Maarten Bijlsma

Maarten Bijlsma

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Maarten Bijlsma

Publications by authors named "Maarten Bijlsma"

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Chemoradiation induces epithelial-to-mesenchymal transition in esophageal adenocarcinoma.

Int J Cancer 2019 Nov 7;145(10):2792-2803. Epub 2019 May 7.

Department of Medical Oncology, Cancer Center Amsterdam, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1002/ijc.32364DOI Listing
November 2019

A marker-independent lineage-tracing system to quantify clonal dynamics and stem cell functionality in cancer tissue.

Nat Protoc 2019 Sep 16;14(9):2648-2671. Epub 2019 Aug 16.

LEXOR, Center for Experimental and Molecular Medicine, Cancer Center Amsterdam and Amsterdam Gastroenterology & Metabolism, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1038/s41596-019-0194-yDOI Listing
September 2019

Smoothened-dependent and -independent pathways in mammalian noncanonical Hedgehog signaling.

J Biol Chem 2019 Jun 16;294(25):9787-9798. Epub 2019 Apr 16.

From the Department of Gastroenterology and Hepatology, Erasmus MC, University Medical Center Rotterdam, PO Box 2040, NL-3000 CA Rotterdam, The Netherlands,

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http://www.jbc.org/lookup/doi/10.1074/jbc.RA119.007956
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http://dx.doi.org/10.1074/jbc.RA119.007956DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6597826PMC
June 2019

The Impact of Unemployment on Antidepressant Purchasing: Adjusting for Unobserved Time-constant Confounding in the g-Formula.

Epidemiology 2019 05;30(3):388-395

From the Max Planck Institute for Demographic Research, Rostock, Germany.

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http://dx.doi.org/10.1097/EDE.0000000000000985DOI Listing
May 2019

Clinical Trials Targeting the Stroma in Pancreatic Cancer: A Systematic Review and Meta-Analysis.

Cancers (Basel) 2019 Apr 26;11(5). Epub 2019 Apr 26.

Department of Medical Oncology, Amsterdam UMC, University of Amsterdam, Cancer Center Amsterdam, Meibergdreef 9, 1105AZ Amsterdam, The Netherlands.

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https://www.mdpi.com/2072-6694/11/5/588
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http://dx.doi.org/10.3390/cancers11050588DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562438PMC
April 2019

Molecular subtyping of cancer: current status and moving toward clinical applications.

Brief Bioinform 2019 03;20(2):572-584

Laboratory for Experimental Oncology and Radiobiology, Center for Experimental and Molecular Medicine, Cancer Center Amsterdam and Academic Medical Center, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1093/bib/bby026DOI Listing
March 2019

Spatiotemporal regulation of clonogenicity in colorectal cancer xenografts.

Proc Natl Acad Sci U S A 2019 03 8;116(13):6140-6145. Epub 2019 Mar 8.

Laboratory for Experimental Oncology and Radiobiology, Center for Experimental and Molecular Medicine, Cancer Center Amsterdam, Amsterdam Gastroenterology & Metabolism, Amsterdam UMC, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands;

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http://dx.doi.org/10.1073/pnas.1813417116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442578PMC
March 2019

Cancer stem cells: here, there, and everywhere.

Mol Cell Oncol 2019 4;6(1):1540235. Epub 2018 Dec 4.

Amsterdam UMC, LEXOR, Center for Experimental and Molecular Medicine, Cancer Center Amsterdam and Amsterdam Gastroenterology & Metabolism, University of Amsterdam, Amsterdam, Netherlands.

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http://dx.doi.org/10.1080/23723556.2018.1540235DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370381PMC
December 2018

The clinical benefit of hyperthermia in pancreatic cancer: a systematic review.

Int J Hyperthermia 2018 11 23;34(7):969-979. Epub 2017 Nov 23.

a Department of Radiation Oncology and Hyperthermia , Academic Medical Center, University of Amsterdam , Amsterdam , The Netherlands.

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http://dx.doi.org/10.1080/02656736.2017.1401126DOI Listing
November 2018

Multidrug-resistant transporter expression does not always result in drug resistance.

Cancer Sci 2018 Oct 8;109(10):3360-3362. Epub 2018 Sep 8.

Medical Oncology, Amsterdam UMC, Cancer Center Amsterdam, VU University Medical Center, Amsterdam, The Netherlands.

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http://doi.wiley.com/10.1111/cas.13756
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http://dx.doi.org/10.1111/cas.13756DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6172061PMC
October 2018

Impact of Different Estimation Methods on Obesity-Attributable Mortality Levels and Trends: The Case of The Netherlands.

Int J Environ Res Public Health 2018 09 29;15(10). Epub 2018 Sep 29.

Population Research Centre, Faculty of Spatial Sciences, University of Groningen, PO Box 800, 9700 AV Groningen, The Netherlands.

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http://dx.doi.org/10.3390/ijerph15102146DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6210009PMC
September 2018

Patched-2 functions to limit Patched-1 deficient skin cancer growth.

Cell Oncol (Dordr) 2018 Aug 4;41(4):427-437. Epub 2018 Jun 4.

Laboratory for Experimental Oncology and Radiobiology, Center for Experimental and Molecular Medicine, Cancer Center Amsterdam and Academic Medical Center, Meibergdreef 9, 1105AZ, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1007/s13402-018-0381-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6105176PMC
August 2018

PAR1 signaling on tumor cells limits tumor growth by maintaining a mesenchymal phenotype in pancreatic cancer.

Oncotarget 2018 Aug 10;9(62):32010-32023. Epub 2018 Aug 10.

Amsterdam UMC, University of Amsterdam, Center of Experimental and Molecular Medicine, Amsterdam, The Netherlands.

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http://www.oncotarget.com/fulltext/25880
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http://dx.doi.org/10.18632/oncotarget.25880DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6112838PMC
August 2018

Past trends in obesity-attributable mortality in eight European countries: an application of age-period-cohort analysis.

Int J Public Health 2018 Jul 4;63(6):683-692. Epub 2018 Jun 4.

Population Research Centre, Faculty of Spatial Sciences, University of Groningen, PO Box 800, 9700 AV, Groningen, The Netherlands.

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http://dx.doi.org/10.1007/s00038-018-1126-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6015618PMC
July 2018

The hepatic pre-metastatic niche in pancreatic ductal adenocarcinoma.

Mol Cancer 2018 06 14;17(1):95. Epub 2018 Jun 14.

Laboratory for Experimental Oncology and Radiobiology, Center of Experimental and Molecular Medicine, Cancer Center Amsterdam and Academic Medical Center, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1186/s12943-018-0842-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6003100PMC
June 2018

The dynamics of HER2 status in esophageal adenocarcinoma.

Oncotarget 2018 Jun 1;9(42):26787-26799. Epub 2018 Jun 1.

Center for Experimental and Molecular Medicine, Laboratory of Experimental Oncology and Radiobiology, Cancer Center Amsterdam, Academic Medical Center, Amsterdam, The Netherlands.

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http://dx.doi.org/10.18632/oncotarget.25507DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6003553PMC
June 2018

Epigenetic regulation of the Hedgehog and Wnt pathways in cancer.

Crit Rev Oncol Hematol 2018 Jan 24;121:23-44. Epub 2017 Nov 24.

Laboratory for Experimental Oncology and Radiobiology, Center of Experimental and Molecular Medicine, Cancer Center Amsterdam and Academic Medical Center, Amsterdam, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.critrevonc.2017.11.013DOI Listing
January 2018

Extracellular Influences: Molecular Subclasses and the Microenvironment in Pancreatic Cancer.

Cancers (Basel) 2018 Jan 27;10(2). Epub 2018 Jan 27.

Laboratory for Experimental Oncology and Radiobiology, Center for Experimental and Molecular Medicine, Academic Medical Center and Cancer Center Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.

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http://dx.doi.org/10.3390/cancers10020034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5836066PMC
January 2018

Unemployment and subsequent depression: A mediation analysis using the parametric G-formula.

Soc Sci Med 2017 12 22;194:142-150. Epub 2017 Oct 22.

Max Planck Institute for Demographic Research, Konrad-Zuse str. 1, 18057 Rostock, Germany; Department of Social Research, University of Helsinki, Unioninkatu 37 (P.O. Box 54), 00014 Helsinki, Finland; Centre for Health Equity Studies (CHESS), Stockholm University and Karolinska Institutet, SE-106 91 Stockholm Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.socscimed.2017.10.011DOI Listing
December 2017

Skin-Derived Vitamin D Protects against Basal Cell Carcinoma.

J Invest Dermatol 2017 12;137(12):2469-2471

Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California, USA.

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http://dx.doi.org/10.1016/j.jid.2017.07.816DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154801PMC
December 2017

Risks versus benefits of medication use during pregnancy: what do women perceive?

Patient Prefer Adherence 2018 20;12:1-8. Epub 2017 Dec 20.

Department of Pediatrics, Medical Center Leeuwarden, Leeuwarden, the Netherlands.

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http://dx.doi.org/10.2147/PPA.S146091DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5741981PMC
December 2017

Influenza Vaccine Effectiveness in the Netherlands from 2003/2004 through 2013/2014: The Importance of Circulating Influenza Virus Types and Subtypes.

PLoS One 2017 9;12(1):e0169528. Epub 2017 Jan 9.

Infectious Disease Research, Diagnostics and Screening, Centre for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0169528PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5222508PMC
August 2017

Stromal SPOCK1 supports invasive pancreatic cancer growth.

Mol Oncol 2017 08 5;11(8):1050-1064. Epub 2017 Jun 5.

Laboratory for Experimental Oncology and Radiobiology, Center for Experimental and Molecular Medicine, Academic Medical Center and Cancer Center Amsterdam, The Netherlands.

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http://dx.doi.org/10.1002/1878-0261.12073DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5537700PMC
August 2017

Molecular subtypes in cancers of the gastrointestinal tract.

Nat Rev Gastroenterol Hepatol 2017 Jun 12;14(6):333-342. Epub 2017 Apr 12.

Laboratory for Experimental Oncology and Radiobiology, Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.

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http://dx.doi.org/10.1038/nrgastro.2017.33DOI Listing
June 2017

An Assessment and Extension of the Mechanism-Based Approach to the Identification of Age-Period-Cohort Models.

Demography 2017 04;54(2):721-743

Centre for Statistical Methodology and Department of Medical Statistics, London School of Hygiene and Tropical Medicine, London, UK.

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http://dx.doi.org/10.1007/s13524-017-0562-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5371644PMC
April 2017

Association Between Workarounds and Medication Administration Errors in Bar Code-Assisted Medication Administration: Protocol of a Multicenter Study.

JMIR Res Protoc 2017 Apr 28;6(4):e74. Epub 2017 Apr 28.

Faculty of Science and Engineering, Unit PharmacoTherapy, -Epidemiology & -Economics, University of Groningen, Groningen, Netherlands.

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http://dx.doi.org/10.2196/resprot.7060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5429431PMC
April 2017

The role of birth cohorts in long-term trends in liver cirrhosis mortality across eight European countries.

Addiction 2017 02 28;112(2):250-258. Epub 2016 Oct 28.

Population Research Centre, Faculty of Spatial Sciences, University of Groningen, Groningen, the Netherlands.

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http://dx.doi.org/10.1111/add.13614DOI Listing
February 2017

A clinical validation study for application of DBS in therapeutic drug monitoring of antidepressants.

Bioanalysis 2016 19;8(5):413-24. Epub 2016 Feb 19.

Laboratory for Drug Analysis & Toxicology, Diaconessen Hospital Meppel & Bethesda Hospital Hoogeveen, Meppel, The Netherlands.

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http://dx.doi.org/10.4155/bio.15.255DOI Listing
December 2016

Three new pancreatic cancer susceptibility signals identified on chromosomes 1q32.1, 5p15.33 and 8q24.21.

Authors:
Mingfeng Zhang Zhaoming Wang Ofure Obazee Jinping Jia Erica J Childs Jason Hoskins Gisella Figlioli Evelina Mocci Irene Collins Charles C Chung Christopher Hautman Alan A Arslan Laura Beane-Freeman Paige M Bracci Julie Buring Eric J Duell Steven Gallinger Graham G Giles Gary E Goodman Phyllis J Goodman Aruna Kamineni Laurence N Kolonel Matthew H Kulke Núria Malats Sara H Olson Howard D Sesso Kala Visvanathan Emily White Wei Zheng Christian C Abnet Demetrius Albanes Gabriella Andreotti Lauren Brais H Bas Bueno-de-Mesquita Daniela Basso Sonja I Berndt Marie-Christine Boutron-Ruault Maarten F Bijlsma Hermann Brenner Laurie Burdette Daniele Campa Neil E Caporaso Gabriele Capurso Giulia Martina Cavestro Michelle Cotterchio Eithne Costello Joanne Elena Ugo Boggi J Michael Gaziano Maria Gazouli Edward L Giovannucci Michael Goggins Myron Gross Christopher A Haiman Manal Hassan Kathy J Helzlsouer Nan Hu David J Hunter Elzbieta Iskierka-Jazdzewska Mazda Jenab Rudolf Kaaks Timothy J Key Kay-Tee Khaw Eric A Klein Manolis Kogevinas Vittorio Krogh Juozas Kupcinskas Robert C Kurtz Maria T Landi Stefano Landi Loic Le Marchand Andrea Mambrini Satu Mannisto Roger L Milne Rachel E Neale Ann L Oberg Salvatore Panico Alpa V Patel Petra H M Peeters Ulrike Peters Raffaele Pezzilli Miquel Porta Mark Purdue J Ramón Quiros Elio Riboli Nathaniel Rothman Aldo Scarpa Ghislaine Scelo Xiao-Ou Shu Debra T Silverman Pavel Soucek Oliver Strobel Malin Sund Ewa Małecka-Panas Philip R Taylor Francesca Tavano Ruth C Travis Mark Thornquist Anne Tjønneland Geoffrey S Tobias Dimitrios Trichopoulos Yogesh Vashist Pavel Vodicka Jean Wactawski-Wende Nicolas Wentzensen Herbert Yu Kai Yu Anne Zeleniuch-Jacquotte Charles Kooperberg Harvey A Risch Eric J Jacobs Donghui Li Charles Fuchs Robert Hoover Patricia Hartge Stephen J Chanock Gloria M Petersen Rachael S Stolzenberg-Solomon Brian M Wolpin Peter Kraft Alison P Klein Federico Canzian Laufey T Amundadottir

Oncotarget 2016 Oct;7(41):66328-66343

Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.

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http://dx.doi.org/10.18632/oncotarget.11041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5340084PMC
October 2016

Bioinformatic analysis reveals pancreatic cancer molecular subtypes specific to the tumor and the microenvironment.

Expert Rev Mol Diagn 2016 07 27;16(7):733-6. Epub 2016 Apr 27.

b Department of Medical Oncology , VU University Medical Center , Amsterdam , The Netherlands.

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http://dx.doi.org/10.1080/14737159.2016.1175940DOI Listing
July 2016

The effect of adherence to statin therapy on cardiovascular mortality: quantification of unmeasured bias using falsification end-points.

BMC Public Health 2016 Apr 11;16:303. Epub 2016 Apr 11.

Unit PharmacoEpidemiology & PharmacoEconomics (PE2), Department of Pharmacy, University of Groningen, A. Deusinglaan 1, PO BOX 9713 AV, Groningen, The Netherlands.

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http://dx.doi.org/10.1186/s12889-016-2986-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4827225PMC
April 2016

Estimating time-varying drug adherence using electronic records: extending the proportion of days covered (PDC) method.

Pharmacoepidemiol Drug Saf 2016 Mar 21;25(3):325-32. Epub 2015 Dec 21.

Unit PharmacoEpidemiology & PharmacoEconomics (PE2), Department of Pharmacy, University of Groningen, Groningen, The Netherlands.

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http://dx.doi.org/10.1002/pds.3935DOI Listing
March 2016

Bidirectional interconversion of stem and non-stem cancer cell populations: A reassessment of theoretical models for tumor heterogeneity.

Mol Cell Oncol 2016 Mar 2;3(2):e1098791. Epub 2015 Dec 2.

Laboratory for Experimental Oncology and Radiobiology, Center for Experimental and Molecular Medicine, Academic Medical Center , Amsterdam, The Netherlands.

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http://dx.doi.org/10.1080/23723556.2015.1098791DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905404PMC
March 2016

Brief Report: Association Between Statin Use and Cardiovascular Mortality at the Population Level: An Ecologic Study.

Epidemiology 2015 Nov;26(6):802-5

From the aDepartment of Pharmacy, Unit PharmacoEpidemiology & Pharmaco Economics (PE2), University of Groningen, Groningen, The Netherlands; bFaculty of Spatial Sciences, Population Research Centre (PRC), University of Groningen, Groningen, The Netherlands; cNetherlands Interdisciplinary Demographic Institute, The Hague, The Netherlands; dDepartment of Vascular Medicine, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands; and eDepartment of Applied Mathematics, Computer Science and Statistics, Ghent University, Ghent, Belgium.

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http://dx.doi.org/10.1097/EDE.0000000000000370DOI Listing
November 2015

Common variation at 2p13.3, 3q29, 7p13 and 17q25.1 associated with susceptibility to pancreatic cancer.

Nat Genet 2015 Aug 22;47(8):911-6. Epub 2015 Jun 22.

1] Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, Maryland, USA. [2] Department of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1038/ng.3341DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4520746PMC
August 2015

Birth cohort appeared to confound effect estimates of guideline changes on statin utilization.

J Clin Epidemiol 2015 Mar 13;68(3):334-40. Epub 2014 Nov 13.

Unit PharmacoEpidemiology & PharmacoEconomics (PE2), Department of Pharmacy, University of Groningen, A. Deusinglaan 1, Groningen 9713 AV, The Netherlands.

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http://dx.doi.org/10.1016/j.jclinepi.2014.10.010DOI Listing
March 2015

The conflicting roles of tumor stroma in pancreatic cancer and their contribution to the failure of clinical trials: a systematic review and critical appraisal.

Cancer Metastasis Rev 2015 Mar;34(1):97-114

Laboratory for Experimental Oncology and Radiobiology, Center for Experimental Molecular Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105AZ, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1007/s10555-014-9541-1DOI Listing
March 2015

Number and frequency of albuminuria measurements in clinical trials in diabetic nephropathy.

Clin J Am Soc Nephrol 2015 Mar 7;10(3):410-6. Epub 2015 Jan 7.

Department of Clinical Pharmacy and Pharmacology, University Medical Center Groningen, Groningen, The Netherlands;

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http://dx.doi.org/10.2215/CJN.07780814DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4348688PMC
March 2015

Blocking Hedgehog release from pancreatic cancer cells increases paracrine signaling potency.

J Cell Sci 2015 Jan 29;128(1):129-39. Epub 2014 Oct 29.

Laboratory for Experimental Oncology and Radiobiology, Center for Experimental Molecular Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105AZ Amsterdam, The Netherlands

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http://dx.doi.org/10.1242/jcs.157966DOI Listing
January 2015

Effectiveness of seasonal influenza vaccine in community-dwelling elderly people: a meta-analysis of test-negative design case-control studies.

Lancet Infect Dis 2014 Dec 6;14(12):1228-39. Epub 2014 Nov 6.

Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands; Department of Mathematics and Computer Science, Eindhoven University of Technology, Eindhoven, Netherlands. Electronic address:

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http://dx.doi.org/10.1016/S1473-3099(14)70960-0DOI Listing
December 2014

G-computation might be used to control for confounding when estimating the population-level impact of interventions through outcome distribution curves.

J Clin Epidemiol 2014 Nov 19;67(11):1286. Epub 2014 Jul 19.

Department of Pharmacy, University of Groningen, Unit PharmacoEpidemiology and PharmacoEconomics (PE(2)), A. Deusinglaan 1, 9713 AV Groningen, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.jclinepi.2014.06.005DOI Listing
November 2014

Ptch2 mediates the Shh response in Ptch1-/- cells.

Development 2014 Sep 1;141(17):3331-9. Epub 2014 Aug 1.

Department of Molecular and Cell Biology, 16 Barker Hall, 3204, University of California, Berkeley, CA 94720, USA

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http://dx.doi.org/10.1242/dev.110056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4199129PMC
September 2014

Shh-mediated degradation of Hhip allows cell autonomous and non-cell autonomous Shh signalling.

Nat Commun 2014 Sep 12;5:4849. Epub 2014 Sep 12.

Department of Molecular and Cell Biology, University of California, 16 Barker Hall, 3204, Berkeley, California 94720, USA.

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http://dx.doi.org/10.1038/ncomms5849DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4163939PMC
September 2014

New places of remembrance: individual web memorials in the Netherlands.

Death Stud 2014 Jan-Jun;38(1-5):283-93. Epub 2013 Aug 28.

a Department of Cultural Geography, Faculty of Spatial Sciences , University of Groningen , Groningen , The Netherlands.

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http://dx.doi.org/10.1080/07481187.2012.742474DOI Listing
August 2014

Assessment of the stromal contribution to Sonic Hedgehog-dependent pancreatic adenocarcinoma.

Mol Oncol 2013 Dec 16;7(6):1031-42. Epub 2013 Aug 16.

Laboratory for Experimental Oncology and Radiobiology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105AZ Amsterdam, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.molonc.2013.08.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3838447PMC
December 2013

Assessing the effect of a guideline change on drug use prevalence by including the birth cohort dimension: the case of benzodiazepines.

Pharmacoepidemiol Drug Saf 2013 Sep 3;22(9):933-41. Epub 2013 Jun 3.

Unit Pharmacoepidemiology and Pharmacoeconomics (PE2), Department of Pharmacy, University of Groningen, Groningen, The Netherlands.

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http://dx.doi.org/10.1002/pds.3466DOI Listing
September 2013

Cancer Stem Cells, EMT, and Developmental Pathway Activation in Pancreatic Tumors.

Cancers (Basel) 2012 Oct 12;4(4):989-1035. Epub 2012 Oct 12.

Laboratory for Experimental Oncology and Radiobiology, Academic Medical Centre, Meibergdreef 9, 1105AZ Amsterdam, The Netherlands.

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http://dx.doi.org/10.3390/cancers4040989DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3712732PMC
October 2012

Inclusion of the birth cohort dimension improved description and explanation of trends in statin use.

J Clin Epidemiol 2012 Oct;65(10):1052-60

Unit PharmacoEpidemiology & PharmacoEconomics (PE(2)), Department of Pharmacy, University of Groningen, A. Deusinglaan 1, Groningen 9713 AV, The Netherlands.

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http://dx.doi.org/10.1016/j.jclinepi.2012.05.009DOI Listing
October 2012

Dichotomy in Hedgehog signaling between human healthy vessel and atherosclerotic plaques.

Mol Med 2012 Sep 25;18:1122-7. Epub 2012 Sep 25.

Department of Gastroenterology and Hepatology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.

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http://dx.doi.org/10.2119/molmed.2011.00250DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3474430PMC
September 2012

Hedgehog-stimulated chemotaxis is mediated by smoothened located outside the primary cilium.

Sci Signal 2012 Aug 21;5(238):ra60. Epub 2012 Aug 21.

Department of Molecular and Cell Biology, University of California, Berkeley, 16 Barker Hall, 3204, Berkeley, CA 94720, USA.

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http://dx.doi.org/10.1126/scisignal.2002798DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4557959PMC
August 2012

Human plasma very low density lipoprotein carries Indian hedgehog.

J Proteome Res 2010 Nov 14;9(11):6052-9. Epub 2010 Sep 14.

Department of Cell Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

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http://dx.doi.org/10.1021/pr100403qDOI Listing
November 2010

Assessing the efficacy of the hedgehog pathway inhibitor vitamin D3 in a murine xenograft model for pancreatic cancer.

Cancer Biol Ther 2010 Jul 26;10(1):79-88. Epub 2010 Jul 26.

Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.

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http://dx.doi.org/10.4161/cbt.10.1.12165DOI Listing
July 2010

Non-cell-autonomous signaling by Shh in tumors: challenges and opportunities for therapeutic targets.

Expert Opin Ther Targets 2010 Jul;14(7):693-702

University of California Berkeley, Department of Molecular and Cell Biology, Berkeley, CA 94720-3204, USA.

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http://dx.doi.org/10.1517/14728222.2010.497488DOI Listing
July 2010

Canonical Hedgehog signaling drives proangiogenic responses in endothelial cells.

Cell Cycle 2010 May 1;9(9):1683. Epub 2010 May 1.

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May 2010

The Hedgehog morphogen in myocardial ischemia-reperfusion injury.

Exp Biol Med (Maywood) 2010 Apr;235(4):447-54

Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA.

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http://dx.doi.org/10.1258/ebm.2009.009303DOI Listing
April 2010

Coagulation factor Xa inhibits cancer cell migration via protease-activated receptor-1 activation.

Thromb Res 2009 Jun 27;124(2):219-25. Epub 2009 Feb 27.

Department of Cell Biology, University of Groningen, Groningen, The Netherlands.

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http://dx.doi.org/10.1016/j.thromres.2009.01.015DOI Listing
June 2009

Establishment and characterization of immortalized Gli-null mouse embryonic fibroblast cell lines.

BMC Cell Biol 2008 Sep 13;9:49. Epub 2008 Sep 13.

Department of Surgery, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.

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http://dx.doi.org/10.1186/1471-2121-9-49DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2542994PMC
September 2008

Endogenous hedgehog expression contributes to myocardial ischemia-reperfusion-induced injury.

Exp Biol Med (Maywood) 2008 Aug 14;233(8):989-96. Epub 2008 May 14.

Center for Experimental and Molecular Medicine, Academic Medical Center, Meibergdreef 9, 1105AZ, Amsterdam, the Netherlands.

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http://dx.doi.org/10.3181/0711-RM-307DOI Listing
August 2008

Leukotriene synthesis is required for hedgehog-dependent neurite projection in neuralized embryoid bodies but not for motor neuron differentiation.

Stem Cells 2008 May 21;26(5):1138-45. Epub 2008 Feb 21.

Center for Experimental and Molecular Medicine, Academic Medical Center, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1634/stemcells.2007-0841DOI Listing
May 2008

(Pro-)vitamin D as treatment option for hedgehog-related malignancies.

Med Hypotheses 2008 17;70(1):202-3. Epub 2007 Sep 17.

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http://dx.doi.org/10.1016/j.mehy.2007.08.003DOI Listing
April 2008

Sonic hedgehog induces transcription-independent cytoskeletal rearrangement and migration regulated by arachidonate metabolites.

Cell Signal 2007 Dec 24;19(12):2596-604. Epub 2007 Aug 24.

Center for Experimental and Molecular Medicine, Room G2-105, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.cellsig.2007.08.011DOI Listing
December 2007

Protease-activated receptor-4 inhibition protects from multiorgan failure in a murine model of systemic inflammation.

Blood 2007 Nov 19;110(9):3176-82. Epub 2007 Jul 19.

Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Meibregdreef 9, 1105 AZ Amsterdam, The Netherlands.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2007-02-07
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http://dx.doi.org/10.1182/blood-2007-02-075440DOI Listing
November 2007

Coagulation factor Xa drives tumor cells into apoptosis through BH3-only protein Bim up-regulation.

Exp Cell Res 2007 Jul 19;313(12):2622-33. Epub 2007 Apr 19.

Center for Experimental and Molecular Medicine, Academic Medical Center, Meibergdreef 9, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.yexcr.2007.04.014DOI Listing
July 2007

Hedgehog turns lipoproteins into Janus-faced particles.

Trends Cardiovasc Med 2006 Oct;16(7):217-20

Academic Medical Center, Laboratory of Experimental Internal Medicine, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.tcm.2006.04.002DOI Listing
October 2006

A dual role for 7-dehydrocholesterol reductase in regulating Hedgehog signalling?

Development 2006 Oct;133(20):3951; author reply 3952-3

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http://dx.doi.org/10.1242/dev.02569DOI Listing
October 2006

Hedgehog morphogen in cardiovascular disease.

Circulation 2006 Oct;114(18):1985-91

Center for Experimental and Molecular Medicine, Academic Medical Center, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.106.619213DOI Listing
October 2006

Repression of smoothened by patched-dependent (pro-)vitamin D3 secretion.

PLoS Biol 2006 Jul;4(8):e232

Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef, Amsterdam, Netherlands.

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https://dx.plos.org/10.1371/journal.pbio.0040232
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http://dx.doi.org/10.1371/journal.pbio.0040232DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1502141PMC
July 2006

Hedgehog: an unusual signal transducer.

Bioessays 2004 Apr;26(4):387-94

Laboratory for Experimental Internal Medicine, Academic Medical Center, Amsterdam, The Netherlands.

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http://doi.wiley.com/10.1002/bies.20007
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April 2004