Publications by authors named "Madderla Sarasija"

3 Publications

  • Page 1 of 1

Indole-fused spirochromenes as potential anti-tubercular agents: design, synthesis and in vitro evaluation.

Mol Divers 2021 Nov 30;25(4):2137-2148. Epub 2020 May 30.

Department of Chemistry, Satavahana University, Karimnagar, Telangana State, 505001, India.

As part of an ongoing effort to develop new anti-tubercular agents, a series of novel indole-fused spirochromene hybrids (7a-l) were efficiently synthesized in excellent yields by the popular 'Fisher-Indole synthesis' approach. The structure elucidation of the target compounds was carried out by different spectral techniques including H-NMR, C-NMR, ESI Mass, and FTIR analysis. Additionally, the proposed structure of 7i was proved by single-crystal X-ray analysis. These compounds (7a-l) were screened for in vitro anti-tubercular activity against Mycobacterium tuberculosis H37Rv (ATCC 27294) strain. The results showed that most of the targets exhibited promising antimycobacterial activity with MICs of 1.56-6.25 μg/mL and weak cytotoxicity (19.93-32.16% at 50 μg/mL). Among them, compound 7l was found to be the most active compound (MIC of 1.56 μg/mL) with a good safety profile (32.16% at 50 μg/mL).
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http://dx.doi.org/10.1007/s11030-020-10108-zDOI Listing
November 2021

Facile synthesis, characterization and enhanced catalytic reduction of 4-nitrophenol using NaBH by undoped and Sm, Gd, Hf doped LaO nanoparticles.

Nano Converg 2019 Apr 10;6(1):12. Epub 2019 Apr 10.

Department of Chemistry, Osmania University, Hyderabad, TS, 500007, India.

This work focuses on the synthesis of undoped and doped lanthanum oxide nanoparticles (LaO NPs) by a simple co-precipitation method for the catalytic reduction of 4-nitrophenol (4-NP) using NaBH as a reducing agent. Their optical properties, morphologies, structure, chemical compositions and electronic properties were carefully characterized by XRD, FTIR, SEM, TEM, PL and UV-visible absorption spectroscopy. The SEM and TEM images showed various shape morphologies and sizes of the particles. The XRD pattern revealed a polycrystalline nature with the hexagonal structure of the LaO NPs. The synthesized undoped and doped LaO NPs were also employed as catalysts for the reduction of 4-nitrophenol, it shows that the doped (Sm, Gd and Hf) LaO NPs provided better catalytic activity than the undoped LaO NPs. Moreover, Hf doped LaO NPs exhibited an enhanced catalytic activity for the reduction of 4-nitrophenol to 4-aminophenol in 90 min. The catalytic conversion was studied by UV-vis spectroscopy with high reduction rate (k = 2.048 min). The applications of the present study may utilize in the removal of toxic pollutants in a cleaning of environmental pollution as well as in industrial applications.
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http://dx.doi.org/10.1186/s40580-019-0181-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456637PMC
April 2019

1,2,3-Triazole-fused spirochromenes as potential anti-tubercular agents: synthesis and biological evaluation.

RSC Adv 2018 May 9;8(30):16997-17007. Epub 2018 May 9.

X-ray Crystallography Division, CSIR-Indian Institute of Chemical Technology Hyderabad-500 007 India.

A facile and convenient approach has been designed for the synthesis of novel prototypes that possess the advantage of the two pharmacophores of chromene and 1,2,3-triazole in a single molecular backbone, were evaluated against H37Rv strain. The new analogues 1,2,3-triazole-fused spirochromenes were accomplished in four step synthetic strategy utilizing click chemistry ([3 + 2] Huisgen cycloaddition) in the ultimate step. The synthesized compounds were established based on the spectral data and X-ray crystal structure for 7a. Among the compounds tested against H37Rv strain, some products exhibited potent antimycobacterial activity with minimum inhibitory concentration (MIC) values ranging from 1.56 to 6.25 μg mL. Compounds exhibiting good potency in the MTB MIC assay were further examined for cytotoxicity in a RAW 264.7 cells. Compounds 7a, 7d, 7i (MIC: 1.56 μg mL) and 7k, 7m (MIC: 3.125 μg mL) exhibited promising hits.
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http://dx.doi.org/10.1039/c8ra03197eDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9080333PMC
May 2018
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