Magdalena Zernicka-Goetz

Magdalena Zernicka-Goetz

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Magdalena Zernicka-Goetz

Magdalena Zernicka-Goetz

Publications by authors named "Magdalena Zernicka-Goetz"

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Living a Sweet Life: Glucose Instructs Cell Fate in the Mouse Embryo.

Dev Cell 2020 Apr;53(1):1-2

Mammalian Embryo and Stem Cell Group, Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 3DY, UK; Division of Biology and Biological Engineering, California Institute of Technology, 1200 E California Blvd, Pasadena, CA 91125, USA. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2020.03.012DOI Listing
April 2020

Building an apical domain in the early mouse embryo: Lessons, challenges and perspectives.

Curr Opin Cell Biol 2020 Feb 21;62:144-149. Epub 2019 Dec 21.

Mammalian Embryo and Stem Cell Group, University of Cambridge, Department of Physiology, Development and Neuroscience, Downing Street, Cambridge, CB2 3DY, UK. Electronic address:

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http://dx.doi.org/10.1016/j.ceb.2019.11.005DOI Listing
February 2020

Self-Organization of Mouse Stem Cells into an Extended Potential Blastoid.

Dev Cell 2019 Dec;51(6):698-712.e8

Mammalian Embryo and Stem Cell Group, Department of Physiology, Development, and Neuroscience, University of Cambridge, Cambridge CB2 3DY, UK; California Institute of Technology, Division of Biology and Biological Engineering, 1200 E. California Boulevard, Pasadena, CA 91125, USA. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2019.11.014DOI Listing
December 2019

Comparative analysis of human and mouse development: From zygote to pre-gastrulation.

Curr Top Dev Biol 2020 26;136:113-138. Epub 2019 Dec 26.

University of Cambridge, Cambridge, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/bs.ctdb.2019.10.002DOI Listing
December 2019

Morphogenesis of extra-embryonic tissues directs the remodelling of the mouse embryo at implantation.

Nat Commun 2019 08 7;10(1):3557. Epub 2019 Aug 7.

Mammalian Embryo and Stem Cell Group, University of Cambridge, Department of Physiology, Development and Neuroscience, Downing Street, Cambridge, CB2 3DY, UK.

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http://dx.doi.org/10.1038/s41467-019-11482-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6686005PMC
August 2019

Delivery of mtZFNs into Early Mouse Embryos.

Methods Mol Biol 2018 ;1867:215-228

Mitochondrial Genetics Group, MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK.

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http://link.springer.com/10.1007/978-1-4939-8799-3_16
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http://dx.doi.org/10.1007/978-1-4939-8799-3_16DOI Listing
July 2019

Concerted cell divisions in embryonic visceral endoderm guide anterior visceral endoderm migration.

Dev Biol 2019 06 30;450(2):132-140. Epub 2019 Mar 30.

Mammalian Embryo and Stem Cell Group, University of Cambridge, Department of Physiology, Development and Neuroscience, Downing Street, Cambridge, CB2 3DY, UK. Electronic address:

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http://dx.doi.org/10.1016/j.ydbio.2019.03.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6553843PMC
June 2019

Self-organization of stem cells into embryos: A window on early mammalian development.

Science 2019 Jun;364(6444):948-951

Mammalian Embryo and Stem Cell Group, Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 3DY, UK.

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http://dx.doi.org/10.1126/science.aax0164DOI Listing
June 2019

Author Correction: Sequential formation and resolution of multiple rosettes drive embryo remodelling after implantation.

Nat Cell Biol 2018 Dec;20(12):1434

Mammalian Embryo and Stem Cell Group, Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1038/s41556-018-0245-6DOI Listing
December 2018

CARM1 and Paraspeckles Regulate Pre-implantation Mouse Embryo Development.

Cell 2018 12;175(7):1902-1916.e13

Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 3EG, UK. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2018.11.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292842PMC
December 2018

Sequential formation and resolution of multiple rosettes drive embryo remodelling after implantation.

Nat Cell Biol 2018 11 15;20(11):1278-1289. Epub 2018 Oct 15.

Mammalian Embryo and Stem Cell Group, Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1038/s41556-018-0211-3DOI Listing
November 2018

Publisher Correction: Self-assembly of embryonic and two extra-embryonic stem cell types into gastrulating embryo-like structures.

Nat Cell Biol 2018 Oct;20(10):1229

Mammalian Embryo and Stem Cell Group, Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1038/s41556-018-0187-zDOI Listing
October 2018

Deconstructing and reconstructing the mouse and human early embryo.

Nat Cell Biol 2018 08 23;20(8):878-887. Epub 2018 Jul 23.

Department of Physiology, Development and Neuroscience, Mammalian Embryo and Stem Cell Group, University of Cambridge, Cambridge, UK.

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http://www.nature.com/articles/s41556-018-0144-x
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http://dx.doi.org/10.1038/s41556-018-0144-xDOI Listing
August 2018

Self-assembly of embryonic and two extra-embryonic stem cell types into gastrulating embryo-like structures.

Nat Cell Biol 2018 08 23;20(8):979-989. Epub 2018 Jul 23.

Mammalian Embryo and Stem Cell Group, Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.

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http://www.nature.com/articles/s41556-018-0147-7
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http://dx.doi.org/10.1038/s41556-018-0147-7DOI Listing
August 2018

In vitro generation of mouse polarized embryo-like structures from embryonic and trophoblast stem cells.

Nat Protoc 2018 07;13(7):1586-1602

Mammalian Embryo and Stem Cell Group, Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.

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http://www.nature.com/articles/s41596-018-0005-x
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http://dx.doi.org/10.1038/s41596-018-0005-xDOI Listing
July 2018

Tracing the origin of heterogeneity and symmetry breaking in the early mammalian embryo.

Nat Commun 2018 05 8;9(1):1819. Epub 2018 May 8.

Mammalian Development and Stem Cell Group, Department of Physiology, Development & Neuroscience, University of Cambridge, Downing Street, Cambridge, CB2 3EG, UK.

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http://dx.doi.org/10.1038/s41467-018-04155-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5940674PMC
May 2018

Pluripotent state transitions coordinate morphogenesis in mouse and human embryos.

Nature 2017 12 29;552(7684):239-243. Epub 2017 Nov 29.

Mammalian Embryo and Stem Cell Group, University of Cambridge, Department of Physiology, Development and Neuroscience, Downing Street, Cambridge CB2 3EG, UK.

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http://dx.doi.org/10.1038/nature24675DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5768241PMC
December 2017

Actomyosin polarisation through PLC-PKC triggers symmetry breaking of the mouse embryo.

Nat Commun 2017 10 13;8(1):921. Epub 2017 Oct 13.

Mammalian Embryo and Stem Cell Group, Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge, CB2 3EG, UK.

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http://www.nature.com/articles/s41467-017-00977-8
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http://dx.doi.org/10.1038/s41467-017-00977-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5640629PMC
October 2017

Delayed APC/C activation extends the first mitosis of mouse embryos.

Sci Rep 2017 08 29;7(1):9682. Epub 2017 Aug 29.

The Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QN, UK.

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http://dx.doi.org/10.1038/s41598-017-09526-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5575289PMC
August 2017

Assembly of embryonic and extraembryonic stem cells to mimic embryogenesis in vitro.

Science 2017 04 2;356(6334). Epub 2017 Mar 2.

Mammalian Embryo and Stem Cell Group, University of Cambridge, Department of Physiology, Development and Neuroscience, Downing Street, Cambridge CB2 3DY, UK.

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http://dx.doi.org/10.1126/science.aal1810DOI Listing
April 2017

The chromatin modifier Satb1 regulates cell fate through Fgf signalling in the early mouse embryo.

Development 2017 04 13;144(8):1450-1461. Epub 2017 Mar 13.

Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 3EG, UK

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http://dx.doi.org/10.1242/dev.144139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5399666PMC
April 2017

The Acquisition of Cell Fate in Mouse Development: How Do Cells First Become Heterogeneous?

Curr Top Dev Biol 2016 21;117:671-95. Epub 2016 Jan 21.

Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/bs.ctdb.2015.11.021DOI Listing
December 2016

Andrzej K. Tarkowski 1933-2016.

Nat Cell Biol 2016 11;18(12):1261

University of Cambridge, Downing Street, Cambridge, CB2 3EG, UK.

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http://www.nature.com/articles/ncb3446
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http://dx.doi.org/10.1038/ncb3446DOI Listing
November 2016

Polarity and cell division orientation in the cleavage embryo: from worm to human.

Mol Hum Reprod 2016 10 9;22(10):691-703. Epub 2015 Dec 9.

Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 3DY, UK

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http://dx.doi.org/10.1093/molehr/gav068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5062000PMC
October 2016

Self-organization of the human embryo in the absence of maternal tissues.

Nat Cell Biol 2016 06 4;18(6):700-708. Epub 2016 May 4.

Mammalian Embryo and Stem Cell Group, University of Cambridge, Department of Physiology, Development and Neuroscience; Downing Street, Cambridge, CB2 3DY, UK.

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http://www.nature.com/articles/ncb3347
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5049689PMC
http://dx.doi.org/10.1038/ncb3347DOI Listing
June 2016

Self-organization of the in vitro attached human embryo.

Nature 2016 05 4;533(7602):251-4. Epub 2016 May 4.

Laboratory of Stem Cell Biology and Molecular Embryology, The Rockefeller University, New York, New York 10065, USA.

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http://dx.doi.org/10.1038/nature17948DOI Listing
May 2016

The BAF chromatin remodelling complex is an epigenetic regulator of lineage specification in the early mouse embryo.

Development 2016 Apr 7;143(8):1271-83. Epub 2016 Mar 7.

Wellcome Trust Cancer Research UK Gurdon Institute, Tennis Court Road, Cambridge CB2 1QN, UK Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 3DY, UK

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http://dx.doi.org/10.1242/dev.131961DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4852518PMC
April 2016

Heterogeneity in Oct4 and Sox2 Targets Biases Cell Fate in 4-Cell Mouse Embryos.

Cell 2016 Mar;165(1):61-74

Department of Physiology, Development & Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 3EG, UK. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2016.01.047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4819611PMC
March 2016

Mouse model of chromosome mosaicism reveals lineage-specific depletion of aneuploid cells and normal developmental potential.

Nat Commun 2016 Mar 29;7:11165. Epub 2016 Mar 29.

Department of Physiology, Development and Neuroscience and Gurdon Institute, University of Cambridge, Downing Street, Cambridge CB2 3EG, UK.

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http://dx.doi.org/10.1038/ncomms11165DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4820631PMC
March 2016

Development of the anterior-posterior axis is a self-organizing process in the absence of maternal cues in the mouse embryo.

Cell Res 2015 Dec 4;25(12):1368-71. Epub 2015 Sep 4.

Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 3DY, UK.

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http://www.nature.com/articles/cr2015104
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http://dx.doi.org/10.1038/cr.2015.104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4670986PMC
December 2015

Mapping the journey from totipotency to lineage specification in the mouse embryo.

Curr Opin Genet Dev 2015 Oct 3;34:71-6. Epub 2015 Sep 3.

Department of Physiology, Development and Neuroscience, University of Cambridge, Anatomy Building, Downing Street, Cambridge CB2 3DY, United Kingdom. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0959437X150008
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http://dx.doi.org/10.1016/j.gde.2015.08.002DOI Listing
October 2015

G&T-seq: parallel sequencing of single-cell genomes and transcriptomes.

Nat Methods 2015 Jun 27;12(6):519-22. Epub 2015 Apr 27.

1] Sanger Institute-EBI Single-Cell Genomics Centre, Wellcome Trust Sanger Institute, Hinxton, UK. [2] Department of Human Genetics, University of Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1038/nmeth.3370DOI Listing
June 2015

Cell death and morphogenesis during early mouse development: are they interconnected?

Bioessays 2015 Apr 15;37(4):372-8. Epub 2015 Jan 15.

Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK; Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1002/bies.201400147DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4409078PMC
April 2015

Maternal-zygotic knockout reveals a critical role of Cdx2 in the morula to blastocyst transition.

Dev Biol 2015 Feb 13;398(2):147-52. Epub 2014 Dec 13.

Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Site, Cambridge CB2 3DY, UK.

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http://dx.doi.org/10.1016/j.ydbio.2014.12.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4319684PMC
February 2015

From pluripotency to differentiation: laying foundations for the body pattern in the mouse embryo.

Philos Trans R Soc Lond B Biol Sci 2014 Dec;369(1657)

Developmental Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA

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http://dx.doi.org/10.1098/rstb.2013.0535DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4216458PMC
December 2014

Developmental plasticity, cell fate specification and morphogenesis in the early mouse embryo.

Philos Trans R Soc Lond B Biol Sci 2014 Dec;369(1657)

Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 3DY, UK

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http://dx.doi.org/10.1098/rstb.2013.0538DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4216461PMC
December 2014

In vitro culture of mouse blastocysts beyond the implantation stages.

Nat Protoc 2014 Dec 30;9(12):2732-9. Epub 2014 Oct 30.

1] Department of Physiology, Development and Neuroscience, Downing Site, University of Cambridge, Cambridge, UK. [2] Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1038/nprot.2014.186DOI Listing
December 2014

The basal position of nuclei is one pre-requisite for asymmetric cell divisions in the early mouse embryo.

Dev Biol 2014 Aug 20;392(2):133-40. Epub 2014 May 20.

The Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK; Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 3DY, UK. Electronic address:

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http://dx.doi.org/10.1016/j.ydbio.2014.05.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4111899PMC
August 2014

A tribute to Sir John Gurdon.

Differentiation 2014 Jul 20;88(1):1-2. Epub 2014 Nov 20.

Scientific Head, Mammalian Development and Stem Cells Group, University of Cambridge, Professor of Mammalian Development and Stem Cell Biology, Department of Physiology, Development & Neuroscience, University of Cambridge, UKWellcome Trust Senior Research Fellow. Electronic address:

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http://dx.doi.org/10.1016/j.diff.2014.11.001DOI Listing
July 2014

Citrullination regulates pluripotency and histone H1 binding to chromatin.

Nature 2014 Mar 26;507(7490):104-8. Epub 2014 Jan 26.

1] The Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK [2] Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK.

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http://dx.doi.org/10.1038/nature12942DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4843970PMC
March 2014

Angiomotin prevents pluripotent lineage differentiation in mouse embryos via Hippo pathway-dependent and -independent mechanisms.

Nat Commun 2013 ;4:2251

The Wellcome Trust/Cancer Research UK Gurdon Institute, the Henry Wellcome Building of Cancer and Developmental Biology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK.

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http://dx.doi.org/10.1038/ncomms3251DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3741640PMC
February 2014

Self-organizing properties of mouse pluripotent cells initiate morphogenesis upon implantation.

Cell 2014 Feb 13;156(5):1032-44. Epub 2014 Feb 13.

Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK; Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 3DY, UK. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2014.01.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3991392PMC
February 2014

Spindle formation in the mouse embryo requires Plk4 in the absence of centrioles.

Dev Cell 2013 Dec 21;27(5):586-97. Epub 2013 Nov 21.

Pluripotency and Differentiation in Early Mouse Development Group, Gurdon Institute and Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 1QN, UK. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2013.09.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3898710PMC
December 2013

The differential response to Fgf signalling in cells internalized at different times influences lineage segregation in preimplantation mouse embryos.

Open Biol 2013 Nov 20;3(11):130104. Epub 2013 Nov 20.

Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK.

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http://dx.doi.org/10.1098/rsob.130104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3843820PMC
November 2013

Quality control of embryo development.

Mol Aspects Med 2013 Oct 4;34(5):903-18. Epub 2013 Apr 4.

Department of Embryology, University of Warsaw, Miecznikowa 1, 02-096 Warsaw, Poland.

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http://dx.doi.org/10.1016/j.mam.2013.03.001DOI Listing
October 2013

Asymmetric localization of Cdx2 mRNA during the first cell-fate decision in early mouse development.

Cell Rep 2013 Feb 31;3(2):442-57. Epub 2013 Jan 31.

The Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, United Kingdom.

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http://dx.doi.org/10.1016/j.celrep.2013.01.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3607255PMC
February 2013

Formation of distinct cell types in the mouse blastocyst.

Results Probl Cell Differ 2012 ;55:203-17

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1007/978-3-642-30406-4_11DOI Listing
January 2013

Development: do mouse embryos play dice?

Curr Biol 2013 Jan;23(1):R15-7

Gurdon Institute, University of Cambridge, Cambridge CB2 1QN, UK.

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http://dx.doi.org/10.1016/j.cub.2012.10.032DOI Listing
January 2013

Advances in embryo selection methods.

F1000 Biol Rep 2012 1;4:11. Epub 2012 Jun 1.

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http://dx.doi.org/10.3410/B4-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3369238PMC
October 2012

Developmental plasticity is bound by pluripotency and the Fgf and Wnt signaling pathways.

Cell Rep 2012 Oct 4;2(4):756-65. Epub 2012 Oct 4.

Wellcome Trust/Cancer Research Gurdon Institute, Cambridge CB2 1QN, UK.

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http://dx.doi.org/10.1016/j.celrep.2012.08.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3607220PMC
October 2012

Protein arginine methyltransferase 6 regulates embryonic stem cell identity.

Stem Cells Dev 2012 Sep 8;21(14):2613-22. Epub 2012 May 8.

Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.

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http://dx.doi.org/10.1089/scd.2011.0330DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5729635PMC
September 2012

Proclaiming fate in the early mouse embryo.

Nat Cell Biol 2011 Feb;13(2):112-4

Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge, UK.

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http://dx.doi.org/10.1038/ncb0211-112DOI Listing
February 2011

The chromosome passenger complex is required for fidelity of chromosome transmission and cytokinesis in meiosis of mouse oocytes.

J Cell Sci 2010 Dec;123(Pt 24):4292-300

University of Cambridge, Wellcome Trust and Cancer Research UK Gurdon Institute, Tennis Court Road, Cambridge, UK CB2 1NR.

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http://dx.doi.org/10.1242/jcs.067447DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2995614PMC
December 2010

Stochasticity versus determinism in development: a false dichotomy?

Nat Rev Genet 2010 Nov 28;11(11):743-4. Epub 2010 Sep 28.

The Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK.

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http://dx.doi.org/10.1038/nrg2886DOI Listing
November 2010

Developmental control of the early mammalian embryo: competition among heterogeneous cells that biases cell fate.

Curr Opin Genet Dev 2010 Oct 14;20(5):485-91. Epub 2010 Jun 14.

The Gurdon Institute, University of Cambridge, Cambridge CB2 1QN, United Kingdom.

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http://dx.doi.org/10.1016/j.gde.2010.05.006DOI Listing
October 2010

Epigenetic modification affecting expression of cell polarity and cell fate genes to regulate lineage specification in the early mouse embryo.

Mol Biol Cell 2010 Aug 16;21(15):2649-60. Epub 2010 Jun 16.

Wellcome Trust/CR UK Gurdon Institute, Cambridge CB2 1QN, United Kingdom.

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http://dx.doi.org/10.1091/mbc.E10-01-0053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2912351PMC
August 2010

Origin and formation of the first two distinct cell types of the inner cell mass in the mouse embryo.

Proc Natl Acad Sci U S A 2010 Apr 22;107(14):6364-9. Epub 2010 Mar 22.

Department of Physiology, Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge, Cambridge CB2 3EH, United Kingdom.

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http://dx.doi.org/10.1073/pnas.0915063107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2852013PMC
April 2010

Making a firm decision: multifaceted regulation of cell fate in the early mouse embryo.

Nat Rev Genet 2009 Jul;10(7):467-77

The Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK. m.zernicka-goetz@

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http://dx.doi.org/10.1038/nrg2564DOI Listing
July 2009

Pluripotency and differentiation in embryos and stem cells.

Int J Dev Biol 2008 ;52(7):801-9

Molecular Embryology and Aging group, Max Planck Institute for Molecular Genetics, Berlin, Germany.

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http://dx.doi.org/10.1387/ijdb.082695jaDOI Listing
January 2009

Maternal Argonaute 2 is essential for early mouse development at the maternal-zygotic transition.

Mol Biol Cell 2008 Oct 13;19(10):4383-92. Epub 2008 Aug 13.

Wellcome Trust/Cancer Research UK Gurdon Institute, Cambridge, CB2 1NR, United Kingdom.

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http://dx.doi.org/10.1091/mbc.e08-02-0219DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2555945PMC
October 2008

Bone morphogenetic protein 4 signaling regulates development of the anterior visceral endoderm in the mouse embryo.

Dev Growth Differ 2008 Sep;50(7):615-21

The Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK.

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http://doi.wiley.com/10.1111/j.1440-169X.2008.01059.x
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http://dx.doi.org/10.1111/j.1440-169X.2008.01059.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3342679PMC
September 2008

Regionalization of the mouse visceral endoderm as the blastocyst transforms into the egg cylinder.

BMC Dev Biol 2007 Aug 16;7:96. Epub 2007 Aug 16.

Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QR, UK.

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http://dx.doi.org/10.1186/1471-213X-7-96DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1978209PMC
August 2007

Dishevelled proteins regulate cell adhesion in mouse blastocyst and serve to monitor changes in Wnt signaling.

Dev Biol 2007 Feb 22;302(1):40-9. Epub 2006 Aug 22.

The Wellcome Trust/Cancer Research UK Gurdon Institute of Cancer and Developmental Biology and Department of Genetics, University of Cambridge, Cambridge, UK.

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http://linkinghub.elsevier.com/retrieve/pii/S001216060601106
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http://dx.doi.org/10.1016/j.ydbio.2006.08.036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3353122PMC
February 2007

Novel gene expression patterns along the proximo-distal axis of the mouse embryo before gastrulation.

BMC Dev Biol 2007 Feb 15;7. Epub 2007 Feb 15.

The Wellcome Trust/Cancer Research UK Gurdon Institute of Cancer and Developmental Biology, Tennis Court Rd, Cambridge, UK.

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http://dx.doi.org/10.1186/1471-213X-7-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1821012PMC
February 2007

Histone arginine methylation regulates pluripotency in the early mouse embryo.

Nature 2007 Jan;445(7124):214-8

The Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK.

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http://www.nature.com/articles/nature05458
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http://dx.doi.org/10.1038/nature05458DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3353120PMC
January 2007

Dynamic distribution of the replacement histone variant H3.3 in the mouse oocyte and preimplantation embryos.

Int J Dev Biol 2006 ;50(5):455-61

The Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge, U.K.

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http://dx.doi.org/10.1387/ijdb.052073mtDOI Listing
August 2006

The first cell-fate decisions in the mouse embryo: destiny is a matter of both chance and choice.

Curr Opin Genet Dev 2006 Aug 23;16(4):406-12. Epub 2006 Jun 23.

The Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK.

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http://dx.doi.org/10.1016/j.gde.2006.06.011DOI Listing
August 2006

Role of TIF1alpha as a modulator of embryonic transcription in the mouse zygote.

J Cell Biol 2006 Jul;174(3):329-38

The Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge, Cambridge CB2 1QR, England, UK.

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http://dx.doi.org/10.1083/jcb.200603146DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2064229PMC
July 2006

Asymmetric positioning and organization of the meiotic spindle of mouse oocytes requires CDC42 function.

Curr Biol 2006 Jun;16(12):1249-54

The Wellcome Trust/Cancer Research UK Gurdon Institute of Cancer and Developmental Biology and Department of Genetics, University of Cambridge, Cambridge CB2 1QR, United Kingdom.

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http://linkinghub.elsevier.com/retrieve/pii/S096098220601606
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http://dx.doi.org/10.1016/j.cub.2006.05.023DOI Listing
June 2006

Regionalised signalling within the extraembryonic ectoderm regulates anterior visceral endoderm positioning in the mouse embryo.

Mech Dev 2006 Apr 3;123(4):288-96. Epub 2006 Mar 3.

The Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK.

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http://dx.doi.org/10.1016/j.mod.2006.01.004DOI Listing
April 2006

Cleavage pattern and emerging asymmetry of the mouse embryo.

Nat Rev Mol Cell Biol 2005 Dec;6(12):919-28

The Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QR, UK.

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http://dx.doi.org/10.1038/nrm1782DOI Listing
December 2005

PAR-1 and the microtubule-associated proteins CLASP2 and dynactin-p50 have specific localisation on mouse meiotic and first mitotic spindles.

Reproduction 2005 Sep;130(3):311-20

University of Cambridge, The Wellcome Trust/Cancer Research UK Gurdon Institute of Cancer and Developmental Biology, Tennis Court Road, Cambridge CB2 1QR, UK.

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http://dx.doi.org/10.1530/rep.1.00651DOI Listing
September 2005

Spatial arrangement of individual 4-cell stage blastomeres and the order in which they are generated correlate with blastocyst pattern in the mouse embryo.

Mech Dev 2005 Apr 18;122(4):487-500. Epub 2004 Dec 18.

Wellcome Trust/Cancer Research UK, Gurdon Institute, Tennis Court Road, Cambridge CB2 1QR, UK.

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http://dx.doi.org/10.1016/j.mod.2004.11.014DOI Listing
April 2005

The first cleavage of the mouse zygote predicts the blastocyst axis.

Nature 2005 Mar;434(7031):391-5

Wellcome Trust and Cancer Research UK Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK.

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http://dx.doi.org/10.1038/nature03388DOI Listing
March 2005

Four-cell stage mouse blastomeres have different developmental properties.

Development 2005 Feb 5;132(3):479-90. Epub 2005 Jan 5.

Wellcome Trust/Cancer Research UK Gurdon Institute and Department of Genetics, Tennis Court Road, Cambridge CB2 1QR, UK.

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http://dx.doi.org/10.1242/dev.01602DOI Listing
February 2005

Downregulation of Par3 and aPKC function directs cells towards the ICM in the preimplantation mouse embryo.

J Cell Sci 2005 Feb 18;118(Pt 3):505-15. Epub 2005 Jan 18.

Wellcome Trust and Cancer Research UK Gurdon Institute, Tennis Court Road, Cambridge CB2 1QR, UK.

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http://dx.doi.org/10.1242/jcs.01666DOI Listing
February 2005