Mary Relling

Mary Relling

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Challenges in clinical implementation of CYP2D6 genotyping: choice of variants to test affects phenotype determination.

Genet Med 2020 01 25;22(1):232-233. Epub 2019 Jul 25.

Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN, USA.

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http://dx.doi.org/10.1038/s41436-019-0614-yDOI Listing
January 2020

The Clinical Pharmacogenetics Implementation Consortium: 10 Years Later.

Clin Pharmacol Ther 2020 Jan 5;107(1):171-175. Epub 2019 Nov 5.

Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.

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http://dx.doi.org/10.1002/cpt.1651DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6925644PMC
January 2020

Global Pharmacogenomics Within Precision Medicine: Challenges and Opportunities.

Clin Pharmacol Ther 2020 Jan 6;107(1):57-61. Epub 2019 Nov 6.

Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/cpt.1664DOI Listing
January 2020

Genomic Medicine Year in Review: 2019.

Am J Hum Genet 2019 Dec 5;105(6):1072-1075. Epub 2019 Dec 5.

National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.ajhg.2019.11.006DOI Listing
December 2019

Preemptively Precise: Returning and Updating Pharmacogenetic Test Results to Realize the Benefits of Preemptive Testing.

Clin Pharmacol Ther 2019 Nov 14;106(5):942-944. Epub 2019 Sep 14.

Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.

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http://dx.doi.org/10.1002/cpt.1613DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6777995PMC
November 2019

Considerations for pharmacogenomic testing in a health system.

Genet Med 2019 08 9;21(8):1886-1887. Epub 2019 Jan 9.

Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN, USA.

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http://www.nature.com/articles/s41436-018-0421-x
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http://dx.doi.org/10.1038/s41436-018-0421-xDOI Listing
August 2019

L-carnitine does not ameliorate asparaginase-associated hepatotoxicity in a C57BL6 mouse model.

Leuk Lymphoma 2019 Aug 4;60(8):2088-2090. Epub 2019 Feb 4.

a Department of Pharmaceutical Sciences , St. Jude Children's Research Hospital , Memphis , TN , USA.

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http://dx.doi.org/10.1080/10428194.2019.1571198DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6635003PMC
August 2019

Pharmacogenomics.

Lancet 2019 08 5;394(10197):521-532. Epub 2019 Aug 5.

Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA.

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http://dx.doi.org/10.1016/S0140-6736(19)31276-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6707519PMC
August 2019

Optimizing thiopurine dosing based on TPMT and NUDT15 genotypes: It takes two to tango.

Am J Hematol 2019 Jul 10;94(7):737-740. Epub 2019 Apr 10.

Department of Pharmacy, University of Patras School of Health Sciences, Patras, Greece.

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http://dx.doi.org/10.1002/ajh.25485DOI Listing
July 2019

Bloodstream infections exacerbate incidence and severity of symptomatic glucocorticoid-induced osteonecrosis.

Pediatr Blood Cancer 2019 06 13;66(6):e27669. Epub 2019 Feb 13.

Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee.

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http://dx.doi.org/10.1002/pbc.27669DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472979PMC
June 2019

The changing burden of long-term health outcomes in survivors of childhood acute lymphoblastic leukaemia: a retrospective analysis of the St Jude Lifetime Cohort Study.

Lancet Haematol 2019 Jun 8;6(6):e306-e316. Epub 2019 May 8.

Department of Epidemiology and Cancer Control, St Jude Children's Research Hospital, Memphis, TN, USA; Department of Oncology, St Jude Children's Research Hospital, Memphis, TN, USA; Departments of Pediatrics and Medicine, University of Tennessee Health Science Center, College of Medicine, Memphis, TN, USA.

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http://dx.doi.org/10.1016/S2352-3026(19)30050-XDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6756152PMC
June 2019

Hypersensitivity reactions to asparaginase in mice are mediated by anti-asparaginase IgE and IgG and the immunoglobulin receptors FcεRI and FcγRIII.

Haematologica 2019 02 20;104(2):319-329. Epub 2018 Sep 20.

Center for Pharmacogenetics and Department of Pharmaceutical Sciences, University of Pittsburgh, PA

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http://dx.doi.org/10.3324/haematol.2018.199448DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355496PMC
February 2019

Immediate Hypersensitivity to Polyethylene Glycols and Polysorbates: More Common Than We Have Recognized.

J Allergy Clin Immunol Pract 2019 May - Jun;7(5):1533-1540.e8. Epub 2018 Dec 14.

Division of Infectious Diseases, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tenn.

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http://dx.doi.org/10.1016/j.jaip.2018.12.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6706272PMC
December 2018

How to solve the problem of hypersensitivity to asparaginase?

Pediatr Blood Cancer 2018 03 22;65(3). Epub 2017 Nov 22.

Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee.

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http://dx.doi.org/10.1002/pbc.26884DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5766401PMC
March 2018

TP53 Germline Variations Influence the Predisposition and Prognosis of B-Cell Acute Lymphoblastic Leukemia in Children.

J Clin Oncol 2018 02 4;36(6):591-599. Epub 2018 Jan 4.

Maoxiang Qian, Xueyuan Cao, Wenjian Yang, Cheng Cheng, Hui Zhang, Takaya Moriyama, Gerard Zambetti, Kim E. Nichols, Ching-Hon Pui, Charles G. Mullighan, William E. Evans, Mary V. Relling, and Jun J. Yang, St Jude Children's Research Hospital, Memphis, TN; Meenakshi Devidas and Yunfeng Dai, University of Florida, Gainesville, FL; Andrew Carroll, University of Alabama at Birmingham, Birmingham, AL; Nyla A. Heerema and Julie M. Gastier-Foster, The Ohio State University and Wexner Medical Center; Julie M. Gastier-Foster and Elaine R. Mardis, Nationwide Children's Hospital, Columbus, OH; Hui Zhang, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong; Heng Xu, West China Hospital, Sichuan University and Collaborative Innovation Center, Chengdu, China; Elizabeth Raetz, University of Utah, Salt Lake City, UT; Eric Larsen, Maine Children's Cancer Program, Scarborough, ME; Naomi Winick, University of Texas Southwestern Medical Center, Dallas; W. Paul Bowman, Cook Children's Medical Center, Fort Worth, TX; Paul L. Martin, Duke University, Durham, NC; Robert Fulton, Washington University School of Medicine, St Louis, MO; Michael Borowitz, Johns Hopkins Medical Institute, Baltimore, MD; Brent Wood, University of Washington, Seattle, WA; William L. Carroll, New York University, New York, NY; Stephen P. Hunger, Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, PA; and Mignon L. Loh, Benioff Children's Hospital and University of California, San Francisco, San Francisco, CA.

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http://dx.doi.org/10.1200/JCO.2017.75.5215DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5815403PMC
February 2018

Klinefelter syndrome and 47,XYY syndrome in children with B cell acute lymphoblastic leukaemia.

Br J Haematol 2017 12 19;179(5):843-846. Epub 2016 Jul 19.

Department of Pediatrics and the Center for Childhood Cancer Research, Children's Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.

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http://dx.doi.org/10.1111/bjh.14258DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5247399PMC
December 2017

Reply to I.J. Cohen.

J Clin Oncol 2017 12 18;35(35):3989-3991. Epub 2017 Oct 18.

Kristina K. Hardy, Children's National Medical Center, Washington, DC; Leanne M. Embry, University of Texas at San Antonio, San Antonio, TX; John A. Kairalla, University of Florida, Gainesville, FL; Shanjun Helian, Merck, Upper Gwynedd, PA; Meenakshi Devidas, University of Florida, Gainesville, FL; F. Daniel Armstrong, University of Miami, Miami, FL; Stephen Hunger, Children's Hospital of Philadelphia, Philadelphia, PA; William L. Carroll, New York University, New York, NY; Eric Larsen, Maine Children's Cancer Program, Scarborough, ME; Elizabeth A. Raetz, University of Utah, Salt Lake City, UT; Mignon L. Loh, University of California at San Francisco, San Francisco, CA; Wenjian Yang and Mary V. Relling, St Jude Children's Research Hospital and University of Tennessee, Memphis, TN; Robert B. Noll, University of Pittsburgh, Pittsburgh, PA; and Naomi Winick, University of Texas Southwestern, Dallas, TX.

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http://dx.doi.org/10.1200/JCO.2017.75.7252DOI Listing
December 2017

Differential effects of thiopurine methyltransferase (TPMT) and multidrug resistance-associated protein gene 4 (MRP4) on mercaptopurine toxicity.

Cancer Chemother Pharmacol 2017 Aug 16;80(2):287-293. Epub 2017 Jun 16.

Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN, 38105-2794, USA.

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http://dx.doi.org/10.1007/s00280-017-3361-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5628515PMC
August 2017

Genetics of pleiotropic effects of dexamethasone.

Pharmacogenet Genomics 2017 08;27(8):294-302

Departments of aPharmaceutical Sciences bBiostatistics cOncology dComprehensive Cancer Center, St Jude Children's Research Hospital, Memphis, Tennessee, USA.

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http://dx.doi.org/10.1097/FPC.0000000000000293DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5523978PMC
August 2017

Neurocognitive Functioning of Children Treated for High-Risk B-Acute Lymphoblastic Leukemia Randomly Assigned to Different Methotrexate and Corticosteroid Treatment Strategies: A Report From the Children's Oncology Group.

J Clin Oncol 2017 Aug 3;35(23):2700-2707. Epub 2017 Jul 3.

Kristina K. Hardy, Children's National Medical Center, Washington, DC; Leanne Embry, The University of Texas Health Science Center at San Antonio, San Antonio; Naomi Winick, University of Texas Southwestern Medical Center, Dallas, TX; John A. Kairalla and Meenakshi Devidas, Colleges of Medicine, Public Health and Health Professions, University of Florida, Gainesville; Daniel Armstrong, University of Miami, Sylvester Comprehensive Cancer Center, Miami, FL; Shanjun Helian, Merck, Upper Gwynedd; Stephen Hunger, Children's Hospital of Philadelphia, Philadelphia; Robert B. Noll, University of Pittsburgh School of Medicine, Pittsburgh, PA; William L. Carroll, New York University Medical Center, New York, NY; Eric Larsen, Maine Children's Cancer Program, Scarborough, ME; Elizabeth A. Raetz, University of Utah, Salt Lake City, UT; Mignon L. Loh, University of California, San Francisco, San Francisco, CA; and Wenjian Yang and Mary V. Relling, St Jude Children's Research Hospital; University of Tennessee Health Science Center, Memphis, TN.

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http://dx.doi.org/10.1200/JCO.2016.71.7587DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5549456PMC
August 2017

Osteonecrosis is unrelated to hip anatomy in children with acute lymphoblastic leukemia.

Pediatr Blood Cancer 2017 Jul 30;64(7). Epub 2016 Dec 30.

Department of Diagnostic Imaging, St. Jude Children's Research Hospital, Memphis, Tennessee.

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http://dx.doi.org/10.1002/pbc.26407DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5596390PMC
July 2017

Mercaptopurine Ingestion Habits, Red Cell Thioguanine Nucleotide Levels, and Relapse Risk in Children With Acute Lymphoblastic Leukemia: A Report From the Children's Oncology Group Study AALL03N1.

J Clin Oncol 2017 May 24;35(15):1730-1736. Epub 2017 Mar 24.

Wendy Landier, Lindsey Hageman, Yanjun Chen, and Smita Bhatia, University of Alabama at Birmingham, Birmingham, AL; Nancy Kornegay, William E. Evans, and Mary V. Relling, St. Jude Children's Research Hospital, Memphis, TN; Bruce C. Bostrom, Children's Hospitals and Clinics of Minnesota, Minneapolis, MN; Jacqueline Casillas, David Geffen School of Medicine at University of California Los Angeles, Los Angeles; Leo Mascarenhas and Amanda M. Termuhlen, Children's Hospital Los Angeles, Los Angeles; F. Lennie Wong, City of Hope, Duarte, CA; David S. Dickens, Helen DeVos Children's Hospital at Spectrum Health/Spectrum Health at Butterworth Campus, Grand Rapids, MI; Anne L. Angiolillo, The George Washington School of Medicine, Washington, DC; Glen Lew, Children's Healthcare of Atlanta, Emory University, Atlanta, GA; Kelly W. Maloney, University of Colorado School of Medicine, Aurora, CO; A. Kim Ritchey, Children's Hospital of Pittsburgh of University of Pittsburgh Medical Center, Pittsburgh, PA; and William L. Carroll, Perlmutter Cancer Center, New York University-Langone Medical Center, New York, NY.

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http://dx.doi.org/10.1200/JCO.2016.71.7579DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5455766PMC
May 2017

Development of a postgraduate year 2 pharmacy residency in clinical pharmacogenetics.

Am J Health Syst Pharm 2017 Mar;74(6):409-415

Pharmaceutical Sciences Department, St. Jude Children's Research Hospital, Memphis, TN.

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http://dx.doi.org/10.2146/ajhp160174DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5499519PMC
March 2017

The impact of the UGT1A1*60 allele on bilirubin serum concentrations.

Pharmacogenomics 2017 Jan 14;18(1):5-16. Epub 2016 Dec 14.

Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN, USA.

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http://dx.doi.org/10.2217/pgs-2016-0135DOI Listing
January 2017

Evidence and resources to implement pharmacogenetic knowledge for precision medicine.

Am J Health Syst Pharm 2016 Dec;73(23):1977-1985

Pharmacogenomics Knowledgebase (PharmGKB), Stanford University School of Medicine, Palo Alto, CA.

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http://dx.doi.org/10.2146/ajhp150977DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5117674PMC
December 2016

Prophylactic Trimethoprim-Sulfamethoxazole Does Not Affect Pharmacokinetics or Pharmacodynamics of Methotrexate.

J Pediatr Hematol Oncol 2016 08;38(6):449-52

Departments of *Pharmaceutical Sciences §Oncology †Biostatistics, St Jude Children's Research Hospital, Memphis, TN ‡Department of Pediatric Oncology, Skejby Hospital, Aarhus University, Aarhus, Denmark.

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http://dx.doi.org/10.1097/MPH.0000000000000606DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4955728PMC
August 2016

Asparaginase Potentiates Glucocorticoid-Induced Osteonecrosis in a Mouse Model.

PLoS One 2016 11;11(3):e0151433. Epub 2016 Mar 11.

Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0151433PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4788417PMC
July 2016

Clinical and Genetic Risk Factors for Acute Pancreatitis in Patients With Acute Lymphoblastic Leukemia.

J Clin Oncol 2016 06 25;34(18):2133-40. Epub 2016 Apr 25.

Chengcheng Liu, Wenjian Yang, Cheng Cheng, Deqing Pei, Colton Smith, Sima Jeha, Ching-Hon Pui, William E. Evans, and Mary V. Relling, St Jude Children's Research Hospital; Scott C. Howard, University of Memphis, Memphis, TN; Meenakshi Devidas, University of Florida, Gainesville, FL; William L. Carroll, New York University Langone Medical Center, New York, NY; Elizabeth A. Raetz, University of Utah, Salt Lake City, UT; W. Paul Bowman, Cook Children's Hospital, Ft Worth; Naomi J. Winick, University of Texas Southwestern Medical Center, Dallas, TX; Eric C. Larsen, Maine Children's Cancer Program, Scarborough, ME; Kelly W. Maloney, University of Colorado Denver, Aurora, CO; Paul L. Martin, Duke University, Durham, NC; Leonard A. Mattano Jr, HARP Pharma Consulting, Mystic, CT; Elaine R. Mardis and Robert S. Fulton, The McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO; Deepa Bhojwani, Children's Hospital of Los Angeles, Los Angeles; Mignon L. Loh, University of California San Francisco Medical Center-Parnassus, San Francisco, CA; and Stephen P. Hunger, Children's Hospital of Philadelphia, Philadelphia, PA.

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http://dx.doi.org/10.1200/JCO.2015.64.5812DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4962704PMC
June 2016

Pharmacogenomics in the clinic.

Nature 2015 Oct;526(7573):343-50

Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee 38105-2794, USA.

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http://dx.doi.org/10.1038/nature15817DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4711261PMC
October 2015

Comparable efficacy with varying dosages of glucarpidase in pediatric oncology patients.

Pediatr Blood Cancer 2015 Sep 28;62(9):1518-22. Epub 2015 Jan 28.

Pharmaceutical Department, St. Jude Children's Research Hospital, Memphis, Tennessee.

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http://dx.doi.org/10.1002/pbc.25395DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4770903PMC
September 2015

Childhood Acute Lymphoblastic Leukemia: Progress Through Collaboration.

J Clin Oncol 2015 Sep 24;33(27):2938-48. Epub 2015 Aug 24.

Ching-Hon Pui, Jun J. Yang, James R. Downing, Williams E. Evans, Mary V. Relling, and Charles G. Mullighan, St Jude Children's Research Hospital and the University of Tennessee Health Science Center, Memphis, TN; Stephen P. Hunger, University of Colorado School of Medicine and the University of Colorado Cancer Center and Children's Hospital Colorado, Aurora, CO; Rob Pieters, Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands; Martin Schrappe, University Medical Center Schleswig-Holstein, Christian-Albrechts-University, Kiel; Gabriele Escherich, Clinic of Pediatric Hematology and Oncology, University Medical Center Hamburg Eppendorf, Hamburg, Germany; Andrea Biondi, Clinica Pediatrica and Centro Ricerca Tettamanti, Università di Milano-Bicocca, Monza, Italy; Ajay Vora, Children's Cancer Group, School of Cancer, Manchester Academic Health Sciences Centre, University of Manchester, Manchester, United Kingdom; André Baruchel, Hôpital Robert Debré and University of Paris Diderot, Paris, France; Lewis B. Silverman, Dana-Farber Cancer Institute and Boston Children's Hospital, Boston, MA; Kjeld Schmiegelow, Institute of Clinical Medicine, University of Copenhagen and Juliane Marie Centre, the University Hospital Rigshospitalet, Copenhagen, Denmark; Keizo Horibe, Nagoya Medical Center, Clinical Research Center, Nagoya, Japan; Yves C.M. Benoit, Universiteit Gent, Gent, Belgium; Shai Izraeli, Chaim Sheba Medical Center and Sackler Medical School, Tel Aviv University, Tel Aviv, Israel; Allen Eng Juh Yeoh, Yong Loo Lin School of Medicine and Cancer Science Institute, National University of Singapore, and Viva-University Children's Cancer Centre, National University Hospital, Singapore; and Der-Cherng Liang, Mackay Memorial Hospital, Taipei, Taiwan.

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http://jco.ascopubs.org/content/early/2015/08/21/JCO.2014.59
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http://200.40.135.66:90/toc/0873/2015/0873-20150920-27-01.pd
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http://jco.ascopubs.org/cgi/doi/10.1200/JCO.2014.59.1636
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http://dx.doi.org/10.1200/JCO.2014.59.1636DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4567699PMC
September 2015

Inherited genetic variation in childhood acute lymphoblastic leukemia.

Blood 2015 Jun 21;125(26):3988-95. Epub 2015 May 21.

Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN.

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http://dx.doi.org/10.1182/blood-2014-12-580001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4481591PMC
June 2015

A new system identification approach to identify genetic variants in sequencing studies for a binary phenotype.

Hum Hered 2014 30;78(2):104-16. Epub 2014 Jul 30.

Department of Biostatistics and Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tenn., USA.

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http://dx.doi.org/10.1159/000363660DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4270367PMC
April 2015

Inherited NUDT15 variant is a genetic determinant of mercaptopurine intolerance in children with acute lymphoblastic leukemia.

J Clin Oncol 2015 Apr 26;33(11):1235-42. Epub 2015 Jan 26.

Jun J. Yang, Wenjian Yang, Chengcheng Liu, Cheng Cheng, Deqing Pei, Kristine R. Crews, Nancy Kornegay, William E. Evans, Ching-Hon Pui, and Mary V. Relling, St Jude Children's Research Hospital, Memphis, TN; and Wendy Landier, Lindsey Hageman, Yanjun Chen, F. Lennie Wong, and Smita Bhatia, City of Hope, Duarte, CA.

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http://jco.ascopubs.org/content/33/11/1235.full.pdf
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http://jco.ascopubs.org/cgi/doi/10.1200/JCO.2014.59.4671
Publisher Site
http://dx.doi.org/10.1200/JCO.2014.59.4671DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4375304PMC
April 2015

Effect of premedications in a murine model of asparaginase hypersensitivity.

J Pharmacol Exp Ther 2015 Mar 8;352(3):541-51. Epub 2015 Jan 8.

Department of Pharmaceutical Sciences (C.A.F., C.S., S.E.K., L.B.R., C.L., W.E.E., M.V.R.) and Department of Oncology (S.E.K., C.-H.P., S.J.), St. Jude Children's Research Hospital, Memphis, Tennessee; Department of Medicine, Cincinnati Veterans Affairs Medical Center, Cincinnati, Ohio (F.D.F.); Department of Internal Medicine, Division of Immunology, Allergy and Rheumatology, University of Cincinnati College of Medicine, Cincinnati, Ohio (F.D.F.); and Division of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio (F.D.F.)

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http://dx.doi.org/10.1124/jpet.114.220780DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4352598PMC
March 2015

Utility of early screening magnetic resonance imaging for extensive hip osteonecrosis in pediatric patients treated with glucocorticoids.

J Clin Oncol 2015 Feb 20;33(6):610-5. Epub 2015 Jan 20.

Sue C. Kaste, Deqing Pei, Cheng Cheng, Michael D. Neel, Raul C. Ribeiro, Monika L. Metzger, Deepa Bhojwani, Hiroto Inaba, Patrick Campbell, Jeffrey E. Rubnitz, Sima Jeha, John T. Sandlund, James R. Downing, Mary V. Relling, Ching-Hon Pui, and Scott C. Howard, St Jude Children's Research Hospital; Sue C. Kaste, University of Tennessee Health Sciences Center, Memphis, TN; and W. Paul Bowman, Cook Children's Medical Center, Fort Worth, TX.

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http://dx.doi.org/10.1200/JCO.2014.57.5480DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4322260PMC
February 2015

Evidence synthesis and guideline development in genomic medicine: current status and future prospects.

Genet Med 2015 Jan 19;17(1):63-7. Epub 2014 Jun 19.

1] Epidemiology and Genomics Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, Maryland, USA [2] Office of Public Health Genomics, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.

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http://dx.doi.org/10.1038/gim.2014.69DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4272332PMC
January 2015

Severe hypertriglyceridaemia during therapy for childhood acute lymphoblastic leukaemia.

Eur J Cancer 2014 Oct 30;50(15):2685-94. Epub 2014 Jul 30.

Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN, USA; Department of Pediatrics, University of Tennessee Health Sciences Center, Memphis, TN, USA.

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http://dx.doi.org/10.1016/j.ejca.2014.06.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4180109PMC
October 2014

A comprehensive evaluation of collapsing methods using simulated and real data: excellent annotation of functionality and large sample sizes required.

Front Genet 2014 15;5:323. Epub 2014 Sep 15.

Institut für Medizinische Biometrie und Statistik, Universität zu Lübeck, Universitätsklinikum Schleswig-Holstein Lübeck, Germany ; Zentrum für Klinische Studien, Universität zu Lübeck Lübeck, Germany ; School of Mathematics, Statistics and Computer Science, University of KwaZulu-Natal Durban, South Africa.

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http://dx.doi.org/10.3389/fgene.2014.00323DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4164031PMC
October 2014

Targetable kinase-activating lesions in Ph-like acute lymphoblastic leukemia.

N Engl J Med 2014 Sep;371(11):1005-15

From the Departments of Pathology (K.G.R., D.P.-T., Y.-L.Y., K. McCastlain, G.S., J.M., S.-C.C., J.C., N.S.-M., I.I., J.W., J.R.D., C.G.M.), Computational Biology and Bioinformatics (Y.L., J.B., M.R., E.H., P.G., P.N., G.W., X.C., J.Z.), Biostatistics (D.P., C.C.), Pharmaceutical Sciences (S.W.P., M.V.R., W.E.E.), and Oncology (C.-H.P., S.J.), the Pediatric Cancer Genome Project (Y.L., L.D., C.L., M.R., J.E., J.C., K.B., R.S.F., E.H., P.G., P.N., G.W., X.C., D.Y., B.V., H.M., M.V.R., W.E.E., E.M., R.K.W., J.R.D., J.Z., C.G.M.), and Cytogenetics Shared Resource (M.V.), St. Jude Children's Research Hospital, Memphis, TN; the University of New Mexico Cancer Center and School of Medicine, Albuquerque (R.C.H., I-M.C., C.L.W.); the Genome Institute at Washington University (L.D., C.L., R.S.F., E.M., R.K.W.), the Department of Genetics, Washington University School of Medicine (L.D., C.L., R.S.F., E.M., R.K.W.), and Siteman Cancer Center, Washington University (E.M., R.K.W.) - all in St. Louis; Epidemiology and Health Policy Research, College of Medicine, University of Florida, Gainesville (M.D.); the Research Institute at Nationwide Children's Hospital (S.R., A.S., J.M.G.-F.), the Department of Pathology, College of Medicine, Ohio State University (N.A.H.), and Ohio State University Comprehensive Cancer Center (G.M., C.D.B., K. Mrózek, J.K.) - all in Columbus, OH; the Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas (N.J.W.), Scott and White Hospitals and Clinics and Texas A&M Health Science Center, Temple (G.G.), the University of Texas Health Science Center San Antonio, San Antonio (M.F.-J.), and the Departments of Leukemia and Stem Cell Transplantation, Division of Cancer Medicine, University of Texas M.D. Anderson Cancer Center, Houston (S.M.K., M.K.) - all in Texas; Maine Children's Cancer Program, Scarborough (E.C.L.); New York University Cancer Institute, New York (W.L.C.), and the Department of Medicine (Oncology), Albert Einstein

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http://dx.doi.org/10.1056/NEJMoa1403088DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4191900PMC
September 2014

Host thiopurine methyltransferase status affects mercaptopurine antileukemic effectiveness in a murine model.

Pharmacogenet Genomics 2014 May;24(5):263-71

Departments of aPharmaceutical Sciences bPathology cBiostatistics dOncology, St Jude Children's Research Hospital (Current address Puma Biotechnology Inc., Los Angeles, CA 90024, USA) eDepartment of Tumor Cell Biology, Howard Hughes Medical Institute, St Jude Children's Research Hospital, Memphis, Tennessee, USA.

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http://dx.doi.org/10.1097/FPC.0000000000000044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4019208PMC
May 2014

Hyaluronan synthase 3 variant and anthracycline-related cardiomyopathy: a report from the children's oncology group.

J Clin Oncol 2014 Mar 27;32(7):647-53. Epub 2014 Jan 27.

Xuexia Wang, University of Wisconsin-Milwaukee, Milwaukee, WI; Wei Liu and Yutaka Yasui, University of Alberta; Sunil Desai, Stollery Children's Hospital, Edmonton, AB, Canada; Can-Lan Sun, Saro H. Armenian, Lindsey Hageman, Yan Ding, Wendy Landier, and Smita Bhatia, City of Hope, Duarte; Lu Chen, University of Southern California, Los Angeles, CA; Hakon Hakonarson and Jill P. Ginsberg, Children's Hospital of Philadelphia, Philadelphia, PA; Javier G. Blanco, Alfo Quiñones, and Daniel Ferguson, The State University of New York at Buffalo, Buffalo; Charles A. Sklar, Memorial Sloan-Kettering Cancer Center, New York City; Irene Cherrick, Upstate Medical University, Syracuse, NY; Naomi Winick, University of Texas Southwestern Medical Center, Dallas; Zoann E. Dreyer, Baylor College of Medicine, Houston, TX; Frank Keller, Children's Healthcare of Atlanta and Emory University School of Medicine, Atlanta, GA; Joseph P. Neglia, University of Minnesota Medical School, Minneapolis, MN; Sharon M. Castellino, Wake Forest University Health Sciences, Winston-Salem, NC; and Melissa M. Hudson, Leslie L. Robison, and Mary V. Relling, St. Jude Children's Research Hospital, Memphis, TN.

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http://dx.doi.org/10.1200/JCO.2013.50.3557DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3927733PMC
March 2014

Methotrexate-induced neurotoxicity and leukoencephalopathy in childhood acute lymphoblastic leukemia.

J Clin Oncol 2014 Mar 18;32(9):949-59. Epub 2014 Feb 18.

All authors: St Jude Children's Research Hospital; and Deepa Bhojwani, Jun J. Yang, Hiroto Inaba, Jeffrey E. Rubnitz, Monika L. Metzger, Scott C. Howard, Raul C. Ribeiro, Sima Jeha, John T. Sandlund, and Ching-Hon Pui, University of Tennessee Health Sciences Center, College of Medicine, Memphis, TN.

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http://dx.doi.org/10.1200/JCO.2013.53.0808DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3948096PMC
March 2014