Pharma Research and Early Development, Penzberg; Frauenklinik vom Roten Kreuz, Munich, Germany; University of North Carolina, Chapel Hill, North Carolina; NN Petrov Research Institute of Oncology, St Petersburg, Russian Federation; NN Blokhin Russian Cancer Centre; Central Clinical Hospital named after N A Semashko, Moscow, Russia; and Memorial Sloan-Kettering Cancer Center, New York, New York.

View Article and Find Full Text PDF
January 2014

Predicting drug responsiveness in human cancers using genetically engineered mice.

Clin Cancer Res 2013 Sep 18;19(17):4889-99. Epub 2013 Jun 18.

Lineberger Comprehensive Cancer Center, Department of Genetics, School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.

View Article and Find Full Text PDF
September 2013

Molecular characterization of basal-like and non-basal-like triple-negative breast cancer.

Oncologist 2013 12;18(2):123-33. Epub 2013 Feb 12.

Medical Oncology Department, Vall d’Hebron Institute of Oncology, Barcelona, Spain.

View Article and Find Full Text PDF
December 2013

Breast cancer subtypes and the risk of local and regional relapse.

J Clin Oncol 2010 Apr 1;28(10):1684-91. Epub 2010 Mar 1.

Department of Radiation Oncology, British Columbia Cancer Agency, Vancouver, British Columbia, Canada V5Z 4E6.

View Article and Find Full Text PDF
April 2010

Ki67 index, HER2 status, and prognosis of patients with luminal B breast cancer.

J Natl Cancer Inst 2009 May 12;101(10):736-50. Epub 2009 May 12.

Genetic Pathology Evaluation Centre, Vancouver Coastal Health Research Institute, British Columbia Cancer Agency, and University of British Columbia, Vancouver, BC, Canada.

View Article and Find Full Text PDF
May 2009

Progesterone receptor is a significant factor associated with clinical outcomes and effect of adjuvant tamoxifen therapy in breast cancer patients.

Breast Cancer Res Treat 2010 Jan 10;119(1):53-61. Epub 2009 Feb 10.

Genetic Pathology Evaluation Centre at Vancouver General Hospital, Prostate Center, University of British Columbia, Vancouver, BC, Canada.

View Article and Find Full Text PDF
January 2010

Basal-like breast cancer defined by five biomarkers has superior prognostic value than triple-negative phenotype.

Clin Cancer Res 2008 Mar;14(5):1368-76

Genetic Pathology Evaluation Centre, Vancouver Coastal Health Research Institute, British Columbia Cancer Agency, and University of British Columbia, Vancouver, British Columbia, Canada.

View Article and Find Full Text PDF
March 2008

Gene expression profiling of breast cancer.

Annu Rev Pathol 2008 ;3:67-97

Genetic Pathology Evaluation Centre, Vancouver Coastal Health Research Institute, British Columbia Cancer Agency, Vancouver, British Columbia V6H 3Z6, Canada.

View Article and Find Full Text PDF
May 2008

Race, breast cancer subtypes, and survival in the Carolina Breast Cancer Study.

JAMA 2006 Jun;295(21):2492-502

Division of Hematology/Oncology, School of Public Health, Department of Epidemiology, University of North Carolina-Lineberger Comprehensive Cancer Center, Chapel Hill, NC 27599-7305, USA.

View Article and Find Full Text PDF
June 2006

Disruption of the Y-box binding protein-1 results in suppression of the epidermal growth factor receptor and HER-2.

Cancer Res 2006 May;66(9):4872-9

Laboratory for Oncogenomic Research, Department of Pediatrics, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada.

View Article and Find Full Text PDF
May 2006

MDM2 protein expression is a negative prognostic marker in breast carcinoma.

Mod Pathol 2006 Jan;19(1):69-74

Genetic Pathology Evaluation Centre of the Department of Pathology, British Columbia Cancer Agency and University of British Columbia, Vancouver, BC, Canada.

View Article and Find Full Text PDF
January 2006

Assessment of Her-1, Her-2, And Her-3 expression and Her-2 amplification in advanced stage ovarian carcinoma.

Int J Gynecol Pathol 2005 Apr;24(2):147-52

Genetic Pathology Evaluation Centre, Vancouver General Hospital and University of BC, Vancouver, BC, Canada.

View Article and Find Full Text PDF
April 2005

Hierarchical clustering analysis of tissue microarray immunostaining data identifies prognostically significant groups of breast carcinoma.

Clin Cancer Res 2004 Sep;10(18 Pt 1):6143-51

Genetic Pathology Evaluation Centre of the Department of Pathology, and Prostate Research Centre of Vancouver General Hospital, British Columbia Cancer Agency and University of British Columbia, Canada.

View Article and Find Full Text PDF
September 2004

Nuclear beta-catenin in mesenchymal tumors.

Mod Pathol 2005 Jan;18(1):68-74

Genetic Pathology Evaluation Centre, University of British Columbia, Vancouver, British Columbia, Canada.

View Article and Find Full Text PDF
January 2005