Madhav Thambisetty

Madhav Thambisetty

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Madhav Thambisetty

Madhav Thambisetty

Publications by authors named "Madhav Thambisetty"

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73Publications

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Bimanual Gesture Imitation Links to Cognition and Olfaction.

J Am Geriatr Soc 2019 Dec 23;67(12):2581-2586. Epub 2019 Aug 23.

Longitudinal Studies Section, National Institute on Aging, Bethesda, Maryland.

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http://dx.doi.org/10.1111/jgs.16151DOI Listing
December 2019

Obesity and Longer Term Risks of Dementia in 65-74 Year Olds.

Age Ageing 2019 May;48(3):367-373

Epidemiology and Public Health, Institute of Biomedical and Clinical Science, University of Exeter Medical School, Barrack Road, Exeter, UK.

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http://dx.doi.org/10.1093/ageing/afz002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6512743PMC
May 2019

Neuropathologic, genetic, and longitudinal cognitive profiles in primary age-related tauopathy (PART) and Alzheimer's disease.

Alzheimers Dement 2019 01 11;15(1):8-16. Epub 2018 Dec 11.

Department of Pathology, Division of Neuropathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jalz.2018.07.215DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6542566PMC
January 2019

Neurotransmitter Imbalance in the Brain and Alzheimer's Disease Pathology.

J Alzheimers Dis 2019 ;72(1):35-43

Clinical and Translational Neuroscience Unit, Laboratory of Behavioural Neuroscience, National Institute on Aging, Baltimore, MD, USA.

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http://dx.doi.org/10.3233/JAD-190577DOI Listing
January 2019

Deep proteomic network analysis of Alzheimer's disease brain reveals alterations in RNA binding proteins and RNA splicing associated with disease.

Mol Neurodegener 2018 10 4;13(1):52. Epub 2018 Oct 4.

Department of Neurology, Emory University School of Medicine, Whitehead Building-Suite 505C, 615 Michael Street, Atlanta, GA, 30322, USA.

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http://dx.doi.org/10.1186/s13024-018-0282-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6172707PMC
October 2018

SPARCL1 Accelerates Symptom Onset in Alzheimer's Disease and Influences Brain Structure and Function During Aging.

J Alzheimers Dis 2018 ;61(1):401-414

Clinical and Translational Neuroscience Unit, Laboratory of Behavioral Neuroscience, National Institute on Aging (NIA), National Institutes of Health (NIH), Baltimore, MD, USA.

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http://dx.doi.org/10.3233/JAD-170557DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5934753PMC
July 2018

Sex-Dependent Associations of Serum Uric Acid with Brain Function During Aging.

J Alzheimers Dis 2017 ;60(2):699-706

Unit of Clinical and Translational Neuroscience, Laboratory of Behavioral Neuroscience, National Institute on Aging, Baltimore, MD, USA.

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http://dx.doi.org/10.3233/JAD-170287DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6112110PMC
April 2018

α2-macroglobulin in Alzheimer's disease: new roles for an old chaperone.

Biomark Med 2018 04 14;12(4):311-314. Epub 2018 Mar 14.

Clinical & Translational Neuroscience Unit, Laboratory of Behavioral Neuroscience, National Institute on Aging (NIA), National Institutes of Health (NIH), Baltimore, MD 21224, USA.

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http://dx.doi.org/10.2217/bmm-2018-0027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5967355PMC
April 2018

Evidence for brain glucose dysregulation in Alzheimer's disease.

Alzheimers Dement 2018 03 19;14(3):318-329. Epub 2017 Oct 19.

Clinical and Translational Neuroscience Unit, Laboratory of Behavioral Neuroscience, National Institute on Aging (NIA), National Institutes of Health (NIH), Baltimore, MD, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jalz.2017.09.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5866736PMC
March 2018

Brain and blood metabolite signatures of pathology and progression in Alzheimer disease: A targeted metabolomics study.

PLoS Med 2018 01 25;15(1):e1002482. Epub 2018 Jan 25.

Clinical and Translational Neuroscience Unit, Laboratory of Behavioral Neuroscience, National Institute on Aging (NIA), National Institutes of Health (NIH), Baltimore, Maryland, United States of America.

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http://dx.doi.org/10.1371/journal.pmed.1002482DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5784884PMC
January 2018

Personality Change in the Preclinical Phase of Alzheimer Disease.

JAMA Psychiatry 2017 12;74(12):1259-1265

National Institute on Aging, National Institutes of Health, Baltimore, Maryland.

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http://dx.doi.org/10.1001/jamapsychiatry.2017.2816DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5710607PMC
December 2017

Understanding mechanisms and seeking cures for Alzheimer's disease: why we must be "extraordinarily diverse".

Am J Physiol Cell Physiol 2017 Oct 14;313(4):C353-C361. Epub 2017 Jun 14.

Clinical and Translational Neuroscience Unit, Laboratory of Behavioral Neuroscience, National Institute on Aging, National Institutes of Health, Baltimore, Maryland

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http://dx.doi.org/10.1152/ajpcell.00111.2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5668578PMC
October 2017

Midlife anticholinergic drug use, risk of Alzheimer's disease, and brain atrophy in community-dwelling older adults.

Alzheimers Dement (N Y) 2017 Sep 19;3(3):471-479. Epub 2017 Jul 19.

Clinical and Translational Neuroscience Unit, Laboratory of Behavioral Neuroscience, National Institute on Aging, Baltimore, MD, USA.

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http://dx.doi.org/10.1016/j.trci.2017.06.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5651434PMC
September 2017

Dysregulation of lipids in Alzheimer's disease and their role as potential biomarkers.

Alzheimers Dement 2017 Jul 24;13(7):810-827. Epub 2017 Feb 24.

Centre for Healthy Brain Ageing, School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, Australia; Neuropsychiatric Institute, Euroa Centre, Prince of Wales Hospital, Sydney, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.jalz.2017.01.008DOI Listing
July 2017

Peril beyond the winner's curse: A small sample size is the bane of biomarker discovery.

Alzheimers Dement 2017 05 21;13(5):606-607. Epub 2017 Jan 21.

King's College, London, United Kingdom.

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http://dx.doi.org/10.1016/j.jalz.2017.01.003DOI Listing
May 2017

Association between fatty acid metabolism in the brain and Alzheimer disease neuropathology and cognitive performance: A nontargeted metabolomic study.

PLoS Med 2017 Mar 21;14(3):e1002266. Epub 2017 Mar 21.

Clinical and Translational Neuroscience Unit, Laboratory of Behavioral Neuroscience, National Institute on Aging, Baltimore, Maryland, United States of America.

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http://dx.doi.org/10.1371/journal.pmed.1002266DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5360226PMC
March 2017

Rho-associated protein kinase 1 (ROCK1) is increased in Alzheimer's disease and ROCK1 depletion reduces amyloid-β levels in brain.

J Neurochem 2016 08 1;138(4):525-31. Epub 2016 Jul 1.

Center for Neurodegeneration and Experimental Therapeutics, University of Alabama at Birmingham, Birmingham, Alabama, USA.

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http://dx.doi.org/10.1111/jnc.13688DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4980252PMC
August 2016

Blood metabolite markers of cognitive performance and brain function in aging.

J Cereb Blood Flow Metab 2016 07 29;36(7):1212-23. Epub 2015 Oct 29.

Clinical and Translational Neuroscience Unit, Laboratory of Behavioral Neuroscience, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA

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http://dx.doi.org/10.1177/0271678X15611678DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4929698PMC
July 2016

Blood glucose levels and cortical thinning in cognitively normal, middle-aged adults.

J Neurol Sci 2016 Jun 14;365:89-95. Epub 2016 Apr 14.

Department of Neurology, Johns Hopkins School of Medicine, 733 N. Broadway, Baltimore, MD 21205, United States. Electronic address:

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http://dx.doi.org/10.1016/j.jns.2016.04.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4876973PMC
June 2016

A Subset of Cerebrospinal Fluid Proteins from a Multi-Analyte Panel Associated with Brain Atrophy, Disease Classification and Prediction in Alzheimer's Disease.

PLoS One 2015 18;10(8):e0134368. Epub 2015 Aug 18.

King's College London, Institute of Psychiatry, Psychology & Neuroscience, London, United Kingdom; NIHR Biomedical Research Centre for Mental Health, London, United Kingdom; NIHR Biomedical Research Unit for Dementia, London, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0134368PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4540455PMC
May 2016

Plasma apolipoprotein J as a potential biomarker for Alzheimer's disease: Australian Imaging, Biomarkers and Lifestyle study of aging.

Alzheimers Dement (Amst) 2016 22;3:18-26. Epub 2015 Dec 22.

School of Medical Sciences, Edith Cowan University, Joondalup, WA, Australia; Cooperative Research Centre for Mental Health, Melbourne, Australia; School of Psychiatry and Clinical Neurosciences, University of Western Australia, Perth, Australia.

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http://dx.doi.org/10.1016/j.dadm.2015.12.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4879652PMC
May 2016

Metabolomic method: UPLC-q-ToF polar and non-polar metabolites in the healthy rat cerebellum using an in-vial dual extraction.

PLoS One 2015 8;10(4):e0122883. Epub 2015 Apr 8.

Institute of Pharmaceutical Sciences, King's College London, Franklin-Wilkins Building, 150 Stamford Street, London, SE1 9NH, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0122883PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4390242PMC
March 2016

State- and trait-dependent associations of vitamin-D with brain function during aging.

Neurobiol Aging 2016 Mar 18;39:38-45. Epub 2015 Nov 18.

Unit of Clinical and Translational Neuroscience, Laboratory of Behavioral Neuroscience, National Institute on Aging, Baltimore, MD, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2015.11.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4773992PMC
March 2016

A Longitudinal Support Vector Regression for Prediction of ALS Score.

IEEE Int Conf Bioinform Biomed Workshops 2015 Nov;2015:1586-1590

Center for Information Technology, National Institutes of Health, Bethesda, MD 20892-5624.

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http://dx.doi.org/10.1109/BIBM.2015.7359912DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4814169PMC
November 2015

Aggregation properties of the small nuclear ribonucleoprotein U1-70K in Alzheimer disease.

J Biol Chem 2014 Dec 29;289(51):35296-313. Epub 2014 Oct 29.

From the Departments of Biochemistry and the Center for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, Georgia 30322 Neurology,

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http://dx.doi.org/10.1074/jbc.M114.562959DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4271217PMC
December 2014

Soluble interleukin-6 receptor levels and risk of dementia: one more signpost on a long road ahead.

J Am Geriatr Soc 2014 Apr;62(4):772-4

Clinical and Translational Neuroscience Unit, Laboratory of Behavioral Neuroscience, National Institute on Aging, National Institutes of Health, Baltimore, Maryland.

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http://dx.doi.org/10.1111/jgs.12737DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4577022PMC
April 2014

Interleukin-6 is linked to longitudinal rates of cortical thinning in aging.

Transl Neurosci 2014 Mar;5(1):1-7

Laboratory of Behavioral Neuroscience, National Institute on Aging, NIH, Baltimore, MD, 21224, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4824945PMC
http://dx.doi.org/10.2478/s13380-014-0203-0DOI Listing
March 2014

Pharmacologic inhibition of ROCK2 suppresses amyloid-β production in an Alzheimer's disease mouse model.

J Neurosci 2013 Dec;33(49):19086-98

Center for Neurodegenerative Disease, and Departments of Neurology, Cell Biology, and Biochemistry, Emory University School of Medicine, Atlanta, Georgia 30322, Medicinal Chemistry, Translational Research Institute, The Scripps Research Institute, Jupiter, Florida 33458, Department of Pathology, University of Washington, Seattle, Washington 98104, Departments of Pathology and Neurology, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, and Unit of Clinical and Translational Neuroscience and Laboratory of Behavioral Neuroscience, National Institute on Aging, Baltimore, Maryland 21224.

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http://dx.doi.org/10.1523/JNEUROSCI.2508-13.2013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3850036PMC
December 2013

Alzheimer's disease risk genes and the age-at-onset phenotype.

Neurobiol Aging 2013 Nov 17;34(11):2696.e1-5. Epub 2013 Jul 17.

Clinical and Translational Neuroscience Unit, Laboratory of Behavioral Neuroscience, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.

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http://dx.doi.org/10.1016/j.neurobiolaging.2013.05.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4038407PMC
November 2013

Abnormal gephyrin immunoreactivity associated with Alzheimer disease pathologic changes.

J Neuropathol Exp Neurol 2013 Nov;72(11):1009-15

From the Department of Neurology (CMH, HR, AIL, JJL, TSW), Center for Neurodegenerative Disease (CMH, HR, NTS, EBD, DMD, MG, AIL, JJL, TSW), Departments of Biochemistry (NTS) and Human Genetics (EBD, TSW), and Pathology and Laboratory Medicine (MG), Emory University School of Medicine, Atlanta, Georgia; Department of Pathology, University of Washington, Seattle, Washington (TJM); Departments of Pathology and Neurology, Johns Hopkins School of Medicine, Baltimore, Maryland (JCT); National Institute of Aging, National Institutes of Health, Bethesda, Maryland (MT); and Atlanta Veterans Administration Medical Center, Atlanta, Georgia (TSW).

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https://academic.oup.com/jnen/article-lookup/doi/10.1097/01.
Publisher Site
http://dx.doi.org/10.1097/01.jnen.0000435847.59828.dbDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4037931PMC
November 2013

Impaired glucose tolerance in midlife and longitudinal changes in brain function during aging.

Neurobiol Aging 2013 Oct 19;34(10):2271-6. Epub 2013 Apr 19.

Clinical and Translational Neuroscience Unit, Laboratory of Behavioral Neuroscience, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.

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http://dx.doi.org/10.1016/j.neurobiolaging.2013.03.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4577027PMC
October 2013

Alzheimer risk variant CLU and brain function during aging.

Biol Psychiatry 2013 Mar 15;73(5):399-405. Epub 2012 Jul 15.

Laboratory of Behavioral Neuroscience, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA.

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http://dx.doi.org/10.1016/j.biopsych.2012.05.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3488132PMC
March 2013

Effect of complement CR1 on brain amyloid burden during aging and its modification by APOE genotype.

Biol Psychiatry 2013 Mar 27;73(5):422-8. Epub 2012 Sep 27.

Laboratory of Behavioral Neuroscience, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1016/j.biopsych.2012.08.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3535537PMC
March 2013

Processing and memory for emotional and neutral material in amyotrophic lateral sclerosis.

Amyotroph Lateral Scler 2012 Oct 8;13(6):592-8. Epub 2012 Aug 8.

King's College London, KHP Centre for Neurodegeneration Research, Department of Psychology, Institute of Psychiatry, London, UK.

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http://dx.doi.org/10.3109/17482968.2012.708936DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5898366PMC
October 2012

Baseline cardiovascular risk predicts subsequent changes in resting brain function.

Stroke 2012 Jun 5;43(6):1542-7. Epub 2012 Apr 5.

Intramural Research Program, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1161/STROKEAHA.111.638437DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3361601PMC
June 2012

The utility of (11)C-arachidonate PET to study in vivo dopaminergic neurotransmission in humans.

J Cereb Blood Flow Metab 2012 Apr 14;32(4):676-84. Epub 2011 Dec 14.

Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3318145PMC
http://dx.doi.org/10.1038/jcbfm.2011.171DOI Listing
April 2012

Longitudinal changes in cortical thickness associated with normal aging.

Neuroimage 2010 Oct 2;52(4):1215-23. Epub 2010 May 2.

Laboratory of Personality and Cognition, National Institute on Aging, Baltimore, MD 21224-2816, USA.

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http://dx.doi.org/10.1016/j.neuroimage.2010.04.258DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2910226PMC
October 2010

Blood-based biomarkers of Alzheimer's disease: challenging but feasible.

Biomark Med 2010 Feb;4(1):65-79

Laboratory of Personality & Cognition, Intramural Research Program, National Institue on Aging, NIH, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2863057PMC
http://dx.doi.org/10.2217/bmm.09.84DOI Listing
February 2010

APOE epsilon4 genotype and longitudinal changes in cerebral blood flow in normal aging.

Arch Neurol 2010 Jan;67(1):93-8

Department of Radiology and Radiological Sciences, Laboratory of Personality and Cognition, National Institute on Aging, National Institutes of Health, Johns Hopkins University, Baltimore, Maryland 21224-6825, USA.

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http://dx.doi.org/10.1001/archneurol.2009.913DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2856443PMC
January 2010

A proposed metabolic strategy for monitoring disease progression in Alzheimer's disease.

Electrophoresis 2009 Apr;30(7):1235-9

Pharmaceutical Sciences Research Division, King's College London, London, UK.

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http://dx.doi.org/10.1002/elps.200800589DOI Listing
April 2009

Proteome-based identification of plasma proteins associated with hippocampal metabolism in early Alzheimer's disease.

J Neurol 2008 Nov 1;255(11):1712-20. Epub 2008 Aug 1.

King's College London, MRC Centre for Neurodegeneration Research, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London SE5 8AF, UK.

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http://dx.doi.org/10.1007/s00415-008-0006-8DOI Listing
November 2008

Proteomics of Alzheimer's disease: understanding mechanisms and seeking biomarkers.

Expert Rev Proteomics 2007 Apr;4(2):227-38

Institute of Psychiatry, MRC Centre for Neurodegeneration Research and NIHR Biomedical Research Centre, KCL, London, UK.

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http://dx.doi.org/10.1586/14789450.4.2.227DOI Listing
April 2007

Fulminant idiopathic intracranial hypertension.

Neurology 2007 Jan;68(3):229-32

Departments of Neurology, Emory University, Atlanta, GA, USA.

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http://dx.doi.org/10.1212/01.wnl.0000251312.19452.ecDOI Listing
January 2007

Diagnosis and management of MELAS.

Expert Rev Mol Diagn 2004 Sep;4(5):631-44

Department of Neurology, Institute of Psychiatry, King's College London, UK.

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http://www.tandfonline.com/doi/full/10.1586/14737159.4.5.631
Publisher Site
http://dx.doi.org/10.1586/14737159.4.5.631DOI Listing
September 2004

Hypertensive brainstem encephalopathy: clinical and radiographic features.

J Neurol Sci 2003 Apr;208(1-2):93-9

Department of Neurology, Emory University School of Medicine, Atlanta, GA, USA.

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http://dx.doi.org/10.1016/s0022-510x(02)00379-9DOI Listing
April 2003

A practical approach to the diagnosis and management of MELAS: case report and review.

Neurologist 2002 Sep;8(5):302-12

Department of Neurology, Emory University School of Medicine, Atlanta, Georgia, USA.

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http://dx.doi.org/10.1097/00127893-200209000-00003DOI Listing
September 2002