Dr. Maged Gomaa Hemida, DVM, MSc, PhD - King Faisal University - Asso Professor

Dr. Maged Gomaa Hemida

DVM, MSc, PhD

King Faisal University

Asso Professor

Al-Hufuf, Al-Ahsa | Saudi Arabia

Additional Specialties: Molecular Virology

ORCID logohttps://orcid.org/0000-0002-5986-7237

Dr. Maged Gomaa Hemida, DVM, MSc, PhD - King Faisal University - Asso Professor

Dr. Maged Gomaa Hemida

DVM, MSc, PhD

Introduction

Primary Affiliation: King Faisal University - Al-Hufuf, Al-Ahsa , Saudi Arabia

Additional Specialties:

Publications

29Publications

321Reads

7Profile Views

64PubMed Central Citations

Middle East Respiratory Syndrome Coronavirus (MERS-CoV): Infection, Immunological Response, and Vaccine Development.

J Immunol Res 2019 7;2019:6491738. Epub 2019 Apr 7.

Department of Microbiology and Parasitology, College of Veterinary Medicine, King Faisal University, Saudi Arabia.

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http://dx.doi.org/10.1155/2019/6491738DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6476043PMC
August 2019

Surveillance of the equine infectious anemia virus in Eastern and Central Saudi Arabia during 2014-2016.

Vet World 2019 May 29;12(5):719-723. Epub 2019 May 29.

Department of Microbiology and Parasitology, College of Veterinary Medicine, King Faisal University, Saudi Arabia.

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http://dx.doi.org/10.14202/vetworld.2019.719-723DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6584864PMC
May 2019

Infectious bronchitis virus from chickens in Al-Hasa, Saudi Arabia 2015-2016.

Vet World 2019 19;12(3):424-433. Epub 2019 Mar 19.

Department of Microbiology and Parasitology, College of Veterinary Medicine, King Faisal University, Saudi Arabia.

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http://www.veterinaryworld.org/Vol.12/March-2019/12.html
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http://dx.doi.org/10.14202/vetworld.2019.424-433DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6487242PMC
March 2019
7 Reads

Evidence of equine influenza A (H3N8) activity in horses from Eastern and Central Saudi Arabia: 2013-2015.

Equine Vet J 2019 Mar 25;51(2):218-221. Epub 2018 Aug 25.

School of Public Health, The University of Hong Kong, Hong Kong, China.

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http://dx.doi.org/10.1111/evj.13001DOI Listing
March 2019
11 Reads
2.374 Impact Factor

Foot-and-mouth disease virus O/ME-SA/Ind 2001 lineage outbreak in vaccinated Holstein Friesian cattle in Saudi Arabia in 2016.

Vet Q 2018 12;38(1):88-98

e Department of Pathology, College of Veterinary medicine , King Faisal University , Saudi Arabia.

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http://dx.doi.org/10.1080/01652176.2018.1539568DOI Listing
December 2018
1 Read
0.652 Impact Factor

Coronavirus infections in horses in Saudi Arabia and Oman.

Transbound Emerg Dis 2017 Dec 13;64(6):2093-2103. Epub 2017 Mar 13.

School of Public Health, The University of Hong Kong, Hong Kong, China.

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http://dx.doi.org/10.1111/tbed.12630DOI Listing
December 2017
14 Reads
2.944 Impact Factor

Molecular and serological surveillance of African horse sickness virus in eastern and central Saudi Arabia.

Rev Sci Tech 2017 12;36(3):889-898

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http://dx.doi.org/10.20506/rst.36.3.2722DOI Listing
December 2017
6 Reads
0.910 Impact Factor

Dromedary Camels and the Transmission of Middle East Respiratory Syndrome Coronavirus (MERS-CoV).

Transbound Emerg Dis 2017 Apr 10;64(2):344-353. Epub 2015 Aug 10.

The School of Public Health, The University of Hong Kong, Hong Kong, China.

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http://doi.wiley.com/10.1111/tbed.12401
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http://dx.doi.org/10.1111/tbed.12401DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4749478PMC
April 2017
3 Reads
2.944 Impact Factor

Seroprevalence of Sheep and Goat Pox, Peste Des Petits Ruminants and Rift Valley Fever in Saudi Arabia.

PLoS One 2015 13;10(10):e0140328. Epub 2015 Oct 13.

Department of Microbiology and Parasitology, College of Veterinary Medicine and Animal Resources, King Faisal University, Al-Hasa, Saudi Arabia; Department of Virology, Faculty of Veterinary Medicine, Kafrelsheikh University, Kafrelsheikh, Egypt.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0140328PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4604144PMC
June 2016
7 Reads
4 Citations
3.234 Impact Factor

Cleavage of DAP5 by coxsackievirus B3 2A protease facilitates viral replication and enhances apoptosis by altering translation of IRES-containing genes.

Cell Death Differ 2016 May 20;23(5):828-40. Epub 2015 Nov 20.

Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.1038/cdd.2015.145DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4832101PMC
May 2016
1 Read
8.184 Impact Factor

Tropism and replication of dromedary camel MERS coronavirus in ex vivo cultures of the human respiratory tract

Lancet Respir Med. 2014 Aug 28. pii: S2213-2600(14)70158-4

Lancet Respir Med.

Summary Background Middle East respiratory syndrome coronavirus (MERS-CoV) is a zoonotic infection causing severe viral pneumonia, with index cases having resided in or recently travelled to the Arabian peninsula, and is a global concern for public health. Limited human-to-human transmission, leading to some case clusters, has been reported. MERS-CoV has been reported in dromedary camels but phenotypic characterisation of such viruses is limited. We aimed to compare MERS-CoV isolates from dromedaries in Saudi Arabia and Egypt with a prototype human MERS-CoV to assess virus replication competence and cell tropism in ex-vivo cultures of human bronchus and lung. Methods We characterised MERS-CoV viruses from dromedaries in Saudi Arabia and Egypt and compared them with a human MERS-CoV reference strain. We assessed viral replication kinetics and competence in Vero-E6 cells (rhesus monkey), tissue tropism in cultures of ex-vivo human bronchial and lung tissues, and cytokine and chemokine induction, gene expression, and quantification of viral RNA in Calu-3 cells (human respiratory tract). We used mock-infected tissue as negative controls for ex-vivo experiments and influenza A H5N1 as a positive control for cytokine and chemokine induction experiments in Calu-3 cells. Findings We isolated three dromedary strains, two from Saudi Arabia (Dromedary/Al-Hasa-KFU-HKU13/2013 [AH13] and Dromedary/Al-Hasa-KFU-HKU19D/2013 [AH19D]), and one from Egypt (Dromedary/Egypt-NRCE-HKU270/2013 [NRCE-HKU270]). The human and dromedary MERS-CoV strains had similar viral replication competence in Vero-E6 cells and respiratory tropism in ex-vivo cultures of the human respiratory tract, and had similar ability to evade interferon responses in the human-respiratory-tract-derived cell line Calu-3. Interpretation The similarity of virus tropism and replication competence of human and dromedary MERS-CoV from the Arabian peninsula, and genetically diverse dromedary viruses from Egypt, in ex-vivo cultures of the human respiratory tract suggests that dromedary viruses from Saudi Arabia and Egypt are probably infectious to human beings. Exposure to zoonotic MERS-CoV is probably occurring in a wider geographical region beyond the Arabian peninsula.

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August 2014
4 Reads

Middle East Respiratory Syndrome Coronavirus in Dromedary Camel Herd, Saudi Arabia

Emerging Infectious Disease journal, Vol, 20, Issue: 7, Article ID: 14-0571

Emerging Infectious Disease journal

Ongoing transmission of Middle East respiratory syndrome coronavirus (MERS-CoV) to humans underscores the need to understand the animal sources of zoonotic infection (1,2). MERS-CoV RNA has been detected in dromedary camels (3,4), and dromedary infection precedes human infection (5). We conducted a prospective study in dromedary herds in Al-Hasa, Saudi Arabia, through the peak calving season (December 2013–February 2014) to document virologic features of MERS-CoV infection in these animals.

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July 2014
8 Reads

Seroepidemiology of Middle East respiratory syndrome (MERS) coronavirus in Saudi Arabia (1993) and Australia (2014) and characterization of assay specificity.

Eurosurveillance. Vol 19, Issue 23

Eurosurveillance

he pseudoparticle virus neutralisation test (ppNT) and a conventional microneutralisation (MN) assay are specific for detecting antibodies to Middle East respiratory syndrome coronavirus (MERS-CoV) when used in seroepidemiological studies in animals. Genetically diverse MERS-CoV appear antigenically similar in MN tests. We confirm that MERS-CoV was circulating in dromedaries in Saudi Arabia in 1993. Preliminary data suggest that feral Australian dromedaries may be free of MERS-CoV but larger confirmatory studies are needed.

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June 2014
11 Reads

Coxsackievirus-induced miR-21 disrupts cardiomyocyte interactions via the downregulation of intercalated disk components.

PLoS Pathog 2014 Apr 10;10(4):e1004070. Epub 2014 Apr 10.

Department of Pathology and Laboratory Medicine, University of British Columbia, The Centre for Heart Lung Innovation, St. Paul's Hospital, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1371/journal.ppat.1004070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3983067PMC
April 2014
16 Reads
12 Citations

Antiviral activity of an isatin derivative via induction of PERK-Nrf2-mediated suppression of cap-independent translation.

ACS Chem Biol 2014 Apr 18;9(4):1015-24. Epub 2014 Feb 18.

Department of Pathology and Laboratory Medicine, University of British Columbia, Institute for Heart and Lung Health, St. Paul's Hospital , Vancouver, BC V6Z 1Y6, Canada.

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http://dx.doi.org/10.1021/cb400775zDOI Listing
April 2014
14 Reads
5.331 Impact Factor

P58(IPK) inhibits coxsackievirus-induced apoptosis via the PI3K/Akt pathway requiring activation of ATF6a and subsequent upregulation of mitofusin 2.

Cell Microbiol 2014 Mar 6;16(3):411-24. Epub 2013 Nov 6.

Department of Pathology and Laboratory Medicine, University of British Columbia, Center for Heart Lung Innovation, St. Paul's Hospital, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1111/cmi.12229DOI Listing
March 2014
69 Reads
4.915 Impact Factor

MiR-126 promotes coxsackievirus replication by mediating cross-talk of ERK1/2 and Wnt/β-catenin signal pathways.

Cell Mol Life Sci 2013 Dec 30;70(23):4631-44. Epub 2013 Jun 30.

Department of Pathology and Laboratory Medicine, The Institute for Heart and Lung Health, St. Paul's Hospital, University of British Columbia, Rm 166, 1081 Burrard Street, Vancouver, BC, V6Z1Y6, Canada.

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http://dx.doi.org/10.1007/s00018-013-1411-4DOI Listing
December 2013
41 Reads
12 Citations
5.810 Impact Factor

Middle East Respiratory Syndrome (MERS) coronavirus seroprevalence in domestic livestock in Saudi Arabia, 2010 to 2013.

Euro Surveill 2013 Dec 12;18(50):20659. Epub 2013 Dec 12.

These authors contributed equally to this work.

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http://dx.doi.org/10.2807/1560-7917.es2013.18.50.20659DOI Listing
December 2013
2 Reads

Middle East Respiratory Syndrome (MERS) coronavirus in domestic livestock in Sauid Arabia, 2010 to 2013.

Eurosurveillance. Volume 18/ Issue 50 Article 5

Eurosurveillance

In Saudi Arabia, including regions of Riyadh and Al Ahsa, pseudoparticle neutralisation (ppNT) and microneutralisation (MNT) tests detected no antibodies to Middle East Respiratory Syndrome coronavirus (MERS-CoV) in sheep (n= 100), goats (n= 45), cattle (n= 50) and chickens (n= 240). Dromedary camels however, had a high prevalence of MERS-CoV antibodies. Bovine coronavirus (BCoV) infected sera from cattle had no cross-reactivity in MERS-CoV ppNT or MNT, while many dromedary camels’ sera reacted to both BCoV and MERS-CoV. Some nevertheless displayed specific serologic reaction profiles to MERS-CoV.

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November 2013
9 Reads

MicroRNA-203 enhances coxsackievirus B3 replication through targeting zinc finger protein-148.

Cell Mol Life Sci 2013 Jan 29;70(2):277-91. Epub 2012 Jul 29.

Department of Pathology and Laboratory Medicine, The James Hogg Research Center, The Institute for Heart and Lung Health, St. Paul's Hospital, University of British Columbia, 1081 Burrard Street, Vancouver, BC, V6Z 1Y6, Canada.

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http://dx.doi.org/10.1007/s00018-012-1104-4DOI Listing
January 2013
7 Reads
9 Citations
5.810 Impact Factor

IRES-Dependent Translational Control during Virus-Induced Endoplasmic Reticulum Stress and Apoptosis.

Front Microbiol 2012 19;3:92. Epub 2012 Mar 19.

Department of Pathology and Laboratory Medicine, The Institute for Heart and Lung Health, St. Paul's Hospital, University of British Columbia Vancouver, BC, Canada.

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http://dx.doi.org/10.3389/fmicb.2012.00092DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3307021PMC
October 2012
5 Reads
8 Citations
3.941 Impact Factor

Targeted delivery of mutant tolerant anti-coxsackievirus artificial microRNAs using folate conjugated bacteriophage Phi29 pRNA.

PLoS One 2011 15;6(6):e21215. Epub 2011 Jun 15.

Department of Pathology and Laboratory Medicine, The Institute for Heart and Lung Health, St. Paul's Hospital, University of British Columbia, Vancouver, British Columbia, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0021215PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3115994PMC
November 2011
2 Reads
15 Citations
3.234 Impact Factor

Exploiting the therapeutic potential of microRNAs in viral diseases: expectations and limitations.

Mol Diagn Ther 2010 Oct;14(5):271-82

Department of Pathology and Laboratory Medicine, University of British Columbia, Heart and Lung Institute, St Paul's Hospital, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.2165/11539540-000000000-00000DOI Listing
October 2010
8 Reads
4 Citations
2.891 Impact Factor

Top co-authors

Decheng Yang
Decheng Yang

University of British Columbia

8
Xin Ye
Xin Ye

Institute of Microbiology

8
Paul J Hanson
Paul J Hanson

St. Paul's Hospital

5
Ye Qiu
Ye Qiu

St. Paul's Hospital

5
Malik Peiris
Malik Peiris

School of Public Health

5
Huifang M Zhang
Huifang M Zhang

University of British Columbia

4
P Wang
P Wang

Hebei North University

2
Huifang Mary Zhang
Huifang Mary Zhang

University of British Columbia

2
Zhen Liu
Zhen Liu

Institute of Pharmaceutical Biology and Biotechnology

2