Publications by authors named "Madhuri Girdhar"

2 Publications

  • Page 1 of 1

Polyhydroxybutyrate-Based Nanocomposites for Bone Tissue Engineering.

Pharmaceuticals (Basel) 2021 Nov 15;14(11). Epub 2021 Nov 15.

Department of Chemistry and Nanotechnology, School of Engineering and Science, Tecnologico de Monterrey, Monterrey 64849, Mexico.

Bone-related diseases have been increasing worldwide, and several nanocomposites have been used to treat them. Among several nanocomposites, polyhydroxybutyrate (PHB)-based nanocomposites are widely used in drug delivery and tissue engineering due to their excellent biocompatibility and biodegradability. However, PHB use in bone tissue engineering is limited due to its inadequate physicochemical and mechanical properties. In the present work, we synthesized PHB-based nanocomposites using a nanoblend and nano-clay with modified montmorillonite (MMT) as a filler. MMT was modified using trimethyl stearyl ammonium (TMSA). Nanoblend and nano-clay were fabricated using the solvent-casting technique. Inspection of the composite structure revealed that the basal spacing of the polymeric matrix material was significantly altered depending on the loading percentage of organically modified montmorillonite (OMMT) nano-clay. The PHB/OMMT nanocomposite displayed enhanced thermal stability and upper working temperature upon heating as compared to the pristine polymer. The dispersed (OMMT) nano-clay assisted in the formation of pores on the surface of the polymer. The pore size was proportional to the weight percentage of OMMT. Further morphological analysis of these blends was carried out through FESEM. The obtained nanocomposites exhibited augmented properties over neat PHB and could have an abundance of applications in the industry and medicinal sectors. In particular, improved porosity, non-immunogenic nature, and strong biocompatibility suggest their effective application in bone tissue engineering. Thus, PHB/OMMT nanocomposites are a promising candidate for 3D organ printing, lab-on-a-chip scaffold engineering, and bone tissue engineering.
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November 2021

Comparative assessment for hyperaccumulatory and phytoremediation capability of three wild weeds.

3 Biotech 2014 Dec 19;4(6):579-589. Epub 2014 Jan 19.

Department of Biotechnology, Lovely Professional University, Chehru, Phagwara, India.

The composition and the organization of soil are changing rapidly by the diverged mankind activities, leading to the contamination of environment. Several methods are employed to clean up the environment from these kinds of contaminants, but most of them are costly and ineffective to yield optimum results. Phytoremediation is a natural green technology, which is eco-friendly for the removal of toxic metals from the polluted environment. Phytoremediation is a cost-effective technique through which the cleanup of contaminated soil laced with heavy metals is performed by wild weeds and small herbal plants. The phytoremediation technique provides a promising tool for hyperaccumulation of heavy metals; arsenic, lead, mercury, copper, chromium, and nickel, etc., by the wild weeds and that has been discussed here in detail in case of Cannabissativa, Solanum nigrum and Rorippa globosa. In general, weeds that have the intrinsic capacity to accumulate metals into their shoots and roots, have the ability to form phytochelates and formation of stable compound with ions. This behavior of accumulation along with chelate and stable compound formation is utilized as a tool for phytoremediation activity.
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December 2014