Macrae F Linton

Macrae F Linton

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Macrae F Linton

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A Genetic Approach to the Association Between PCSK9 and Sepsis.

JAMA Netw Open 2019 Sep 4;2(9):e1911130. Epub 2019 Sep 4.

Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.

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http://dx.doi.org/10.1001/jamanetworkopen.2019.11130DOI Listing
September 2019

Lipoprotein modulation of proteinuric renal injury.

Lab Invest 2019 Jul 24;99(8):1107-1116. Epub 2019 Apr 24.

Departments of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA.

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http://dx.doi.org/10.1038/s41374-019-0253-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6658349PMC
July 2019

Akt Signaling in Macrophage Polarization, Survival, and Atherosclerosis.

Int J Mol Sci 2019 Jun 1;20(11). Epub 2019 Jun 1.

Atherosclerosis Research Unit, Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University School of Medicine, 2220 Pierce Avenue, Nashville, TN 37232-6300, USA.

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http://dx.doi.org/10.3390/ijms20112703DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6600269PMC
June 2019

Imaging mass spectrometry reveals heterogeneity of proliferation and metabolism in atherosclerosis.

JCI Insight 2019 Jun 6;4(11). Epub 2019 Jun 6.

Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

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http://dx.doi.org/10.1172/jci.insight.128528DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6629145PMC
June 2019

Loss of in Monocyte/Macrophages Suppresses Their Proliferation and Viability Reducing Atherosclerosis in LDLR Null Mice.

Front Immunol 2018 13;9:215. Epub 2018 Feb 13.

Atherosclerosis Research Unit, Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, United States.

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http://dx.doi.org/10.3389/fimmu.2018.00215DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5816794PMC
April 2019

Dual inhibition of endothelial miR-92a-3p and miR-489-3p reduces renal injury-associated atherosclerosis.

Atherosclerosis 2019 Mar 30;282:121-131. Epub 2019 Jan 30.

Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA. Electronic address:

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http://dx.doi.org/10.1016/j.atherosclerosis.2019.01.023DOI Listing
March 2019

Loss of 2 Akt (Protein Kinase B) Isoforms in Hematopoietic Cells Diminished Monocyte and Macrophage Survival and Reduces Atherosclerosis in Ldl Receptor-Null Mice.

Arterioscler Thromb Vasc Biol 2019 Feb;39(2):156-169

From the Atherosclerosis Research Unit, Division of Cardiovascular Medicine, Department of Medicine (V.R.B., L.D., Y.Z., J.M.M., K.C.V., M.F.L.), Vanderbilt University School of Medicine, Nashville, TN.

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https://www.ahajournals.org/doi/10.1161/ATVBAHA.118.312206
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http://dx.doi.org/10.1161/ATVBAHA.118.312206DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344270PMC
February 2019

Myeloid-Specific Deletion of Epsins 1 and 2 Reduces Atherosclerosis by Preventing LRP-1 Downregulation.

Circ Res 2019 Feb;124(4):e6-e19

From the Vascular Biology Program and Department of Surgery, Boston Children's Hospital (M.L.B., Y.D., K.S., K.Z., A.W., H.W., Y.L., S.W., L.Y., J.B., H.C.), Harvard Medical School, MA.

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http://dx.doi.org/10.1161/CIRCRESAHA.118.313028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375743PMC
February 2019

Administration of N-Acyl-Phosphatidylethanolamine Expressing Bacteria to Low Density Lipoprotein Receptor Mice Improves Indices of Cardiometabolic Disease.

Sci Rep 2019 Jan 23;9(1):420. Epub 2019 Jan 23.

Division of Clinical Pharmacology, Department of Pharmacology, 2220 Pierce Avenue, Vanderbilt University, 556 Robinson Research Building, Nashville, TN, 37221, USA.

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http://dx.doi.org/10.1038/s41598-018-37373-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344515PMC
January 2019

A case of severe acquired hypertriglyceridemia in a 7-year-old girl.

J Clin Lipidol 2017 Nov - Dec;11(6):1480-1484. Epub 2017 Aug 12.

Department of Medicine, Center for Preventive Cardiology, Knight Cardiovascular Institute, Oregon Health & Science University, Portland, OR, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jacl.2017.08.003DOI Listing
July 2018

Hepatocyte estrogen receptor alpha mediates estrogen action to promote reverse cholesterol transport during Western-type diet feeding.

Mol Metab 2018 02 29;8:106-116. Epub 2017 Dec 29.

VA Tennessee Valley Healthcare System, USA; Department of Molecular, Physiology and Biophysics, Vanderbilt University, USA; Division of Diabetes, Endocrinology, & Metabolism, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molmet.2017.12.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5985047PMC
February 2018

High-Density Lipoprotein Cholesterol Concentration and Acute Kidney Injury After Cardiac Surgery.

J Am Heart Assoc 2017 Dec 9;6(12). Epub 2017 Dec 9.

Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, TN.

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http://dx.doi.org/10.1161/JAHA.117.006975DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5779016PMC
December 2017

Loss of SPRR3 in ApoE-/- mice leads to atheroma vulnerability through Akt dependent and independent effects in VSMCs.

PLoS One 2017 8;12(9):e0184620. Epub 2017 Sep 8.

Department of Pathology Microbiology and Immunology; Vanderbilt University Medical Center; Nashville, TN, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0184620PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5590986PMC
October 2017

SR-BI: A Multifunctional Receptor in Cholesterol Homeostasis and Atherosclerosis.

Trends Endocrinol Metab 2017 06 1;28(6):461-472. Epub 2017 Mar 1.

Atherosclerosis Research Unit, Cardiovascular Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232-6300, USA. Electronic address:

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http://dx.doi.org/10.1016/j.tem.2017.02.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5438771PMC
June 2017

Autoantibodies against GPIHBP1 as a Cause of Hypertriglyceridemia.

N Engl J Med 2017 04 5;376(17):1647-1658. Epub 2017 Apr 5.

From the Departments of Medicine (A.P.B., M.A.M., N.P.S., X.H., C.M.A., M.L., L.G.F., S.G.Y.), Rheumatology (M.A.M.), Human Genetics (K.R., S.G.Y.), and Pathology and Laboratory Medicine (P.T.), David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, and the Cardiovascular Research Institute and Department of Physiological Nursing, University of California, San Francisco, San Francisco (C.R.P.); the Department of Clinical Laboratory Medicine, Gunma University Graduate School of Medicine, Maebashi (K.M., T.M., M.M., K.N.), and the Department of Insured Medical Care Management, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo (M.A.) - both in Japan; the Finsen Laboratory, Rigshospitalet, Copenhagen (M.P.); the Department of Medicine, University of Cape Town, Cape Town, South Africa (D.J.B.); the Departments of Medicine and Pharmacology, Vanderbilt University Medical Center, Nashville (M.F.L.); the Department of Medicine, Faculty of Medicine, Chulalongkorn University and Thai Red Cross Society, Bangkok, Thailand (W.K.); Clinique de Prévention Cardiovasculaire, Institut de Recherches Cliniques de Montréal, University of Montreal, Montreal (R.D.); the Department of Medicine, University of Texas Southwestern Medical Center, Dallas (A.G.); the Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, New York University School of Medicine, New York (I.J.G.); and Fédération d'Endocrinologie, Groupement Hospitalier Est, Hospices Civils de Lyon, INSERM UMR-1060 Carmen, Université de Lyon, Lyon, France (P.M., S.C.).

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http://dx.doi.org/10.1056/NEJMoa1611930DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5555413PMC
April 2017

Macrophage Apoptosis and Efferocytosis in the Pathogenesis of Atherosclerosis.

Circ J 2016 Oct 8;80(11):2259-2268. Epub 2016 Oct 8.

Atherosclerosis Research Unit, Cardiovascular Medicine, Department of Medicine, Vanderbilt University Medical Center.

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http://dx.doi.org/10.1253/circj.CJ-16-0924DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5459487PMC
October 2016

Loss of Macrophage Low-Density Lipoprotein Receptor-Related Protein 1 Confers Resistance to the Antiatherogenic Effects of Tumor Necrosis Factor-α Inhibition.

Arterioscler Thromb Vasc Biol 2016 08 30;36(8):1483-95. Epub 2016 Jun 30.

From the Division of Cardiovascular Medicine (L.Z., R.C., L.D., Y.Z., A.S.M., M.F.L.), Division of Diabetes, Endocrinology, and Metabolism (L.Z., J.M.S.), Division of Rheumatology, Department of Medicine (M.O.), Vanderbilt University Medical Center, Nashville, TN; Tennessee Valley Healthcare System, Nashville (L.Z., J.M.S.); and Center for Preventive Cardiology, Knight Cardiovascular Institute, Oregon Health & Science University, Portland (I.G., H.T., S.F.).

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https://www.ahajournals.org/doi/10.1161/ATVBAHA.116.307736
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http://dx.doi.org/10.1161/ATVBAHA.116.307736DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5346022PMC
August 2016

Treatment Gaps in Adults With Heterozygous Familial Hypercholesterolemia in the United States: Data From the CASCADE-FH Registry.

Circ Cardiovasc Genet 2016 Jun 24;9(3):240-9. Epub 2016 Mar 24.

From the University of Pennsylvania, Philadelphia (E.M.d., D.J.R.); University of Texas Southwestern, Dallas (Z.S.A.); Duke Clinical Research Institute, Durham, NC (E.C.O., P.S., M.T.R.); The FH Foundation, South Pasadena, CA (I.K., C.D.A., K.W.); New York University School of Medicine (C.B.N.); Mid America Heart Institute, Kansas City, MO (Y.P.); Preventive Cardiology Inc, Boca Raton, FL (S.J.B.); Massachusetts General Hospital, Boston (L.C. Hemphill); The Rogosin Institute, New York, NY (L.C. Hudgins); Nemours Cardiac Center, Wilmington, DE (S.S.G.); Thomas Jefferson University Hospital, Philadelphia, PA (D.D.); West Virginia University, Morgantown (W.N.); Baylor College of Medicine, Houston, TX (C.M.B.); Vanderbilt University School of Medicine, Nashville, TN (M.F.L.); Oregon Health and Science University, Portland, OR (P.B.D., M.D.S.); University of Kansas Medical Center (P.M.M.); and Stanford University, CA (J.W.K.).

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http://dx.doi.org/10.1161/CIRCGENETICS.116.001381DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5315030PMC
June 2016

Jnk1 Deficiency in Hematopoietic Cells Suppresses Macrophage Apoptosis and Increases Atherosclerosis in Low-Density Lipoprotein Receptor Null Mice.

Arterioscler Thromb Vasc Biol 2016 06 21;36(6):1122-31. Epub 2016 Apr 21.

From the Departments of Medicine (V.R.B., M.Y., L.D., Y.Z., J.M.M., M.F.L.) and Pharmacology (M.F.L.), Vanderbilt University Medical Center, Nashville, TN; Department of Molecular Biology and Genetics, Bilkent University, Ankara, Turkey (E.E.); Department of Medicine, Oregon Health & Science University, Portland, OR (S.F.); and Department of Genetics & Complex Diseases & Sabri Ulker Center, Harvard School of Public Health, Boston, MA (G.S.H.).

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http://dx.doi.org/10.1161/ATVBAHA.116.307580DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4882236PMC
June 2016

Human PCSK9 promotes hepatic lipogenesis and atherosclerosis development via apoE- and LDLR-mediated mechanisms.

Cardiovasc Res 2016 May 15;110(2):268-78. Epub 2016 Mar 15.

Knight Cardiovascular Institute, Center for Preventive Cardiology, Oregon Health and Science University, Portland, OR, USA

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http://dx.doi.org/10.1093/cvr/cvw053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4836631PMC
May 2016

Macrophage IKKα Deficiency Suppresses Akt Phosphorylation, Reduces Cell Survival, and Decreases Early Atherosclerosis.

Arterioscler Thromb Vasc Biol 2016 Apr 4;36(4):598-607. Epub 2016 Feb 4.

From the Atherosclerosis Research Unit, Department of Medicine (V.R.B., L.D., Y.Z., J.M.M., M.R.F.L.) and Pharmacology (M.R.F.L.), Vanderbilt University Medical Center, Nashville, TN; Center for Cancer Research, National Cancer Institute, Frederick, MD (P.C.L.); and Department of Medicine, Center of Preventive Cardiology, Oregon Health & Science University, Portland, OR (S.F.).

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https://www.ahajournals.org/doi/10.1161/ATVBAHA.115.306931
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http://dx.doi.org/10.1161/ATVBAHA.115.306931DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4808396PMC
April 2016

HDL: Beyond Atheroprotection.

J Am Soc Nephrol 2016 Feb 28;27(2):341-4. Epub 2015 Aug 28.

Medicine, and Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee.

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http://dx.doi.org/10.1681/ASN.2015070793DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4731133PMC
February 2016

Local effects of human PCSK9 on the atherosclerotic lesion.

J Pathol 2016 Jan 13;238(1):52-62. Epub 2015 Nov 13.

Knight Cardiovascular Institute, Center for Preventive Cardiology, Oregon Health and Science University, Portland, OR, USA.

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http://dx.doi.org/10.1002/path.4630DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5346023PMC
January 2016

Atherosclerosis following renal injury is ameliorated by pioglitazone and losartan via macrophage phenotype.

Atherosclerosis 2015 Sep 4;242(1):56-64. Epub 2015 Jul 4.

Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA. Electronic address:

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http://dx.doi.org/10.1016/j.atherosclerosis.2015.06.055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4850906PMC
September 2015

Macrophage SR-BI mediates efferocytosis via Src/PI3K/Rac1 signaling and reduces atherosclerotic lesion necrosis.

J Lipid Res 2015 Aug 9;56(8):1449-60. Epub 2015 Jun 9.

Department of Medicine, Atherosclerosis Research Unit, Division of Cardiovascular Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232.

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http://dx.doi.org/10.1194/jlr.M056689DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4513986PMC
August 2015

Sex-Specific Parental Effects on Offspring Lipid Levels.

J Am Heart Assoc 2015 Jun 30;4(7). Epub 2015 Jun 30.

Department of Genetics, Geisel School of Medicine, Dartmouth College, Hanover, NH (R.S.S., J.B., S.M.W.).

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http://dx.doi.org/10.1161/JAHA.115.001951DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4608079PMC
June 2015

Macrophage apoAI protects against dyslipidemia-induced dermatitis and atherosclerosis without affecting HDL.

J Lipid Res 2015 Mar 15;56(3):635-43. Epub 2015 Jan 15.

Knight Cardiovascular Institute, Center for Preventive Cardiology, Oregon Health and Science University, Portland, OR.

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http://dx.doi.org/10.1194/jlr.M056408DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4340310PMC
March 2015

Dysfunctional high-density lipoproteins in children with chronic kidney disease.

Metabolism 2015 Feb 25;64(2):263-73. Epub 2014 Oct 25.

Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN. Electronic address:

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http://dx.doi.org/10.1016/j.metabol.2014.10.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4277938PMC
February 2015

Identification of small proline-rich repeat protein 3 as a novel atheroprotective factor that promotes adaptive Akt signaling in vascular smooth muscle cells.

Arterioscler Thromb Vasc Biol 2014 Dec 2;34(12):2527-36. Epub 2014 Oct 2.

From the Department of Pathology, Microbiology, and Immunology (A.K.S., B.L., S.F., J.B.A., P.P.Y.) and Departments of Veterans Affairs Medical Center (J.B.A., P.P.Y.), Pharmacology (M.F.L.), and Medicine (Y.Z., V.R.B., S.F., M.F.L., P.P.Y.), Vanderbilt University Medical Center, Nashville, TN; Department of Neurodegenerative Diseases, Institute of Neurology, University College London, Queen Square, London, United Kingdom (P.J.); Department of Pathology and Laboratory Medicine, Nationwide Children's Hospital, Columbus, OH (A.L.P.); and Department of Pathology, The Ohio State University, Columbus (A.L.P.).

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http://dx.doi.org/10.1161/ATVBAHA.114.303644DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4239161PMC
December 2014

Angiotensin-induced abdominal aortic aneurysms in hypercholesterolemic mice: role of serum cholesterol and temporal effects of exposure.

PLoS One 2014 23;9(1):e84517. Epub 2014 Jan 23.

Department of Medicine, Vanderbilt University Medical Center (VUMC), Nashville, Tennessee, United States of America ; Department of Pathology, Microbiology and Immunology, VUMC, Nashville, Tennessee, United States of America ; Department of Radiology and Radiological Sciences, VUMC, Nashville, Tennessee, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0084517PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3900396PMC
November 2014

Macrophage deficiency of Akt2 reduces atherosclerosis in Ldlr null mice.

J Lipid Res 2014 Nov 19;55(11):2296-308. Epub 2014 Sep 19.

Atherosclerosis Research Unit, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232 Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232.

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http://dx.doi.org/10.1194/jlr.M050633DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4617132PMC
November 2014

Macrophage-derived apoESendai suppresses atherosclerosis while causing lipoprotein glomerulopathy in hyperlipidemic mice.

J Lipid Res 2014 Oct 2;55(10):2073-81. Epub 2014 Sep 2.

Knight Cardiovascular Institute, Center for Preventive Cardiology, Oregon Health and Science University, Portland, OR Section of Cardiovascular Disease Prevention, Division of Cardiovascular Medicine, Departments of Medicine, Vanderbilt University Medical Center, Nashville, TN Pathology, Immunology, and Microbiology, Vanderbilt University Medical Center, Nashville, TN.

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http://dx.doi.org/10.1194/jlr.M049874DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4174000PMC
October 2014

Proprotein convertase subtilisin kexin type 9 promotes intestinal overproduction of triglyceride-rich apolipoprotein B lipoproteins through both low-density lipoprotein receptor-dependent and -independent mechanisms.

Circulation 2014 Jul 23;130(5):431-41. Epub 2014 May 23.

From the Department of Pharmacology, Dalhousie University, Halifax, NS, and Saint John, NB, Canada (S.R.); Department of Medicine, Section of Cardiovascular Disease Prevention, Vanderbilt University, Nashville, TN (H.T., M.F.L., J.H., I.G., S.F.); Oregon Health and Science University, Portland (H.T., I.G.); and Department of Biostatistics, Faculty of Medicine, University of Toronto and Cancer Care Ontario, Toronto, ON, Canada (P.E.B.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.113.006720DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4115295PMC
July 2014

Oral retinoids and plasma lipids.

Dermatol Ther 2013 Sep-Oct;26(5):404-10

Section of Prevention of Cardiovascular Disease, Vanderbilt University Medical Center, Nashville, Tennessee.

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http://dx.doi.org/10.1111/dth.12085DOI Listing
June 2014

Response to Duell et al.

Circ Res 2014 Jun;115(1):e5

Vanderbilt University Medical Center, Section of Cardiovascular Disease Prevention, Nashville, TN.

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http://dx.doi.org/10.1161/CIRCRESAHA.114.304199DOI Listing
June 2014

Loss of plasma proprotein convertase subtilisin/kexin 9 (PCSK9) after lipoprotein apheresis.

Circ Res 2013 Dec 11;113(12):1290-5. Epub 2013 Oct 11.

From the Section of Cardiovascular Disease Prevention, Division of Cardiovascular Medicine, Department of Medicine (H.T., I.G., M.F.L., S.F.), and Departments of Pharmacology (M.F.L.) and Pathology, Immunology and Microbiology (S.F.), Vanderbilt University Medical Center, Nashville, TN.

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http://dx.doi.org/10.1161/CIRCRESAHA.113.302655DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3939022PMC
December 2013

Dysfunctional high-density lipoprotein in patients on chronic hemodialysis.

J Am Coll Cardiol 2012 Dec 7;60(23):2372-9. Epub 2012 Nov 7.

Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S07351097120465
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http://dx.doi.org/10.1016/j.jacc.2012.09.013DOI Listing
December 2012

When it looks like familial hypercholesterolemia...but is not.

Circ Cardiovasc Genet 2012 Dec;5(6):599-601

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http://dx.doi.org/10.1161/CIRCGENETICS.112.965137DOI Listing
December 2012

Benzo[a]pyrene potentiates the pathogenesis of abdominal aortic aneurysms in apolipoprotein E knockout mice.

Cell Physiol Biochem 2012 1;29(1-2):121-30. Epub 2012 Mar 1.

Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232-6300, USA.

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http://dx.doi.org/10.1159/000337593DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3711770PMC
July 2012

Residual cardiovascular risk despite optimal LDL cholesterol reduction with statins: the evidence, etiology, and therapeutic challenges.

Curr Atheroscler Rep 2012 Feb;14(1):1-10

Department of Medicine, Vanderbilt University Medical Center, Atherosclerosis Research Unit, 383 PRB - 2220 Pierce Avenue, Nashville, TN 37232-6300, USA.

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http://dx.doi.org/10.1007/s11883-011-0219-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3697085PMC
February 2012

Dyslipidemias in children.

Pediatr Ann 2012 Feb 8;41(2):e1-7. Epub 2012 Feb 8.

Vanderbilt Children's Hospital, Nashville, TN, USA.

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http://www.slackinc.com/doi/resolver.asp?doi=10.3928/0090448
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http://dx.doi.org/10.3928/00904481-20120110-08DOI Listing
February 2012

Macrophage polarization by angiotensin II-type 1 receptor aggravates renal injury-acceleration of atherosclerosis.

Arterioscler Thromb Vasc Biol 2011 Dec 6;31(12):2856-64. Epub 2011 Oct 6.

Department of Pediatrics, Vanderbilt University Medical Center, 1161 21st Avenue South, C-4204 Medical Center North, Nashville, TN 37232-2584, USA.

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http://atvb.ahajournals.org/content/31/12/2856.full.pdf
Web Search
http://atvb.ahajournals.org/cgi/doi/10.1161/ATVBAHA.111.2371
Publisher Site
http://dx.doi.org/10.1161/ATVBAHA.111.237198DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3227118PMC
December 2011

Novel domain interaction regulates secretion of proprotein convertase subtilisin/kexin type 9 (PCSK9) protein.

J Biol Chem 2011 Dec 25;286(50):43054-61. Epub 2011 Oct 25.

Department of Cell Biology and Anatomy, School of Medicine, University of South Carolina, Columbia, South Carolina 29209, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M111.273474
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http://dx.doi.org/10.1074/jbc.M111.273474DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3234880PMC
December 2011

Liver enzymes, type 2 diabetes, and metabolic syndrome in middle-aged, urban Chinese men.

Metab Syndr Relat Disord 2011 Aug 15;9(4):305-11. Epub 2011 Apr 15.

Department of Medicine, Vanderbilt Epidemiology Center, Nashville, Tennessee, USA.

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http://dx.doi.org/10.1089/met.2011.0016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3142636PMC
August 2011

High-density lipoprotein therapeutics and cardiovascular prevention.

J Clin Lipidol 2010 Sep-Oct;4(5):411-9. Epub 2010 Aug 17.

Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Atherosclerosis Research Unit, 383 PRB-2220 Pierce Avenue, Nashville, TN 37232-6300, USA.

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http://dx.doi.org/10.1016/j.jacl.2010.08.004DOI Listing
July 2011

Are statins diabetogenic?

Curr Opin Cardiol 2011 Jul;26(4):342-7

Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232-6300, USA.

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http://dx.doi.org/10.1097/HCO.0b013e3283470359DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3341610PMC
July 2011

Low-density lipoprotein receptor-related protein 1 prevents early atherosclerosis by limiting lesional apoptosis and inflammatory Ly-6Chigh monocytosis: evidence that the effects are not apolipoprotein E dependent.

Circulation 2011 Jul 5;124(4):454-64. Epub 2011 Jul 5.

Atherosclerosis Research Unit, Division of Cardiology, Department of Medicine, Vanderbilt University Medical Center, 2220 Pierce Avenue, Nashville, TN 37232, USA.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.111.032268DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3144781PMC
July 2011

Tie1 attenuation reduces murine atherosclerosis in a dose-dependent and shear stress-specific manner.

J Clin Invest 2011 Apr 7;121(4):1624-35. Epub 2011 Mar 7.

Department of Pediatrics, Division of Cardiology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0439, USA.

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http://dx.doi.org/10.1172/JCI42040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3069759PMC
April 2011

Mechanism of down-regulation of RNA polymerase III-transcribed non-coding RNA genes in macrophages by Leishmania.

J Biol Chem 2011 Feb 13;286(8):6614-26. Epub 2010 Dec 13.

Department of Microbiology and Immunology, Meharry Medical College, Nashville, Tennessee 37208, USA.

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http://dx.doi.org/10.1074/jbc.M110.181735DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3057815PMC
February 2011

Selective macrophage ascorbate deficiency suppresses early atherosclerosis.

Free Radic Biol Med 2011 Jan 23;50(1):27-36. Epub 2010 Oct 23.

Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

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http://dx.doi.org/10.1016/j.freeradbiomed.2010.10.702DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3014415PMC
January 2011

Atherosclerosis in chronic kidney disease: the role of macrophages.

Nat Rev Nephrol 2011 Jan 23;7(1):45-54. Epub 2010 Nov 23.

Department of Pediatrics, Vanderbilt University Medical Center, 383 Preston Research Building, 2220 Pierce Avenue, Nashville, TN 37332-6300, USA.

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http://dx.doi.org/10.1038/nrneph.2010.157DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3810304PMC
January 2011

Combined vitamin C and vitamin E deficiency worsens early atherosclerosis in apolipoprotein E-deficient mice.

Arterioscler Thromb Vasc Biol 2010 Sep 17;30(9):1751-7. Epub 2010 Jun 17.

Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232-0475, USA.

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https://www.ahajournals.org/doi/10.1161/ATVBAHA.110.209502
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http://dx.doi.org/10.1161/ATVBAHA.110.209502DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2924448PMC
September 2010

6-Mercaptopurine, monocytes, and atherosclerosis.

Arterioscler Thromb Vasc Biol 2010 Aug;30(8):1494-6

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http://dx.doi.org/10.1161/ATVBAHA.110.208264DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2922006PMC
August 2010

Insights into atherosclerosis using nanotechnology.

Curr Atheroscler Rep 2010 May;12(3):209-15

Department of Chemistry, Vanderbilt University, VU Station B Box 351822, Nashville, TN 37232, USA.

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http://dx.doi.org/10.1007/s11883-010-0106-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2863145PMC
May 2010

Macrophage LRP-1 controls plaque cellularity by regulating efferocytosis and Akt activation.

Arterioscler Thromb Vasc Biol 2010 Apr 11;30(4):787-95. Epub 2010 Feb 11.

Division of Cardiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

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http://dx.doi.org/10.1161/ATVBAHA.109.202051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2845445PMC
April 2010

Renal dysfunction potentiates foam cell formation by repressing ABCA1.

Arterioscler Thromb Vasc Biol 2009 Sep 10;29(9):1277-82. Epub 2009 Aug 10.

Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232-2584, USA.

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https://www.ahajournals.org/doi/10.1161/ATVBAHA.109.188995
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http://dx.doi.org/10.1161/ATVBAHA.109.188995DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2748735PMC
September 2009

Fenofibrate and risk of minor amputations in diabetes.

Lancet 2009 May;373(9677):1740-1

Division of Cardiovascular Medicine, Atherosclerosis Research Unit, Vanderbilt University Medical Center, Nashville, TN 37232-6300, USA.

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http://dx.doi.org/10.1016/S0140-6736(09)60959-4DOI Listing
May 2009

Quantum dot mediated imaging of atherosclerosis.

Nanotechnology 2009 Apr 31;20(16):165102. Epub 2009 Mar 31.

Department of Biomedical Engineering, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.

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http://dx.doi.org/10.1088/0957-4484/20/16/165102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2718756PMC
April 2009

Prevalence and determinants of metabolic syndrome according to three definitions in middle-aged Chinese men.

Metab Syndr Relat Disord 2009 Feb;7(1):37-45

Vanderbilt Epidemiology Center, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37203-1738, USA.

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http://dx.doi.org/10.1089/met.2008.0042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3135894PMC
February 2009

Macrophage EP4 deficiency increases apoptosis and suppresses early atherosclerosis.

Cell Metab 2008 Dec;8(6):492-501

Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232-6300, USA.

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http://dx.doi.org/10.1016/j.cmet.2008.09.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2614698PMC
December 2008

Lipoprotein subclasses and particle size determined by nuclear magnetic resonance spectroscopy in systemic lupus erythematosus.

Clin Rheumatol 2008 Oct 18;27(10):1227-33. Epub 2008 Apr 18.

Department of Medicine, Vanderbilt University, Nashville, TN 37232-6602, USA.

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http://dx.doi.org/10.1007/s10067-008-0890-4DOI Listing
October 2008

Correlates of high serum C-reactive protein levels in a socioeconomically disadvantaged population.

Dis Markers 2008 ;24(6):351-9

Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, Nashville, TN, USA.

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http://dx.doi.org/10.1155/2008/509138DOI Listing
October 2008

Lentiviral transduction of apoAI into hematopoietic progenitor cells and macrophages: applications to cell therapy of atherosclerosis.

Arterioscler Thromb Vasc Biol 2008 Aug 22;28(8):1439-46. Epub 2008 May 22.

Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville TN 37232-6300, USA.

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http://dx.doi.org/10.1161/ATVBAHA.107.160093DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2744493PMC
August 2008

Evidence of metabolic syndrome in lean children with premature pubarche at diagnosis.

Metabolism 2008 Jun;57(6):733-40

Department of Pediatrics, Vanderbilt University, Nashville, TN 37232, USA.

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June 2008