Madhurima Saxena

Epigenetic Signatures and Plasticity of Intestinal and Other Stem Cells.

Authors:

Annu Rev Physiol 2020 Nov 24. Epub 2020 Nov 24.

Department of Medical Oncology and Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA; email:

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November 2020

Krüppel-like Factor 5 Regulates Stemness, Lineage Specification, and Regeneration of Intestinal Epithelial Stem Cells.

Authors:

Chang-Kyung Kim Madhurima Saxena Kasmika Maharjan Jane J Song Kenneth R Shroyer Agnieszka B Bialkowska Ramesh A Shivdasani Vincent W Yang

Cell Mol Gastroenterol Hepatol 2020 25;9(4):587-609. Epub 2019 Nov 25.

Department of Medicine, Stony Brook University Renaissance School of Medicine, Stony Brook, New York; Department of Physiology and Biophysics, Stony Brook University Renaissance School of Medicine, Stony Brook, New York. Electronic address:

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November 2019

The lineage-specific transcription factor CDX2 navigates dynamic chromatin to control distinct stages of intestine development.

Authors:

Namit Kumar Yu-Hwai Tsai Lei Chen Anbo Zhou Kushal K Banerjee Madhurima Saxena Sha Huang Natalie H Toke Jinchuan Xing Ramesh A Shivdasani Jason R Spence Michael P Verzi

Development 2019 03 1;146(5). Epub 2019 Mar 1.

Rutgers, the State University of New Jersey, Department of Genetics, Piscataway, NJ 08854, USA

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March 2019

Enhancer, transcriptional, and cell fate plasticity precedes intestinal determination during endoderm development.

Authors:

Kushal K Banerjee Madhurima Saxena Namit Kumar Lei Chen Alessia Cavazza Natalie H Toke Nicholas K O'Neill Shariq Madha Unmesh Jadhav Michael P Verzi Ramesh A Shivdasani

Genes Dev 2018 11 26;32(21-22):1430-1442. Epub 2018 Oct 26.

Department of Medical Oncology, Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA.

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November 2018

Transcription factor-dependent 'anti-repressive' mammalian enhancers exclude H3K27me3 from extended genomic domains.

Authors:

Madhurima Saxena Adrianna K San Roman Nicholas K O'Neill Rita Sulahian Unmesh Jadhav Ramesh A Shivdasani

Genes Dev 2017 12 10;31(23-24):2391-2404. Epub 2018 Jan 10.

Department of Medical Oncology, Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA.

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December 2017

Dynamic Reorganization of Chromatin Accessibility Signatures during Dedifferentiation of Secretory Precursors into Lgr5+ Intestinal Stem Cells.

Authors:

Unmesh Jadhav Madhurima Saxena Nicholas K O'Neill Assieh Saadatpour Guo-Cheng Yuan Zachary Herbert Kazutaka Murata Ramesh A Shivdasani

Cell Stem Cell 2017 07 22;21(1):65-77.e5. Epub 2017 Jun 22.

Department of Medical Oncology and Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Medicine, Harvard Medical School, Boston, MA 02215, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA; Department of Medicine, Brigham and Women's Hospital, Boston, MA 02215, USA. Electronic address:

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July 2017

Single-Cell Transcript Profiles Reveal Multilineage Priming in Early Progenitors Derived from Lgr5(+) Intestinal Stem Cells.

Authors:

Tae-Hee Kim Assieh Saadatpour Guoji Guo Madhurima Saxena Alessia Cavazza Niyati Desai Unmesh Jadhav Lan Jiang Miguel N Rivera Stuart H Orkin Guo-Cheng Yuan Ramesh A Shivdasani

Cell Rep 2016 08 11;16(8):2053-2060. Epub 2016 Aug 11.

Department of Medical Oncology and Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Medicine, Harvard Medical School, Boston, MA 02215, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA. Electronic address:

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August 2016

Acquired Tissue-Specific Promoter Bivalency Is a Basis for PRC2 Necessity in Adult Cells.

Authors:

Unmesh Jadhav Kodandaramireddy Nalapareddy Madhurima Saxena Nicholas K O'Neill Luca Pinello Guo-Cheng Yuan Stuart H Orkin Ramesh A Shivdasani

Cell 2016 Jun 19;165(6):1389-1400. Epub 2016 May 19.

Department of Medical Oncology and Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Medicine, Brigham and Women's Hospital, Boston, MA 02215, USA; Department of Medicine, Harvard Medical School, Boston, MA 02215, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA. Electronic address:

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June 2016

The Arf-like GTPase Arl8b is essential for three-dimensional invasive growth of prostate cancer in vitro and xenograft formation and growth in vivo.

Authors:

Samantha S Dykes Alana L Gray David T Coleman Madhurima Saxena Charles A Stephens Jennifer L Carroll Kevin Pruitt James A Cardelli

Oncotarget 2016 May;7(21):31037-52

Department of Microbiology and Immunology, LSU Health Shreveport, Shreveport, LA, USA.

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May 2016

Frizzled 7 expression is positively regulated by SIRT1 and β-catenin in breast cancer cells.

Authors:

Glenn E Simmons Somnath Pandey Ana Nedeljkovic-Kurepa Madhurima Saxena Allison Wang Kevin Pruitt

PLoS One 2014 4;9(6):e98861. Epub 2014 Jun 4.

Department of Molecular and Cellular Physiology, LSU Health Sciences Center School of Medicine in Shreveport, Shreveport, Louisiana, United States of America; The Feist-Weiller Cancer Center, LSU Health Sciences Center School of Medicine in Shreveport, Shreveport, Louisiana, United States of America.

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August 2015

SIRT1 positively regulates breast cancer associated human aromatase (CYP19A1) expression.

Authors:

Kimberly R Holloway Andreia Barbieri Svitlana Malyarchuk Madhurima Saxena Ana Nedeljkovic-Kurepa Mathieu Cameron Mehl Allison Wang Xin Gu Kevin Pruitt

Mol Endocrinol 2013 Mar 22;27(3):480-90. Epub 2013 Jan 22.

Departments of Molecular and Cellular Physiology, Louisiana State University Health, Sciences Center School of Medicine in Shreveport, Shreveport, LA 71130, USA.

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March 2013

Chromosomal aberration in the post-implantation embryos sired by tamoxifen treated male rats.

Authors:

Neelam Kedia-Mokashi Aida E L Makawy Madhurima Saxena N H Balasinor

Mutat Res 2010 Dec 27;703(2):169-73. Epub 2010 Aug 27.

Division of Neuroendocrinology, National Institute for Research in Reproductive Health (ICMR), Parel, Mumbai 400012, India.

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December 2010

Disrupted imprinting status at the H19 differentially methylated region is associated with the resorbed embryo phenotype in rats.

Authors:

Shilpa Pathak Madhurima Saxena Ryan D'Souza N H Balasinor

Reprod Fertil Dev 2010 ;22(6):939-48

Division of Neuroendocrinology, National Institute for Research in Reproductive Health, Indian Council of Medical Research, Parel, Mumbai, India.

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September 2010

SIRT1 regulates Dishevelled proteins and promotes transient and constitutive Wnt signaling.

Authors:

Kimberly R Holloway Tara N Calhoun Madhurima Saxena Cheynita F Metoyer Ethan F Kandler Chantal A Rivera Kevin Pruitt

Proc Natl Acad Sci U S A 2010 May 3;107(20):9216-21. Epub 2010 May 3.

Department of Molecular and Cellular Physiology, School of Medicine, and Feist-Weiller Cancer Center, Louisiana State University Health Sciences Center, Shreveport, LA 71130, USA.

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May 2010