Maarten J G Leening

Maarten J G Leening

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Maarten J G Leening

Publications by authors named "Maarten J G Leening"

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Genetic predisposition, modifiable-risk-factor profile and long-term dementia risk in the general population.

Nat Med 2019 09 26;25(9):1364-1369. Epub 2019 Aug 26.

Department of Epidemiology, Erasmus MC-University Medical Center Rotterdam, Rotterdam, the Netherlands.

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http://dx.doi.org/10.1038/s41591-019-0547-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6739225PMC
September 2019

Safety and Tolerability of Sustained Lipid-Lowering Therapy: Trial Data and Public Perception in a World Where Vaccines and Statins Are About to Collide.

JAMA Cardiol 2019 Sep 25. Epub 2019 Sep 25.

Departments of Cardiology and Epidemiology, Erasmus MC-University Medical Center Rotterdam, Rotterdam, the Netherlands.

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http://dx.doi.org/10.1001/jamacardio.2019.3528DOI Listing
September 2019

Development and Validation of a Dementia Risk Prediction Model in the General Population: An Analysis of Three Longitudinal Studies.

Am J Psychiatry 2019 Jul 11;176(7):543-551. Epub 2018 Dec 11.

The Department of Epidemiology (Licher, Leening, Yilmaz, Wolters, Heeringa, Vernooij, M.K. Ikram, M.A. Ikram), the Department of Neurology (Wolters, M.K. Ikram), the Department of Cardiology (Leening), the Department of Radiology and Nuclear Medicine (Yilmaz, Vernooij), and the Department of General Practice (Bindels), Erasmus MC-University Medical Center Rotterdam, Rotterdam, the Netherlands; the Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston (Leening, Wolters); the Institute of Health and Society, Newcastle University, Newcastle, U.K. (Stephan); the Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, the Netherlands (Steyerberg); and the Center for Medical Decision Making, Department of Public Health, Erasmus MC-University Medical Center Rotterdam, Rotterdam, the Netherlands (Steyerberg).

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http://dx.doi.org/10.1176/appi.ajp.2018.18050566DOI Listing
July 2019

Interpretation of Studies on the Occurrence of Atrial Fibrillation in Elite Athletes.

JAMA Cardiol 2019 Apr;4(4):392

Department of Epidemiology, Erasmus MC-University Medical Center Rotterdam, Rotterdam, the Netherlands.

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http://dx.doi.org/10.1001/jamacardio.2019.0382DOI Listing
April 2019

Lifetime risk of common neurological diseases in the elderly population.

J Neurol Neurosurg Psychiatry 2019 Feb 2;90(2):148-156. Epub 2018 Oct 2.

Department of Epidemiology, Erasmus MC - University Medical Center Rotterdam, Rotterdam, The Netherlands

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http://dx.doi.org/10.1136/jnnp-2018-318650DOI Listing
February 2019

Comparison of Cardiovascular Risk Factors for Coronary Heart Disease and Stroke Type in Women.

J Am Heart Assoc 2018 10;7(19):e007514

1 Center for Cardiovascular Disease Prevention Divisions of Preventive Medicine and Cardiology Brigham and Women's Hospital Harvard Medical School Boston MA.

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https://www.ahajournals.org/doi/10.1161/JAHA.117.007514
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http://dx.doi.org/10.1161/JAHA.117.007514DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6404882PMC
October 2018

Leveraging the coronary calcium scan beyond the coronary calcium score.

Eur Radiol 2018 Jul 30;28(7):3082-3087. Epub 2018 Jan 30.

Department of Epidemiology, Erasmus MC - University Medical Centre Rotterdam, P.O. Box 2040, 3000 CA, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1007/s00330-017-5264-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5986828PMC
July 2018

Primary prevention of cardiovascular disease: The past, present, and future of blood pressure- and cholesterol-lowering treatments.

PLoS Med 2018 03 20;15(3):e1002539. Epub 2018 Mar 20.

Department of Epidemiology, Erasmus MC - University Medical Center Rotterdam, Rotterdam, the Netherlands.

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https://dx.doi.org/10.1371/journal.pmed.1002539
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http://dx.doi.org/10.1371/journal.pmed.1002539DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5860691PMC
March 2018

Absolute vs Additive Net Reclassification Index.

JAMA 2018 02;319(6):616

Department of Biostatistics and Bioinformatics, Duke Clinical Research Institute, Durham, North Carolina.

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http://dx.doi.org/10.1001/jama.2017.20541DOI Listing
February 2018

Pulmonary function and diffusion capacity are associated with pulmonary arterial systolic pressure in the general population: The Rotterdam Study.

Respir Med 2017 Nov 21;132:50-55. Epub 2017 Sep 21.

Department of Epidemiology, Erasmus MC - University Medical Center Rotterdam, Rotterdam, The Netherlands; Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium; Department of Respiratory Medicine, Erasmus MC - University Medical Center Rotterdam, Rotterdam, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.rmed.2017.09.009DOI Listing
November 2017

Should we reconsider the role of age in treatment allocation for primary prevention of cardiovascular disease?

Eur Heart J 2017 05;38(20):1542-1547

Center for Cardiovascular Disease Prevention, Divisions of Preventive Medicine and Cardiology, Brigham and Women's Hospital, Boston, MA, USA.

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http://dx.doi.org/10.1093/eurheartj/ehw287DOI Listing
May 2017

Large-scale genome-wide analysis identifies genetic variants associated with cardiac structure and function.

Authors:
Philipp S Wild Janine F Felix Arne Schillert Alexander Teumer Ming-Huei Chen Maarten J G Leening Uwe Völker Vera Großmann Jennifer A Brody Marguerite R Irvin Sanjiv J Shah Setia Pramana Wolfgang Lieb Reinhold Schmidt Alice V Stanton Dörthe Malzahn Albert Vernon Smith Johan Sundström Cosetta Minelli Daniela Ruggiero Leo-Pekka Lyytikäinen Daniel Tiller J Gustav Smith Claire Monnereau Marco R Di Tullio Solomon K Musani Alanna C Morrison Tune H Pers Michael Morley Marcus E Kleber Jayashri Aragam Emelia J Benjamin Joshua C Bis Egbert Bisping Ulrich Broeckel Susan Cheng Jaap W Deckers Fabiola Del Greco M Frank Edelmann Myriam Fornage Lude Franke Nele Friedrich Tamara B Harris Edith Hofer Albert Hofman Jie Huang Alun D Hughes Mika Kähönen Knhi Investigators Jochen Kruppa Karl J Lackner Lars Lannfelt Rafael Laskowski Lenore J Launer Margrét Leosdottir Honghuang Lin Cecilia M Lindgren Christina Loley Calum A MacRae Deborah Mascalzoni Jamil Mayet Daniel Medenwald Andrew P Morris Christian Müller Martina Müller-Nurasyid Stefania Nappo Peter M Nilsson Sebastian Nuding Teresa Nutile Annette Peters Arne Pfeufer Diana Pietzner Peter P Pramstaller Olli T Raitakari Kenneth M Rice Fernando Rivadeneira Jerome I Rotter Saku T Ruohonen Ralph L Sacco Tandaw E Samdarshi Helena Schmidt Andrew S P Sharp Denis C Shields Rossella Sorice Nona Sotoodehnia Bruno H Stricker Praveen Surendran Simon Thom Anna M Töglhofer André G Uitterlinden Rolf Wachter Henry Völzke Andreas Ziegler Thomas Münzel Winfried März Thomas P Cappola Joel N Hirschhorn Gary F Mitchell Nicholas L Smith Ervin R Fox Nicole D Dueker Vincent W V Jaddoe Olle Melander Martin Russ Terho Lehtimäki Marina Ciullo Andrew A Hicks Lars Lind Vilmundur Gudnason Burkert Pieske Anthony J Barron Robert Zweiker Heribert Schunkert Erik Ingelsson Kiang Liu Donna K Arnett Bruce M Psaty Stefan Blankenberg Martin G Larson Stephan B Felix Oscar H Franco Tanja Zeller Ramachandran S Vasan Marcus Dörr

J Clin Invest 2017 May 10;127(5):1798-1812. Epub 2017 Apr 10.

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https://www.jci.org/articles/view/84840
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http://dx.doi.org/10.1172/JCI84840DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5409098PMC
May 2017

The Revised Framingham Stroke Risk Profile in a Primary Prevention Population: The Rotterdam Study.

Circulation 2017 05;135(22):2207-2209

From Departments of Epidemiology (D.B., M.A.I., M.J.G.L., M.K.I.), Radiology and Nuclear Medicine (D.B., M.A.I.), Neurology (M.A.I., M.K.I.), and Cardiology (M.J.G.L.), Erasmus MC-University Medical Center Rotterdam, The Netherlands; and Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA (D.B., M.J.G.L.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.117.028429DOI Listing
May 2017

Coronary calcium scores: From histology to preventive cardiology.

Int J Cardiol 2017 Feb 6;229:34. Epub 2016 Dec 6.

Department of Epidemiology, Erasmus MC - University Medical Center Rotterdam, Rotterdam, The Netherlands; Department of Epidemiology, Harvard School of Public Health, Boston, MA, United States; Department of Cardiology, Erasmus MC - University Medical Center Rotterdam, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.ijcard.2016.11.299DOI Listing
February 2017

Comparison of ACC/AHA and ESC Guideline Recommendations Following Trial Evidence for Statin Use in Primary Prevention of Cardiovascular Disease: Results From the Population-Based Rotterdam Study.

JAMA Cardiol 2016 09;1(6):708-13

Department of Epidemiology, Erasmus MC-University Medical Center Rotterdam, Rotterdam, the Netherlands3Department of Cardiology, Erasmus MC-University Medical Center Rotterdam, Rotterdam, the Netherlands6Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, Massachusetts.

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http://dx.doi.org/10.1001/jamacardio.2016.1577DOI Listing
September 2016

Lifetime Perspectives on Primary Prevention of Atherosclerotic Cardiovascular Disease.

JAMA 2016 Apr;315(14):1449-50

Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.

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http://dx.doi.org/10.1001/jama.2016.1654DOI Listing
April 2016

Subclinical Abnormalities in Echocardiographic Parameters and Risk of Sudden Cardiac Death in a General Population: The Rotterdam Study.

J Card Fail 2016 Jan 18;22(1):17-23. Epub 2015 Jun 18.

Department of Epidemiology, Erasmus Medical Center-University Medical Center Rotterdam, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.cardfail.2015.06.007DOI Listing
January 2016

Lifetime risk of developing impaired glucose metabolism and eventual progression from prediabetes to type 2 diabetes: a prospective cohort study.

Lancet Diabetes Endocrinol 2016 Jan 11;4(1):44-51. Epub 2015 Nov 11.

Department of Epidemiology, Erasmus University Medical Center, Rotterdam, Netherlands. Electronic address:

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http://dx.doi.org/10.1016/S2213-8587(15)00362-9DOI Listing
January 2016

Comparison of Atherosclerotic Calcification in Major Vessel Beds on the Risk of All-Cause and Cause-Specific Mortality: The Rotterdam Study.

Circ Cardiovasc Imaging 2015 Dec;8(12)

From the Departments of Radiology (D.B., A.L., M.W.V., M.A.I.), Epidemiology (D.B., M.J.G.L., M.K., A.H., O.H.F., M.W.V., M.A.I.), Cardiology (M.J.G.L.), and Neurology (M.A.I.), Erasmus MC, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1161/CIRCIMAGING.115.003843DOI Listing
December 2015

Association Between Mind-Body Practice and Cardiometabolic Risk Factors: The Rotterdam Study.

Psychosom Med 2015 Sep;77(7):775-83

From the Departments of Cardiology (Younge, Leening, Roos-Hesselink), Epidemiology (Younge, Leening, Tiemeier, Franco, Kiefte-de Jong, Hofman, Hunink), Psychiatry (Tiemeier), and Radiology (Hunink), Erasmus Medical Center Rotterdam, Rotterdam, the Netherlands; and Department of Health Policy and Management (Hunink), Harvard T.H. Chan School of Public Health, Boston, Massachusetts.

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http://dx.doi.org/10.1097/PSY.0000000000000213DOI Listing
September 2015

Graphical assessment of incremental value of novel markers in prediction models: From statistical to decision analytical perspectives.

Biom J 2015 Jul 18;57(4):556-70. Epub 2014 Jul 18.

Department of Biostatistics and Bioinformatics, Duke Clinical Research Institute, Duke University, Durham, NC, USA.

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http://dx.doi.org/10.1002/bimj.201300260DOI Listing
July 2015

Association of Cardiometabolic Multimorbidity With Mortality.

JAMA 2015 07;314(1):52-60

University of Cambridge, Cambridge, England.

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http://dx.doi.org/10.1001/jama.2015.7008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4664176PMC
July 2015

Assessing Prolongation of the Heart Rate Corrected QT Interval in Users of Tricyclic Antidepressants: Advice to Use Fridericia Rather Than Bazett's Correction.

J Clin Psychopharmacol 2015 Jun;35(3):260-5

From the Departments of *Internal Medicine, †Epidemiology, ‡Medical Informatics, and §Cardiology, Erasmus MC-University Medical Center Rotterdam, Rotterdam: ∥Inspectorate of Health Care; and ¶Apotheek Haagse Ziekenhuizen-HAGA, The Hague, The Netherlands.

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http://pdfs.journals.lww.com/psychopharmacology/2015/06000/A
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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/JCP.0000000000000321DOI Listing
June 2015

Subclinical cardiac dysfunction increases the risk of stroke and dementia: the Rotterdam Study.

Neurology 2015 Feb 28;84(8):833-40. Epub 2015 Jan 28.

From the Departments of Epidemiology (R.F.A.G.d.B., M.L.P.P., M.J.G.L., M.J.B., A.H., M.W.V., O.H.F., M.A.I.), Neurology (R.F.A.G.d.B., M.L.P.P., P.J.K., M.A.I.), Cardiology (M.J.G.L.), Radiology (A.v.d.L., W.J.N., M.W.V., M.A.I.), and Medical Informatics (W.J.N.), Erasmus Medical Center, Rotterdam; and Imaging Science and Technology (W.J.N.), Faculty of Applied Sciences, Delft University of Technology, the Netherlands.

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http://www.neurology.org/content/84/8/833.full.pdf
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http://www.neurology.org/cgi/doi/10.1212/WNL.000000000000128
Publisher Site
http://dx.doi.org/10.1212/WNL.0000000000001289DOI Listing
February 2015

Declining incidence of sudden cardiac death from 1990-2010 in a general middle-aged and elderly population: The Rotterdam Study.

Heart Rhythm 2015 Jan 30;12(1):123-9. Epub 2014 Sep 30.

Department of Epidemiology, Erasmus MC-University Medical Center Rotterdam, Rotterdam, the Netherlands; Department of Internal Medicine, Erasmus MC-University Medical Center Rotterdam, Rotterdam, the Netherlands.

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http://dx.doi.org/10.1016/j.hrthm.2014.09.054DOI Listing
January 2015

Associations of heart failure with sleep quality: the Rotterdam Study.

J Clin Sleep Med 2015 Jan 15;11(2):117-21. Epub 2015 Jan 15.

Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands: Department of Child and Adolescent Psychiatry, Erasmus Medical Center, Rotterdam, The Netherlands: Department of Psychiatry, Erasmus Medical Center, Rotterdam, The Netherlands.

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http://dx.doi.org/10.5664/jcsm.4454DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4298768PMC
January 2015

Use of coumarin anticoagulants and cerebral microbleeds in the general population.

Stroke 2014 Nov 14;45(11):3436-9. Epub 2014 Oct 14.

From the Departments of Epidemiology (S.A., S.K.L.D., M.J.G.L., A.H., B.H.S., M.A.I., M.W.V.), Radiology (S.A., A.v.d.L., M.A.I., M.W.V.), Neurology (S.A., P.J.K., M.A.I.), and Cardiology (M.J.G.L.), Erasmus MC, Rotterdam, the Netherlands; and Inspectorate of Health Care, The Hague, the Netherlands (B.H.S.).

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http://dx.doi.org/10.1161/STROKEAHA.114.007112DOI Listing
November 2014

Net reclassification improvement and integrated discrimination improvement require calibrated models: relevance from a marker and model perspective.

Stat Med 2014 Aug;33(19):3415-8

Department of Epidemiology, Erasmus MC - University Medical Center Rotterdam, Rotterdam, The Netherlands; Department of Cardiology, Erasmus MC - University Medical Center Rotterdam, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1002/sim.6133DOI Listing
August 2014

Healthy volunteer effect and cardiovascular risk.

Epidemiology 2014 May;25(3):470-1

Department of Epidemiology, Erasmus MC-University Medical Center Rotterdam, Rotterdam, The Netherlands Department of Cardiology, Erasmus MC-University Medical Center Rotterdam, Rotterdam, The Netherlands Department of Epidemiology, Erasmus MC-University Medical Center Rotterdam, Rotterdam, The Netherlands,

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http://dx.doi.org/10.1097/EDE.0000000000000091DOI Listing
May 2014

Performance of Framingham cardiovascular disease (CVD) predictions in the Rotterdam Study taking into account competing risks and disentangling CVD into coronary heart disease (CHD) and stroke.

Int J Cardiol 2014 Feb 27;171(3):413-8. Epub 2013 Dec 27.

Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands; Department of Radiology, Erasmus MC, Rotterdam, The Netherlands; Department of Health Policy and Management, Harvard School of Public Health, Boston, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01675273130224
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http://dx.doi.org/10.1016/j.ijcard.2013.12.036DOI Listing
February 2014

Unrecognized myocardial infarction and risk of atrial fibrillation: the Rotterdam Study.

Int J Cardiol 2013 Sep 17;168(2):1453-7. Epub 2013 Jan 17.

Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands; Netherlands Consortium for Healthy Aging (NCHA), The Netherlands.

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http://dx.doi.org/10.1016/j.ijcard.2012.12.057DOI Listing
September 2013

Clopidogrel use is associated with an increased prevalence of cerebral microbleeds in a stroke-free population: the Rotterdam study.

J Am Heart Assoc 2013 Sep 26;2(5):e000359. Epub 2013 Sep 26.

Department of Epidemiology, Erasmus MC University Medical Center Rotterdam, Rotterdam, the Netherlands.

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http://dx.doi.org/10.1161/JAHA.113.000359DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3835244PMC
September 2013

Resting heart rate and the risk of heart failure in healthy adults: the Rotterdam Study.

Circ Heart Fail 2013 May 18;6(3):403-10. Epub 2013 Apr 18.

Department of Ambulatory Care and Community Medicine, University of Lausanne, Lausanne, Switzerland.

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http://dx.doi.org/10.1161/CIRCHEARTFAILURE.112.000171DOI Listing
May 2013

Net reclassification improvement: a link between statistics and clinical practice.

Eur J Epidemiol 2013 Jan 5;28(1):21-3. Epub 2013 Jan 5.

Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1007/s10654-012-9759-6DOI Listing
January 2013