Maddalena Fratelli

Maddalena Fratelli

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Maddalena Fratelli

Maddalena Fratelli

Publications by authors named "Maddalena Fratelli"

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45Publications

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Computational deconvolution of transcriptomic data for the study of tumor-infiltrating immune cells.

Int J Biol Markers 2020 Feb;35(1_suppl):20-22

Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milano, Italy.

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http://dx.doi.org/10.1177/1724600820903317DOI Listing
February 2020

Establishment of patient-derived tumor xenograft models of mucinous ovarian cancer.

Am J Cancer Res 2020 1;10(2):572-580. Epub 2020 Feb 1.

Laboratory of Molecular Pharmacology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS Milan 20156, Italy.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7061742PMC
February 2020

The ATRA-21 gene-expression model predicts retinoid sensitivity in CEBPA double mutant, t(8;21) and inv(16) AML patients.

Blood Cancer J 2019 09 30;9(10):76. Epub 2019 Sep 30.

Laboratory of Molecular Biology, IRCCS-Istituto di Ricerche Farmacologiche "Mario Negri", Milano, Italy.

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http://dx.doi.org/10.1038/s41408-019-0241-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6769013PMC
September 2019

Overcoming platinum-acquired resistance in ovarian cancer patient-derived xenografts.

Ther Adv Med Oncol 2019 24;11:1758835919839543. Epub 2019 Jun 24.

Department of Oncology, Laboratory of Molecular Pharmacology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy.

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http://dx.doi.org/10.1177/1758835919839543DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6591669PMC
June 2019

HER2-positive breast-cancer cell lines are sensitive to KDM5 inhibition: definition of a gene-expression model for the selection of sensitive cases.

Oncogene 2019 04 11;38(15):2675-2689. Epub 2018 Dec 11.

Laboratory of Molecular Biology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, via La Masa 19, 20157, Milano, Italy.

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http://dx.doi.org/10.1038/s41388-018-0620-6DOI Listing
April 2019

Generation of a new mouse model of glaucoma characterized by reduced expression of the AP-2β and AP-2δ proteins.

Sci Rep 2017 09 11;7(1):11140. Epub 2017 Sep 11.

Laboratory of Molecular Biology, IRCCS-Istituto di Ricerche Farmacologiche "Mario Negri", via La Masa 19, 20156, Milano, Italy.

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http://dx.doi.org/10.1038/s41598-017-11752-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5593953PMC
September 2017

Lipid-sensors, enigmatic-orphan and orphan nuclear receptors as therapeutic targets in breast-cancer.

Oncotarget 2016 Jul;7(27):42661-42682

Laboratory of Molecular Biology, IRCCS-Istituto di Ricerche Farmacologiche "Mario Negri", Milano, Italy.

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http://dx.doi.org/10.18632/oncotarget.7410DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5173165PMC
July 2016

Mouse aldehyde-oxidase-4 controls diurnal rhythms, fat deposition and locomotor activity.

Sci Rep 2016 07 26;6:30343. Epub 2016 Jul 26.

Laboratory of Molecular Biology, Department of Molecular Biochemistry and Pharmacology, IRCCS-Istituto di Ricerche Farmacologiche "Mario Negri", via La Masa 19, 20156, Milano, Italy.

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http://dx.doi.org/10.1038/srep30343DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4960552PMC
July 2016

Association of CFHR1 homozygous deletion with acute myelogenous leukemia in the European population.

Leuk Lymphoma 2016 May 2;57(5):1234-7. Epub 2016 Mar 2.

a Laboratory of Molecular Biology , IRCCS-Istituto di Ricerche Farmacologiche "Mario Negri", via La Masa 19, 20156 , Milano , Italy ;

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http://dx.doi.org/10.3109/10428194.2015.1082180DOI Listing
May 2016

Structure and function of mammalian aldehyde oxidases.

Arch Toxicol 2016 Apr 26;90(4):753-80. Epub 2016 Feb 26.

Laboratory of Molecular Biology, IRCCS-Istituto di Ricerche Farmacologiche "Mario Negri", via La Masa 19, 20156, Milan, Italy.

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http://dx.doi.org/10.1007/s00204-016-1683-1DOI Listing
April 2016

Retinoids and breast cancer: from basic studies to the clinic and back again.

Cancer Treat Rev 2014 Jul 18;40(6):739-49. Epub 2014 Jan 18.

Laboratory of Molecular Biology, IRCCS-Istituto di Ricerche Farmacologiche "Mario Negri", via La Masa 19, 20156 Milano, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.ctrv.2014.01.001DOI Listing
July 2014

Long-duration epilepsy affects cell morphology and glutamatergic synapses in type IIB focal cortical dysplasia.

Acta Neuropathol 2013 Aug 21;126(2):219-35. Epub 2013 Jun 21.

Experimental Neurophysiology and Epileptology Department, Molecular Neuroanatomy and Pathogenesis Unit, Neurological Institute C. Besta, Via Temolo 4, 20126, Milan, Italy.

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http://dx.doi.org/10.1007/s00401-013-1143-4DOI Listing
August 2013

Structure and evolution of vertebrate aldehyde oxidases: from gene duplication to gene suppression.

Cell Mol Life Sci 2013 May 21;70(10):1807-30. Epub 2012 Dec 21.

Laboratory of Molecular Biology, Istituto di Ricerche Farmacologiche "Mario Negri", via La Masa 19, 20156, Milan, Italy.

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http://dx.doi.org/10.1007/s00018-012-1229-5DOI Listing
May 2013

Antiproliferative and differentiating activities of a novel series of histone deacetylase inhibitors.

ACS Med Chem Lett 2010 Nov 20;1(8):411-5. Epub 2010 Jul 20.

Laboratory of Molecular Biology, Istituto di Ricerche Farmacologiche "Mario Negri", via La Masa 19, 20156 Milano, Italy.

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http://dx.doi.org/10.1021/ml1001163DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4007903PMC
November 2010

The mammalian aldehyde oxidase gene family.

Hum Genomics 2009 Dec;4(2):119-30

Laboratory of Molecular Biology, Department of Biochemistry and Molecular Pharmacology, Istituto di Ricerche Farmacologiche Mario Negri, via La Masa 19, 20156 Milano, Italy.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3525200PMC
http://dx.doi.org/10.1186/1479-7364-4-2-119DOI Listing
December 2009

Role of the molybdoflavoenzyme aldehyde oxidase homolog 2 in the biosynthesis of retinoic acid: generation and characterization of a knockout mouse.

Mol Cell Biol 2009 Jan 3;29(2):357-77. Epub 2008 Nov 3.

Laboratory of Molecular Biology, Department of Biochemistry and Molecular Pharmacology, Istituto di Ricerche Farmacologiche Mario Negri, via La Masa 19, 20156 Milan, Italy.

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http://dx.doi.org/10.1128/MCB.01385-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2612517PMC
January 2009

Avian and canine aldehyde oxidases. Novel insights into the biology and evolution of molybdo-flavoenzymes.

J Biol Chem 2006 Jul 3;281(28):19748-61. Epub 2006 May 3.

Laboratory of Molecular Biology, Centro Catullo e Daniela Borgomainerio, Istituto di Ricerche Farmacologiche Mario Negri, via Eritrea 62, 20157 Milano, Italy.

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http://dx.doi.org/10.1074/jbc.M600850200DOI Listing
July 2006

Thiol-disulfide balance: from the concept of oxidative stress to that of redox regulation.

Antioxid Redox Signal 2005 Jul-Aug;7(7-8):964-72

Mario Negri Institute for Pharmacological Research, Milan, Italy.

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http://dx.doi.org/10.1089/ars.2005.7.964DOI Listing
September 2005

Gene expression profiling reveals a signaling role of glutathione in redox regulation.

Proc Natl Acad Sci U S A 2005 Sep 19;102(39):13998-4003. Epub 2005 Sep 19.

Laboratory of Neuroimmunology "Mario Negri," Institute for Pharmacological Research, 20157 Milan, Italy.

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http://dx.doi.org/10.1073/pnas.0504398102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1236550PMC
September 2005

Redox proteomics: identification and functional role of glutathionylated proteins.

Expert Rev Proteomics 2004 Oct;1(3):365-76

Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, I-20157 Milan, Italy.

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http://dx.doi.org/10.1586/14789450.1.3.365DOI Listing
October 2004

Glutathionylation of human thioredoxin: a possible crosstalk between the glutathione and thioredoxin systems.

Proc Natl Acad Sci U S A 2002 Jul 15;99(15):9745-9. Epub 2002 Jul 15.

Mario Negri Institute for Pharmacological Research, Department of Biochemistry, 20157 Milan, Italy.

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http://dx.doi.org/10.1073/pnas.152168599DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC125000PMC
July 2002

Monitoring the effects of drug treatment in rat models of disease by serum protein analysis.

J Chromatogr B Analyt Technol Biomed Life Sci 2002 May;771(1-2):107-30

Dipartimento di Scienze Farmacologiche, Università degli Studi di Milano via Balzaretti 9, I-20133 Milan, Italy.

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http://dx.doi.org/10.1016/s0378-4347(01)00562-xDOI Listing
May 2002