Magali Giral

Magali Giral

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Magali Giral

Magali Giral

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Terminally Differentiated Effector Memory CD8 T Cells Identify Kidney Transplant Recipients at High Risk of Graft Failure.

J Am Soc Nephrol 2020 Mar 12. Epub 2020 Mar 12.

Université de Nantes, Inserm, Centre de Recherche en Transplantation et Immunologie (CRTI), UMR 1064, Nantes, France;

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http://dx.doi.org/10.1681/ASN.2019080847DOI Listing
March 2020

External Validation of the DynPG for Kidney Transplant Recipients.

Transplantation 2020 Feb 27. Epub 2020 Feb 27.

INSERM UMR 1246 - SPHERE, Nantes University, Tours University, Nantes, France.

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http://dx.doi.org/10.1097/TP.0000000000003209DOI Listing
February 2020

Unique and specific Proteobacteria diversity in urinary microbiota of tolerant kidney transplanted recipients.

Am J Transplant 2020 Jan 9;20(1):145-158. Epub 2019 Sep 9.

Centre de Recherche en Transplantation et Immunologie UMR1064, INSERM, Université de Nantes, Nantes, France.

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http://dx.doi.org/10.1111/ajt.15549DOI Listing
January 2020

Comparison of longitudinal quality of life outcomes in preemptive and dialyzed patients on waiting list for kidney transplantation.

Qual Life Res 2019 Nov 29. Epub 2019 Nov 29.

UMR INSERM 1246, SPHERE "MethodS in Patient-centered outcomes and HEalth ResEarch", Université de Nantes, Université de Tours, 22 Boulevard Benoni Goullin, Nantes, France.

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http://dx.doi.org/10.1007/s11136-019-02372-wDOI Listing
November 2019

Analyses of the short- and long-term graft survival after kidney transplantation in Europe between 1986 and 2015.

Kidney Int 2018 11 24;94(5):964-973. Epub 2018 Jul 24.

Department of Microbiology and Immunology, KU Leuven, University of Leuven, Leuven, Belgium; Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Leuven, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.kint.2018.05.018DOI Listing
November 2018

Optimal threshold estimator of a prognostic marker by maximizing a time-dependent expected utility function for a patient-centered stratified medicine.

Stat Methods Med Res 2018 06 20;27(6):1847-1859. Epub 2016 Oct 20.

1 EA 4275 SPHERE - methodS in Patient-centered outcomes & HEalth ResEarch, Nantes University, France.

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http://dx.doi.org/10.1177/0962280216671161DOI Listing
June 2018

Increased degradation of ATP is driven by memory regulatory T cells in kidney transplantation tolerance.

Kidney Int 2018 05 15;93(5):1154-1164. Epub 2018 Feb 15.

Centre de Recherche en Transplantation et Immunologie UMR 1064, INSERM, Université de Nantes, Nantes, France; Institut de Transplantation Urologie Néphrologie (ITUN), CHU Nantes, Nantes, France; LabEx IGO "Immunotherapy, Graft, Oncology," Nantes, France; Centre d'Investigation Clinique (CIC) Biothérapie, CHU Nantes, Nantes, France. Electronic address:

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http://dx.doi.org/10.1016/j.kint.2017.12.004DOI Listing
May 2018

Horizontal mixture model for competing risks: a method used in waitlisted renal transplant candidates.

Eur J Epidemiol 2018 03 30;33(3):275-286. Epub 2017 Oct 30.

Université de Nantes, Université de Tours, INSERM, SPHERE (INSERM U1246): methodS in Patient-centered outcomes and HEalth ResEarch - IRS2, 22 Boulevard Bénoni Goullin, 44200, Nantes, France.

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http://dx.doi.org/10.1007/s10654-017-0322-3DOI Listing
March 2018

A multistate additive relative survival semi-Markov model.

Stat Methods Med Res 2017 Aug 7;26(4):1700-1711. Epub 2015 Jun 7.

1 EA 4275 - SPHERE - bioStatistics, Pharmacoepidemiology and Human sciEnces REsearch team, Université de Nantes, Nantes, France.

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http://dx.doi.org/10.1177/0962280215586456DOI Listing
August 2017

A composite score associated with spontaneous operational tolerance in kidney transplant recipients.

Kidney Int 2017 06 24;91(6):1473-1481. Epub 2017 Feb 24.

Centre de Recherche en Transplantation et Immunologie UMR1064, INSERM, Université de Nantes, Nantes, France; Institut de Transplantation Urologie Néphrologie (ITUN), CHU Nantes, Nantes, France; CIC Biotherapy, CHU Nantes, Nantes, France. Electronic address:

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http://dx.doi.org/10.1016/j.kint.2016.12.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5432017PMC
June 2017

Sialylation of antibodies in kidney recipients with de novo donor specific antibody, with or without antibody mediated rejection.

Hum Immunol 2016 Nov 10;77(11):1076-1083. Epub 2015 Nov 10.

Institut National de la Sante Et de la Recherche Médicale INSERM U1064, and Institut de Transplantation Urologie Néphrologie du Centre Hospitalier Universitaire Hôtel Dieu, LabEx Transplantex, CHU de Nantes, 30 Boulevard Jean Monnet, 44093 Nantes Cedex 01, France; CIC Biothérapie, 5, allée de l'Ile Gloriette, 44093 Nantes Cedex 0144035, Nantes, France; CHU Nantes, CRB, 9 quai Moncousu, 44093 Nantes Cedex 1, Nantes F-44093, France. Electronic address:

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http://dx.doi.org/10.1016/j.humimm.2015.10.021DOI Listing
November 2016

The DESCARTES-Nantes survey of kidney transplant recipients displaying clinical operational tolerance identifies 35 new tolerant patients and 34 almost tolerant patients.

Nephrol Dial Transplant 2016 06 12;31(6):1002-13. Epub 2016 Jan 12.

Nephrology-Renal Transplantation Department, Universitair Ziekenhuis Antwerp, Antwerp, Belgium Université Libre de Bruxelles (ULB), Brussels, Belgium.

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http://dx.doi.org/10.1093/ndt/gfv437DOI Listing
June 2016

A joint model for longitudinal and time-to-event data to better assess the specific role of donor and recipient factors on long-term kidney transplantation outcomes.

Eur J Epidemiol 2016 05 1;31(5):469-79. Epub 2016 Feb 1.

EA4275 SPHERE - bioStatistics, Pharmacoepidemiology and Human sciEnces REsearch, Nantes University, 1 rue Gaston Veil, 44035, Nantes, France.

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http://dx.doi.org/10.1007/s10654-016-0121-2DOI Listing
May 2016

Comparison of survival outcomes between Expanded Criteria Donor and Standard Criteria Donor kidney transplant recipients: a systematic review and meta-analysis.

Transpl Int 2016 Apr 12;29(4):403-15. Epub 2016 Feb 12.

EA 4275 SPHERE - bioStatistics, Pharmacoepidemiology and Human sciEnces REsearch, Nantes University, Nantes, France.

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http://dx.doi.org/10.1111/tri.12736DOI Listing
April 2016

Comparisons of the performance of different statistical tests for time-to-event analysis with confounding factors: practical illustrations in kidney transplantation.

Stat Med 2016 Mar 29;35(7):1103-16. Epub 2015 Oct 29.

SPHERE (EA 4275): bioStatistics, Pharmacoepidemiology & Human sciEnces REsearch, University of Nantes, Nantes, France.

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http://dx.doi.org/10.1002/sim.6777DOI Listing
March 2016

Vitamin D deficiency is an independent risk factor for PTDM after kidney transplantation.

Transpl Int 2016 Feb 29;29(2):207-15. Epub 2015 Oct 29.

Institute of Transplantation, Urology and Nephrology (ITUN), Nantes University Hospital, Nantes, France.

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http://doi.wiley.com/10.1111/tri.12697
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http://dx.doi.org/10.1111/tri.12697DOI Listing
February 2016

Tolerant Kidney Transplant Patients Produce B Cells with Regulatory Properties.

J Am Soc Nephrol 2015 Oct 2;26(10):2588-98. Epub 2015 Feb 2.

Joint Research Unit 1064, French Institute of Health and Medical Research, Nantes, France; Faculty of Medicine, Nantes University, Nantes, France; and Institute of Transplantation Urology and Nephrology, Nantes University Hospital, Nantes, France

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http://dx.doi.org/10.1681/ASN.2014040404DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4587683PMC
October 2015

Central Role of CD45RA- Foxp3hi Memory Regulatory T Cells in Clinical Kidney Transplantation Tolerance.

J Am Soc Nephrol 2015 Aug 2;26(8):1795-805. Epub 2015 Jan 2.

French Institute of Health and Medical Research Unit 1064, Research Institute on Urology, Nephrology, and Transplantation, and Biotherapy Clinical Investigation Center, Hôtel Dieu University Hospital, Nantes, France; and

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http://dx.doi.org/10.1681/ASN.2014050480DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4520169PMC
August 2015

Reconsidering the detection of tolerance to individualize immunosuppression minimization and to improve long-term kidney graft outcomes.

Transpl Int 2015 Aug 21;28(8):938-59. Epub 2015 Apr 21.

INSERM, UMR 1064, Nantes, France.

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http://dx.doi.org/10.1111/tri.12578DOI Listing
August 2015

Long term outcomes of transplantation using kidneys from expanded criteria donors: prospective, population based cohort study.

BMJ 2015 Jul 31;351:h3557. Epub 2015 Jul 31.

Paris Translational Research Centre for Organ Transplantation, INSERM, UMR-S970, Paris Descartes University, 75015 Paris, France DIVAT (Données Informatiques VAlidées en Transplantation Network), France Department of Kidney Transplantation, Necker Hospital, Assistance Publique Hôpitaux de Paris, Sorbonne Paris

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http://www.bmj.com/content/bmj/351/bmj.h3557.full.pdf
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4521904PMC
http://dx.doi.org/10.1136/bmj.h3557DOI Listing
July 2015

Differential modulation of donor-specific antibodies after B-cell depleting therapies to cure chronic antibody mediated rejection.

Transplantation 2015 Jan;99(1):63-8

1 Institut National de la Sante Et de la Recherche Medicale INSERM U1064, Nantes, France. 2 Institut de Transplantation Urologie Néphrologie du Centre Hospitalier Universitaire Hôtel Dieu, Nantes, France. 3 Etablissement Français du Sang (EFS), Laboratoire HLA, Nantes, France. 4 Service D'anatomie Pathologique, Centre Hospitalier Universitaire Hôtel Dieu, Nantes, France. 5 Faculté De Médecine, Université de Nantes, Nantes, France. 6 CIC Biotherapy, Centre Hospitalier Universitaire Hôtel Dieu, Nantes, France.

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http://pdfs.journals.lww.com/transplantjournal/2015/01150/Di
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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/TP.0000000000000285DOI Listing
January 2015

A useful scoring system for the prediction and management of delayed graft function following kidney transplantation from cadaveric donors.

Kidney Int 2014 Dec 4;86(6):1130-9. Epub 2014 Jun 4.

1] Institut de Transplantation et de Recherche en Transplantation, ITUN, CHU Nantes, RTRS « Centaure », Nantes and Inserm U1064 (Immunointervention dans les Allo et Xénotransplantation), Nantes University, boulevard Jean Monnet, Nantes, France [2] EA 4275 SPHERE-Biostatistics, Clinical Research and Pharmaco-Epidemiology, Nantes University, Nantes, France.

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http://dx.doi.org/10.1038/ki.2014.188DOI Listing
December 2014

Expansion of highly differentiated cytotoxic terminally differentiated effector memory CD8+ T cells in a subset of clinically stable kidney transplant recipients: a potential marker for late graft dysfunction.

J Am Soc Nephrol 2014 Aug 20;25(8):1856-68. Epub 2014 Mar 20.

Institut National de la Santé et de la Recherche Médicale, Unité Mixte de Recherche 1064, Nantes, France; Centre Hospitalier Universitaire de Nantes, Institut de Transplantation Urologie-Néphrologie, Nantes, France; Faculté de Médecine, Université de Nantes, Nantes, France;

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http://dx.doi.org/10.1681/ASN.2013080848DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116064PMC
August 2014

Net time-dependent ROC curves: a solution for evaluating the accuracy of a marker to predict disease-related mortality.

Stat Med 2014 Jun 8;33(14):2379-89. Epub 2014 Jan 8.

SPHERE EA 4275 Biostatistics, Clinical Research and Subjective Measurements in Health Sciences, University of Nantes, 1 rue Gaston Veil, 44035 Nantes, France.

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http://dx.doi.org/10.1002/sim.6079DOI Listing
June 2014

MicroRNAs, Major Players in B Cells Homeostasis and Function.

Front Immunol 2014 11;5:98. Epub 2014 Mar 11.

Institut National de la Santé et de la Recherche Médicale, U1064, Institut de Transplantation Urologie Néphrologie , Nantes , France ; Faculté de Médecine, Université de Nantes , Nantes , France ; Centre Hospitalier Universitaire, Hôtel Dieu , Nantes , France.

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http://dx.doi.org/10.3389/fimmu.2014.00098DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3949129PMC
June 2014

An original approach was used to better evaluate the capacity of a prognostic marker using published survival curves.

J Clin Epidemiol 2014 Apr;67(4):441-8

Department of Biostatistics, Pharmacoepidemiology and Subjective Measures in Health Sciences, EA 4275, Nantes University, 1 rue Gaston Veil, 44035 Nantes, France.

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http://dx.doi.org/10.1016/j.jclinepi.2013.10.022DOI Listing
April 2014

An alternative approach to estimate age-related mortality of kidney transplant recipients compared to the general population: results in favor of old-to-old transplantations.

Transpl Int 2014 Feb 20;27(2):219-25. Epub 2013 Dec 20.

EA 4275 Biostatistics, Clinical Research and Subjective Measures in Health Sciences, Nantes University, Nantes, France; Institut de Transplantation Urologie Néphrologie (ITUN), Nantes Hospital and University, INSERM 1064, CENTAURE, Nantes, France.

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http://dx.doi.org/10.1111/tri.12241DOI Listing
February 2014

Influence of anemia on patient and graft survival after renal transplantation: results from the French DIVAT cohort.

Transplantation 2014 Jan;97(2):168-75

1 Service de Néphrologie, CHU Lapeyronie, Université de Montpellier, Montpellier, France. 2 Institut de Transplantation et de Recherche en Transplantation, CHU Nantes, RTRS « Centaure », et Inserm U1064, Université de Nantes, Nantes, France. 3 Service de Transplantation Rénale et de Soins Intensifs, Hôpital Necker, Paris, France. 4 Universités Paris Descartes et Sorbonne Paris Cité, Paris, France. 5 Service de Néphrologie et Transplantation Rénale, CHU Brabois, Nancy, France. 6 Service de Néphrologie, HTA, Dialyse et Transplantation d'Organes, CHU Rangueil, Toulouse, France. 7 Université Paul Sabatier, Toulouse, France. 8 Service de Néphrologie, Transplantation et Immunologie Clinique, Hôpital Edouard Herriot, Lyon, France. 9 Address correspondence to: Georges Mourad, M.D., Service de Néphrologie, Dialyse et Transplantation, Hôpital Lapeyronie, University of Montpellier, Montpellier 05, France.

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http://dx.doi.org/10.1097/TP.0b013e3182a94a4dDOI Listing
January 2014

Comparison of the risk factors effects between two populations: two alternative approaches illustrated by the analysis of first and second kidney transplant recipients.

BMC Med Res Methodol 2013 Aug 6;13:102. Epub 2013 Aug 6.

Department of Biostatistics EA 4275, Clinical Research and Subjective Measures in Health Sciences, University of Nantes, 1 rue Gaston Veil, Nantes 44035, France.

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http://dx.doi.org/10.1186/1471-2288-13-102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3750352PMC
August 2013

Adherence with immunosuppressive treatment after transplantation: results from the French trial PREDICT.

Clin Transplant 2012 May-Jun;26(3):E293-9

Maladies de l'Appareil Digestif et de Nutrition, Pôle Médicochirurgical Huriez, Hopital Claude Huriez, CHRU Lille, Lille, France.

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http://dx.doi.org/10.1111/j.1399-0012.2012.01652.xDOI Listing
December 2012

Upregulation of miR-142-3p in peripheral blood mononuclear cells of operationally tolerant patients with a renal transplant.

J Am Soc Nephrol 2012 Apr 26;23(4):597-606. Epub 2012 Jan 26.

Institut National de la Santé Et de la Recherche Médicale UMR643 and Institut de Transplantation Urologie, Néphrologie, Nantes, France.

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http://www.jasn.org/cgi/doi/10.1681/ASN.2011060543
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http://dx.doi.org/10.1681/ASN.2011060543DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3312506PMC
April 2012

Profiling posttransplant circulating antibodies in kidney transplantation using donor endothelial cells.

Transplantation 2012 Feb;93(3):257-64

INSERM UMR643, Institute for Transplantation, Urology and Nephrology, CHU de Nantes, Université de Nantes, Faculté de Médecine, Nantes, France.

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http://dx.doi.org/10.1097/TP.0b013e31823ec0ecDOI Listing
February 2012

Cut-off estimation and medical decision making based on a continuous prognostic factor: the prediction of kidney graft failure.

Int J Biostat 2012 Jan 6;8(1). Epub 2012 Jan 6.

Institut of Transplantation and Research in Transplantation, Department of Biostatistics, Nantes University.

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http://www.degruyter.com/view/j/ijb.2012.8.issue-1/1557-4679
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http://dx.doi.org/10.2202/1557-4679.1215DOI Listing
January 2012

Six months anti-viral prophylaxis significantly decreased cytomegalovirus disease compared with no anti-viral prophylaxis following renal transplantation.

Transpl Int 2010 Sep 10;23(9):897-906. Epub 2010 Mar 10.

Institut de Transplantation et de Recherche en Transplantation, ITERT, Nantes University Hospital, Nantes, France.

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http://dx.doi.org/10.1111/j.1432-2277.2010.01073.xDOI Listing
September 2010

Bortezomib in the treatment of antibody-mediated rejection--a report of 3 cases.

Clin Transpl 2009 :361-8

INSERM 643, Institut de Transplantation et de Recherche en Transplantation (ITERT), Universite de Nantes, France.

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July 2010

Kidney and recipient weight incompatibility reduces long-term graft survival.

J Am Soc Nephrol 2010 Jun 20;21(6):1022-9. Epub 2010 May 20.

Institut de Transplantation et de Recherche en Transplantation, ITERT, CHU Nantes, Réseau Thématique de Recherche et de Soins Centaure, Nantes and INSERM U643 (Immunointervention dans les Allo et Xénotransplantation), Centre d'Investigation Clinique biothérapie, 30 bd Jean Monnet, 44093, Nantes, France.

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http://dx.doi.org/10.1681/ASN.2009121296DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2900958PMC
June 2010

Regulatory, effector, and cytotoxic T cell profiles in long-term kidney transplant patients.

J Am Soc Nephrol 2009 May 8;20(5):1113-22. Epub 2009 Apr 8.

INSERM, U643, Institut de Transplantation et de Recherche en Transplantation, Centre Hospitalier Universitaire de Nantes, Nantes, France.

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http://dx.doi.org/10.1681/ASN.2008050450DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2678031PMC
May 2009

Can immune monitoring help to minimize immunosuppression in kidney transplantation?

Transpl Int 2009 Jan 1;22(1):110-9. Epub 2008 Sep 1.

INSERM, Institute de Transplantation Et de Recherche en Transplantation, Nantes, France.

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http://dx.doi.org/10.1111/j.1432-2277.2008.00748.xDOI Listing
January 2009

Tribbles-1 as a novel biomarker of chronic antibody-mediated rejection.

J Am Soc Nephrol 2008 Jun 27;19(6):1116-27. Epub 2008 Mar 27.

INSERM U643, Centre Hospitalier Universitaire Nantes, Institut de Transplantation et de Recherche en Transplantation, Nantes, France.

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http://dx.doi.org/10.1681/ASN.2007101056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2396937PMC
June 2008

A semi-Markov model for multistate and interval-censored data with multiple terminal events. Application in renal transplantation.

Stat Med 2007 Dec;26(30):5381-93

Laboratoire de Biostatistique, Institut Universitaire de Recherche Clinique, 641 av. du doyen Gaston Giraud, 34093 Montpellier, France.

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http://dx.doi.org/10.1002/sim.3100DOI Listing
December 2007

Identification of a peripheral blood transcriptional biomarker panel associated with operational renal allograft tolerance.

Proc Natl Acad Sci U S A 2007 Sep 14;104(39):15448-53. Epub 2007 Sep 14.

Institut National de la Santé et de la Recherche Médicale, U643, Centre Hospitalier Universitaire de Nantes, Institut de Transplantation et de Recherche en Transplantation, and Université de Nantes, Faculte de Medicine, F-44000 Nantes, France.

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http://www.pnas.org/content/104/39/15448.full.pdf
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http://www.pnas.org/cgi/doi/10.1073/pnas.0705834104
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http://dx.doi.org/10.1073/pnas.0705834104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2000539PMC
September 2007

Effect of brain-dead donor resuscitation on delayed graft function: results of a monocentric analysis.

Transplantation 2007 May;83(9):1174-81

Institut de Transplantation Et de Recherche en Transplantation and INSERM U643, Immunointervention dans les Allo et Xénotransplantation, Nantes, France.

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http://dx.doi.org/10.1097/01.tp.0000259935.82722.11DOI Listing
May 2007

Chronic rejection of human kidney allografts.

Expert Rev Clin Immunol 2006 May;2(3):393-402

Institut National de la Santé Et de la Recherche Médicale (INSERM), 30 Bd Jean Monnet, 44093, Nantes, Cedex 01, France.

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http://dx.doi.org/10.1586/1744666X.2.3.393DOI Listing
May 2006

Phenotypically and functionally distinct CD8+ lymphocyte populations in long-term drug-free tolerance and chronic rejection in human kidney graft recipients.

J Am Soc Nephrol 2006 Jan 7;17(1):294-304. Epub 2005 Dec 7.

Institut National de la Santé Et de la Recherche Médicale (INSERM), Unité 643: "Immunointervention dans les Allo- et Xénotransplantations," and Institut de Transplantation Et de Recherche en Transplantation (ITERT), Nantes, France.

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http://dx.doi.org/10.1681/ASN.2005020178DOI Listing
January 2006

Steroid avoidance versus steroid withdrawal after simultaneous pancreas-kidney transplantation.

Am J Transplant 2005 Jun;5(6):1332-8

Institut de Transplantation et de Recherche en Transplantation (ITERT), Centre Hospitalier et Universitaire de Nantes, France.

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http://dx.doi.org/10.1111/j.1600-6143.2005.00816.xDOI Listing
June 2005